Published in Nat Med on August 01, 1997
Structure--function relationships in HIV-1 Nef. EMBO Rep (2001) 2.87
Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. J Virol (2001) 1.80
Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression. J Virol (2000) 1.66
PAK1 as a therapeutic target. Expert Opin Ther Targets (2010) 1.48
Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1. J Virol (1999) 1.47
Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J Virol (2000) 1.46
Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. EMBO J (1999) 1.45
Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. J Virol (2006) 1.41
Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques. J Virol (2001) 1.33
Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism. J Virol (2005) 1.29
The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo. J Virol (1999) 1.26
Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques. J Virol (1998) 1.23
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J Virol (2004) 1.20
Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques. J Virol (2004) 1.12
Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. J Virol (2003) 1.11
A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2. J Virol (2006) 1.10
Regions of human immunodeficiency virus type 1 nef required for function in vivo. J Virol (1998) 1.09
Mechanisms of HIV-1 Nef function and intracellular signaling. J Neuroimmune Pharmacol (2011) 1.04
T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques. J Virol (2002) 1.02
Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol (2010) 0.98
CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection. J Exp Med (2003) 0.98
Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques. J Virol (2000) 0.96
Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation. J Virol (2001) 0.95
Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques. J Virol (2006) 0.92
Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation. J Virol (2005) 0.92
Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo. Retrovirology (2009) 0.91
Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs. J Virol (2006) 0.91
Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation. J Virol (1999) 0.90
Meta-analysis to test the association of HIV-1 nef amino acid differences and deletions with disease progression. J Virol (2010) 0.88
Simian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques. J Virol (2001) 0.83
Effect of the attenuating deletion and of sequence alterations evolving in vivo on simian immunodeficiency virus C8-Nef function. J Virol (1999) 0.82
Altered plaque formation by recombinant vaccinia virus expressing simian immunodeficiency virus Nef. J Virol (1998) 0.77
The KT Jeang Retrovirology prize 2016: Frank Kirchhoff. Retrovirology (2016) 0.75
Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science (1992) 9.30
Hospitalization costs associated with homelessness in New York City. N Engl J Med (1998) 5.90
Improvement of PCR amplified DNA sequencing with the aid of detergents. Nucleic Acids Res (1990) 5.13
Hospital characteristics and mortality rates. N Engl J Med (1989) 4.97
Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol (2011) 3.55
Nucleotide sequence of the envelope gene of Friend murine leukemia virus. J Virol (1983) 3.41
Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. J Virol (1993) 3.37
GFAP promoter-controlled EGFP-expressing transgenic mice: a tool to visualize astrocytes and astrogliosis in living brain tissue. Glia (2001) 3.20
Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus. J Gen Virol (1987) 3.18
The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J (1998) 3.17
Exosomes are released by cultured cortical neurones. Mol Cell Neurosci (2006) 3.07
DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J Virol (2001) 2.95
Defining the beginning and end of KpnI family segments. EMBO J (1984) 2.84
Expression of a cytoplasmic LINE-1 transcript is regulated in a human teratocarcinoma cell line. Proc Natl Acad Sci U S A (1985) 2.72
Shedding and interspecies type sero-reactivity of the envelope glycopolypeptide gp120 of the human immunodeficiency virus. J Gen Virol (1986) 2.65
High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J Virol (1996) 2.61
Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J (1997) 2.57
CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals. Proc Natl Acad Sci U S A (1993) 2.51
A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol (1998) 2.50
Carbohydrates of human immunodeficiency virus. Structures of oligosaccharides linked to the envelope glycoprotein 120. J Biol Chem (1988) 2.48
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J (1997) 2.27
Rapid infection of oral mucosal-associated lymphoid tissue with simian immunodeficiency virus. Science (1999) 2.21
Rapid mucosal CD4(+) T-cell depletion and enteropathy in simian immunodeficiency virus-infected rhesus macaques. Gastroenterology (1999) 2.20
Properties of mouse leukemia viruses. VII. The major viral glycoprotein of friend leukemia virus. Isolation and physicochemical properties. Virology (1974) 2.09
Subregions of a conserved part of the HIV gp41 transmembrane protein are differentially recognized by antibodies of infected individuals. EMBO J (1986) 2.01
Evaluation of the HCFA model for the analysis of mortality following hospitalization. Health Serv Res (1992) 1.99
