Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMID 9311779)

Published in Nature on September 25, 1997

Authors

Z Z Pan1, S A Tershner, H L Fields

Author Affiliations

1: Department of Neurology, University of California, San Francisco 94143, USA. zzp@itsa.ucsf.edu

Articles citing this

Dynorphin, stress, and depression. Brain Res (2009) 2.45

Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med (2011) 2.17

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain (2011) 1.82

Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. J Neurosci (2010) 1.37

Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron (2014) 1.28

Preclinical and early clinical investigations related to monoaminergic pain modulation. Neurotherapeutics (2009) 1.26

Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro. Br J Pharmacol (1999) 1.15

Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward. Proc Natl Acad Sci U S A (2007) 1.09

Synaptic mechanism for functional synergism between delta- and mu-opioid receptors. J Neurosci (2010) 1.06

CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist. Neuropharmacology (2007) 1.02

Unique, common, and interacting cortical correlates of thirst and pain. Proc Natl Acad Sci U S A (2006) 0.97

Nerve growth factor-regulated emergence of functional delta-opioid receptors. J Neurosci (2010) 0.96

The role of kappa-opioid receptor activation in mediating antinociception and addiction. Acta Pharmacol Sin (2010) 0.95

Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception. Mol Pharmacol (2011) 0.93

MeCP2 repression of G9a in regulation of pain and morphine reward. J Neurosci (2014) 0.89

Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. Br J Pharmacol (2003) 0.88

Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats. Mol Pain (2005) 0.85

Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus. J Physiol (2003) 0.84

Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation. Mol Pharmacol (2013) 0.82

Persistent inflammation-induced up-regulation of brain-derived neurotrophic factor (BDNF) promotes synaptic delivery of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 subunits in descending pain modulatory circuits. J Biol Chem (2014) 0.81

Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro. J Physiol (2001) 0.79

GABAergic transmission and enhanced modulation by opioids and endocannabinoids in adult rat rostral ventromedial medulla. J Physiol (2014) 0.78

Effects of combined opioids on pain and mood in mammals. Pain Res Treat (2012) 0.78

Kappa Opioid Receptor Agonist and Brain Ischemia. Transl Perioper Pain Med (2014) 0.77

A life switch in pain. Pain (2012) 0.76

Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors. Pharmacol Res (2016) 0.75

Dynorphin A analogs for the treatment of chronic neuropathic pain. Future Med Chem (2016) 0.75

Opioid-receptor antagonism increases pain and decreases pleasure in obese and non-obese individuals. Psychopharmacology (Berl) (2016) 0.75

Articles by these authors

Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci (1984) 4.87

The mechanism of placebo analgesia. Lancet (1978) 4.10

The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex. Proc Natl Acad Sci U S A (2001) 2.71

Endogenous pain control mechanisms: review and hypothesis. Ann Neurol (1978) 2.63

Multiple opiate receptor sites on primary afferent fibres. Nature (1980) 2.34

A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin. Neuron (2000) 1.71

The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat. J Neurosci (1983) 1.69

An analgesia circuit activated by cannabinoids. Nature (1998) 1.68

The narcotic antagonist naloxone enhances clinical pain. Nature (1978) 1.66

Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain. Nature (1979) 1.63

Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation. Neurology (1999) 1.59

Peptides and the primary afferent nociceptor. J Neurosci (1993) 1.58

Brainstem control of spinal pain-transmission neurons. Annu Rev Physiol (1978) 1.45

Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway. Proc Natl Acad Sci U S A (1976) 1.43

Anatomy and physiology of a nociceptive modulatory system. Philos Trans R Soc Lond B Biol Sci (1985) 1.39

Evidence that disinhibition of brain stem neurones contributes to morphine analgesia. Nature (1984) 1.28

Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neuroscience (1992) 1.27

Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla. Neuroscience (1994) 1.24

Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J Comp Neurol (1978) 1.24

Contributions of the amygdala and medial prefrontal cortex to incentive cue responding. Neuroscience (2008) 1.23

Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia. Brain Res (1979) 1.22

Cutaneous innervation density in the allodynic form of postherpetic neuralgia. Neurobiol Dis (1996) 1.21

