Published in Leukemia on October 01, 1997
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci U S A (2002) 3.19
A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A (2002) 2.19
Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening. Cancer Res (2012) 2.01
Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med (2006) 1.88
Detection of FLT3 internal tandem duplication and D835 mutations by a multiplex polymerase chain reaction and capillary electrophoresis assay. J Mol Diagn (2003) 1.82
RNAi screen for rapid therapeutic target identification in leukemia patients. Proc Natl Acad Sci U S A (2009) 1.81
AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J Exp Med (2002) 1.65
Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proc Natl Acad Sci U S A (2002) 1.57
Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications. J Hematol Oncol (2011) 1.40
Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors. J Cell Biol (2006) 1.36
Potential role of sorafenib in the treatment of acute myeloid leukemia. Leuk Lymphoma (2008) 1.35
Current findings for recurring mutations in acute myeloid leukemia. J Hematol Oncol (2011) 1.33
RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Blood (2007) 1.33
FLT3 tyrosine kinase inhibitors in acute myeloid leukemia: clinical implications and limitations. Leuk Lymphoma (2013) 1.21
Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med (2010) 1.15
The role of the c-Met pathway in lung cancer and the potential for targeted therapy. Ther Adv Med Oncol (2011) 1.11
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A (2004) 1.10
FLT3 inhibition as therapy in acute myeloid leukemia: a record of trials and tribulations. Oncologist (2011) 1.05
Further activation of FLT3 mutants by FLT3 ligand. Oncogene (2011) 1.04
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells. Blood (2008) 0.98
The MET axis as a therapeutic target. Update Cancer Ther (2009) 0.98
AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cells. J Biol Chem (2008) 0.97
Treatment of FLT3-ITD acute myeloid leukemia. Am J Blood Res (2011) 0.97
Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. Mol Cancer (2013) 0.96
The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status. Haematologica (2012) 0.96
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia. Blood (2012) 0.94
FLT3 mutations in myelodysplastic syndrome and chronic myelomonocytic leukemia. Am J Hematol (2012) 0.93
Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin. Blood (2007) 0.92
PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res (2010) 0.90
JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells. EMBO J (2002) 0.89
Δ-PCR, A Simple Method to Detect Translocations and Insertion/Deletion Mutations. J Mol Diagn (2010) 0.89
FLT3-regulated antigens as targets for leukemia-reactive cytotoxic T lymphocytes. Blood Cancer J (2011) 0.84
The Biology and Targeting of FLT3 in Pediatric Leukemia. Front Oncol (2014) 0.83
Low frequency and variability of FLT3 mutations in Korean patients with acute myeloid leukemia. J Korean Med Sci (2008) 0.80
NFATc1 as a therapeutic target in FLT3-ITD-positive AML. Leukemia (2015) 0.79
Emerging FMS-like tyrosine kinase 3 inhibitors for the treatment of acute myelogenous leukemia. Expert Opin Emerg Drugs (2011) 0.79
Fms-like tyrosine kinase (FLT) 3 and FLT3 internal tandem duplication in different types of adult leukemia: analysis of 147 patients. Croat Med J (2008) 0.79
Characteristics and Prognosis of Adult Acute Myeloid Leukemia with Internal Tandem Duplication in the FLT3 Gene. Oman Med J (2013) 0.78
Dasatinib impairs long-term expansion of leukemic progenitors in a subset of acute myeloid leukemia cases. Ann Hematol (2010) 0.78
FLT3 Internal Tandem Duplication and D835 Mutations in Patients with Acute Lymphoblastic Leukemia and its Clinical Significance. Mediterr J Hematol Infect Dis (2014) 0.78
Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation. Mol Cell Biol (2003) 0.77
MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1. PLoS One (2012) 0.77
Anthracycline dose intensification in young adults with acute myeloid leukemia. Ther Adv Hematol (2012) 0.77
Detection of FLT3 oncogene mutations in acute myeloid leukemia using conformation sensitive gel electrophoresis. Int J Mol Sci (2008) 0.77
The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy. J Clin Med (2015) 0.76
Frequency and Prognostic Relevance of FLT3 Mutations in Saudi Acute Myeloid Leukemia Patients. Adv Hematol (2014) 0.76
The E3 ubiquitin ligase TRAF6 inhibits LPS-induced AKT activation in FLT3-ITD-positive MV4-11 AML cells. J Cancer Res Clin Oncol (2012) 0.76
FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors. Oncotarget (2017) 0.76
RNA-mediated gene silencing in hematopoietic cells. J Biomed Biotechnol (2006) 0.76
DB2: a probabilistic approach for accurate detection of tandem duplication breakpoints using paired-end reads. BMC Genomics (2014) 0.75
