Published in J Virol on December 01, 2005
HIV-1 Nef: at the crossroads. Retrovirology (2008) 1.88
Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells. EMBO J (2006) 1.64
A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2. J Virol (2006) 1.10
Suppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration. Mol Cell (2009) 1.10
The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infection. J Virol (2008) 1.04
CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable. Virology (2006) 0.92
Inhibition of HIV-1 infection and replication by enhancing viral incorporation of innate anti-HIV-1 protein A3G: a non-pathogenic Nef mutant-based anti-HIV strategy. J Biol Chem (2009) 0.85
Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix. Retrovirology (2012) 0.85
Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2. Retrovirology (2011) 0.84
Intra- and intersubtype alternative Pak2-activating structural motifs of human immunodeficiency virus type 1 Nef. J Virol (2006) 0.79
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Activation/proliferation and apoptosis of bystander goat lymphocytes induced by a macrophage-tropic chimeric caprine arthritis encephalitis virus expressing SIV Nef. Virology (2007) 0.78
Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques. Virology (2010) 0.75
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Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature (2005) 13.15
Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature (2005) 11.12
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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
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Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell (2003) 2.23
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity (2001) 1.92
HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc Natl Acad Sci U S A (1999) 1.92
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem (2002) 1.82
Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family. J Virol (1996) 1.69
Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression. Oncogene (2004) 1.61
The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol (2005) 1.60
Identification of the Nef-associated kinase as p21-activated kinase 2. Curr Biol (1999) 1.58
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Nef: agent of cell subversion. Microbes Infect (2002) 1.41
Deficiency of small GTPase Rac2 affects T cell activation. J Exp Med (2001) 1.33
Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function. Oncogene (2004) 1.32
Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization. J Biol Chem (2004) 1.30
Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins. Oncogene (1999) 1.22
Lentivirus Nef specifically activates Pak2. J Virol (2000) 1.18
Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts. J Virol (2004) 0.97
Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates. J Virol (2001) 0.95
The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function. J Biol Chem (2005) 0.94
HIV: viral blitzkrieg. Nature (2005) 0.92
NF2: the wizardry of merlin. Genes Chromosomes Cancer (2003) 0.89
A novel role for p21-activated protein kinase 2 in T cell activation. J Immunol (2004) 0.87
Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex. J Virol (2005) 0.83
Integrative genomic profiling of human prostate cancer. Cancer Cell (2010) 23.61
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell (2011) 7.32
Perturbations of the AKT signaling pathway in human cancer. Oncogene (2005) 6.64
Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med (2008) 5.81
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat Med (2006) 5.36
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell (2010) 3.79
Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1. J Exp Med (2007) 3.75
Overcoming mutation-based resistance to antiandrogens with rational drug design. Elife (2013) 3.49
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene (2004) 2.67
Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism. Am J Respir Crit Care Med (2002) 2.56
Inhibition of endosomal/lysosomal degradation increases the infectivity of human immunodeficiency virus. J Virol (2002) 2.43
BAP1 and cancer. Nat Rev Cancer (2013) 2.23
Mesothelioma epidemiology, carcinogenesis, and pathogenesis. Curr Treat Options Oncol (2008) 2.20
Generation of HIV latency in humanized BLT mice. J Virol (2011) 2.20
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov (2013) 2.15
TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci U S A (2006) 2.14
Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection. J Virol (2005) 2.05
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
Chromosomal imbalances in human lung cancer. Oncogene (2002) 2.00
Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proc Natl Acad Sci U S A (2008) 1.97
Dengue fever in humanized NOD/SCID mice. J Virol (2005) 1.96
Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis (2004) 1.92
HIV-1 Nef: at the crossroads. Retrovirology (2008) 1.88
Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice. PLoS One (2010) 1.88
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell (2010) 1.85
A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor. Cancer J (2004) 1.85
GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. Mol Cell Biol (2006) 1.85
The pathogenesis of mesothelioma. Semin Oncol (2002) 1.80
APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol (2006) 1.78
Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model. Cell Host Microbe (2010) 1.77
RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res (2007) 1.76
RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. Clin Cancer Res (2007) 1.72
Frequent activation of AKT2 kinase in human pancreatic carcinomas. J Cell Biochem (2002) 1.70
Production of transgenic rats by lentiviral transduction of male germ-line stem cells. Proc Natl Acad Sci U S A (2002) 1.68
The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol (2005) 1.60
Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biol Ther (2004) 1.58
Cellular and molecular parameters of mesothelioma. J Cell Biochem (2006) 1.57
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene (2005) 1.48
Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study. J Clin Oncol (2007) 1.46
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene (2002) 1.44
The development of vaccine viruses against pandemic A(H1N1) influenza. Vaccine (2011) 1.44
Nef: agent of cell subversion. Microbes Infect (2002) 1.41
Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. J Virol (2006) 1.41
Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth. Oncogene (2005) 1.41
Novel humanized murine models for HIV research. Curr HIV/AIDS Rep (2009) 1.40
A mouse model recapitulating molecular features of human mesothelioma. Cancer Res (2005) 1.39
mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary. Clin Cancer Res (2009) 1.39
Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. Proc Natl Acad Sci U S A (2009) 1.38
Diverse mechanisms of AKT pathway activation in human malignancy. Curr Cancer Drug Targets (2013) 1.33
Molecular mechanisms of autosomal recessive hypercholesterolemia. Hum Mol Genet (2002) 1.33
Human breast milk and antiretrovirals dramatically reduce oral HIV-1 transmission in BLT humanized mice. PLoS Pathog (2012) 1.30
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood (2012) 1.29
Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med (2011) 1.27
Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus. J Virol (2004) 1.24
Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors. Blood (2003) 1.23
Detection and characterization of clade 7 high pathogenicity avian influenza H5N1 viruses in chickens seized at ports of entry and live poultry markets in Vietnam. Avian Dis (2010) 1.23
Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection. J Reprod Immunol (2011) 1.22
Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling. Biol Reprod (2004) 1.21
Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance. Cancer Res (2004) 1.20
A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer Res (2008) 1.19
Antigenic and genetic diversity of highly pathogenic avian influenza A (H5N1) viruses isolated in Egypt. Avian Dis (2010) 1.19
Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells. J Clin Invest (2011) 1.18
Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome. Genes Chromosomes Cancer (2011) 1.18
Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly. J Biol Chem (2007) 1.18
FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis. Cell Cycle (2009) 1.15
Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice. Trends Microbiol (2012) 1.15
Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes. Retrovirology (2012) 1.14
Development and activation of human dendritic cells in vivo in a xenograft model of human hematopoiesis. Stem Cells (2005) 1.14
A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities. Cancer Biol Ther (2004) 1.11
Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse. J Virol (2011) 1.11
Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. Oncogene (2004) 1.11
SV40-dependent AKT activity drives mesothelial cell transformation after asbestos exposure. Cancer Res (2005) 1.11
Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway. J Virol (2007) 1.10
A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2. J Virol (2006) 1.10
High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors. Genes Chromosomes Cancer (2009) 1.10
Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts. Endocrinology (2002) 1.09
Nuclear β-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer. J Transl Med (2013) 1.09
Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. J Biol Chem (2002) 1.08
Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model. Ann N Y Acad Sci (2010) 1.08
One hundred years of Arctic surface temperature variation due to anthropogenic influence. Sci Rep (2013) 1.08
Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis. Am J Pathol (2009) 1.07
Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol Cancer Res (2012) 1.06
Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Clin Cancer Res (2004) 1.06
Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem (2009) 1.06
HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway. Am J Respir Cell Mol Biol (2007) 1.05
Macrophages sustain HIV replication in vivo independently of T cells. J Clin Invest (2016) 1.04
Mechanisms of HIV-1 Nef function and intracellular signaling. J Neuroimmune Pharmacol (2011) 1.04
Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin. Mol Cancer (2010) 1.04
Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer. Mol Cell Biol (2009) 1.03
Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clin Cancer Res (2004) 1.02
SV40 infection induces telomerase activity in human mesothelial cells. Oncogene (2002) 1.01
ERK2 is essential for the growth of human epithelioid malignant mesotheliomas. Int J Cancer (2011) 1.00