Published in Infect Immun on November 01, 1997
Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus. Infect Immun (1999) 2.35
Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action. J Clin Invest (1998) 2.29
Staphylococcus aureus α-toxin: nearly a century of intrigue. Toxins (Basel) (2013) 1.99
Expression of Staphylococcus aureus clumping factor A in Lactococcus lactis subsp. cremoris using a new shuttle vector. Infect Immun (2000) 1.97
Regulated antisense RNA eliminates alpha-toxin virulence in Staphylococcus aureus infection. J Bacteriol (1999) 1.88
Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors? Front Cell Infect Microbiol (2012) 1.84
Alpha-toxin is required for biofilm formation by Staphylococcus aureus. J Bacteriol (2003) 1.73
Selective activation of sar promoters with the use of green fluorescent protein transcriptional fusions as the detection system in the rabbit endocarditis model. Infect Immun (1998) 1.72
Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus. J Clin Invest (2003) 1.56
In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother (2011) 1.44
Platelets in defense against bacterial pathogens. Cell Mol Life Sci (2009) 1.35
Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency. Clin Vaccine Immunol (2012) 1.33
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia. Antimicrob Agents Chemother (2013) 1.25
Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). FEMS Immunol Med Microbiol (2012) 1.19
Study of Staphylococcus aureus pathogenic genes by transfer and expression in the less virulent organism Streptococcus gordonii. Infect Immun (2001) 1.18
Impact of the high-affinity proline permease gene (putP) on the virulence of Staphylococcus aureus in experimental endocarditis. Infect Immun (1999) 1.17
Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog (2011) 1.11
Multicenter evaluation of the clinical outcomes of daptomycin with and without concomitant β-lactams in patients with Staphylococcus aureus bacteremia and mild to moderate renal impairment. Antimicrob Agents Chemother (2012) 1.07
Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses. Vaccine (2012) 1.04
Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood (2013) 1.03
A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis. Infect Immun (2005) 0.94
The H35A mutated alpha-toxin interferes with cytotoxicity of staphylococcal alpha-toxin. Infect Immun (2008) 0.93
Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease. MBio (2015) 0.89
Influence of platelets and platelet microbicidal protein susceptibility on the fate of Staphylococcus aureus in an in vitro model of infective endocarditis. Infect Immun (2000) 0.89
Staphylococcal alpha-toxin is not sufficient to mediate escape from phagolysosomes in upper-airway epithelial cells. Infect Immun (2009) 0.88
Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis. Cell Host Microbe (2015) 0.87
Staphylococcus aureus, Platelets, and the Heart. Curr Infect Dis Rep (2000) 0.87
Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-alpha toxin antibody fragment and alpha toxin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.86
Staphylococcus aureus gene expression in a rat model of infective endocarditis. Genome Med (2014) 0.82
Staphylococcus aureus α-hemolysin promotes platelet-neutrophil aggregate formation. J Infect Dis (2013) 0.82
Identification of single nucleotide polymorphisms associated with hyperproduction of alpha-toxin in Staphylococcus aureus. PLoS One (2011) 0.81
Salicylic acid: an old dog, new tricks, and staphylococcal disease. J Clin Invest (2003) 0.79
Staphylococcus aureus α-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets. Toxins (Basel) (2011) 0.79
Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA SprX1. Med Microbiol Immunol (2016) 0.77
Infective endocarditis. Nat Rev Dis Prim (2016) 0.75
Effects of Tedizolid Phosphate on Survival Outcomes and Suppression of Production of Staphylococcal Toxins in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia. Antimicrob Agents Chemother (2017) 0.75
