Published in Comput Biomed Res on August 01, 1978
Metformin kinetics in healthy subjects and in patients with diabetes mellitus. Br J Clin Pharmacol (1981) 2.38
Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys. Antimicrob Agents Chemother (1991) 1.00
Pharmacokinetics of cefotiam administered intravenously and intramuscularly to healthy adults. Antimicrob Agents Chemother (1984) 0.98
Blood concentrations and pharmacodynamic effects of betaxolol (SL 75212) a new beta-adrenoceptor antagonist after oral and intravenous administration. Br J Clin Pharmacol (1980) 0.94
Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying. Proc Natl Acad Sci U S A (1982) 0.84
Pharmacokinetics of theophylline: a dose-range study. Br J Clin Pharmacol (1982) 0.83
Chloroquine excretion following malaria prophylaxis. Br J Clin Pharmacol (1987) 0.82
The pharmacokinetics of dermatan sulphate MF701 in healthy human volunteers. Br J Clin Pharmacol (1991) 0.79
Pharmacokinetics of (-)-folinic acid after oral and intravenous administration of the racemate. Br J Clin Pharmacol (1989) 0.76
Comparative bioavailability of tetracycline and lymecycline. Br J Clin Pharmacol (1984) 0.76
Hydrolysis of cefamandole nafate in dialysis patients. Antimicrob Agents Chemother (1979) 0.75
A new population-enrichment strategy to improve efficiency of placebo-controlled clinical trials of antidepressant drugs. Clin Pharmacol Ther (2010) 2.74
PHARM--an interactive graphic program for individual and population pharmacokinetic parameter estimation. Comput Biol Med (1984) 2.09
Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline. Br J Clin Pharmacol (1975) 1.63
A two-step iterative algorithm for estimation in nonlinear mixed-effect models with an evaluation in population pharmacokinetics. J Biopharm Stat (1995) 1.54
Joint modeling of efficacy, dropout, and tolerability in flexible-dose trials: a case study in depression. Clin Pharmacol Ther (2012) 1.41
[Comparative study of gastro-intestinal blood loss after antrafenine, aspirin and placebo in healthy volunteers (author's transl)]. Therapie (1981) 1.28
Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment. Clin Pharmacokinet (1976) 1.25
Influence of age on mianserin pharmacokinetics. Psychopharmacology (Berl) (1982) 1.13
Studies on the mechanism of the vasodilator effects of prazosin in dogs and rabbits. Eur J Pharmacol (1978) 1.13
Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [3H]imipramine reuptake in the primary fibromyalgia syndrome. Rheumatology (Oxford) (2001) 1.04
Adaptive-optimal design in PET occupancy studies. Clin Pharmacol Ther (2010) 0.96
Steady-state pharmacokinetics of ciprofloxacin in plasma from patients with nosocomial pneumonia: penetration of the bronchial mucosa. Antimicrob Agents Chemother (1991) 0.93
Time-course analysis of the cardiovascular effects of clonidine resulting from the activation of cardiac pre- and vascular postsynaptic alpha-adrenoceptors in the pithed rat [proceedings]. Br J Pharmacol (1978) 0.92
Evaluation of memory function in a population of epileptic patients and matched controls. Acta Neurol Scand Suppl (1980) 0.91
Systemic and regional hemodynamic characterization of alpha-1 and alpha-2 adrenoceptor agonists in pithed rats. J Pharmacol Exp Ther (1987) 0.89
Pharmacokinetics and pharmacodynamics of vecuronium (ORG NC 45) in patients with cirrhosis. Anesthesiology (1985) 0.89
A comparison between propranolol, practolol and betaxolol (SL75212) on the circulatory and metabolic responses to insulin-induced hypoglycaemia. Eur J Clin Pharmacol (1981) 0.87
Sulpiride pharmacokinetics in humans after intramuscular administration at three dose levels. J Pharm Sci (1984) 0.87
Ximoprofen in ankylosing spondylitis. A double blind placebo controlled dose ranging study. Scand J Rheumatol (1994) 0.86
Pharmacokinetics of propranolol in normal healthy volunteers. J Pharmacokinet Biopharm (1977) 0.85
Endotracheal and aerosol administrations of ceftazidime in patients with nosocomial pneumonia: pharmacokinetics and absolute bioavailability. Antimicrob Agents Chemother (1992) 0.85
Bayesian estimate of vinorelbine pharmacokinetic parameters in elderly patients with advanced metastatic cancer. Clin Cancer Res (2000) 0.85
Beta-adrenoceptor blocking effects and pharmacokinetics of betaxolol (SL 75212) in man. Br J Clin Pharmacol (1980) 0.84
Circadian rhythm of 5-fluorouracil population pharmacokinetics in patients with metastatic colorectal cancer. Cancer Chemother Pharmacol (1999) 0.84
Functional and biochemical evidence for the lack of cardiac presynaptic alpha-2 adrenoceptor stimulant properties of cirazoline (LD 3098), a potent alpha-1 adrenoceptor agonist in dogs and rats. J Pharmacol Exp Ther (1982) 0.84
