Published in Proc Natl Acad Sci U S A on April 29, 1997
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev (2008) 5.39
Genetics of congenital heart disease: the glass half empty. Circ Res (2013) 1.90
Actin cytoskeleton and small heat shock proteins: how do they interact? Cell Stress Chaperones (2002) 1.84
Smooth muscle signalling pathways in health and disease. J Cell Mol Med (2008) 1.72
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Mol Cell Biol (2003) 1.71
Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy. J Clin Invest (1999) 1.64
Early myocardial function affects endocardial cushion development in zebrafish. PLoS Biol (2004) 1.59
Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen (2012) 1.47
The actin gene family: function follows isoform. Cytoskeleton (Hoboken) (2010) 1.39
CD44 enhances neuregulin signaling by Schwann cells. J Cell Biol (2000) 1.38
Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci U S A (2009) 1.33
Functional nonequivalency of actin isovariants in Arabidopsis. Mol Biol Cell (2002) 1.29
Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development. Circ Res (2008) 1.22
ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation. Mol Biol Cell (2005) 1.22
Mice lacking skeletal muscle actin show reduced muscle strength and growth deficits and die during the neonatal period. Mol Cell Biol (2002) 1.18
Cardiac myosin binding protein-C: redefining its structure and function. Biophys Rev (2012) 1.15
Cell biology of embryonic migration. Birth Defects Res C Embryo Today (2008) 1.14
Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol Biol Cell (2004) 1.09
Both vegetative and reproductive actin isovariants complement the stunted root hair phenotype of the Arabidopsis act2-1 mutation. Plant Physiol (2002) 1.07
LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes. Proc Natl Acad Sci U S A (2006) 1.06
Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy. J Cell Biol (2004) 1.03
Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene. Am J Hum Genet (2001) 1.01
Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform. Mol Biol Cell (2006) 0.99
Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin. J Cell Biol (2009) 0.99
Context-dependent functional substitution of alpha-skeletal actin by gamma-cytoplasmic actin. FASEB J (2009) 0.99
Gamma tropomyosin gene products are required for embryonic development. Mol Cell Biol (2004) 0.93
Rapid and efficient purification of actin from nonmuscle sources. Cell Motil Cytoskeleton (1998) 0.93
Differential effects of thin and thick filament disruption on zebrafish smooth muscle regulatory proteins. Neurogastroenterol Motil (2010) 0.86
Smooth muscle α actin (Acta2) and myofibroblast function during hepatic wound healing. PLoS One (2013) 0.86
Rodent models of heart failure: an updated review. Heart Fail Rev (2013) 0.85
Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure. Biochim Biophys Acta (2014) 0.84
Delineating the role of alterations in lipid metabolism to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review Series: Genetics of Human Lipid Diseases. J Lipid Res (2011) 0.84
The cardiac isoform of alpha-actin in regenerating and atrophic skeletal muscle, myopathies and rhabdomyomatous tumors: an immunohistochemical study using monoclonal antibodies. Virchows Arch (2006) 0.84
Plant vegetative and animal cytoplasmic actins share functional competence for spatial development with protists. Plant Cell (2012) 0.83
Distinct functional interactions between actin isoforms and nonsarcomeric myosins. PLoS One (2013) 0.83
Smooth muscle α actin is specifically required for the maintenance of lactation. Dev Biol (2011) 0.81
The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression. PLoS One (2015) 0.80
The functional diversity of essential genes required for mammalian cardiac development. Genesis (2014) 0.79
The W-loop of alpha-cardiac actin is critical for heart function and endocardial cushion morphogenesis in zebrafish. Mol Cell Biol (2012) 0.78
Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide. Int J Mol Sci (2014) 0.77
AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Nucleus (2015) 0.77
Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels. PLoS One (2013) 0.76
Differential roles of α-, β-, and γ-actin in axon growth and collateral branch formation in motoneurons. J Cell Biol (2017) 0.75
