Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

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Published in Nat Rev Neurosci on May 01, 2010

Authors

Victoria E Johnson1, William Stewart, Douglas H Smith

Author Affiliations

1: Brain Injury and Repair, Departmentof Neurosurgery, University of Pennsylvania School of Medicine, 3320 Smith Walk, Hayden Hall 105, Philadelphia, Pennsylvania 19104, USA; University of Glasgow, University Avenue, Glasgow G12 8QQ, UK.

Associated clinical trials:

Cardiovascular and Neurovascular Regulation in GWI | NCT04586049

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Lipid rafts and signal transduction. Nat Rev Mol Cell Biol (2000) 25.87

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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology (1993) 14.54

Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol (1991) 14.25

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Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function. J Lipid Res (2006) 6.11

Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci (2007) 5.72

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science (2005) 5.49

Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain (2006) 5.42

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The aftermath of boxing. Psychol Med (1973) 4.92

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Chronic traumatic encephalopathy in a National Football League player. Neurosurgery (2005) 4.67

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron (2007) 3.98

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Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat Med (2004) 3.93

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci (1999) 3.92

Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology (1995) 3.91

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Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry (2003) 3.87

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Diffuse axonal injury due to nonmissile head injury in humans: an analysis of 45 cases. Ann Neurol (1982) 3.82

Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nat Med (1995) 3.77

Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias. Neurology (2000) 3.61

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell (1999) 3.58

Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA (1997) 3.43

Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology (1989) 3.24

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron (2000) 2.94

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature (2001) 2.84

Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. J Neurosci (2002) 2.80

Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol (1991) 2.63

Association of apolipoprotein E polymorphism with outcome after head injury. Lancet (1997) 2.57

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans (2002) 2.55

Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science (2008) 2.53

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Development of dementing illnesses in an 80-year-old volunteer cohort. Ann Neurol (1989) 2.49

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J Biol Chem (2005) 2.47

The occult aftermath of boxing. J Neurol Neurosurg Psychiatry (1990) 2.41

beta A4 amyloid protein deposition in brain after head trauma. Lancet (1991) 2.41

Chronic traumatic encephalopathy in a national football league player: part II. Neurosurgery (2006) 2.40

Association of interleukin-1 gene polymorphisms with Alzheimer's disease. Ann Neurol (2000) 2.37

Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury. Neurosci Lett (1993) 2.35

Head injury and the risk of AD in the MIRAGE study. Neurology (2000) 2.34

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron (1993) 2.29

Abeta-degrading enzymes in Alzheimer's disease. Brain Pathol (2008) 2.26

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology. Pharmacol Rev (1993) 2.24

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease. J Neurol Neurosurg Psychiatry (1994) 2.24

The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function. Bioessays (2001) 2.23

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury. Exp Neurol (2004) 2.21

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci (1994) 2.19

Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Exp Neurol (2007) 2.15

Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci (2005) 2.04

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A case-control study of Alzheimer's disease in Australia. Neurology (1990) 1.98

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Traumatic brain injury and time to onset of Alzheimer's disease: a population-based study. Am J Epidemiol (1999) 1.81

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Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem (2007) 1.61

Head injury as a risk factor for Alzheimer's disease. Neurology (1985) 1.60

Amyloid beta accumulation in axons after traumatic brain injury in humans. J Neurosurg (2003) 1.60

The association between head trauma and Alzheimer's disease. Am J Epidemiol (1990) 1.58

APOE influences on neuropsychological function after mild head injury: within-person comparisons. Neurology (2004) 1.58

Biomechanical analysis of experimental diffuse axonal injury. J Neurotrauma (1995) 1.57

Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. J Neuropathol Exp Neurol (1999) 1.55

Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacol Ther (2005) 1.54

Alzheimer's disease after remote head injury: an incidence study. J Neurol Neurosurg Psychiatry (1997) 1.53

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Beta-amyloid precursor protein staining of nonaccidental central nervous system injury in pediatric autopsies. J Neurotrauma (2003) 1.52

Risk factors for clinically diagnosed Alzheimer's disease: a case-control study of an Italian population. Neurology (1986) 1.48

Specificity and sensitivity of betaAPP in head injury. Clin Neuropathol (2001) 1.48

Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci (1997) 1.48

Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease. Acta Neuropathol (2001) 1.48

Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Sci Int (2004) 1.48

Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1). J Neural Transm (Vienna) (2004) 1.47

A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury. Brain Pathol (2008) 1.46

Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci (2008) 1.43

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Imipramine treatment improves cognitive outcome associated with enhanced hippocampal neurogenesis after traumatic brain injury in mice. J Neurotrauma (2011) 0.92

