Published in Arch Int Physiol Biochim on October 01, 1979
A new population-enrichment strategy to improve efficiency of placebo-controlled clinical trials of antidepressant drugs. Clin Pharmacol Ther (2010) 2.74
PHARM--an interactive graphic program for individual and population pharmacokinetic parameter estimation. Comput Biol Med (1984) 2.09
IGPHARM: interactive graphic package for pharmacokinetic analysis. Comput Biomed Res (1978) 1.71
Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline. Br J Clin Pharmacol (1975) 1.63
PET visualization of microglia in multiple sclerosis patients using [11C]PK11195. Eur J Neurol (2003) 1.59
A two-step iterative algorithm for estimation in nonlinear mixed-effect models with an evaluation in population pharmacokinetics. J Biopharm Stat (1995) 1.54
Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA. Mol Psychiatry (2007) 1.43
Joint modeling of efficacy, dropout, and tolerability in flexible-dose trials: a case study in depression. Clin Pharmacol Ther (2012) 1.41
Fluorimetric determination of 5-hydroxyindoleacetic acid in human urine and cerebrospinal fluid. Clin Chim Acta (1969) 1.40
beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Eur J Neurosci (2000) 1.25
Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment. Clin Pharmacokinet (1976) 1.25
Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid. Biochem Pharmacol (1971) 1.23
Noradrenergic neurons: morphine inhibition of spontaneous activity. Eur J Pharmacol (1974) 1.21
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study. Mult Scler (2005) 1.17
One brain, two selves. Neuroimage (2003) 1.14
Exposure to chronic psychosocial stress and corticosterone in the rat: effects on spatial discrimination learning and hippocampal protein kinase Cgamma immunoreactivity. Hippocampus (1997) 1.14
Studies on the mechanism of the vasodilator effects of prazosin in dogs and rabbits. Eur J Pharmacol (1978) 1.13
Influence of age on mianserin pharmacokinetics. Psychopharmacology (Berl) (1982) 1.13
Antidopaminergic properties of yohimbine. J Pharmacol Exp Ther (1980) 1.09
Amine metabolism in the human brain: further evaluation of the probenecid test. Brain Res (1971) 1.09
The peripheral GABAergic system as a target in endocrine disorders. Auton Neurosci (2005) 1.04
Increased turnover of norepinephrine in the rat cerebral cortex during stress: role of the locus coeruleus. Neuropharmacology (1973) 1.02
Migraine and function of the immune system: a meta-analysis of clinical literature published between 1966 and 1999. Cephalalgia (2001) 1.01
On the significance of regional dopamine metabolism in the rat brain for the classification of centrally acting drugs. Eur J Pharmacol (1977) 1.00
Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain. Eur J Pharmacol (1975) 0.99
Cerebral monoamines and depression. An investigation with the Probenecid technique. Arch Gen Psychiatry (1973) 0.99
Neuroanatomy of cardiac activity-regulating circuitry: a transneuronal retrograde viral labelling study in the rat. Eur J Neurosci (1996) 0.99
5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid. Nature (1970) 0.98
A long-term serological survey on Aujeszky's disease virus infections in wild boar in East Germany. Epidemiol Infect (2011) 0.98
Dopamine release in substantia nigra? Nature (1976) 0.97
Adaptive-optimal design in PET occupancy studies. Clin Pharmacol Ther (2010) 0.96
Effects of stress and exercise on rat hippocampus and striatum extracellular lactate. Am J Physiol (1990) 0.96
Neurone-specific enolase and N-acetyl-aspartate as potential peripheral markers of ischaemic stroke. Eur J Clin Invest (1999) 0.93
Steady-state pharmacokinetics of ciprofloxacin in plasma from patients with nosocomial pneumonia: penetration of the bronchial mucosa. Antimicrob Agents Chemother (1991) 0.93
Cyclic AMP in cerebrospinal fluid: accumulaiton following probenecid and biogenic amines. Exp Neurol (1975) 0.93
Time-course analysis of the cardiovascular effects of clonidine resulting from the activation of cardiac pre- and vascular postsynaptic alpha-adrenoceptors in the pithed rat [proceedings]. Br J Pharmacol (1978) 0.92
Regional rat brain levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid: concurrent fluorometric measurement and influence of drugs. Eur J Pharmacol (1976) 0.91