Cardiac phenotype induced by a dysfunctional α 1C transgene: a general problem for the transgenic approach. Channels (Austin) (2011) 0.75
A gain-of-function ACTC1 3'UTR mutation that introduces a miR-139-5p target site may be associated with a dominant familial atrial septal defect. Sci Rep (2016) 0.75
Localizations of γ-Actins in Skin, Hair, Vibrissa, Arrector Pili Muscle and Other Hair Appendages of Developing Rats. Acta Histochem Cytochem (2016) 0.75
Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease. Heart Fail Rev (2016) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (1992) 16.46
HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature (1987) 10.32
A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol (1986) 6.83
The complete amino acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle, and rabbit slow skeletal muscle. A protein-chemical analysis of muscle actin differentiation. Differentiation (1979) 5.90
Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J Biol Chem (1991) 4.34
Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci U S A (1988) 4.23
Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution. Mol Cell Biol (1983) 4.01
A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA. Cell (1982) 3.55
Actin isoforms. Curr Opin Cell Biol (1993) 3.02
Transcripts of alpha-cardiac and alpha-skeletal actins are early markers for myogenesis in the mouse embryo. Development (1988) 2.57
Two monoclonal antibodies to actin: one muscle selective and one generally reactive. Cell Motil Cytoskeleton (1988) 2.47
Number and organization of actin-related sequences in the mouse genome. J Mol Biol (1983) 2.13
Sequential activation of alpha-actin genes during avian cardiogenesis: vascular smooth muscle alpha-actin gene transcripts mark the onset of cardiomyocyte differentiation. J Cell Biol (1988) 1.94
Evolution of the human sarcomeric-actin genes: evidence for units of selection within the 3' untranslated regions of the mRNAs. J Mol Evol (1984) 1.94
Expression of the genes coding for the skeletal muscle and cardiac actions in the heart. Nucleic Acids Res (1984) 1.93
Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts. Circ Res (1986) 1.90
The functional importance of multiple actin isoforms. Bioessays (1990) 1.77
Simultaneous expression of skeletal muscle and heart actin proteins in various striated muscle tissues and cells. A quantitative determination of the two actin isoforms. J Biol Chem (1986) 1.61
Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells. Proc Natl Acad Sci U S A (1990) 1.53
Cellular distribution of smooth muscle actins during mammalian embryogenesis: expression of the alpha-vascular but not the gamma-enteric isoform in differentiating striated myocytes. J Cell Biol (1989) 1.49
Alpha-smooth muscle actin is transiently expressed in embryonic rat cardiac and skeletal muscles. Differentiation (1988) 1.39
A comprehensive analysis of the developmental and tissue-specific expression of the isoactin multigene family in the rat. Dev Biol (1991) 1.38
The development expression of the rat alpha-vascular and gamma-enteric smooth muscle isoactins: isolation and characterization of a rat gamma-enteric actin cDNA. Mol Cell Biol (1988) 1.32
Dominant negative effect of cytoplasmic actin isoproteins on cardiomyocyte cytoarchitecture and function. J Cell Biol (1995) 1.30
The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load. J Clin Invest (1991) 1.24
Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. II. Rhabdomyosarcomas. Am J Pathol (1988) 1.22
Molecular analysis of smooth muscle development in the mouse. Dev Dyn (1995) 1.20
Alpha-skeletal actin is associated with increased contractility in the mouse heart. Circ Res (1994) 1.17
The skeletal and cardiac alpha-actin genes are coexpressed in early embryonic striated muscle. Dev Biol (1986) 1.17
Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts. J Clin Invest (1991) 1.11
A 5' duplication of the alpha-cardiac actin gene in BALB/c mice is associated with abnormal levels of alpha-cardiac and alpha-skeletal actin mRNAs in adult cardiac tissue. EMBO J (1986) 1.02
Activation of smooth muscle myosin by smooth and skeletal muscle actins. FEBS Lett (1981) 1.01
Genetic analysis of the interaction between cardiac and skeletal actin gene expression in striated muscle of the mouse. J Mol Biol (1990) 0.92
Onset of expression and regional deposition of alpha-smooth and sarcomeric actin during avian heart development. Dev Dyn (1992) 0.92
