Published in J Mol Biol on October 17, 1997
Calcium-dependent and -independent interactions of the S100 protein family. Biochem J (2006) 2.62
Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution. Proc Natl Acad Sci U S A (1998) 1.31
Regulation of skeletal muscle tension redevelopment by troponin C constructs with different Ca2+ affinities. Biophys J (1999) 1.20
A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy. J Biol Chem (2009) 1.16
The role of thin filament cooperativity in cardiac length-dependent calcium activation. Biophys J (2010) 1.15
Differential effects of a green tea-derived polyphenol (-)-epigallocatechin-3-gallate on the acidosis-induced decrease in the Ca(2+) sensitivity of cardiac and skeletal muscle. Pflugers Arch (2008) 1.12
Bepridil opens the regulatory N-terminal lobe of cardiac troponin C. Proc Natl Acad Sci U S A (2000) 1.05
Cooperative cross-bridge activation of thin filaments contributes to the Frank-Starling mechanism in cardiac muscle. Biophys J (2009) 1.03
Genomic organization, expression, and analysis of the troponin C gene pat-10 of Caenorhabditis elegans. J Cell Biol (1999) 1.02
Interaction of cardiac troponin with cardiotonic drugs: a structural perspective. Biochem Biophys Res Commun (2007) 1.01
All three Ca2+-binding loops of photoproteins bind calcium ions: the crystal structures of calcium-loaded apo-aequorin and apo-obelin. Protein Sci (2005) 0.88
Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene (2015) 0.88
Proximity relationships between residue 117 of rabbit skeletal troponin-I and residues in troponin-C and actin. Biophys J (2001) 0.87
Flexibility of EF-hand motifs: structural and thermodynamic studies of Calcium Binding Protein-1 from Entamoeba histolytica with Pb2+, Ba2+, and Sr2+. BMC Biophys (2012) 0.86
A model of troponin-I in complex with troponin-C using hybrid experimental data: the inhibitory region is a beta-hairpin. Protein Sci (2000) 0.85
Observation of microsecond time-scale protein dynamics in the presence of Ln3+ ions: application to the N-terminal domain of cardiac troponin C. J Biomol NMR (2006) 0.83
Mutations in the N- and D-helices of the N-domain of troponin C affect the C-domain and regulatory function. Biophys J (1999) 0.83
Calcium induced regulation of skeletal troponin--computational insights from molecular dynamics simulations. PLoS One (2013) 0.79
Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype. Front Physiol (2016) 0.76
The cytoplasmic domain of rat synaptotagmin I enhances synaptic transmission. Cell Mol Neurobiol (2014) 0.76
Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC. Genome Biol Evol (2016) 0.76
Molecular Basis of S100A1 Activation at Saturating and Subsaturating Calcium Concentrations. Biophys J (2016) 0.75
Structural preference for changes in the direction of the Ca2+-induced transition: a study of the regulatory domain of skeletal troponin-C. Biophys J (2003) 0.75
Structural implications of Ca(2+)-dependent actin-bundling function of human EFhd2/Swiprosin-1. Sci Rep (2016) 0.75
Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution. Nature (1992) 5.06
Crystal structures of the helix-loop-helix calcium-binding proteins. Annu Rev Biochem (1989) 4.42
Evolutionary similarities between pancreatic proteolytic enzymes. Nature (1965) 3.18
A phosphorylated light-chain component of myosin from skeletal muscle. Biochem J (1973) 2.74
Structure and refinement of penicillopepsin at 1.8 A resolution. J Mol Biol (1983) 2.66
A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex. Nat Struct Biol (1996) 2.66
Structure of the calcium regulatory muscle protein troponin-C at 2.8 A resolution. Nature (1985) 2.65
Comparative studies of the amino acid and nucleotide sequences of pilin derived from Pseudomonas aeruginosa PAK and PAO. J Bacteriol (1985) 2.53
Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes. Protein Sci (1998) 2.52
Structural evidence for gene duplication in the evolution of the acid proteases. Nature (1978) 2.47
Amino acid sequence of pilin isolated from pseudomonas aeruginosa PAK. FEBS Lett (1983) 2.38
An algorithm for determining the conformation of polypeptide segments in proteins by systematic search. Proteins (1986) 2.38
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases. Nature (1994) 2.37
Production, characterization, and partial amino acid sequence of xylanase A from Schizophyllum commune. Appl Environ Microbiol (1978) 2.29
Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution. Nat Struct Biol (1994) 2.15
Preparation and identification of alpha- and beta-tropomyosins. Methods Enzymol (1982) 2.11
The amino acid sequence of rabbit skeletal alpha-tropomyosin. The NH2-terminal half and complete sequence. J Biol Chem (1978) 2.03
Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution. Biochemistry (1983) 1.95
Refined X-ray crystallographic structure of the poliovirus 3C gene product. J Mol Biol (1997) 1.87
Calcium-binding sites in proteins: a structural perspective. Adv Protein Chem (1991) 1.86
2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity. J Med Chem (1990) 1.85
A comparison of the amino acid sequences of rabbit skeletal muscle alpha- and beta-tropomyosins. J Biol Chem (1980) 1.84
Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Cell (2001) 1.84
Refined crystal structure of troponin C from turkey skeletal muscle at 2.0 A resolution. J Mol Biol (1988) 1.84
Crystal and molecular structure of the serine proteinase inhibitor CI-2 from barley seeds. Biochemistry (1987) 1.82
A model for the Ca2+-induced conformational transition of troponin C. A trigger for muscle contraction. J Biol Chem (1986) 1.82
Structures of the troponin C regulatory domains in the apo and calcium-saturated states. Nat Struct Biol (1995) 1.80
Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 A resolution. Nature (1986) 1.74
Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution. J Mol Biol (1987) 1.71
