Published in J Biol Chem on October 24, 1997
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A (2001) 6.70
The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov (2012) 3.18
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest (2003) 1.73
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Mol Biol Cell (2000) 1.62
The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments. Mol Biol Cell (2000) 1.25
A protein-based therapeutic for human cytomegalovirus infection. Proc Natl Acad Sci U S A (2000) 1.23
Site-specific cleavage of BMP4 by furin, PC6, and PC7. J Biol Chem (2009) 1.06
The proprotein convertase PC7: unique zymogen activation and trafficking pathways. J Biol Chem (2010) 0.98
Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. J Biol Chem (2011) 0.91
Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proc Natl Acad Sci U S A (2013) 0.89
Glycine decarboxylase mediates a postbinding step in duck hepatitis B virus infection. J Virol (2004) 0.89
Generation and characterization of non-competitive furin-inhibiting nanobodies. Biochem J (2012) 0.89
Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization. Biochem J (2000) 0.89
Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments. Biochem J (1998) 0.88
Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif. J Biol Chem (2012) 0.87
Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1). Proc Natl Acad Sci U S A (2003) 0.85
Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease. J Virol (2010) 0.83
Alterations in expression profile of iron-related genes in colorectal cancer. Mol Biol Rep (2013) 0.82
Autoproteolytic Activation of a Symbiosis-regulated Truffle Phospholipase A2. J Biol Chem (2012) 0.77
Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometry. Nature (1981) 6.18
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet (1997) 4.77
Construction and characterization of genomic libraries from specific human chromosomes. Proc Natl Acad Sci U S A (1982) 3.86
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet (1992) 3.43
Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet (1995) 3.27
A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. J Cell Biol (2000) 2.98
The nonstructural components of polyproteins encoded by replication-defective mammalian transforming retroviruses are phosphorylated and have associated protein kinase activity. Virology (1980) 2.77
Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen. Proc Natl Acad Sci U S A (1987) 2.75
Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein. EMBO J (1986) 2.73
A novel adaptor-related protein complex. J Cell Biol (1996) 2.69
The role of intraorganellar Ca(2+) in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J Cell Biol (2000) 2.46
Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. Hum Mol Genet (1997) 2.45
Regional mapping of the human immunoglobulin lambda light chain to the Philadelphia chromosome in chronic myeloid leukaemia. Leuk Res (1984) 2.44
Characterization of a fourth adaptor-related protein complex. Mol Biol Cell (1999) 2.27
Construction, arraying, and high-density screening of large insert libraries of human chromosomes X and 21: their potential use as reference libraries. Proc Natl Acad Sci U S A (1991) 2.21
Characterization of human c-fes/fps reveals a new transcription unit (fur) in the immediately upstream region of the proto-oncogene. Mol Biol Rep (1986) 2.16
Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2. Nucleic Acids Res (1990) 2.15
Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene (2007) 2.14
Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependent. J Cell Biol (1998) 2.12
Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes. Mol Biol Rep (1990) 2.12
MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis. Leukemia (2007) 2.05
Rapid isolation of human chromosome-specific DNA probes from a somatic cell hybrid. Genomics (1990) 1.99
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development (1998) 1.98
Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion. Mol Biol Cell (2000) 1.95
LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics (1996) 1.93
Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat Genet (1997) 1.92
Random association of Epstein-Barr virus genomes with host cell metaphase chromosomes in Burkitt's lymphoma-derived cell lines. J Virol (1985) 1.91
Kinetic studies of gene frequency. I. Use of a DNA copy of reticulocyte 9 S RNA to estimate globin gene dosage in mouse tissues. J Mol Biol (1974) 1.87
Lysosome-endosome fusion and lysosome biogenesis. J Cell Sci (2000) 1.82
Kinetic studies of gene frequency. II. Complexity of globin complementary DNA and its hybridization characteristics. J Mol Biol (1974) 1.78
The structure of the human c-fes/fps proto-oncogene. EMBO J (1985) 1.70
Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland. Cancer Res (1997) 1.65
High-resolution analysis of human peripheral lymphocyte chromosomes by flow cytometry. Proc Natl Acad Sci U S A (1981) 1.65
A kinetic estimation of base sequence complexity of nuclear poly(A)-containing RNA in mouse Friend cells. Cell (1975) 1.63
A new method for the preparation of metaphase chromosomes for flow analysis. J Histochem Cytochem (1981) 1.63
fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas. J Clin Invest (1987) 1.63