Lack of FLT3-TKD835 gene mutation in toxicity of sulfur mustard in Iranian veterans. Iran J Basic Med Sci (2015) 0.75
Internal tandem duplication and tyrosine kinase domain mutations in FLT3 alter the response to daunorubicin in Ba/F3 cells. Biomed Rep (2015) 0.75
Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns. BMC Cancer (2016) 0.75
Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia. ACS Omega (2017) 0.75
Cytogenetic Profile and FLT3 Gene Mutations of Childhood Acute Lymphoblastic Leukemia. Clin Med Insights Oncol (2017) 0.75
RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia. Leuk Res (2017) 0.75
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
The relation between health insurance coverage and clinical outcomes among women with breast cancer. N Engl J Med (1993) 6.37
Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med (1993) 5.32
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood (2001) 5.17
Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology (1998) 5.15
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia (1996) 5.06
Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging (1999) 4.94
Identification of the coding sequence for a reverse transcriptase-like enzyme in a transposable genetic element in Drosophila melanogaster. Nature (1985) 4.31
slender rice, a constitutive gibberellin response mutant, is caused by a null mutation of the SLR1 gene, an ortholog of the height-regulating gene GAI/RGA/RHT/D8. Plant Cell (2001) 4.22
Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region. Nat Genet (1994) 4.04
Array-based genomic resequencing of human leukemia. Oncogene (2010) 3.77
Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA (2000) 3.69
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56
Application of typing by pulsed-field gel electrophoresis to the study of Clostridium difficile in a neonatal intensive care unit. J Clin Microbiol (1994) 3.51
Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci (1997) 3.49
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood (1999) 3.46
Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Res (1996) 3.37
Genetic and phenotypic analysis of Borrelia miyamotoi sp. nov., isolated from the ixodid tick Ixodes persulcatus, the vector for Lyme disease in Japan. Int J Syst Bacteriol (1995) 3.27
Artificial surfactant therapy in hyaline-membrane disease. Lancet (1980) 3.21
Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. Antimicrob Agents Chemother (1991) 3.05
Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother (1981) 3.03
Epidemiologic and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission. J Am Vet Med Assoc (1989) 2.97
DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell (2001) 2.90
Modeling and predicting transcriptional units of Escherichia coli genes using hidden Markov models. Bioinformatics (1999) 2.89
Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol (1994) 2.74
Naturally occurring variation in the restriction map of the amy region of Drosophila melanogaster. Genetics (1988) 2.74
Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene (2000) 2.73
What is the optimal goal of primary cytoreductive surgery for bulky stage IIIC epithelial ovarian carcinoma (EOC)? Gynecol Oncol (2006) 2.69
Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA. Cell (2001) 2.64
Two new flavonoids and other constituents in licorice root: their relative astringency and radical scavenging effects. Chem Pharm Bull (Tokyo) (1988) 2.64
Steady-state current-voltage relationship of the Na/K pump in guinea pig ventricular myocytes. J Gen Physiol (1989) 2.61
Voltage dependence of Na translocation by the Na/K pump. Nature (1986) 2.60
Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. Eur J Epidemiol (2003) 2.52
Giant Rashba-type spin splitting in bulk BiTeI. Nat Mater (2011) 2.49
Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome. Neurology (2008) 2.45
Structural genomics projects in Japan. Nat Struct Biol (2000) 2.40
Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. J Exp Med (2000) 2.37
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia (1998) 2.35
Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat Cell Biol (2001) 2.23
Widespread intraspecies cross-contamination of human tumor cell lines arising at source. Int J Cancer (1999) 2.20
MMDB: Entrez's 3D structure database. Nucleic Acids Res (1999) 2.17
False leukemia-lymphoma cell lines: an update on over 500 cell lines. Leukemia (2003) 2.09
Role of type 1 fimbriae in the pathogenesis of ascending urinary tract infection induced by escherichia coli in mice. Infect Immun (1983) 2.06
An accurate maxillary superior repositioning technique without intraoperative measurement in bimaxillary orthognathic surgery. Int J Oral Maxillofac Surg (2012) 2.06