alpha-Actin proteins and gene transcripts are colocalized in embryonic mouse muscle. Development (1991) 0.85
Ventrolateral regionalization of Xenopus laevis mesoderm is characterized by the expression of alpha-smooth muscle actin. Development (1992) 0.81
Muscle isoactin expression during in vitro differentiation of murine embryonic stem cells. Pediatr Res (1997) 0.81
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (1992) 16.46
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell (1998) 13.56
The Sleep Heart Health Study: design, rationale, and methods. Sleep (1997) 7.55
Methods of assessing prevalent cardiovascular disease in the Cardiovascular Health Study. Ann Epidemiol (1995) 7.28
Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell (1998) 6.44
TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development (1997) 6.31
Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res (1994) 5.01
Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature (1991) 4.60
Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc Natl Acad Sci U S A (1992) 4.47
Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology (1991) 4.47
Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet (1995) 4.46
Isolation and characterization of the mouse cardiac myosin heavy chain genes. J Biol Chem (1991) 4.45
The performance of intensive care units: does good management make a difference? Med Care (1994) 4.41
Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J Biol Chem (1991) 4.34
Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet (1998) 3.96
Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci U S A (1997) 3.89
BTS guidelines for the insertion of a chest drain. Thorax (2003) 3.85
Prospective multicenter study of thyroiscarcinoma treatment: initial analysis of staging and outcome. National Thyroid Cancer Treatment Cooperative Study Registry Group. Cancer (1998) 3.55
Daytime sleepiness predicts mortality and cardiovascular disease in older adults. The Cardiovascular Health Study Research Group. J Am Geriatr Soc (2000) 3.48
Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease. Circulation (1992) 3.31
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci U S A (1995) 3.20
Transgenesis by means of blastocyst-derived embryonic stem cell lines. Proc Natl Acad Sci U S A (1986) 3.11
Self-reported causes of physical disability in older people: the Cardiovascular Health Study. CHS Collaborative Research Group. J Am Geriatr Soc (1994) 3.05
Postchemotherapy rheumatism. J Clin Oncol (1993) 3.01
The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen. J Cell Biol (1988) 2.85
Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol (2001) 2.79
The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor. Biochem Biophys Res Commun (1993) 2.67
Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart. J Clin Invest (1996) 2.63
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1989) 2.59
Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells. Virology (1992) 2.58
Observations of fouling biofilm formation. Can J Microbiol (1981) 2.56
Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice. Circ Res (2001) 2.51
Percutaneous biliary drainage in patients with nondilated intrahepatic bile ducts. AJR Am J Roentgenol (1999) 2.49
Molecular mechanics of cardiac myosin-binding protein C in native thick filaments. Science (2012) 2.48
Cardiac physiology in transgenic mice. Circ Res (1998) 2.47
Tubulin: a factor necessary for the synthesis of both Sendai virus and vesicular stomatitis virus RNAs. Proc Natl Acad Sci U S A (1986) 2.45
Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science (1998) 2.39
Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation. Circ Res (2000) 2.38
Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart. Circ Res (1991) 2.34
Neuropsychiatric correlates and treatment of lenticulostriatal diseases: a review of the literature and overview of research opportunities in Huntington's, Wilson's, and Fahr's diseases. A report of the ANPA Committee on Research. American Neuropsychiatric Association. J Neuropsychiatry Clin Neurosci (1998) 2.28
Incidence of fractures compared to cardiovascular disease and breast cancer: the Women's Health Initiative Observational Study. Osteoporos Int (2008) 2.27
Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain (2005) 2.26
BTS guidelines for the management of malignant pleural effusions. Thorax (2003) 2.24
Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice. Circulation (2001) 2.23
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest (1999) 2.22
Isolated systolic hypertension and subclinical cardiovascular disease in the elderly. Initial findings from the Cardiovascular Health Study. JAMA (1992) 2.21
Fibroblast growth factor 2 control of vascular tone. Nat Med (1998) 2.21
Cloning and sequencing of a putative Escherichia coli [NiFe] hydrogenase-1 operon containing six open reading frames. J Bacteriol (1990) 2.20
The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: I. Conceptual foundation and item development. Dysphagia (2000) 2.18
Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J Clin Invest (2000) 2.18
Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol (1993) 2.17
Autologous mesenchymal stem cell-mediated repair of tendon. Tissue Eng (1999) 2.16
Age effects on the temporal evolution of isometric and swallowing pressure. J Gerontol A Biol Sci Med Sci (2000) 2.15
Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. J Biol Chem (1999) 2.15
Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development (1988) 2.12
Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy. Mol Cell Biol (1993) 2.12
Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts. Cardiovasc Res (1999) 2.12
Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol Biol Cell (1995) 2.10
Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J Biol Chem (1998) 2.10
The clinical spectrum of the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Clinical features in 20 patients and aspects of pathophysiology. Ann Intern Med (1990) 2.06
Transgenic remodeling of the contractile apparatus in the mammalian heart. Circ Res (1996) 2.05
Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res (1999) 2.01
Improving intensive care: observations based on organizational case studies in nine intensive care units: a prospective, multicenter study. Crit Care Med (1993) 1.97
Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. Br J Ophthalmol (1998) 1.95
Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. J Clin Invest (1999) 1.95
Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nat Neurosci (1999) 1.93
Association of MSX1 and TGFB3 with nonsyndromic clefting in humans. Am J Hum Genet (1998) 1.89
Immunolocalization of the gamma isoform of nonmuscle actin in cultured cells. J Cell Biol (1986) 1.89
Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem (2001) 1.88
A phase II study of vinflunine in bladder cancer patients progressing after first-line platinum-containing regimen. Br J Cancer (2006) 1.85
Mouse model of desmin-related cardiomyopathy. Circulation (2001) 1.84
Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan. J Clin Endocrinol Metab (1995) 1.84
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy. Circ Res (2001) 1.83
High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study. Am J Clin Nutr (1998) 1.82
Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. Proc Natl Acad Sci U S A (1995) 1.81
Plasmodesmata: gatekeepers for cell-to-cell transport of developmental signals in plants. Annu Rev Cell Dev Biol (2000) 1.79
A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest (1998) 1.77
Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. J Biol Chem (1998) 1.77
Prevalence of subclinical atherosclerosis and cardiovascular disease and association with risk factors in the Cardiovascular Health Study. Am J Epidemiol (1994) 1.74
Apolipoprotein J: structure and tissue distribution. Biochemistry (1990) 1.73
The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: II. Item reduction and preliminary scaling. Dysphagia (2000) 1.72
Mutational analysis and characterization of the Escherichia coli hya operon, which encodes [NiFe] hydrogenase 1. J Bacteriol (1991) 1.71
Immunological studies of Y protein. A major cytoplasmic organic anion-binding protein in rat liver. J Clin Invest (1972) 1.71
Antibiotic use in Ontario facilities that provide chronic care. J Gen Intern Med (2001) 1.70
Esophagectomy for cancer in the patient aged 70 years and older. Ann Thorac Surg (1997) 1.69
Breast cancer and breast self-examination: what do Scottish women know? Soc Sci Med (1984) 1.69
Comparison of effortful and noneffortful swallows in healthy middle-aged and older adults. Arch Phys Med Rehabil (2001) 1.68
Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005. Vaccine (2006) 1.67