Published in J Neurosci Res on January 15, 1998
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10. Proc Natl Acad Sci U S A (2001) 2.87
Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease? Nat Rev Neurosci (2010) 2.34
Microglia in Alzheimer's disease and transgenic models. How close the fit? Am J Pathol (1999) 1.09
Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker. PLoS One (2011) 1.01
Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection. J Neurosci (2014) 0.88
The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury. Aging Dis (2016) 0.84
Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4. Alzheimers Res Ther (2010) 0.80
Expression of amyloid precursor protein-like molecule in astroglial cells of the subventricular zone and rostral migratory stream of the adult rat forebrain. J Anat (2004) 0.77
Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res Mol Brain Res (1998) 4.87
Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A beta-lactamase isolated from Escherichia coli. Antimicrob Agents Chemother (1995) 4.81
A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun (1996) 3.08
Cloning and sequencing of the gene encoding Toho-2, a class A beta-lactamase preferentially inhibited by tazobactam. Antimicrob Agents Chemother (1998) 3.06
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54
Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Neuron (2000) 2.38
The origin and cell lineage of microglia: new concepts. Brain Res Rev (2006) 2.36
Crystal structure of the E166A mutant of extended-spectrum beta-lactamase Toho-1 at 1.8 A resolution. J Mol Biol (1999) 2.14
PAX6 expression in the developing human eye. Br J Ophthalmol (1999) 1.94
Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci (2000) 1.74
Microglia: activation and their significance in the central nervous system. J Biochem (2001) 1.73
Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J Neurochem (2000) 1.63
Studies on penem antibiotics. II. In vitro activity of SUN5555, a new oral penem. J Antibiot (Tokyo) (1989) 1.50
New method for obliterative treatment of an anterior wall aneurysm in the internal carotid artery: encircling silicone sheet clip procedure--technical case report. Neurosurgery (2001) 1.47
Touchdown of the Hayabusa spacecraft at the Muses Sea on Itokawa. Science (2006) 1.43
Level of red blood cells in the urinary sediment reflects the degree of renal activity in Wegener's granulomatosis. Clin Nephrol (1998) 1.43
Induction of protective immunity in animals vaccinated with recombinant vaccinia viruses that express PreM and E glycoproteins of Japanese encephalitis virus. J Virol (1990) 1.42
Cloning and characterization of the Bacillus sphaericus genes controlling the bioconversion of pimelate into dethiobiotin. Gene (1990) 1.42
A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions. Mol Cell Biol (1994) 1.39
Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. J Biol Chem (2001) 1.37
Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy. Nephrol Dial Transplant (1998) 1.31
Visualization of microglia in living tissues using Iba1-EGFP transgenic mice. J Neurosci Res (2005) 1.29
Characteristics of aneurysms arising from the horizontal portion of the anterior cerebral artery. Surg Neurol (2001) 1.24
Detailed images of asteroid 25143 Itokawa from Hayabusa. Science (2006) 1.24
Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins. Biochemistry (1973) 1.23
The microglia/macrophage response in the neonatal rat facial nucleus following axotomy. Brain Res (1998) 1.22
Bootstrap approach for constructing confidence intervals for population pharmacokinetic parameters. I: A use of bootstrap standard error. Stat Med (1999) 1.20
Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J Neurochem (2001) 1.19
Identification of elastase as a secretory protease from cultured rat microglia. J Neurochem (1992) 1.18
Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells. Eur J Neurosci (1999) 1.16
Iba1 is an actin-cross-linking protein in macrophages/microglia. Biochem Biophys Res Commun (2001) 1.16
A single amino acid substitution converts cytochrome P450(14DM) to an inactive form, cytochrome P450SG1: complete primary structures deduced from cloned DNAS. Biochem Biophys Res Commun (1988) 1.15
A new antibiotic CJ-17,665 from Aspergillus ochraceus. J Antibiot (Tokyo) (2001) 1.13
High-level expression of the Japanese encephalitis virus E protein by recombinant vaccinia virus and enhancement of its extracellular release by the NS3 gene product. Virology (1993) 1.12
Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro. J Neurosci Res (1996) 1.12
Significance of glomerular activation of the alternative pathway and lectin pathway in lupus nephritis. Lupus (2011) 1.11
Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Biochem Biophys Res Commun (2000) 1.10
Induction of CHOP and apoptosis by nitric oxide in p53-deficient microglial cells. FEBS Lett (2001) 1.10
Plasminogen binds specifically to alpha-enolase on rat neuronal plasma membrane. J Neurochem (1994) 1.10
Nucleotide sequence of the bioH gene of Escherichia coli. Nucleic Acids Res (1989) 1.10
A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom. Biochem J (1997) 1.05
Neurotrophin secretion from cultured microglia. J Neurosci Res (2001) 1.04
Production and secretion of plasminogen in cultured rat brain microglia. FEBS Lett (1992) 1.01
Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats. Brain Res (1988) 1.01
Microglia and the development of spongiform change in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol (1998) 0.99
Synovial sarcoma of the prostate with t(X;18)(p11.2;q11.2). Am J Surg Pathol (1999) 0.98
Physiologically based pharmacokinetics of a new penem, SUN5555, for evaluation of in vivo efficacy. Drug Metab Dispos (1990) 0.97
Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. Br J Pharmacol (1998) 0.97
Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function. J Neurochem (2001) 0.96
Isolation of Bacillus sphaericus biotin synthesis control mutants: evidence for transcriptional regulation of bio genes. Gene (1991) 0.96
Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels. Biochemistry (1997) 0.96
cDNA microarray analysis of cancer associated gene expression profiles in malignant peripheral nerve sheath tumours. J Clin Pathol (2006) 0.95
Ability of rat microglia to uptake extracellular glutamate. Neurosci Lett (2001) 0.95
Early immunohistochemical detection of axonal damage and glial activation in extremely immature brains with periventricular leukomalacia. Clin Neuropathol (2001) 0.95
Short arm of chromosome 1 aberration recurrently found in pigmented villonodular synovitis. Cancer Genet Cytogenet (1996) 0.94
Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment. Biochemistry (1972) 0.94
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. Neurology (2004) 0.94
A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice. Neuroscience (2012) 0.94
Predominant expression of platelet-activating factor receptor in the rat brain microglia. J Neurosci (1996) 0.93
A case of lipoblastoma with t(3;8)(q12;q11.2). Cancer Genet Cytogenet (1992) 0.93
The amino-terminal region of amyloid precursor protein is responsible for neurite outgrowth in rat neocortical explant culture. Biochem Biophys Res Commun (1997) 0.93
The mutation in the ATP-binding region of JAK1, identified in human uterine leiomyosarcomas, results in defective interferon-gamma inducibility of TAP1 and LMP2. Oncogene (2006) 0.93
Microglia isolated from rat brain secrete a urokinase-type plasminogen activator. Brain Res (1992) 0.93
Generation and characterization of a microglial cell line, MG5, derived from a p53-deficient mouse. Glia (1997) 0.93
Differential expression of MHC class II molecules by microglia and neoplastic astroglia: relevance for the escape of astrocytoma cells from immune surveillance. Neuropathol Appl Neurobiol (1998) 0.92
Expression of prophenoloxidase mRNA during silkworm hemocyte development. Biosci Biotechnol Biochem (2000) 0.91
Neurotrophic and neuroprotective effects of neuron-specific enolase on cultured neurons from embryonic rat brain. Neurosci Res (1995) 0.91
Pathogenesis of hyponatremia following subarachnoid hemorrhage due to ruptured cerebral aneurysm. Surg Neurol (1996) 0.91
ATP stimulation of Ca2+ -dependent plasminogen release from cultured microglia. Br J Pharmacol (1998) 0.90
Delayed-type hypersensitivity as revealed on the footpads of mice to azobenzenearsonate-acetyl bovine serum albumin. Int Arch Allergy Appl Immunol (1981) 0.90
Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. J Biochem (1996) 0.90
Mycoplasma pneumoniae infection may cause striatal lesions leading to acute neurologic dysfunction. Neurology (1993) 0.90
Lipopolysaccharide enhances synthesis of brain-derived neurotrophic factor in cultured rat microglia. J Neurosci Res (1997) 0.90
Inhibitory effects of female sex hormones on urinary stone formation in rats. Kidney Int (1999) 0.90
Gender difference of slow wave sleep in middle aged and elderly subjects. Psychiatry Clin Neurosci (1999) 0.89
Hepatocyte growth factor-induced differential activation of phospholipase cgamma 1 and phosphatidylinositol 3-kinase is regulated by tyrosine phosphatase SHP-1 in astrocytes. J Biol Chem (2000) 0.89
Active-site residues of the transpeptidase domain of penicillin-binding protein 2 from Escherichia coli: similarity in catalytic mechanism to class A beta-lactamases. Biochemistry (1992) 0.89
The amino acid sequences of two large glycopeptides derived from the carbohydrate-carrying region of alpha 1-acid glycoprotein. Biochem Biophys Res Commun (1971) 0.89
A clinical survey on the compliance of exercise therapy for diabetic outpatients. Diabetes Res Clin Pract (1995) 0.89
Effects of training and training cessation on insulin action. Int J Sports Med (1991) 0.89
Complement activation through the lectin pathway in patients with Henoch-Schönlein purpura nephritis. Am J Kidney Dis (2000) 0.89
Neuronal survival factor from bovine brain is identical to neuron-specific enolase. J Neurochem (1991) 0.89
Renal primitive neuroectodermal tumor: an immunohistochemical and cytogenetic analysis. Pathol Int (1996) 0.89
Malignant fibrous histiocytoma. A tumor of facultative histiocytes showing mesenchymal differentiation in cultured cell lines. Cancer (1992) 0.89
Isolation and chemical properties of a ricin variant from castor bean. Toxicon (1976) 0.88
Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy. Brain Res Mol Brain Res (2000) 0.88
Functional roles of microglia in the brain. Neurosci Res (1993) 0.88
Cytokine production inhibitors produced by a fungus, Oidiodendron griseum. J Antibiot (Tokyo) (2001) 0.88
Oral contraceptives and intrahepatic biliary cystadenoma having an increased level of estrogen receptor. Hepatogastroenterology (1988) 0.87
Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection. Virology (2001) 0.87
PGl2 analogue mitigates the progression rate of renal dysfunction improving renal blood flow without glomerular hyperfiltration in patients with chronic renal insufficiency. Prostaglandins Leukot Essent Fatty Acids (2001) 0.86
Pathological study on mucosal changes in small intestine of rat by oral administration of ricin. I. Microscopical observation. Acta Pathol Jpn (1986) 0.86
Upregulated expression of Iba1 molecules in the central nervous system of mice in response to neurovirulent influenza A virus infection. Microbiol Immunol (2000) 0.86
Neurotrophins regulate the function of cultured microglia. Glia (1998) 0.86