Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.

PubWeight™: 1.63‹?› | Rank: Top 4%

🔗 View Article (PMID 9286755)

Published in J Bone Miner Res on September 01, 1997

Authors

B J Votta1, M A Levy, A Badger, J Bradbeer, R A Dodds, I E James, S Thompson, M J Bossard, T Carr, J R Connor, T A Tomaszek, L Szewczuk, F H Drake, D F Veber, M Gowen

Author Affiliations

1: Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA.

Articles citing this

Osteopetrosis. Orphanet J Rare Dis (2009) 3.69

Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II. Am J Pathol (2004) 1.31

High bone mineral density in pycnodysostotic patients with a novel mutation in the propeptide of cathepsin K. Osteoporos Int (2007) 1.22

Design of potent and selective human cathepsin K inhibitors that span the active site. Proc Natl Acad Sci U S A (1997) 1.10

Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference. Clin Cancer Res (2008) 1.00

Effects of orthopedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells. J Biomed Mater Res A (2010) 0.96

Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis? Future Med Chem (2009) 0.95

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporos Int (2011) 0.89

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporos Int (2011) 0.89

The imbalance between osteoprotegerin and cathepsin K in the serum of patients with longstanding rheumatoid arthritis. Rheumatol Int (2007) 0.81

Serum cathepsin K levels of patients with longstanding rheumatoid arthritis: correlation with radiological destruction. Arthritis Res Ther (2004) 0.80

(+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activation. PLoS One (2014) 0.80

NOD2 contributes to Porphyromonas gingivalis-induced bone resorption. J Dent Res (2014) 0.79

Identification of proteins with potential osteogenic activity present in the water-soluble matrix proteins from Crassostrea gigas nacre using a proteomic approach. ScientificWorldJournal (2012) 0.79

Is cathepsin K truly involved in bone resorption? J Bone Miner Res (1998) 0.76

Articles by these authors

Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature (1995) 9.39

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature (1988) 6.12

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature (2003) 5.84

Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science (1991) 5.82

Intensive versus standard case management for severe psychotic illness: a randomised trial. UK 700 Group. Lancet (1999) 4.54

Vibrio parahaemolyticus infections in the United States, 1973-1998. J Infect Dis (2000) 4.35

Randomised controlled trial of follow up care in general practice of patients with myocardial infarction and angina: final results of the Southampton heart integrated care project (SHIP). The SHIP Collaborative Group. BMJ (1999) 4.03

Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem (1998) 3.88

An interleukin 1 like factor stimulates bone resorption in vitro. Nature (1984) 3.71

Handheld cellular telephone use and risk of brain cancer. JAMA (2000) 3.59

National surveillance of antimicrobial resistance in Neisseria gonorrhoeae. The Gonococcal Isolate Surveillance Project. JAMA (1990) 3.25

Enteroaggregative Escherichia coli as a major etiologic agent in traveler's diarrhea in 3 regions of the world. Clin Infect Dis (2001) 3.08

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J Med Chem (1988) 3.04

Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med (1983) 2.78

Discrepancies in tuberculin skin test results with two commercial products in a population of intravenous drug users. J Infect Dis (1993) 2.77

Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor. J Immunol (1992) 2.64

Joint teleconsultations (virtual outreach) versus standard outpatient appointments for patients referred by their general practitioner for a specialist opinion: a randomised trial. Lancet (2002) 2.62

pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos. Cell (1995) 2.61

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions. Proc Natl Acad Sci U S A (1988) 2.57

The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem (1998) 2.48

The role of Gulf Coast oysters harvested in warmer months in Vibrio vulnificus infections in the United States, 1988-1996. Vibrio Working Group. J Infect Dis (1998) 2.46

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem (1996) 2.33

Costs and cost effectiveness of cardiovascular screening and intervention: the British family heart study. BMJ (1996) 2.27

A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis. Neurology (2008) 2.21

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells. Cell Growth Differ (1991) 2.20

Randomised controlled trial of treatment of chronic suppurative otitis media in Kenyan schoolchildren. Lancet (1996) 2.16

Randomized controlled trial of brief cognitive behaviour therapy versus treatment as usual in recurrent deliberate self-harm: the POPMACT study. Psychol Med (2003) 2.16

Production of cloned pigs from in vitro systems. Nat Biotechnol (2000) 2.15

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins. Biochem Biophys Res Commun (1988) 2.14

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues. Nature (1990) 2.13

The response of symptomatic neurosyphilis to high-dose intravenous penicillin G in patients with human immunodeficiency virus infection. N Engl J Med (1994) 2.08