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers. Br J Clin Pharmacol (1980) 0.83
Carbamazepine plasma levels in children and adults: influence of age, dose, and associated therapy. Ther Drug Monit (1980) 0.83
Learning impairment in epileptic patients. Epilepsia (1983) 0.82
A Kinetic Model for Simultaneous Fit of Clozapine and Norclozapine Concentrations in Chronic Schizophrenic Patients during Long-Term Treatment. Clin Drug Investig (1998) 0.82
The blood pressure lowering effects of intravenous versus intracerebroventricular prazosin in anaesthetised cats. Eur J Pharmacol (1978) 0.82
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocker SL 75212 in healthy volunteers [proceedings]. Br J Clin Pharmacol (1979) 0.82
Meal-dependent absorption of enteric-coated sodium valproate. Epilepsia (1980) 0.81
Heart rate lowering effects of N,N-di-n-propyl-dopamine in rats: evidence for stimulation of central dopamine receptors leading to inhibition of sympathetic tone and enhancement of parasympathetic outflow. J Pharmacol Exp Ther (1981) 0.81
Comparison of mianserin with desipramine, maprotiline and phentolamine on cardiac presynaptic and vascular postsynaptic alpha-adrenoceptors and noradrenaline reuptake in pithed normotensive rats. Br J Pharmacol (1980) 0.81
Model-based approach and signal detection theory to evaluate the performance of recruitment centers in clinical trials with antidepressant drugs. Clin Pharmacol Ther (2008) 0.81
Population pharmacokinetics of mycophenolic acid in kidney transplant pediatric and adolescent patients. Ther Drug Monit (2005) 0.81
Comparison of single-dose pharmacokinetics of imipramine and maprotiline in the elderly. Psychopharmacology (Berl) (1980) 0.81
Blood pressure lowering effects of N,N-di-n-propyl-dopamine in rats: evidence for stimulation of peripheral dopamine receptors leading to inhibition of sympathetic vascular tone. J Pharmacol Exp Ther (1981) 0.80
Pharmacokinetics and metabolism of diltiazem in man. Acta Cardiol (1980) 0.80
Pharmacokinetics and time-course of D(2) receptor occupancy induced by atypical antipsychotics in stabilized schizophrenic patients. J Psychopharmacol (2008) 0.80
Plasma concentrations and cardiotoxic effects of desipramine and protriptyline in the rat. Br J Pharmacol (1977) 0.80
Population pharmacokinetics of amikacin in critically ill patients. Antimicrob Agents Chemother (1996) 0.80
Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog Neuropsychopharmacol Biol Psychiatry (1987) 0.79
A limited sampling method to estimate methotrexate pharmacokinetics in patients with rheumatoid arthritis using a Bayesian approach and the population data modeling program P-PHARM. Eur J Clin Pharmacol (1996) 0.79
Pharmacokinetics of the new beta-adrenoceptor blocking agent betaxolol (SL 75212) in man after repeated oral administration. Arzneimittelforschung (1980) 0.79
Kinetics of distribution of di-propranolol in various organs and discrete brain areas of the rat. J Pharmacol Exp Ther (1980) 0.79
Blood concentrations and pharmacodynamic effects of SL 75212, a new beta-adrenoceptor antagonist, after oral and intravenous administration [proceedings]. Br J Clin Pharmacol (1979) 0.79
Turnover of free and conjugated (sulphonyloxy) dihydroxyphenylacetic acid and homovanillic acid in rat striatum. J Neurochem (1979) 0.79
Predictive performance of a semiparametric method to estimate population pharmacokinetic parameters using NONMEM. J Pharmacokinet Biopharm (1998) 0.79
Effects of mianserin on noradrenaline uptake, cardiac presynaptic and vascular postsynaptic alpha-adrenoceptors in rats [proceedings]. Br J Pharmacol (1979) 0.78
Comparison of the beta-adrenoceptor blocking properties and pharmacokinetics of SL 75212 and propranolol in man [proceedings]. Br J Clin Pharmacol (1979) 0.78
Pharmacokinetics of the new beta-adrenoceptor blocker SL 75212 in man after repeated oral administration [proceedings]. Br J Clin Pharmacol (1979) 0.78
An application of nonlinear mixed-effects modeling to pharmacokinetic data exhibiting nonlinear and time-dependent behavior. J Pharm Sci (2003) 0.78
[Study in man of butobarbital pharmacokinetics, under polygraphic monitoring]. Therapie (1978) 0.78
Mechanism of antihypertensive activity of orally administered prazosin in spontaneously hypertensive rats. J Cardiovasc Pharmacol (1980) 0.78
Multiple-dose pharmacokinetics of ceftibuten after oral administration to healthy volunteers. J Pharm Sci (1994) 0.78
A conversational graphic program for the analysis of the sigmoid curve. Comput Biomed Res (1980) 0.77
Pharmacokinetic-pharmacodynamic modelling of recombinant human erythropoietin in athletes. Int J Sports Med (2003) 0.77