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Mol Biol Cell (2000) 1.62
Molecular characterization of a complex chromosomal rearrangement in a pleomorphic salivary gland adenoma involving the 3'-UTR of HMGIC. Cancer Genet Cytogenet (1997) 1.61
The isolation of a human Ig V lambda gene from a recombinant library of chromosome 22 and estimation of its copy number. Nucleic Acids Res (1984) 1.61
The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins. Proc Natl Acad Sci U S A (1995) 1.58
Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases. Crit Rev Oncog (1993) 1.56
Bcl-2/JH rearrangements in benign lymphoid tissues with follicular hyperplasia. Oncogene (1991) 1.56
The significance of circulating cells carrying t(14;18) in long remission from follicular lymphoma. J Clin Oncol (1991) 1.55
The diversity of the messenger RNA population in growing Friend cells. Cell Differ (1974) 1.53
Localisation of Nramp1 in macrophages: modulation with activation and infection. J Cell Sci (1998) 1.50
Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. Cancer Res (1999) 1.49
Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis. J Biol Chem (1993) 1.48
A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood (1995) 1.48
Prevalence and clinical correlations of MLL gene rearrangements in AML-M4/5. Blood (1994) 1.44
Gene mapping by enzymatic amplification from flow-sorted chromosomes. Genomics (1989) 1.44
Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum. J Biol Chem (1995) 1.43
Abelson murine leukemia virus transformation-defective mutants with impaired P120-associated protein kinase activity. J Virol (1980) 1.42
Characterization of a 170,000-dalton polyprotein encoded by the McDonough strain of feline sarcoma virus. J Virol (1980) 1.41
Detection of cells bearing the t(14;18) translocation following myeloablative treatment and autologous bone marrow transplantation for follicular lymphoma. J Clin Oncol (1994) 1.41
A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation. J Biol Chem (1995) 1.41
Complexity and specificity of polysomal poly(A+) RNA in mouse tissues. Biochemistry (1976) 1.40
Determination of the DNA content of human chromosomes by flow cytometry. Cytogenet Cell Genet (1986) 1.40
The role of calcium and other ions in sorting and delivery in the late endocytic pathway. Biochem Soc Trans (2007) 1.40
PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Cancer Res (2000) 1.39
The role of ADP-ribosylation factor and phospholipase D in adaptor recruitment. J Cell Biol (1997) 1.38
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding. Leukemia (2012) 1.35
Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases. Eur J Biochem (1994) 1.34
Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation. J Mol Biol (2000) 1.33
Anemia- and polycythemia-inducing isolates of Friend spleen focus-forming virus. Biological and molecular evidence for two distinct viral genomes. J Exp Med (1980) 1.29
HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors. Oncogene (1996) 1.26
HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas. Oncogene (1997) 1.25
Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J Biol Chem (1998) 1.25
The effects of cytochalasin D and phorbol myristate acetate on the apical endocytosis of ricin in polarised Caco-2 cells. J Cell Sci (1996) 1.24
Menin interacts directly with the homeobox-containing protein Pem. Biochem Biophys Res Commun (2001) 1.23
The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood (1995) 1.22
13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia. Leukemia (2010) 1.21
Tumor necrosis factor-alpha induces apoptosis of human adipose cells. Diabetes (1997) 1.21
Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations. Leukemia (2010) 1.19
Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse. Blood (1999) 1.17
Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma. Leukemia (2007) 1.17
Histone acetylation-mediated regulation of genes in leukaemic cells. Eur J Cancer (2003) 1.17
Processing of wild-type and mutant proinsulin-like growth factor-IA by subtilisin-related proprotein convertases. J Biol Chem (1997) 1.16
Differences in mechanisms of transformation by independent feline sarcoma virus isolates. J Virol (1981) 1.16
Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia. Nature (1987) 1.16
Structure and nucleotide sequence of the 5' region of the human and feline c-sis proto-oncogenes. Nucleic Acids Res (1986) 1.16
Translational products encoded by newly acquired sequences of independently derived feline sarcoma virus isolates are structurally related. J Virol (1980) 1.15
Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif. J Biol Chem (1992) 1.15
Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML. Leukemia (2007) 1.14
Regulation of HMGIC expression: an architectural transcription factor involved in growth control and development. Oncogene (1999) 1.13
Nucleotide sequence of the DNA region immediately upstream of the human c-sis proto-oncogene. Nucleic Acids Res (1987) 1.12
Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia. Genomics (1998) 1.12
Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2. J Biol Chem (1995) 1.12
Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements. J Biol Chem (1995) 1.11