Frequency-Dependent Selection for Plasmid-Containing Cells of ESCHERICHIA COLI. Genetics (1979) 2.07

Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification. J Biol Chem (1996) 2.06

A dual-radioisotope technique for the evaluation of penile blood flow during tumescence. J Nucl Med (1992) 2.04

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. Mol Cell Biol (1991) 2.03

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. Mol Cell Biol (1994) 2.03

Perioperative corticosteroid supplementation and dento-alveolar surgery. Dent Update (2003) 2.02

Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: an in vitro and ex vivo study of remodeling bone. J Bone Miner Res (1995) 2.01

Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro. Biochim Biophys Acta (1984) 2.00

Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro. J Immunol (1986) 1.93

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem Pharmacol (1985) 1.92

Rat model of perinatal hypoxic-ischemic brain damage. J Neurosci Res (1999) 1.86

Decline in prevalence of neural tube defects in a high-risk region of the United States. Pediatrics (2000) 1.85

Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas. Clin Cancer Res (1999) 1.84

The pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast. EMBO J (1998) 1.83

Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: implications for osteopenic disorders. J Bone Miner Res (1998) 1.81

Cardiovascular risk factors for people with mental illness. Aust N Z J Psychiatry (2001) 1.81

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials. Pharmacol Ther (1999) 1.80

Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest (1989) 1.79

The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities. J Immunol (1985) 1.78

Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem Pharmacol (1994) 1.76

Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate. J Bone Miner Res (2001) 1.76

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology (2000) 1.75

Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Arch Biochem Biophys (2000) 1.73

Aminopyridine block of transient potassium current. J Gen Physiol (1982) 1.73

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis Rheum (2000) 1.72

Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel. J Clin Invest (1991) 1.71

Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proc Natl Acad Sci U S A (1986) 1.69

Conformationally restricted bicyclic analogs of somatostatin. Proc Natl Acad Sci U S A (1978) 1.69

DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM-2. Proc Natl Acad Sci U S A (1993) 1.66

Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J Neurochem (1995) 1.65

Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism. Biochemistry (1991) 1.63

Towards a genetic dissection of the basis of triplet decoding, and its natural subversion: programmed reading frame shifts and hops. Annu Rev Genet (1991) 1.62

Site-directed mutations in the Sindbis virus 6K protein reveal sites for fatty acylation and the underacylated protein affects virus release and virion structure. Virology (1990) 1.61

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes. Proc Natl Acad Sci U S A (1989) 1.58

Iron in the brain. Nutr Rev (1993) 1.58

The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties. Proc Natl Acad Sci U S A (1994) 1.57

Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae. J Bone Miner Res (1991) 1.57

Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models. J Neurosci Res (2004) 1.57

Restriction of dietary protein and progression of renal failure in diabetic nephropathy. Lancet (1989) 1.55

Characterization of a human tRNA gene cluster. Biochem Soc Trans (1990) 1.55

Effects of hypertonic saline, alternate day and daily rhDNase on healthcare use, costs and outcomes in children with cystic fibrosis. Thorax (2002) 1.54

Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation. Mol Cell Biol (1995) 1.53

Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. Proc Natl Acad Sci U S A (1986) 1.53

The nucleotide sequence of the first externally suppressible--1 frameshift mutant, and of some nearby leaky frameshift mutants. EMBO J (1983) 1.52

Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res (1987) 1.51

Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. Glia (2001) 1.51

Purification and biochemical characterization of recombinant simian immunodeficiency virus protease and comparison to human immunodeficiency virus type 1 protease. Biochemistry (1991) 1.50

Presence of antibodies to the major anaerobically induced gonococcal outer membrane protein in sera from patients with gonococcal infections. Microb Pathog (1988) 1.48

Ultrastructural and biochemical analysis of the stress granule in chicken embryo fibroblasts. J Cell Biol (1988) 1.48

Gender differences in smoking and risk for oral cancer. Cancer Res (1996) 1.47

Availability of on-site catheterization and clinical outcomes in patients receiving fibrinolysis for ST-elevation myocardial infarction. Eur Heart J (2001) 1.47

Obstacles to timely neonatal screening in North Thames. J Med Screen (1998) 1.47

Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors. Proc Natl Acad Sci U S A (1989) 1.47

Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr (1997) 1.45

Gene amplification to detect fetal nucleated cells in pregnant women. Lancet (1989) 1.45

Anticardiolipin and antineutrophil antibodies in giant cell arteritis. J Rheumatol (1990) 1.45

Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum (1998) 1.44

Assessing the needs of breast cancer patients and their families. Qual Manag Health Care (1993) 1.43