Neurobiology and neuroimmunology of Tourette's syndrome: an update. Cell Mol Life Sci (2004) 0.91
Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels? J Cereb Blood Flow Metab (1998) 0.91
Manganese-induced hydroxyl radical formation in rat striatum is not attenuated by dopamine depletion or iron chelation in vivo. Exp Neurol (1996) 0.91
Trigeminal nociception-induced cerebral Fos expression in the conscious rat. Cephalalgia (2001) 0.90
Fluorometric determination of homovanillic acid in biological material after isolation on Sephadex G-10. Anal Biochem (1971) 0.90
Relative changes in regional cerebral blood flow during spinal cord stimulation in patients with refractory angina pectoris. Eur J Neurosci (1997) 0.89
Systemic and regional hemodynamic characterization of alpha-1 and alpha-2 adrenoceptor agonists in pithed rats. J Pharmacol Exp Ther (1987) 0.89
Pharmacokinetics and pharmacodynamics of vecuronium (ORG NC 45) in patients with cirrhosis. Anesthesiology (1985) 0.89
Regional levels of GABA in the brain: rapid semiautomated assay and prevention of postmortem increase by 3-mercapto-propionic acid. J Neurochem (1978) 0.89
In vivo identification and quantitative evaluation of carrier-mediated transport of lactate at the cellular level in the striatum of conscious, freely moving rats. J Cereb Blood Flow Metab (1988) 0.89
Epizootiological investigations of canine distemper virus in free-ranging carnivores from Germany. Vet Microbiol (2000) 0.89
gamma-Aminobutyric acid (GABA) receptor stimulation. III. Effect of progabide (SL 76002) on norepinephrine, dopamine and 5-hydroxytryptamine turnover in rat brain areas. J Pharmacol Exp Ther (1982) 0.88
Retarded depression and the dopamine metabolism. Psychopharmacologia (1971) 0.88
Interruptions of early cortical development affect limbic association areas and social behaviour in rats; possible relevance for neurodevelopmental disorders. Brain Res (1999) 0.88
The corticosterone synthesis inhibitor metyrapone prevents hypoxia/ischemia-induced loss of synaptic function in the rat hippocampus. Stroke (2000) 0.88
Desmethylimipramine enhances the release of endogenous GABA and other neurotransmitter amino acids from the rat thalamus. J Neurochem (1983) 0.88
Cobalt-55 positron emission tomography of ipsilateral thalamic and crossed cerebellar hypometabolism after supratentorial ischaemic stroke. Cerebrovasc Dis (1999) 0.87
In vivo binding of N-n-propylnorapomorphine in the rat brain: regional localization, quantification in striatum and lack of correlation with dopamine metabolism. Eur J Pharmacol (1983) 0.87
Sulpiride pharmacokinetics in humans after intramuscular administration at three dose levels. J Pharm Sci (1984) 0.87
A comparison between propranolol, practolol and betaxolol (SL75212) on the circulatory and metabolic responses to insulin-induced hypoglycaemia. Eur J Clin Pharmacol (1981) 0.87
Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex. Implications for schizophrenia. Ann N Y Acad Sci (2000) 0.87
Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment. Neuropharmacology (2005) 0.86
Classical swine fever virus: clinical, virological, serological and hematological findings after infection of domestic pigs and wild boars with the field isolate "Spante" originating from wild boar. Berl Munch Tierarztl Wochenschr (2001) 0.86
Wilson's disease and monoamines. Arch Neurol (1978) 0.86
[Predictive value of the probenecid test for the effect of L-DOPA therapy in Parkinson's disease]. Nat New Biol (1972) 0.86
Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice. Neuroreport (1997) 0.86
High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients. Biol Psychiatry (1991) 0.85
Pharmacokinetics of propranolol in normal healthy volunteers. J Pharmacokinet Biopharm (1977) 0.85
Extracellular lactic acid as an indicator of brain metabolism: continuous on-line measurement in conscious, freely moving rats with intrastriatal dialysis. J Cereb Blood Flow Metab (1988) 0.85
Endotracheal and aerosol administrations of ceftazidime in patients with nosocomial pneumonia: pharmacokinetics and absolute bioavailability. Antimicrob Agents Chemother (1992) 0.85
Bayesian estimate of vinorelbine pharmacokinetic parameters in elderly patients with advanced metastatic cancer. Clin Cancer Res (2000) 0.85
