A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice.

PubWeight™: 1.42‹?› | Rank: Top 5%

🔗 View Article (PMID 9321854)

Published in Am J Physiol on September 01, 1997

Authors

J G Fewell1, H Osinska, R Klevitsky, W Ng, G Sfyris, F Bahrehmand, J Robbins

Author Affiliations

1: Department of Pediatrics, Children's Hospital Research Foundation, Cincinnati 45229-3039, USA.

Articles citing this

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat Med (2008) 2.49

Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc Natl Acad Sci U S A (2001) 2.26

A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J Clin Invest (1998) 1.65

Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest (2013) 1.41

Minimal force-frequency modulation of inotropy and relaxation of in situ murine heart. J Physiol (2001) 1.28

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci U S A (2008) 1.21

Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy. Proc Natl Acad Sci U S A (2007) 1.12

Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice. J Clin Invest (1998) 1.09

Small and large animal models in cardiac contraction research: advantages and disadvantages. Pharmacol Ther (2013) 1.08

Calcineurin protects the heart in a murine model of dilated cardiomyopathy. J Mol Cell Cardiol (2009) 0.98

Murine strain differences in contractile function are temperature- and frequency-dependent. Pflugers Arch (2006) 0.95

Functional role of CLC-2 chloride inward rectifier channels in cardiac sinoatrial nodal pacemaker cells. J Mol Cell Cardiol (2009) 0.94

Phenotyping cardiac gene therapy in mice. Methods Mol Biol (2011) 0.94

Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function. J Biol Chem (2009) 0.92

Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves. J Mol Cell Cardiol (2013) 0.92

Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Hum Mol Genet (2014) 0.87

Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilatation in calponin knockout mice. J Physiol (2003) 0.86

Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis. J Mol Cell Cardiol (2010) 0.86

Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations. J Muscle Res Cell Motil (2015) 0.85

A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice. Endocrinology (2013) 0.85

Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice. Physiol Genomics (2009) 0.82

Activation of volume regulated chloride channels protects myocardium from ischemia/reperfusion damage in second-window ischemic preconditioning. Cell Physiol Biochem (2011) 0.82

P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Hum Mol Genet (2014) 0.81

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism. Diabetes (2015) 0.80

Physiological stress increases renal injury in eNOS-knockout mice. Hypertens Res (2011) 0.80

Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations. Front Physiol (2014) 0.79

Moderate-intensity treadmill exercise training decreases murine cardiomyocyte cross-sectional area. Physiol Rep (2015) 0.78

Endurance exercise effects on cardiac hypertrophy in mice. J Phys Ther Sci (2014) 0.77

Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities. Proc Natl Acad Sci U S A (2016) 0.76

Role of myosin light chain phosphatase in cardiac physiology and pathophysiology. J Mol Cell Cardiol (2016) 0.75

Articles by these authors

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell (1998) 13.56

The Sleep Heart Health Study: design, rationale, and methods. Sleep (1997) 7.55

Methods of assessing prevalent cardiovascular disease in the Cardiovascular Health Study. Ann Epidemiol (1995) 7.28

Isolation and characterization of the mouse cardiac myosin heavy chain genes. J Biol Chem (1991) 4.45

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J Biol Chem (1991) 4.34

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J (2000) 4.09

Prospective multicenter study of thyroiscarcinoma treatment: initial analysis of staging and outcome. National Thyroid Cancer Treatment Cooperative Study Registry Group. Cancer (1998) 3.55

Daytime sleepiness predicts mortality and cardiovascular disease in older adults. The Cardiovascular Health Study Research Group. J Am Geriatr Soc (2000) 3.48

Self-reported causes of physical disability in older people: the Cardiovascular Health Study. CHS Collaborative Research Group. J Am Geriatr Soc (1994) 3.05

The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen. J Cell Biol (1988) 2.85

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J Clin Invest (1996) 2.63

Observations of fouling biofilm formation. Can J Microbiol (1981) 2.56

Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice. Circ Res (2001) 2.51

Molecular mechanics of cardiac myosin-binding protein C in native thick filaments. Science (2012) 2.48

Cardiac physiology in transgenic mice. Circ Res (1998) 2.47

Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science (1998) 2.39

Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation. Circ Res (2000) 2.38

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart. Circ Res (1991) 2.34

Incidence of fractures compared to cardiovascular disease and breast cancer: the Women's Health Initiative Observational Study. Osteoporos Int (2008) 2.27

Isolated systolic hypertension and subclinical cardiovascular disease in the elderly. Initial findings from the Cardiovascular Health Study. JAMA (1992) 2.21

The significance of sexual partner contact networks for the transmission dynamics of HIV. J Acquir Immune Defic Syndr (1990) 2.20

Cloning and sequencing of a putative Escherichia coli [NiFe] hydrogenase-1 operon containing six open reading frames. J Bacteriol (1990) 2.20

The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: I. Conceptual foundation and item development. Dysphagia (2000) 2.18

Age effects on the temporal evolution of isometric and swallowing pressure. J Gerontol A Biol Sci Med Sci (2000) 2.15

Transgenic remodeling of the contractile apparatus in the mammalian heart. Circ Res (1996) 2.05

Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Stroke (1997) 1.95

Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest (1999) 1.95

Mouse model of desmin-related cardiomyopathy. Circulation (2001) 1.84

Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan. J Clin Endocrinol Metab (1995) 1.84

Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy. Circ Res (2001) 1.83

High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study. Am J Clin Nutr (1998) 1.82