The mutated staphylococcal H35A α-toxin inhibits adhesion and invasion of Staphylococcus aureus and group A streptococci. Virulence (2013) 0.75
Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science (1996) 16.69
Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol (1972) 8.33
Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr. Proc Natl Acad Sci U S A (1992) 6.95
Alpha-toxin of Staphylococcus aureus. Microbiol Rev (1991) 6.14
Construction of single-copy integration vectors for Staphylococcus aureus. Gene (1991) 4.43
Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest (1994) 4.39
Bacterial adherence in the pathogenesis of endocarditis. Interaction of bacterial dextran, platelets, and fibrin. J Clin Invest (1978) 4.38
A method to isolate RNA from gram-positive bacteria and mycobacteria. Anal Biochem (1994) 4.24
Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions. J Pathol (1975) 3.96
Inactivation of the alpha-haemolysin gene of Staphylococcus aureus 8325-4 by site-directed mutagenesis and studies on the expression of its haemolysins. Microb Pathog (1986) 3.87
Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis. Infect Immun (1995) 3.65
Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr. J Bacteriol (1994) 3.54
Gentamicin-resistant menadione and hemin auxotrophic Staphylococcus aureus persist within cultured endothelial cells. J Infect Dis (1994) 2.91
Regulation of alpha- and beta-hemolysins by the sar locus of Staphylococcus aureus. J Bacteriol (1994) 2.82
Partial characterization and staphylocidal activity of thrombin-induced platelet microbicidal protein. Infect Immun (1992) 2.53
Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model. Infect Immun (1994) 2.25
Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland. Infect Immun (1989) 2.23
Effect of thrombocytopenia on the early course of streptococcal endocarditis. J Infect Dis (1993) 2.18
Assay of hemolytic toxins. Methods Enzymol (1988) 2.16
Purification and in vitro activities of rabbit platelet microbicidal proteins. Infect Immun (1997) 1.96
Staphylococcus aureus induces tissue factor expression in cultured human cardiac valve endothelium. J Infect Dis (1988) 1.95
Assembly of the oligomeric membrane pore formed by Staphylococcal alpha-hemolysin examined by truncation mutagenesis. J Biol Chem (1992) 1.93
Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits. Infect Immun (1994) 1.92
In vitro resistance to platelet microbicidal protein correlates with endocarditis source among bacteremic staphylococcal and streptococcal isolates. Antimicrob Agents Chemother (1994) 1.83
Influence of agr on fibrinogen binding in Staphylococcus aureus Newman. Infect Immun (1996) 1.81
Phenotypic characterization of Streptococcus sanguis virulence factors associated with bacterial endocarditis. Infect Immun (1990) 1.81
Staphylococcal alpha toxin promotes blood coagulation via attack on human platelets. J Exp Med (1988) 1.79
Effects of interleukin-1, lipopolysaccharide, and streptococci on procoagulant activity of cultured human cardiac valve endothelial and stromal cells. Infect Immun (1989) 1.71
Purification of staphylococcal alpha-toxin by adsorption chromatography on glass. Infect Immun (1976) 1.64
The platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditis. Infect Immun (1992) 1.57
Phenotypic resistance to thrombin-induced platelet microbicidal protein in vitro is correlated with enhanced virulence in experimental endocarditis due to Staphylococcus aureus. Infect Immun (1997) 1.51
Involvement of bactericidal factors from thrombin-stimulated platelets in clearance of adherent viridans streptococci in experimental infective endocarditis. Infect Immun (1995) 1.50
Cytotoxic effects of ingested Staphylococcus aureus on bovine endothelial cells: role of S. aureus alpha-hemolysin. Microb Pathog (1988) 1.46
Diminished platelet binding in vitro by Staphylococcus aureus is associated with reduced virulence in a rabbit model of infective endocarditis. Infect Immun (1996) 1.45
Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis. Infect Immun (1994) 1.45
Resistance to platelet microbicidal protein results in increased severity of experimental Candida albicans endocarditis. Infect Immun (1996) 1.39