Properties of mouse leukemia viruses. VIII. The major viral glycoprotein of Friend leukemia virus. Seroimmunological, interfering and hemagglutinating capacities. Virology (1974) 1.98
Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nat Med (1998) 1.89
Mechanism for down-regulation of CD28 by Nef. EMBO J (2001) 1.87
Association between fulminant hepatic failure and a strain of GBV virus C. Lancet (1996) 1.82
Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. J Virol (2001) 1.80
Analysis of the systemic and intrathecal humoral immune response in progressive multifocal leukoencephalopathy. J Infect Dis (1997) 1.79
Ioxaglate-induced light and electron microscopic alterations in the renal proximal tubular epithelium of rats. Invest Radiol (1991) 1.75
[Production of substantial amounts of Friend leukemia virus by a suspension tissue culture line (Eveline suspension cells) (author's transl)]. Z Naturforsch C (1976) 1.69
Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proc Natl Acad Sci U S A (1995) 1.69
Generation of monoclonal antibodies against human prion proteins in PrP0/0 mice. Mol Med (1996) 1.68
Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression. J Virol (2000) 1.66
Characteristics of fatal ambulance crashes in the United States: an 11-year retrospective analysis. Prehosp Emerg Care (2001) 1.64
Polypeptides of mammalian oncornaviruses. II Characterization of murine leukemia virus polypeptide (p 15) bearing interspecies reactivity. Virology (1975) 1.63
Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses. Virology (1973) 1.59
The abundant LINE-1 family of repeated DNA sequences in mammals: genes and pseudogenes. Cold Spring Harb Symp Quant Biol (1986) 1.55
Cellular immune response of rhesus monkeys infected with a partially attenuated nef deletion mutant of the simian immunodeficiency virus. Virology (1995) 1.55
Distribution of human endogenous retrovirus HERV-K genomes in humans and different primates. Hum Genet (1995) 1.52
Normal immune function and inability to isolate virus in culture in an individual with long-term human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses (1994) 1.51
vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys. J Virol (1995) 1.51
Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure. Kidney Int (1999) 1.51
Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning. Biochem Biophys Res Commun (1986) 1.50
Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Dev Biol (2000) 1.49
Metabolic disorder as early consequence of simian immunodeficiency virus infection in rhesus macaques. Lancet (1991) 1.48
Polypeptides of mammalian oncornaviruses. III. Localization of p 15 and reactivity with natural antibody. Virology (1975) 1.48
Properties of mouse leukemia viruses. X. Occurrence of viral structural antigens on the cell surface as revealed by a cytotoxicity test. Virology (1976) 1.47
Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors. Ann Oncol (2013) 1.46
Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes. Blood (2000) 1.46
Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J Virol (2000) 1.46
Evidence for the cooperation of gp120 amino acids 322 and 448 in SIVmac entry. Virology (1993) 1.45
Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. EMBO J (1999) 1.45
Glia: the fulcrum of brain diseases. Cell Death Differ (2007) 1.45
Immunoprevention of Friend virus-induced erythroleukemia by vaccination with viral envelope glycoprotein complexes. Virology (1981) 1.43
Prestige of training programs and experience of bypass surgeons as factors in adjusted patient mortality rates. Med Care (1999) 1.41
The relationship between adjusted hospital mortality and the results of peer review. Health Serv Res (1993) 1.40
C-type particles produced by a permanent cell line from a leukemic pig. I. Origin and properties of the host cells and some evidence for the occurrence of C-type-like particles. Virology (1974) 1.38
Acute renal endothelial injury during marrow recovery in a cohort of combined kidney and bone marrow allografts. Am J Transplant (2011) 1.38
[Assisted suicide in dementia. Ethical considerations between paternalism and autonomy]. Nervenarzt (1997) 1.38
Properties of mouse leukemia viruses. IX. Active and passive immunization of mice against Friend leukemia with isolated viral GP71 glycoprotein and its corresponding antiserum. Virology (1975) 1.37
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc Natl Acad Sci U S A (1995) 1.37
Cellular and humoral immune response in progressive multifocal leukoencephalopathy. Ann Neurol (2001) 1.35
Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. Biochem J (1991) 1.34
Astrocytes of the mouse neocortex express functional N-methyl-D-aspartate receptors. FASEB J (2001) 1.33
Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques. J Virol (2001) 1.33
Neutralizing antibodies and the course of HIV-induced disease. AIDS Res Hum Retroviruses (1987) 1.29
Gene expression during preimplantation mouse development. Genes Dev (1992) 1.28
Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus. J Gen Virol (1996) 1.27
Mgmt methylation is a prognostic biomarker in elderly patients with newly diagnosed glioblastoma. Neurology (2009) 1.27
DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions. J Virol (2001) 1.27
The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo. J Virol (1999) 1.26
Properties of mouse leukemia viruses. XI. Immunoelectron microscopic studies on viral structural antigens on the cell surface. Virology (1976) 1.25