Recessive desmin-null muscular dystrophy with central nuclei and mitochondrial abnormalities. Acta Neuropathol (2013) 0.91

American Society of Echocardiography and Society of Cardiovascular Anesthesiologists task force guidelines for training in perioperative echocardiography. J Am Soc Echocardiogr (2002) 0.87

Dendritic alterations after dynamic axonal stretch injury in vitro. Exp Neurol (2010) 0.87

tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury. J Neurotrauma (2012) 0.87

Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury. Brain (2004) 0.86

An integrative medicine clinic in a community hospital. Am J Public Health (2003) 0.86

Evidence That the Blood Biomarker SNTF Predicts Brain Imaging Changes and Persistent Cognitive Dysfunction in Mild TBI Patients. Front Neurol (2013) 0.86

Harvested human neurons engineered as live nervous tissue constructs: implications for transplantation. Laboratory investigation. J Neurosurg (2008) 0.86

Microthrombosis after experimental subarachnoid hemorrhage: time course and effect of red blood cell-bound thrombin-activated pro-urokinase and clazosentan. Exp Neurol (2011) 0.86

Establishment of human ovarian serous carcinomas cell lines in serum free media. Methods (2012) 0.85

Approaches to mapping genetically correlated complex traits. BMC Genet (2003) 0.85

Hypertonic saline resuscitation of hemorrhagic shock does not decrease in vivo neutrophil interactions with endothelium in the blood-brain microcirculation. J Trauma (2011) 0.85

Patterns of early emotional and neuropsychological sequelae after mild traumatic brain injury. J Neurotrauma (2014) 0.85

Neuroprotective effects of progesterone in traumatic brain injury: blunted in vivo neutrophil activation at the blood-brain barrier. Am J Surg (2013) 0.84

American Society of Echocardiography and Society of Cardiovascular Anesthesiologists task force guidelines for training in perioperative echocardiography. Anesth Analg (2002) 0.84

Microtissue engineered constructs with living axons for targeted nervous system reconstruction. Tissue Eng Part A (2012) 0.84

The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. J Endocrinol (2008) 0.83

Blast-induced color change in photonic crystals corresponds with brain pathology. J Neurotrauma (2011) 0.83

Atypical adult medulloblastoma. Acta Neurochir (Wien) (2011) 0.83

Updating memory after mild traumatic brain injury and orthopedic injuries. J Neurotrauma (2013) 0.83

Hemostatic and neuroprotective effects of human recombinant activated factor VII therapy after traumatic brain injury in pigs. Exp Neurol (2008) 0.83

Neural tissue engineering for neuroregeneration and biohybridized interface microsystems in vivo (Part 2). Crit Rev Biomed Eng (2011) 0.82

Developing a tissue-engineered neural-electrical relay using encapsulated neuronal constructs on conducting polymer fibers. J Neural Eng (2008) 0.82

Neural engineering to produce in vitro nerve constructs and neurointerface. Neurosurgery (2007) 0.82

Similar effects of hypertonic saline and mannitol on the inflammation of the blood-brain barrier microcirculation after brain injury in a mouse model. J Trauma Acute Care Surg (2012) 0.81

Traumatic brain injury induces biphasic upregulation of ApoE and ApoJ protein in rats. J Neurosci Res (2005) 0.80

Spatiotemporal distribution of spectrin breakdown products induced by anoxia in adult rat optic nerve in vitro. J Cereb Blood Flow Metab (2006) 0.80

Inhibition of Nogo-66 receptor 1 enhances recovery of cognitive function after traumatic brain injury in mice. J Neurotrauma (2013) 0.79

The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons. Biorheology (2003) 0.79

A novel neuroprosthetic interface with the peripheral nervous system using artificially engineered axonal tracts. Neurol Res (2008) 0.79

Does enoxaparin interfere with HMGB1 signaling after TBI? A potential mechanism for reduced cerebral edema and neurologic recovery. J Trauma Acute Care Surg (2016) 0.79

Changes in left ventricular morphology and function after mitral valve surgery. Am J Cardiol (2012) 0.78

Color changing photonic crystals detect blast exposure. Neuroimage (2010) 0.78

Head motions while riding roller coasters: implications for brain injury. Am J Forensic Med Pathol (2009) 0.78

Enoxaparin ameliorates post-traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo. J Trauma Acute Care Surg (2015) 0.78

Acute treatment with MgSO4 attenuates long-term hippocampal tissue loss after brain trauma in the rat. J Neurosci Res (2004) 0.77

Allotransplanted neurons used to repair peripheral nerve injury do not elicit overt immunogenicity. PLoS One (2012) 0.77