A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest (1998) 1.77

Prevalence of subclinical atherosclerosis and cardiovascular disease and association with risk factors in the Cardiovascular Health Study. Am J Epidemiol (1994) 1.74

Apolipoprotein J: structure and tissue distribution. Biochemistry (1990) 1.73

The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: II. Item reduction and preliminary scaling. Dysphagia (2000) 1.72

Mutational analysis and characterization of the Escherichia coli hya operon, which encodes [NiFe] hydrogenase 1. J Bacteriol (1991) 1.71

Immunological studies of Y protein. A major cytoplasmic organic anion-binding protein in rat liver. J Clin Invest (1972) 1.71

Comparison of effortful and noneffortful swallows in healthy middle-aged and older adults. Arch Phys Med Rehabil (2001) 1.68

Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Proc Natl Acad Sci U S A (1997) 1.68

Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005. Vaccine (2006) 1.67

A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J Clin Invest (1998) 1.65

Structure-function relationships among the nickel-containing hydrogenases. FEMS Microbiol Rev (1992) 1.62

Predicting hospital choice for rural Medicare beneficiaries: the role of severity of illness. Health Serv Res (1991) 1.61

Expression of the beta (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects. Am J Physiol Heart Circ Physiol (2000) 1.60

Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2. J Biol Chem (1999) 1.60

Parasite-accessory cell interactions in murine leishmaniasis. II. Leishmania donovani suppresses macrophage expression of class I and class II major histocompatibility complex gene products. J Immunol (1987) 1.60

Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice. J Clin Invest (1998) 1.59

Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains. J Mol Cell Cardiol (2001) 1.59

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. J Clin Invest (2000) 1.58

Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study. J Biol Chem (1991) 1.56

Cloned genomic DNA sequences from Mycoplasma hyorhinis encoding antigens expressed in Escherichia coli. Proc Natl Acad Sci U S A (1983) 1.54

DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors. Cancer Res (1998) 1.53

The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem (2001) 1.53

Factors associated with healthy aging: the cardiovascular health study. J Am Geriatr Soc (2001) 1.51

In vivo analysis of the murine beta-myosin heavy chain gene promoter. J Biol Chem (1993) 1.50

Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy. Circ Res (2000) 1.49

Forskolin inhibits and reverses the effects of brefeldin A on Golgi morphology by a cAMP-independent mechanism. J Cell Biol (1991) 1.48

In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation. J Biol Chem (1993) 1.45

The isolation and partial characterization of recombinant DNA containing genomic globin sequences from the goat. J Biol Chem (1979) 1.44

Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice. Cardiovasc Res (2000) 1.42

Depression in primary care: patient factors that influence recognition. Fam Med (1997) 1.39

Transgenic remodeling of the regulatory myosin light chains in the mammalian heart. Circ Res (1997) 1.39

Thyrotropin suppression and disease progression in patients with differentiated thyroid cancer: results from the National Thyroid Cancer Treatment Cooperative Registry. Thyroid (1998) 1.33

Kinetics of gamma interferon binding and induction of major histocompatibility complex class II mRNA in Leishmania-infected macrophages. Proc Natl Acad Sci U S A (1988) 1.32

The sequence of an embryonic myosin heavy chain gene and isolation of its corresponding cDNA. J Biol Chem (1987) 1.31

Thermal application reduces the duration of stage transition in dysphagia after stroke. Dysphagia (1996) 1.30

Test-retest variability in normal swallowing. Dysphagia (1990) 1.30

Modulation of in vitro monocyte cytokine responses to Leishmania donovani. Interferon-gamma prevents parasite-induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1. J Clin Invest (1990) 1.29

Transgenic analysis of the thyroid-responsive elements in the alpha-cardiac myosin heavy chain gene promoter. J Biol Chem (1993) 1.29

Characterization of a macrolide, lincosamide, and streptogramin resistance plasmid in Staphylococcus epidermidis. J Bacteriol (1981) 1.28

Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse. Am J Physiol (1997) 1.27

Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts. Proc Natl Acad Sci U S A (1980) 1.25

The impact of age and gender on papillary thyroid cancer survival. J Clin Endocrinol Metab (2012) 1.25

Myosin heavy chain regulation and myocyte contractile depression after LV hypertrophy in aortic-banded mice. Am J Physiol (1994) 1.24

Molecular basis of thyroid hormone regulation of myelin basic protein gene expression in rodent brain. J Biol Chem (1991) 1.23

Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice. J Clin Invest (1997) 1.23

Relation of smoking with carotid artery wall thickness and stenosis in older adults. The Cardiovascular Health Study. The Cardiovascular Health Study (CHS) Collaborative Research Group. Circulation (1994) 1.22

Carboxy-terminal processing of the large subunit of [NiFe] hydrogenases. FEBS Lett (1993) 1.21

Isolation of multiple genomic sequences coding for chicken myosin heavy chain protein. J Biol Chem (1982) 1.20

Comparison of normal, hypodynamic, and hyperdynamic mouse hearts using isolated work-performing heart preparations. Am J Physiol (1993) 1.19

Antithyroid effects of lithium. J Clin Invest (1970) 1.19

Abnormal thyroglobin in congenital goiter of cattle. Endocrinology (1966) 1.19

Effect of hydrogen sulfide and methyl mercaptan on the permeability of oral mucosa. J Dent Res (1984) 1.18

Alpha-skeletal actin is associated with increased contractility in the mouse heart. Circ Res (1994) 1.17

Thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion. JAMA (1982) 1.16