Published in Eur J Epidemiol on January 01, 2003
The Relationship Between Uric Acid and Inflammatory Markers | NCT01323335
Uric acid and cardiovascular risk. N Engl J Med (2008) 12.20
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33
SLC2A9 is a high-capacity urate transporter in humans. PLoS Med (2008) 2.87
Uric acid and inflammatory markers. Eur Heart J (2006) 2.81
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev (2009) 2.65
Uric acid and the development of metabolic syndrome in women and men. Metabolism (2008) 2.09
Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes (2011) 1.82
Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids (2008) 1.76
Associations of serum uric acid with cardiovascular events and mortality in moderate chronic kidney disease. Nephrol Dial Transplant (2008) 1.31
Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index? Eur J Nutr (2007) 1.24
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? J Comp Physiol B (2008) 1.23
Uric acid and insulin sensitivity and risk of incident hypertension. Arch Intern Med (2009) 1.21
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal? Curr Hypertens Rep (2013) 1.20
High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PLoS One (2013) 1.17
Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years. Am J Cardiol (2007) 1.14
Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study. PLoS One (2011) 1.11
Fructose and vitamin C intake do not influence risk for developing hypertension. J Am Soc Nephrol (2009) 1.08
Relationship between hyperuricemia and metabolic syndrome. J Zhejiang Univ Sci B (2007) 1.07
Hyperuricemia is independently associated with coronary heart disease and renal dysfunction in patients with type 2 diabetes mellitus. PLoS One (2011) 1.05
Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. PLoS One (2014) 1.04
A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population. BMC Med Genomics (2014) 1.02
No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach. Diabetologia (2011) 0.99
Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men's Health Study. Nutr Metab Cardiovasc Dis (2011) 0.98
Uric acid is more strongly associated with impaired glucose regulation in women than in men from the general population: the KORA F4-Study. PLoS One (2012) 0.98
Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis. Rheumatol Int (2009) 0.96
Serum uric acid levels are associated with polymorphism in the SAA1 gene in Chinese subjects. PLoS One (2012) 0.94
Serum uric acid predicts both current and future components of the metabolic syndrome. Metab Syndr Relat Disord (2013) 0.94
Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach. PLoS One (2012) 0.94
Association between Serum Uric Acid Levels and Diabetes Mellitus. Int J Endocrinol (2011) 0.93
Potential role of uric Acid as a risk factor for cardiovascular disease. Korean J Intern Med (2010) 0.91
Serum uric acid is an independent predictor of metabolic syndrome in a Japanese health screening population. Heart Vessels (2013) 0.91
Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout. QJM (2013) 0.90
Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals. BMC Cardiovasc Disord (2014) 0.90
Serum urate association with hypertension in young adults: analysis from the Coronary Artery Risk Development in Young Adults cohort. Ann Rheum Dis (2012) 0.90
Serum uric acid is more strongly associated with impaired fasting glucose in women than in men from a community-dwelling population. PLoS One (2013) 0.89
The role of uric acid in pediatric hypertension. J Ren Nutr (2007) 0.89
Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis. Biomed Res Int (2015) 0.88
Serum uri acid: neuroprotection in thrombolysis. The Bergen NORSTROKE study. BMC Neurol (2011) 0.87
Serum uric acid and appropriate cutoff value for prediction of metabolic syndrome among Chinese adults. J Clin Biochem Nutr (2012) 0.87
The association between blood pressure level and serum uric acid concentration in hemodialysis patients. J Nephropathol (2015) 0.86
Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men. Metab Syndr Relat Disord (2010) 0.86
Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes. Am J Obstet Gynecol (2009) 0.85
Diabetes and its chronic complications in the She ethnic minority group of China. Diabetes Technol Ther (2012) 0.85
The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese. Exp Diabetes Res (2011) 0.83
Serum uric acid levels and the risk of impaired fasting glucose: a prospective study in adults of north China. PLoS One (2013) 0.83
Uric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney disease. Nephrol Dial Transplant (2015) 0.83
Association between serum uric acid level and metabolic syndrome components. J Diabetes Metab Disord (2015) 0.82
Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study. J Intern Med (2014) 0.82
Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study. PLoS One (2014) 0.81
Comorbidities in patients with crystal diseases and hyperuricemia. Rheum Dis Clin North Am (2014) 0.81
New and improved strategies for the treatment of gout. Int J Nephrol Renovasc Dis (2010) 0.81
Comparing the effects of inorganic nitrate and allopurinol in renovascular complications of metabolic syndrome in rats: role of nitric oxide and uric acid. Arch Med Sci (2013) 0.80
Association of Serum Uric Acid with Cardiovascular Disease in Taiwanese Patients with Primary Hypertension. Zhonghua Minguo Xin Zang Xue Hui Za Zhi (2015) 0.80