Growth of Staphylococcus aureus with nafcillin in vitro induces alpha-toxin production and increases the lethal activity of sterile broth filtrates in a murine model. J Infect Dis (1995) 1.01
Platelet aggregation by Streptococcus pyogenes. Infect Immun (1983) 0.97
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet (1998) 5.24
Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest (1994) 4.39
The molecular architecture of the sar locus in Staphylococcus aureus. J Bacteriol (1996) 3.46
SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J Biol Chem (1999) 3.11
Molecular interactions between two global regulators, sar and agr, in Staphylococcus aureus. J Biol Chem (1998) 3.09
Survival of Staphylococcus aureus inside neutrophils contributes to infection. J Immunol (2000) 3.08
Characterization of the sar locus and its interaction with agr in Staphylococcus aureus. J Bacteriol (1996) 3.05
The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level. Arch Microbiol (1997) 2.65
Staphylococcus aureus RN6390 replicates and induces apoptosis in a pulmonary epithelial cell line. Infect Immun (2000) 2.54
Evaluation of a tetracycline-inducible promoter in Staphylococcus aureus in vitro and in vivo and its application in demonstrating the role of sigB in microcolony formation. Infect Immun (2001) 2.49
Transcriptional analysis of different promoters in the sar locus in Staphylococcus aureus. J Bacteriol (1998) 2.48
Effect of thrombocytopenia on the early course of streptococcal endocarditis. J Infect Dis (1993) 2.18
Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophthalmitis. Infect Immun (1997) 2.13
SarA level is a determinant of agr activation in Staphylococcus aureus. Mol Microbiol (1998) 2.09
Characterization of sarR, a modulator of sar expression in Staphylococcus aureus. Infect Immun (2001) 2.01
Characterization of RAT, an autolysis regulator in Staphylococcus aureus. Mol Microbiol (2003) 2.01
Purification and in vitro activities of rabbit platelet microbicidal proteins. Infect Immun (1997) 1.96
Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits. Infect Immun (1994) 1.92
Characterization and biological properties of a new staphylococcal exotoxin. J Exp Med (1994) 1.91
SarT, a repressor of alpha-hemolysin in Staphylococcus aureus. Infect Immun (2001) 1.89
In vitro resistance to platelet microbicidal protein correlates with endocarditis source among bacteremic staphylococcal and streptococcal isolates. Antimicrob Agents Chemother (1994) 1.83
Influence of agr on fibrinogen binding in Staphylococcus aureus Newman. Infect Immun (1996) 1.81
Staphylocidal action of thrombin-induced platelet microbicidal protein is not solely dependent on transmembrane potential. Infect Immun (1996) 1.79
In vitro antibacterial activities of platelet microbicidal protein and neutrophil defensin against Staphylococcus aureus are influenced by antibiotics differing in mechanism of action. Antimicrob Agents Chemother (1999) 1.77
In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity. Infect Immun (2000) 1.73
sigma(B) activity in Staphylococcus aureus is controlled by RsbU and an additional factor(s) during bacterial growth. Infect Immun (2001) 1.63
Expression of an antisense hla fragment in Staphylococcus aureus reduces alpha-toxin production in vitro and attenuates lethal activity in a murine model. Infect Immun (1997) 1.56
Reversible fluconazole resistance in Candida albicans: a potential in vitro model. Antimicrob Agents Chemother (1997) 1.54
Phenotypic resistance to thrombin-induced platelet microbicidal protein in vitro is correlated with enhanced virulence in experimental endocarditis due to Staphylococcus aureus. Infect Immun (1997) 1.51
Crystal structure of the SarR protein from Staphylococcus aureus. Proc Natl Acad Sci U S A (2001) 1.48
Factors affecting the collagen binding capacity of Staphylococcus aureus. Infect Immun (1998) 1.48
Insertional inactivation of a chromosomal locus that modulates expression of potential virulence determinants in Staphylococcus aureus. J Bacteriol (1995) 1.47