Capsaicin evoked pain and allodynia in post-herpetic neuralgia. Pain (2000) 1.18

Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? Muscle Nerve (1999) 1.18

Nucleus accumbens dopamine release is necessary and sufficient to promote the behavioral response to reward-predictive cues. Neuroscience (2005) 1.17

Analgesic responses to morphine and placebo in individuals with postoperative pain. Pain (1981) 1.15

Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system. Ann Neurol (1983) 1.14

Pain due to peripheral nerve damage: an hypothesis. Neurology (1984) 1.14

The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. J Comp Neurol (1979) 1.13

Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission. Brain Res (1986) 1.11

Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology (1991) 1.11

Putative nociceptive modulating neurons in the rostral ventromedial medulla of the rat: firing of on- and off-cells is related to nociceptive responsiveness. Somatosens Mot Res (1989) 1.11

Positive neuropathic sensory symptoms as endpoints in diabetic neuropathy trials. J Neurol Sci (2001) 1.10

Kappa opioid receptor inhibition of glutamatergic transmission in the nucleus accumbens shell. J Neurophysiol (2001) 1.10

Role of pain in placebo analgesia. Proc Natl Acad Sci U S A (1979) 1.08

Putative pain modulating neurons in the rostral ventral medulla: reflex-related activity predicts effects of morphine. Brain Res (1986) 1.08

Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons. Brain Res (1977) 1.08

The relationship of pain, allodynia and thermal sensation in post-herpetic neuralgia. Brain (1996) 1.08

Antinociception following opioid stimulation of the basolateral amygdala is expressed through the periaqueductal gray and rostral ventromedial medulla. Brain Res (1998) 1.05

Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla. J Neurosci (1994) 1.04

Basolateral amygdala lesions impair both cue- and cocaine-induced reinstatement in animals trained on a discriminative stimulus task. Neuroscience (2003) 1.04

Hyperalgesia during naloxone-precipitated withdrawal from morphine is associated with increased on-cell activity in the rostral ventromedial medulla. Somatosens Mot Res (1990) 1.03

Nucleus accumbens opioids regulate flavor-based preferences in food consumption. Neuroscience (2006) 1.03

Convergent, not serial, striatal and pallidal circuits regulate opioid-induced food intake. Neuroscience (2009) 1.02

Afferent and efferent connections of the rat tail flick reflex (a model used to analyze pain control mechanisms). J Comp Neurol (1982) 1.00

Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons. J Neurophysiol (1998) 1.00

Relations among threshold, spike height, electrode distance, and conduction velocity in electrical stimulation of certain medullospinal neurons. J Neurophysiol (1984) 0.99

Circuitry linking opioid-sensitive nociceptive modulatory systems in periaqueductal gray and spinal cord with rostral ventromedial medulla. Neuroscience (1992) 0.98

Postsympathectomy neuralgia. Amelioration with diphenylhydantoin and carbamazepine. Am J Surg (1974) 0.97

Putative nociceptive modulatory neurons in the rostral ventromedial medulla of the rat display highly correlated firing patterns. Somatosens Mot Res (1989) 0.97

Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla. J Neurosci (1991) 0.96

Lesions of the periaqueductal gray and rostral ventromedial medulla disrupt antinociceptive but not cardiovascular aversive conditional responses. J Neurosci (1994) 0.96

Brain stem neuronal circuitry underlying the antinociceptive action of opiates. Prog Brain Res (1988) 0.96

Response of medullary raphe neurons to peripheral stimulation and to systemic opiates. Brain Res (1977) 0.95

Brainstem pain modulating circuitry is sexually dimorphic with respect to mu and kappa opioid receptor function. Pain (2000) 0.95

Lumbar intrathecal naloxone blocks analgesia produced by microstimulation of the ventromedial medulla in the rat. Brain Res (1982) 0.94

Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla. Neuroreport (1998) 0.93

Effects of intrathecally administered methysergide and yohimbine on microstimulation-produced antinociception in the rat. Brain Res (1985) 0.93

Topical lidocaine gel relieves postherpetic neuralgia. Ann Neurol (1995) 0.92

Somatic and visceral receptive field properties of fibers in ventral quadrant white matter of the cat spinal cord. J Neurophysiol (1970) 0.92