Health Implications of High-Fructose Intake and Current Research. Adv Nutr (2015) 0.79
Asymptomatic hyperuricemia: is it time to intervene? Clin Rheumatol (2017) 0.79
Physical activity offsets the negative effects of a high-fructose diet. Med Sci Sports Exerc (2014) 0.79
Serum uric acid level and the incidence of metabolic syndrome in middle-aged Korean men: a 5-year follow-up study. J Prev Med Public Health (2014) 0.78
Serum uric acid and disorders of glucose metabolism: the role of glycosuria. Braz J Med Biol Res (2014) 0.77
Resistance Training in Type 2 Diabetic Patients Improves Uric Acid levels. J Hum Kinet (2014) 0.76
The association of hypomagnesaemia, high normal uricaemia and dyslipidaemia in the patients with diabetic retinopathy. J Clin Diagn Res (2013) 0.76
Relationship between hyperuricemia and dietary risk factors in Chinese adults: a cross-sectional study. Rheumatol Int (2015) 0.76
Hyperuricemia as a Potential Determinant of Metabolic Syndrome. J Lifestyle Med (2013) 0.75
Urate oxidase knockdown decreases oxidative stress in a murine hepatic cell line. Oxid Med Cell Longev (2010) 0.75
Positive relationship between total antioxidant status and chemokines observed in adults. Oxid Med Cell Longev (2014) 0.75
Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema. Blood Coagul Fibrinolysis (2015) 0.75
The Impacts of Serum Uric Acid on arterial hemodynamics and Cardiovascular Risks. Zhonghua Minguo Xin Zang Xue Hui Za Zhi (2013) 0.75
The relevance of hyperuricemia and metabolic syndrome and the effect of blood lead level on uric Acid concentration in steelmaking workers. Ann Occup Environ Med (2013) 0.75
Serum uric acid and low-density lipoprotein cholesterol levels are independent predictors of coronary artery disease in Asian Indian patients with type 2 diabetes mellitus. J Nat Sci Biol Med (2016) 0.75
The Association between Serum Uric Acid Level and Incidence of Metabolic Syndrome according to Menopausal Status in Korean Women. J Menopausal Med (2014) 0.75
Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study. PLoS One (2015) 0.75
Mid-gestational serum uric acid concentration effect on neonate birth weight and insulin resistance in pregnant women. Int J Crit Illn Inj Sci (2015) 0.75
Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study. Oncotarget (2017) 0.75
A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study. PLoS One (2017) 0.75
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol (2001) 13.98
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (1999) 12.32
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell (1999) 9.05
DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature (1998) 7.38
Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal. Neurology (2007) 6.61
A novel integron-like element carrying the metallo-beta-lactamase gene blaIMP. Antimicrob Agents Chemother (1995) 6.00
Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli. Mol Gen Genet (1986) 5.95
Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site. Proc Natl Acad Sci U S A (1980) 5.55
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell (2001) 5.39
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07
In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone. Antimicrob Agents Chemother (1989) 4.79
Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res (1998) 4.39
Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc Natl Acad Sci U S A (1993) 4.35
Identification of the coding sequence for a reverse transcriptase-like enzyme in a transposable genetic element in Drosophila melanogaster. Nature (1985) 4.31
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells. Development (1997) 4.14
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature (1998) 4.06
Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus. Antimicrob Agents Chemother (1994) 3.96
New ages for the last Australian megafauna: continent-wide extinction about 46,000 years ago. Science (2001) 3.91
gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli. Antimicrob Agents Chemother (1989) 3.67
Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells (1996) 3.58
Formation and reversion of Streptomycete protoplasts: cultural condition and morphological study. J Gen Microbiol (1974) 3.56
Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res (2001) 3.51
TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci (2001) 3.50
Molecular structure of a gene, VMA1, encoding the catalytic subunit of H(+)-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. J Biol Chem (1990) 3.47
Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med (2000) 3.44
Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol Biol Cell (2001) 3.41
A prospective randomised study of "covered" versus "uncovered" diamond stents for the management of distal malignant biliary obstruction. Gut (2004) 3.35
Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol (1998) 3.34
Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci U S A (1987) 3.32
Induction of various autoantibodies by mutant gene lpr in several strains of mice. J Immunol (1984) 3.20
Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. J Immunol (1999) 3.18
An infectious molecular clone of a Japanese genotype 1b hepatitis C virus. Hepatology (1999) 3.00
Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A (2001) 2.97
The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell (2001) 2.97
Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. J Exp Med (2001) 2.96
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (1999) 2.96
Adrenoleukodystrophy. A clinical and pathological study of 17 cases. Arch Neurol (1975) 2.86
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem (1996) 2.85
Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut (1998) 2.84
Phylogenetic analysis of the coryneform bacteria by 5S rRNA sequences. J Bacteriol (1987) 2.83
Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A (1986) 2.83
Naturally occurring variation in the restriction map of the amy region of Drosophila melanogaster. Genetics (1988) 2.74
Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF. EMBO J (1991) 2.68
Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65
Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nat Genet (1995) 2.64
Structure and physiological function of calpains. Biochem J (1997) 2.62
Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology (2001) 2.62
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology (1996) 2.59
Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem (1983) 2.58
Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol (1999) 2.55
In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity (1998) 2.54
Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell (1996) 2.53
Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein? Nature (1985) 2.52
Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998. Jpn J Infect Dis (1999) 2.52
Globoid cell leucodystrophy (Krabbe's disease): deficiency of galactocerebroside beta-galactosidase. Proc Natl Acad Sci U S A (1970) 2.48
Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature (1997) 2.46
A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family. Cell (1988) 2.44
Leukocytosis-promoting factor of Bordetella pertussis. 3. Its identity with protective antigen. Infect Immun (1974) 2.43
Structural genomics projects in Japan. Nat Struct Biol (2000) 2.40
Gene cloning of chitinase A1 from Bacillus circulans WL-12 revealed its evolutionary relationship to Serratia chitinase and to the type III homology units of fibronectin. J Biol Chem (1990) 2.38
Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun (1999) 2.38
Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. J Exp Med (2000) 2.37
Blood clearance rates of adenovirus type 5 in mice. J Gen Virol (2000) 2.36
Dog and rat pancreatic phospholipases A2: complete amino acid sequences deduced from complementary DNAs. J Biochem (1986) 2.36
Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J (1994) 2.33
Comparative study on adhesive performance of functional monomers. J Dent Res (2004) 2.32
Use of recombinant human bone morphogenetic protein-2 to enhance tendon healing in a bone tunnel. Am J Sports Med (1999) 2.29
Functional expression and germline transmission of a human chromosome fragment in chimaeric mice. Nat Genet (1997) 2.28
Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene (2007) 2.27
Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. Gut (1999) 2.25
Expression and self-assembly of empty virus-like particles of hepatitis E virus. J Virol (1997) 2.25
Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun (1989) 2.23
Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study. Am J Cardiol (1982) 2.22
Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase. J Clin Invest (1996) 2.21
Widespread intraspecies cross-contamination of human tumor cell lines arising at source. Int J Cancer (1999) 2.20
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development (2001) 2.19
MMDB: Entrez's 3D structure database. Nucleic Acids Res (1999) 2.17
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature (1997) 2.17
Characterization of pseudotype VSV possessing HCV envelope proteins. Virology (2001) 2.15
Crossed aphasia elicited by direct cortical stimulation. Neurology (2006) 2.15
Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice. Circ Res (2001) 2.14
Specific restrictions in the progression of Venezuelan equine encephalitis virus-induced disease resulting from single amino acid changes in the glycoproteins. Virology (1995) 2.14
Tissue-specific expression of three distinct types of rabbit protein kinase C. Nature (1987) 2.14
Pericardial closure using fascia lata in patients undergoing pneumonectomy with pericardiectomy. Ann Thorac Surg (1998) 2.13
Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med (1999) 2.13
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. Eur J Biochem (1990) 2.13
A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem (1990) 2.12
Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores. Plant Physiol (1999) 2.11
Erythrocyte antioxidant enzymes are reduced in patients with rheumatoid arthritis. J Rheumatol (1988) 2.09
Proline-directed and non-proline-directed phosphorylation of PHF-tau. J Biol Chem (1995) 2.09
False leukemia-lymphoma cell lines: an update on over 500 cell lines. Leukemia (2003) 2.09
A case of Cushing's syndrome due to adrenocortical carcinoma with recurrence 19 months after laparoscopic adrenalectomy. J Urol (1997) 2.08
The relationship between facet joint osteoarthritis and disc degeneration of the lumbar spine: an MRI study. Eur Spine J (1999) 2.07
A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. J Biol Chem (1989) 2.06
Genomic DNA released by dying cells induces the maturation of APCs. J Immunol (2001) 2.03