Magnifying endoscopy, stereoscopic microscopy, and the microvascular architecture of superficial esophageal carcinoma. Endoscopy (2002) 2.01
Muscle-fiber pennation angles are greater in hypertrophied than in normal muscles. J Appl Physiol (1985) (1993) 2.01
Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas. AJR Am J Roentgenol (1998) 2.00
Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication. Am J Hum Genet (1980) 1.97
Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. Biochim Biophys Acta (2000) 1.97
Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells. EMBO J (2001) 1.88
Differential isolation of microvillous and basolateral plasma membranes from intestinal mucosa: mutually exclusive distribution of digestive enzymes and ouabain-sensitive ATPase. Biochim Biophys Acta (1972) 1.86
Mitochondrial DNA polymorphism among five Asian populations. Am J Hum Genet (1988) 1.86
A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome. Nat Genet (2001) 1.86
Endoscopic ultrasound examination for mediastinal lymph node metastases of lung cancer. Chest (1990) 1.85
Phylogenetic analysis of Borrelia species based on flagellin gene sequences and its application for molecular typing of Lyme disease borreliae. Int J Syst Bacteriol (1996) 1.84
Bisulfite sequencing and dinucleotide content analysis of 15 imprinted mouse differentially methylated regions (DMRs): paternally methylated DMRs contain less CpGs than maternally methylated DMRs. Cytogenet Genome Res (2006) 1.84
Role of anti-oncomirs miR-143 and -145 in human colorectal tumors. Cancer Gene Ther (2010) 1.81
Molecular characterization of two proximal deletion breakpoint regions in both Prader-Willi and Angelman syndrome patients. Am J Hum Genet (1995) 1.78
Autologous peripheral blood stem cell transplantation for POEMS syndrome. Neurology (2006) 1.77
In vitro antibacterial activity of SM-1652, a new broad-spectrum cephalosporin with antipseudomonal activity. Antimicrob Agents Chemother (1983) 1.77
Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br J Cancer (2001) 1.77
Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms. Mol Cell Biol (1999) 1.75
Treatment of esophageal and gastric tumors. Endoscopy (1999) 1.75
Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia. Blood (1997) 1.72
Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res (1991) 1.71
Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET. Eur J Biochem (2001) 1.68
Structure and regulation of rat long-chain acyl-CoA synthetase. J Biol Chem (1990) 1.68
Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization. Genes Chromosomes Cancer (1999) 1.68
Does Campylobacter jejuni infection elicit "demyelinating" Guillain-Barre syndrome? Neurology (2004) 1.67
Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues. Br J Cancer (2000) 1.67
Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning. Circulation (1995) 1.67
Highly specific sodium-potassium-activated adenosine triphosphatase from various tissues of rabbit. Biochem Biophys Res Commun (1965) 1.66
Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia (1997) 1.66
Epstein-Barr virus-encoded poly(A)(-) RNA supports Burkitt's lymphoma growth through interleukin-10 induction. EMBO J (2000) 1.66
Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial. Br J Cancer (2003) 1.63
Specificity and distribution of alpha antigens of Mycobacterium avium-intracellulare, Mycobacterium scrofulaceum, and related species of mycobacteria. Am Rev Respir Dis (1985) 1.62
Cholesterol granuloma in the petrous apex: case report and review. Acta Neurochir (Wien) (2001) 1.61
International prognostic scoring system and TP53 mutations are independent prognostic indicators for patients with myelodysplastic syndrome. Br J Haematol (2001) 1.59
A technique of cervical aortic graft transplantation in mice. J Heart Lung Transplant (2001) 1.59
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. Leukemia (2005) 1.59
Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice. Infect Immun (1997) 1.58
Continuous release of endostatin from microencapsulated engineered cells for tumor therapy. Nat Biotechnol (2001) 1.57
Crry, a complement regulatory protein, modulates renal interstitial disease induced by proteinuria. Kidney Int (1999) 1.57
Bickerstaff's brainstem encephalitis and Fisher syndrome form a continuous spectrum: clinical analysis of 581 cases. J Neurol (2008) 1.57
Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I. Antimicrob Agents Chemother (1992) 1.56
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts. Oncogene (1999) 1.55
Extensive lymphopenia due to apoptosis of uninfected lymphocytes in acute measles patients. Arch Virol (2000) 1.55
Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells (1998) 1.54
Immunogenicity of human amniotic membrane in experimental xenotransplantation. Invest Ophthalmol Vis Sci (2001) 1.54