Cerebral cation shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin. Exp Neurol (1988) 0.85
Supplementation of a low dose of DHA or DHA+AA does not prevent peripartum depressive symptoms in a small population based sample. Prog Neuropsychopharmacol Biol Psychiatry (2008) 0.85
Beta-adrenoceptor blocking effects and pharmacokinetics of betaxolol (SL 75212) in man. Br J Clin Pharmacol (1980) 0.84
Regional calcium accumulation and cation shifts in rat brain by kainate. J Neurochem (1984) 0.84
Circadian rhythm of 5-fluorouracil population pharmacokinetics in patients with metastatic colorectal cancer. Cancer Chemother Pharmacol (1999) 0.84
A pilot study of some kinetic aspects of the metabolism of 5-hydroxytryptamine in depressive patients. Biol Psychiatry (1971) 0.84
A single social stress-experience alters glutamate receptor-binding in rat hippocampal CA3 area. Neurosci Lett (1993) 0.84
Functional and biochemical evidence for the lack of cardiac presynaptic alpha-2 adrenoceptor stimulant properties of cirazoline (LD 3098), a potent alpha-1 adrenoceptor agonist in dogs and rats. J Pharmacol Exp Ther (1982) 0.84
Antidepressive effect of mirtazapine in post-myocardial infarction depression is associated with soluble TNF-R1 increase: data from the MIND-IT. Neuropsychobiology (2011) 0.84
Different localization of histidine decarboxylase and histamine-N-methyltransferase in the rat brain. Brain Res (1978) 0.83
L-deprenyl reduces brain damage in rats exposed to transient hypoxia-ischemia. Stroke (1995) 0.83
Divergent axon collaterals of rat locus coeruleus neurons: demonstration by a fluorescent double labeling technique. Brain Res (1981) 0.83
Biochemical evidence for a transmitter role of dopamine in the rat hippocampus. Brain Res (1979) 0.83
Low essential fatty acid and B-vitamin status in a subgroup of patients with schizophrenia and its response to dietary supplementation. Prostaglandins Leukot Essent Fatty Acids (2005) 0.83
Amino acids in rat striatal dialysates: methodological aspects and changes after electroconvulsive shock. J Neurochem (1985) 0.83
Monitoring arterio-venous differences of glucose and lactate in the anesthetized rat with or without brain damage with ultrafiltration and biosensor technology. J Neurosci Res (2001) 0.83
Transneuronal viral labelling of rat heart left ventricle controlling pathways. Neuroreport (1993) 0.83
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers. Br J Clin Pharmacol (1980) 0.83
Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. Psychol Med (1975) 0.83
Methylazoxymethanol acetate-induced abnormalities in the entorhinal cortex of the rat; parallels with morphological findings in schizophrenia. Brain Res (1998) 0.83
Down-regulation of the hypothalamo-pituitary-adrenal axis reduces brain damage and number of seizures following hypoxia/ischaemia in rats. Brain Res (1995) 0.82
Serum tryptophan decreased, brain tryptophan increased and brain serotonin synthesis unchanged after probenecid loading. Brain Res (1972) 0.82
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocker SL 75212 in healthy volunteers [proceedings]. Br J Clin Pharmacol (1979) 0.82
Central monoamine deficiency in depressions: causative of secondary phenomenon? Pharmakopsychiatr Neuropsychopharmakol (1975) 0.82
Stimulation and destruction of the locus coeruleus: opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex. Eur J Pharmacol (1973) 0.82
The blood pressure lowering effects of intravenous versus intracerebroventricular prazosin in anaesthetised cats. Eur J Pharmacol (1978) 0.82
Protective effect of fasting upon cerebral hypoxic-ischemic injury. Metab Brain Dis (1988) 0.82
Determination of nanogram amounts of homovanillic acid in the central nervous system with a rapid semiautomated fluorometric method. Biochem Med (1975) 0.82
A Kinetic Model for Simultaneous Fit of Clozapine and Norclozapine Concentrations in Chronic Schizophrenic Patients during Long-Term Treatment. Clin Drug Investig (1998) 0.82
Fengabine, a novel antidepressant GABAergic agent. II. Effect on cerebral noradrenergic, serotonergic and GABAergic transmission in the rat. J Pharmacol Exp Ther (1987) 0.81
Meal-dependent absorption of enteric-coated sodium valproate. Epilepsia (1980) 0.81