Heterogeneity for mutations in the CFTR gene and clinical correlations in patients with congenital absence of the vas deferens. Hum Reprod (2000) 1.47
Diminished platelet binding in vitro by Staphylococcus aureus is associated with reduced virulence in a rabbit model of infective endocarditis. Infect Immun (1996) 1.45
Clumping factor A mediates binding of Staphylococcus aureus to human platelets. Infect Immun (2001) 1.39
In vitro resistance to thrombin-induced platelet microbicidal protein is associated with enhanced progression and hematogenous dissemination in experimental Staphylococcus aureus infective endocarditis. Infect Immun (1998) 1.37
Staphylococcus aureus induces platelet aggregation via a fibrinogen-dependent mechanism which is independent of principal platelet glycoprotein IIb/IIIa fibrinogen-binding domains. Infect Immun (1995) 1.36
Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells. Carcinogenesis (2000) 1.35
Analysis by gel electrophoresis, Western blot, and peptide mapping of protein A heterogeneity in Staphylococcus aureus strains. Infect Immun (1987) 1.33
The cytoplasmic membrane is a primary target for the staphylocidal action of thrombin-induced platelet microbicidal protein. Infect Immun (1997) 1.27
Staphylocidal action of thrombin-induced platelet microbicidal protein is influenced by microenvironment and target cell growth phase. Infect Immun (1996) 1.21
Downregulation and abnormal expression of E-cadherin and beta-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis. Hum Pathol (1999) 1.20
Role of the staphylococcal accessory gene regulator (sar) in septic arthritis. Infect Immun (1996) 1.17
Protective efficacy of protein A-specific antibody against bacteremic infection due to Staphylococcus aureus in an infant rat model. Infect Immun (1989) 1.14
In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source. Antimicrob Agents Chemother (1998) 1.12
Recombinant expression and characterization of the major beta-lactamase of Mycobacterium tuberculosis. Antimicrob Agents Chemother (1998) 1.12
Next generation diagnostics of cystic fibrosis and CFTR-related disorders by targeted multiplex high-coverage resequencing of CFTR. J Med Genet (2013) 1.10
Susceptibility of Coxiella burnetii to pefloxacin and ofloxacin in ovo and in persistently infected L929 cells. Antimicrob Agents Chemother (1989) 1.07
Perinatal outcome of pregnancies complicated by diabetes and by maternal daily hyperglycemia not related to diabetes. A retrospective 10-year analysis. Gynecol Obstet Invest (2000) 1.06
Adherence properties of Staphylococcus aureus under static and flow conditions: roles of agr and sar loci, platelets, and plasma ligands. Infect Immun (2001) 1.04
Influence of in vitro susceptibility phenotype against thrombin-induced platelet microbicidal protein on treatment and prophylaxis outcomes of experimental Staphylococcus aureus endocarditis. J Infect Dis (1999) 1.02
Thrombin-induced platelet microbicidal protein susceptibility phenotype influences the outcome of oxacillin prophylaxis and therapy of experimental Staphylococcus aureus endocarditis. Antimicrob Agents Chemother (2000) 1.01
Growth of Staphylococcus aureus with nafcillin in vitro induces alpha-toxin production and increases the lethal activity of sterile broth filtrates in a murine model. J Infect Dis (1995) 1.01
High heterogeneity for cystic fibrosis in Spanish families: 75 mutations account for 90% of chromosomes. Hum Genet (1997) 1.01
Testicular CFTR splice variants in patients with congenital absence of the vas deferens. Hum Mol Genet (1998) 1.01
Plasmid-mediated resistance to thrombin-induced platelet microbicidal protein in staphylococci: role of the qacA locus. Antimicrob Agents Chemother (1999) 0.99
Characterization of a sar homolog of Staphylococcus epidermidis. Infect Immun (1998) 0.99
Diversity in antistaphylococcal mechanisms among membrane-targeting antimicrobial peptides. Infect Immun (2001) 0.98
In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source. J Infect Dis (2000) 0.97
Membrane permeabilization by thrombin-induced platelet microbicidal protein 1 is modulated by transmembrane voltage polarity and magnitude. Infect Immun (1999) 0.97
