Published in J Biol Chem on January 09, 1998
Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol (2009) 5.83
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol (2002) 4.89
beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol (2000) 4.29
Sphingosine 1-phosphate signalling in mammalian cells. Biochem J (2000) 3.33
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther (2006) 3.15
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell (2001) 2.66
Endosomes: a legitimate platform for the signaling train. Proc Natl Acad Sci U S A (2009) 2.33
Phospholipase D: molecular and cell biology of a novel gene family. Biochem J (2000) 2.27
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Proc Natl Acad Sci U S A (2002) 2.26
A critical role for endocytosis in Wnt signaling. BMC Cell Biol (2006) 2.09
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol Biol Cell (1999) 2.02
GPCR monomers and oligomers: it takes all kinds. Trends Neurosci (2008) 1.97
GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. Mol Cell Biol (2006) 1.85
The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes Cancer (2011) 1.74
Endocytosis, actin cytoskeleton, and signaling. Plant Physiol (2004) 1.67
Distinct dynamin-dependent and -independent mechanisms target structurally homologous dopamine receptors to different endocytic membranes. J Cell Biol (1999) 1.62
Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance. Pharmacol Rev (2011) 1.61
Discovery of regulators of receptor internalization with high-throughput flow cytometry. Mol Pharmacol (2012) 1.61
β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation. Nat Cell Biol (2016) 1.54
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
PKC controls HGF-dependent c-Met traffic, signalling and cell migration. EMBO J (2004) 1.51
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proc Natl Acad Sci U S A (2000) 1.50
Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction. Br J Pharmacol (2007) 1.49
Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. Mol Cell Biol (2000) 1.42
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis. J Exp Med (2001) 1.40
G-protein coupled receptor kinases as modulators of G-protein signalling. J Physiol (1999) 1.37
Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling. J Cell Physiol (2008) 1.34
Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling. Neuropharmacology (2007) 1.31
Activation of p38 mitogen-activated protein kinase promotes epidermal growth factor receptor internalization. Traffic (2006) 1.24
Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence. J Neurosci (1999) 1.22
kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila. Genetics (2000) 1.21
The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain. EMBO J (2000) 1.15
Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat Chem Biol (2014) 1.15
GPCR signaling along the endocytic pathway. Curr Opin Cell Biol (2013) 1.13
Β-arrestin: a signaling molecule and potential therapeutic target for heart failure. J Mol Cell Cardiol (2010) 1.11
Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex. Proc Natl Acad Sci U S A (2013) 1.08
Diversity of G protein-coupled receptor signaling pathways to ERK/MAP kinase. Neurosignals (2002) 1.07
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol (2002) 1.05
The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation. J Biol Chem (2010) 1.03
Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking. J Biol Chem (2001) 1.02
Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells. Biochem J (2003) 0.98
Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney. Am J Physiol Regul Integr Comp Physiol (2011) 0.97
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1. J Neurosci (2008) 0.96
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96
Translation of striatal-enriched protein tyrosine phosphatase (STEP) after beta1-adrenergic receptor stimulation. J Neurochem (2007) 0.95
Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells. J Biol Chem (2013) 0.94
Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. J Pharmacol Exp Ther (2011) 0.93
Role of phospholipase D in parathyroid hormone type 1 receptor signaling and trafficking. Mol Endocrinol (2009) 0.93
Recycling and resensitization of delta opioid receptors. DNA Cell Biol (2000) 0.93
Regulation of ERK1/2 activity by ghrelin-activated growth hormone secretagogue receptor 1A involves a PLC/PKCvarepsilon pathway. Br J Pharmacol (2006) 0.92
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. J Biol Chem (2008) 0.92
G protein-coupled receptor (GPCR) kinase 2 regulates agonist-independent Gq/11 signaling from the mouse cytomegalovirus GPCR M33. J Biol Chem (2006) 0.91
Heterotrimeric G protein subunits are located on rat liver endosomes. BMC Physiol (2004) 0.91
G protein-coupled receptors--recent advances. Acta Biochim Pol (2012) 0.90
Mu-opioid agonist inhibition of kappa-opioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. J Neurochem (2000) 0.90
Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis. Traffic (2009) 0.90
Plectin regulates the signaling and trafficking of the HIV-1 co-receptor CXCR4 and plays a role in HIV-1 infection. Exp Cell Res (2007) 0.90
Reciprocal regulation of endocytosis and metabolism. Cold Spring Harb Perspect Biol (2014) 0.89
Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors. Biochem J (1999) 0.88
Effects of endocytosis on receptor-mediated signaling. Curr Opin Cell Biol (2015) 0.87
Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine H(1) receptor in DDT(1)MF-2 cells. Br J Pharmacol (2001) 0.86
Serotonin receptor signaling and regulation via β-arrestins. Crit Rev Biochem Mol Biol (2010) 0.86
Regulated and constitutive activation of specific signalling pathways by the human S1P5 receptor. Br J Pharmacol (2003) 0.85
β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem (2012) 0.85
Roles of proteolysis in regulation of GPCR function. Br J Pharmacol (2013) 0.84
Ligand internalization and recycling by human recombinant somatostatin type 4 (h sst(4)) receptors expressed in CHO-K1 cells. Br J Pharmacol (2001) 0.84
Activation of B-Raf and regulation of the mitogen-activated protein kinase pathway by the G(o) alpha chain. Mol Biol Cell (2000) 0.83
S-nitrosylation-regulated GPCR signaling. Biochim Biophys Acta (2011) 0.83
Change in functional selectivity of morphine with the development of antinociceptive tolerance. Br J Pharmacol (2014) 0.83
Gi-mediated tyrosine phosphorylation of Grb2 (growth-factor-receptor-bound protein 2)-bound dynamin-II by lysophosphatidic acid. Biochem J (1999) 0.83
Autocrine, mitogenic pheromone receptor loop of the ciliate Euplotes raikovi: pheromone-induced receptor internalization. Eukaryot Cell (2005) 0.83
The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β2-adrenergic receptor recycling and ERK activation. Biochem J (2013) 0.82
Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells. Adv Enzyme Regul (2007) 0.82