Ritodrine sulphation in the human liver and duodenal mucosa: interindividual variability. Eur J Drug Metab Pharmacokinet (1998) 0.77
Captopril methylation in human liver and kidney: interindividual variability. Xenobiotica (1996) 0.77
A double Weibull input function describes the complex absorption of sustained-release oral sodium valproate. J Pharm Sci (1994) 0.76
Pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis. Anesthesiology (1994) 0.76
Effects in man of progabide on prolactin release induced by haloperidol or domperidone. Psychoneuroendocrinology (1984) 0.76
Plasma and intracellular kinetics of lithium after oral administration of various lithium salts. Eur J Clin Pharmacol (1977) 0.76
A kinetic study of the fate of SL 73033 (antrafenine) in the rat [proceedings]. Br J Pharmacol (1978) 0.75
Pharmacokinetics of amitriptyline in the elderly. Int J Clin Pharmacol Ther Toxicol (1981) 0.75
Total and free methotrexate pharmacokinetics in rheumatoid arthritis patients. Ther Drug Monit (1996) 0.75
OMNE: a new robust membership-set estimator for the parameters of nonlinear models. J Pharmacokinet Biopharm (1987) 0.75
Pinazepam: a precursor of N-desmethyldiazepam. Eur J Clin Pharmacol (1982) 0.75
Betaxolol kinetics in hypertensive children with normal and abnormal renal function. Clin Pharmacol Ther (1984) 0.75
Pharmacokinetic parameters of antipyrine in dog after hepatectomy. Biopharm Drug Dispos (1995) 0.75
Effect of high plasma choline on brain area acetylcholine content: drug intervention. Pharmacol Res Commun (1979) 0.75
The action of the new beta-adrenoceptor blocker SL 75212 on the metabolic response to insulin-induced hypoglycaemia in man [proceedings]. Br J Clin Pharmacol (1979) 0.75
Stereotyped behavior and hyperthermia in dogs: correlation with the levels of amphetamine and p-hydroxyamphetamine in plasma and CSF. Psychopharmacology (Berl) (1978) 0.75
Age-related differences in kinetics and side-effects of viloxazine in man and their clinical implications. Psychopharmacology (Berl) (1983) 0.75
Glycine binding to rat CNS membranes: possible cooperative interaction. Adv Biochem Psychopharmacol (1983) 0.75
[Information systems for phase III and IV clinical trials]. J Pharmacol (1986) 0.75
AUTOMOD: a polyalgorithm for an integrated analysis of linear pharmacokinetic models. Comput Biol Med (1979) 0.75
(-)-salbutamol sulphation in the human liver and duodenal mucosa: interindividual variability. Xenobiotica (1997) 0.75
Comparison of a direct and indirect population pharmacodynamic model: application to recombinant human erythropoietin in athletes. J Pharmacokinet Biopharm (1997) 0.75
[Pharmacokinetics of antrafenine after single and repeated administration in aged patients]. Therapie (1981) 0.75
Pharmacokinetics of pinazepam in healthy volunteers. Int J Clin Pharmacol Res (1983) 0.75
Pharmacological evidence favoring a similarity between alpha adrenoceptors mediating sleep in chicks and cardiac presynaptic alpha-2 receptors in rats. J Pharmacol Exp Ther (1982) 0.75
A new polyalgorithmic method for time-course analysis of pharmacological data describable by a multiexponential function [proceedings]. Br J Pharmacol (1978) 0.75
Plasma levels of primidone and its metabolite phenobarbital: effect of age and associated therapy. Ther Drug Monit (1983) 0.75
A model of dopamine metabolism in rat brain, assessed by the influence of drugs [proceedings]. Arch Int Physiol Biochim (1979) 0.75
The metabolism and kinetics of tiflorex in the rat. Drug Metab Dispos (1981) 0.75
A novel metric to assess the clinical utility of a drug in the presence of efficacy and dropout information. Clin Pharmacol Ther (2011) 0.75
[Comparative pharmacokinetics of antrafenine in healthy volunteers and in patients with chronic renal failure (author's transl)]. Therapie (1981) 0.75
A population approach to the forecasting of amikacin plasma and urinary levels using a prescribed dosage regimen. Eur J Drug Metab Pharmacokinet (1999) 0.75
Pharmacokinetic-pharmacodynamic modelling of recombinant human erythropoietin in athletes : a population approach. Clin Drug Investig (2003) 0.75
Quantitative determination of doxepin and desmethyldoxepin in rat plasma by means of gas-liquid chromatography-mass fragmentography. J Chromatogr (1977) 0.75
Carbamazepine pharmacokinetics in young, adult and pregnant rats. Relation to pharmacological effects. Arch Int Pharmacodyn Ther (1976) 0.75
Pharmacokinetics of SL 75212 and propranolol in old age, uraemia and in healthy young adults [proceedings]. Br J Clin Pharmacol (1980) 0.75
Elimination kinetics of desmethyldiazepam in two young and two elderly subjects. Eur J Drug Metab Pharmacokinet (1982) 0.75
Pharmacokinetic studies on ditazole, a novel inhibitor of platelet aggregation. J Pharm Sci (1978) 0.75