Spectrum of mutations in the CFTR gene in cystic fibrosis patients of Spanish ancestry. Ann Hum Genet (2007) 0.95
E-cadherin expression is commonly downregulated by CpG island hypermethylation in esophageal carcinoma cells. Cancer Lett (2001) 0.95
Analysis of the CFTR gene confirms the high genetic heterogeneity of the Spanish population: 43 mutations account for only 78% of CF chromosomes. Hum Genet (1994) 0.94
Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity. Antimicrob Agents Chemother (2006) 0.94
Bronchiectasis in adult patients: an expression of heterozygosity for CFTR gene mutations? Clin Genet (2004) 0.93
Extensive analysis of 40 infertile patients with congenital absence of the vas deferens: in 50% of cases only one CFTR allele could be detected. Hum Genet (1995) 0.93
Failure of hypophysectomy to alter brain content of opioid peptides (endorphins). Life Sci (1976) 0.91
Influence of platelets and platelet microbicidal protein susceptibility on the fate of Staphylococcus aureus in an in vitro model of infective endocarditis. Infect Immun (2000) 0.89
Effects of neurotrophic factors on motoneuron survival following axonal injury in newborn rats. Neuroreport (2000) 0.89
New approaches to the prevention and treatment of severe S. aureus infections. Drugs Today (Barc) (2000) 0.86
Effect of p53 on centrosome amplification in prostate cancer cells. Biochim Biophys Acta (2001) 0.83
Study of the evolution of the placenta and fetal pancreas in the pathophysiology of growth retardation intrauterine due to restricted maternal diet. Sao Paulo Med J (1999) 0.81
Clinical relevance of HPV 16/18 testing methods in cervical squamous cell carcinoma. Appl Immunohistochem Mol Morphol (2000) 0.81
Linezolid: a new antibiotic. Drugs Today (Barc) (2000) 0.79
Correlations between blood compatibility and heparin adsorptivity for an impermeable isotropic pyrolytic carbon. J Biomed Mater Res (1969) 0.78
Downregulation of hemidesmosomal proteins in nasopharyngeal carcinoma cells. Cancer Lett (2001) 0.78
Heparin sorptivity and blood compatibility of carbon surfaces. J Biomed Mater Res (1970) 0.78
Adenosine triphosphate-binding cassette superfamily transporter gene expression in severe male infertility. Biol Reprod (2001) 0.78
Are the structures of SarA and SarR similar? Trends Microbiol (2001) 0.78
Molecular evaluation of CFTR sequence variants in male infertility of testicular origin. Int J Androl (2005) 0.78
Missense mutation R1066C in the second transmembrane domain of CFTR causes a severe cystic fibrosis phenotype: study of 19 heterozygous and 2 homozygous patients. Hum Mutat (1997) 0.77
Teratogenic effects of 5-bromodexyuridine on the external morphology of Drosophila melanogaster. Teratology (1973) 0.77
ATB(0)/SLC1A5 gene. Fine localisation and exclusion of association with the intestinal phenotype of cystic fibrosis. Eur J Hum Genet (2001) 0.76
Cystic fibrosis in a southern Brazilian population: characteristics of 90% of the alleles. Clin Genet (2007) 0.76
Paternal origin of a de novo novel CFTR mutation (L1065R) causing cystic fibrosis. Hum Mutat (1998) 0.75
The use of autogenous peritoneum for heart valve replacement. J Thorac Cardiovasc Surg (1970) 0.75
Hypertensive disorders in pregnant women with diabetes mellitus. Gynecol Obstet Invest (1997) 0.75
Prenatal diagnosis of cystic fibrosis in a highly heterogeneous population. Prenat Diagn (1996) 0.75
The detection of small relative simulated field defects using multifocal VEPs. Ophthalmic Physiol Opt (2005) 0.75
Enlarging the lumen of the carotid sinus. An experimental treatment of systemic arterial hypertension. Arch Surg (1969) 0.75
Diabetes and experimental pregnancy in rats: course of maternal blood glucose levels and its repercussions on the blood glucose levels and pancreas of newborn pups. Braz J Med Biol Res (1995) 0.75
Endorphins in brains of decapitated and microwave-killed mice. Life Sci (1977) 0.75
Abnormal proteins in Drosophila melanogaster subsequent to 5-bromodeoxyuridine administration. Comp Biochem Physiol B (1974) 0.75