Gαs regulates the post-endocytic sorting of G protein-coupled receptors. Nat Commun (2014) 0.82
The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons. J Neurochem (2007) 0.81
α1A-adrenergic receptor induces activation of extracellular signal-regulated kinase 1/2 through endocytic pathway. PLoS One (2011) 0.81
Lipid raft-dependent glucagon-like peptide-2 receptor trafficking occurs independently of agonist-induced desensitization. Mol Biol Cell (2004) 0.81
Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways. J Biol Chem (2012) 0.80
Follicle-stimulating hormone (FSH) activates extracellular signal-regulated kinase phosphorylation independently of beta-arrestin- and dynamin-mediated FSH receptor internalization. Reprod Biol Endocrinol (2006) 0.79
Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes. Nat Rev Mol Cell Biol (2016) 0.79
Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors. J Biol Chem (2010) 0.79
Nanoconjugation: A Materials Approach to Enhance Epidermal Growth Factor Induced Apoptosis. Biomater Sci (2014) 0.78
Internalization of glial cell-derived neurotrophic factor receptor GFR alpha 1 in the absence of the ret tyrosine kinase coreceptor. Cell Mol Neurobiol (2003) 0.77
Delayed internalization and lack of recycling in a beta2-adrenergic receptor fused to the G protein alpha-subunit. BMC Cell Biol (2008) 0.77
Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold. Microbes Infect (2014) 0.76
The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence. Channels (Austin) (2015) 0.76
Chemerin C9 peptide induces receptor internalization through a clathrin-independent pathway. Acta Pharmacol Sin (2014) 0.76
Identification of novel transplantable GPCR recycling motif for drug discovery. Biochem Pharmacol (2016) 0.75
Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists. Mol Endocrinol (2015) 0.75
Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase. Genes Cancer (2017) 0.75
Dopamine receptors: from structure to function. Physiol Rev (1998) 8.90
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science (1999) 7.57
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (1996) 7.26
Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature (1986) 7.06
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J Biol Chem (1980) 6.06
Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells. Curr Biol (1998) 5.94
Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg (1997) 5.88
Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1977) 5.87
Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem (1991) 5.70
G protein-coupled receptor kinases. Annu Rev Biochem (1998) 5.53
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature (1997) 5.31
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science (2000) 5.20
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science (2001) 5.05
Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell (1999) 4.93
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science (1994) 4.84
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science (1999) 4.70
Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci U S A (1987) 4.66
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A (1987) 4.61
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci U S A (2001) 4.56
beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science (1990) 4.53
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem (1993) 4.52
Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem (2000) 4.46
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science (1996) 4.38
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science (1995) 4.18
Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J (1990) 4.05
Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science (1999) 4.04
Regulation of transmembrane signaling by receptor phosphorylation. Cell (1987) 3.74
Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. Nature (1985) 3.74
Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science (1988) 3.60
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science (1987) 3.47
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science (1992) 3.45
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A (1999) 3.43
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature (2000) 3.42
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature (1998) 3.41
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A (1986) 3.38
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature (1987) 3.33
International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev (1994) 3.26
Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol Pharmacol (1982) 3.23
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature (1994) 3.21
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. Proc Natl Acad Sci U S A (1988) 3.18
Cocaine self-administration in dopamine-transporter knockout mice. Nat Neurosci (1998) 3.16
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science (1999) 3.13
Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A (1998) 3.12
A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. J Biol Chem (1997) 3.12
Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. Proc Natl Acad Sci U S A (1998) 3.07
Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. J Biol Chem (1999) 3.02
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem (1992) 2.97
Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J Biol Chem (1989) 2.95
A family of receptors coupled to guanine nucleotide regulatory proteins. Biochemistry (1987) 2.91
Binding of G protein beta gamma-subunits to pleckstrin homology domains. J Biol Chem (1994) 2.91
Molecular basis for interactions of G protein betagamma subunits with effectors. Science (1998) 2.88
Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol (1999) 2.86
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A (2001) 2.86
HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. EMBO J (1997) 2.86
Cloning and expression of a functional serotonin transporter from rat brain. Nature (1991) 2.86
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. Proc Natl Acad Sci U S A (1988) 2.78
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci U S A (1998) 2.76
Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci (1998) 2.72
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A (1998) 2.68
Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature (1995) 2.64
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science (1998) 2.64
Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. J Clin Invest (1976) 2.58
International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol Rev (1995) 2.53
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J Biol Chem (1994) 2.53
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci U S A (2001) 2.52
Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci U S A (2001) 2.46
The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem (2000) 2.44