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition. J Virol (1997) 1.68
Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure. J Mol Biol (1985) 1.67
Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 A resolution. A model for serine protease catalysis. J Mol Biol (1980) 1.64
Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. J Biol Chem (2000) 1.62
Calcium-induced structural transition in the regulatory domain of human cardiac troponin C. Biochemistry (1997) 1.61
Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain. J Biol Chem (1997) 1.61
Protein structure refinement: Streptomyces griseus serine protease A at 1.8 A resolution. J Mol Biol (1979) 1.60
A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism. Proc Natl Acad Sci U S A (1985) 1.59
Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo. Biochemistry (1988) 1.57
The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution. J Biol Chem (1994) 1.56
Structural and kinetic characterization of a beta-lactamase-inhibitor protein. Nature (1994) 1.53
Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution. J Mol Biol (1990) 1.51
Critical evaluation of comparative model building of Streptomyces griseus trypsin. Biochemistry (1984) 1.49
Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase. Nat Struct Biol (1996) 1.48
A critical assessment of comparative molecular modeling of tertiary structures of proteins. Proteins (1995) 1.46
Sequence repeats in alpha-tropomyosin. J Mol Biol (1975) 1.46
Histidine sequences in the active centres of some 'serine' proteinases. Biochem J (1966) 1.44
Amino-acid sequence of rabbit skeletal tropomyosin and its coiled-coil structure. Proc Natl Acad Sci U S A (1972) 1.42
The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure (1994) 1.41
Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes. Biochemistry (1998) 1.40
Lysozyme revisited: crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site D. J Mol Biol (1991) 1.40
Studies on the primary structure and antigenic determinants of pilin isolated from Pseudomonas aeruginosa K. Can J Biochem Cell Biol (1985) 1.39
Stretch sensitivity of the lateral wall of the auditory outer hair cell from the guinea pig. Neurosci Lett (1991) 1.38
Observation of an antimatter hypernucleus. Science (2010) 1.38
Amino acid sequence of equine platelet tropomyosin. Correlation with interaction properties. FEBS Lett (1983) 1.37
Carboxyl-carboxylate interactions in proteins. Nature (1982) 1.34
X-ray crystallography of the binding of the bacterial cell wall trisaccharide NAM-NAG-NAM to lysozyme. Nature (1980) 1.34
Refined 1.7 A X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity. J Mol Biol (1994) 1.34
Structural and regulatory functions of the NH2- and COOH-terminal regions of skeletal muscle troponin I. J Biol Chem (1994) 1.32
Crystal and molecular structure of chymotrypsin inhibitor 2 from barley seeds in complex with subtilisin Novo. Proc Natl Acad Sci U S A (1985) 1.31
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis. EMBO J (1999) 1.30
Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution. J Mol Biol (1987) 1.30
Quantification of the calcium-induced secondary structural changes in the regulatory domain of troponin-C. Protein Sci (1994) 1.30
Effects of troponin-I plus-C on the binding of troponin-T and its fragments to alpha-tropomyosin. Ca2+ sensitivity and cooperativity. J Biol Chem (1983) 1.30
Binding of troponin-T fragments to several types of tropomyosin. Sensitivity to Ca2+ in the presence of troponin-C. J Biol Chem (1982) 1.29
Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes. Nature (1975) 1.28
Quantitative proteome analysis reveals annexin A3 as a novel biomarker in lung adenocarcinoma. J Pathol (2009) 1.28
Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin. Nature (1977) 1.28
Penicillopepsin from Penicillium janthinellum crystal structure at 2.8 A and sequence homology with porcine pepsin. Nature (1977) 1.28
Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1. J Biol Chem (2001) 1.27
Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle. Proc Natl Acad Sci U S A (1978) 1.27
Structural interpretation of the two-site binding of troponin on the muscle thin filament. J Mol Biol (1981) 1.26
The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. J Mol Biol (1996) 1.26
Chemical evidence for chain heterogeneity in rabbit muscle tropomyosin. Biochem Biophys Res Commun (1970) 1.24
Crystal structure of human pepsin and its complex with pepstatin. Protein Sci (1995) 1.21
Regulation of skeletal muscle tension redevelopment by troponin C constructs with different Ca2+ affinities. Biophys J (1999) 1.20
Modulation of Ca2+ exchange with the Ca(2+)-specific regulatory sites of troponin C. J Biol Chem (1994) 1.19
A detailed structural description of Escherichia coli succinyl-CoA synthetase. J Mol Biol (1999) 1.19
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution. Science (1989) 1.19
Amino-acid sequence of tropomyosin-binding component of rabbit skeletal muscle troponin. Proc Natl Acad Sci U S A (1976) 1.18
Refined crystal structure of Streptomyces griseus trypsin at 1.7 A resolution. J Mol Biol (1988) 1.17
Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides. Biochemistry (1992) 1.16
Amino acid sequence alignment of bacterial and mammalian pancreatic serine proteases based on topological equivalences. Can J Biochem (1978) 1.16
Isolation and characterization of an abundant and novel 22-kDa protein (SM22) from chicken gizzard smooth muscle. J Biol Chem (1987) 1.16
The effects of troponin T fragments T1 and T2 on the binding of nonpolymerizable tropomyosin to F-actin in the presence and absence of troponin I and troponin C. J Biol Chem (1987) 1.16
Primary structure of alpha-lytic protease: a bacterial homologue of the pancreatic serine proteases. Nature (1970) 1.16