Evidence that raphe-spinal neurons mediate opiate and midbrain stimulation-produced analgesias. Pain (1978) 0.92

Evidence for GABA-mediated control of putative nociceptive modulating neurons in the rostral ventromedial medulla: iontophoresis of bicuculline eliminates the off-cell pause. Somatosens Mot Res (1991) 0.92

Reflex role played by efferent control of an invertebrate stretch receptor. J Neurophysiol (1967) 0.92

Treatment of intractable pain with topical large-dose capsaicin: preliminary report. Anesth Analg (1998) 0.91

Putative nociceptive modulatory neurons in the dorsolateral pontomesencephalic reticular formation. Brain Res (1989) 0.90

Segmental and descending influences on intraspinal thresholds of single C-fibers. J Neurophysiol (1979) 0.89

Nucleus accumbens opioid signaling conditions short-term flavor preferences. Neuroscience (2007) 0.89

Pronounced changes in the activity of nociceptive modulatory neurons in the rostral ventromedial medulla in response to prolonged thermal noxious stimuli. J Neurophysiol (1994) 0.89

Evidence for two classes of nociceptive modulating neurons in the periaqueductal gray. J Neurosci (1987) 0.89

Cholecystokinin and enkephalin in brain stem pain modulating circuits. Neuroreport (1997) 0.89

Some properties of spinal neurons projecting to the medial brain-stem reticular formation. Exp Neurol (1975) 0.89

Convergence of visceral and somatic input onto spinal neurons. Exp Neurol (1970) 0.88

Potentiation of morphine antinociception by monoamine reuptake inhibitors in the rat spinal cord. Pain (1985) 0.88

Opposing effects of intra-nucleus accumbens mu and kappa opioid agonists on sensory specific satiety. Neuroscience (2007) 0.88

Axonal trajectories and terminations of on- and off-cells in the cat lower brainstem. J Comp Neurol (1989) 0.87

The contribution of the rostral ventromedial medulla to the antinociceptive effects of systemic morphine in restrained and unrestrained rats. Neuroscience (1998) 0.87

Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat. Pain (1988) 0.87

Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla. Brain Res (1989) 0.86

Causalgia treated by selective large fibre stimulation of peripheral nerve. Brain (1972) 0.86

Treatment of trigeminal neuralgia. N Engl J Med (1996) 0.86

Pain--mechanics and management. West J Med (1984) 0.86

Do benzodiazepines have a role in chronic pain management? Pain (1994) 0.86

Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through alpha2-adrenergic receptors. J Neurophysiol (1998) 0.86

Dissociation of supraspinal and spinal actions of morphine: a quantitative evaluation. Brain Res (1980) 0.85

Post-operative pain: effect of extent of injury and attention. Brain Res (1982) 0.85

Morphine presynaptically inhibits a ganglionic cholinergic synapse. Neurosci Lett (1979) 0.85

Recent advances in research on pain and analgesia. NIDA Res Monogr (1983) 0.85

Functional role of muscle receptor organs in crayfish. Nature (1965) 0.85

Biology of placebo analgesia. Am J Med (1981) 0.84

The density and distribution of serotonergic appositions onto identified neurons in the rat rostral ventromedial medulla. J Neurosci (1995) 0.84

Morphine microinjected into the periaqueductal gray has differential effects on 3 classes of medullary neurons. Brain Res (1986) 0.84

Tail-flick related activity in medullospinal neurons. Brain Res (1984) 0.84

Bi-directional changes in affective state elicited by manipulation of medullary pain-modulatory circuitry. Neuroscience (2000) 0.84

Experimental study of tetrodotoxin, a long-acting topical anesthetic. Am J Ophthalmol (1998) 0.84

Naloxone-reversible analgesia produced by microstimulation in the rat medulla. Brain Res (1981) 0.83

Morphine analgesia and acute physical dependence: rapid onset of two opposing, dose-related processes. Brain Res (1990) 0.83

Interactions of cortical and retinal projections on single neurons of the cat's superior colliculus. J Neurophysiol (1971) 0.83

ACTH1-24 blocks opiate - induced analgesia in the rat. Brain Res (1981) 0.83

Inhibition and facilitation of different nocifensor reflexes by spatially remote noxious stimuli. J Neurophysiol (1994) 0.83