PubRank

E Harlow

Author PubWeight™ 295.25‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989 16.54
2 Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol 1981 15.59
3 Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 1988 10.98
4 Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993 8.13
5 Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J 1989 7.69
6 Cellular targets for transformation by the adenovirus E1A proteins. Cell 1989 7.53
7 New functional activities for the p21 family of CDK inhibitors. Genes Dev 1997 6.97
8 The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 1989 6.68
9 A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 1992 6.32
10 Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products. J Virol 1985 5.69
11 Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev 1993 5.54
12 Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 1994 5.18
13 A family of human cdc2-related protein kinases. EMBO J 1992 4.96
14 Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. J Virol 1980 4.88
15 Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 1996 4.80
16 Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. Proc Natl Acad Sci U S A 1996 4.70
17 Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 1991 4.36
18 Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature 1992 4.21
19 Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev 1993 4.14
20 Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol Cell Biol 1986 4.14
21 Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev 1992 3.96
22 p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 1994 3.95
23 The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol 1993 3.75
24 Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev 1996 3.61
25 Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol 1993 3.54
26 Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev 1994 3.47
27 Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 1995 3.41
28 Point mutational inactivation of the retinoblastoma antioncogene. Science 1989 3.37
29 Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A 1998 3.27
30 The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J 1991 3.15
31 Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol Cell Biol 1985 3.09
32 A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell 1989 3.08
33 Two regions of the adenovirus early region 1A proteins are required for transformation. J Virol 1988 3.02
34 The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene 1993 2.99
35 The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 1989 2.98
36 Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol 1992 2.97
37 NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev 2000 2.90
38 The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J 1990 2.80
39 Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev 1996 2.71
40 p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev 1995 2.60
41 Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells. J Virol 1981 2.60
42 Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet 1998 2.53
43 pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci U S A 1998 2.49
44 Nuclear organization of DNA replication in primary mammalian cells. Genes Dev 2000 2.48
45 Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol 1990 2.40
46 Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science 1992 2.39
47 Adenovirus E1A targets key regulators of cell proliferation. Cancer Surv 1992 2.29
48 Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production. J Virol 1986 2.27
49 Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene 1993 2.20
50 Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol Cell Biol 1991 2.20
51 Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev 1998 2.14
52 RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Mol Cell Biol 2001 2.14
53 Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science 1992 2.13
54 Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 1993 2.09
55 Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol Cell 1998 2.02
56 In vivo association of E2F and DP family proteins. Mol Cell Biol 1995 1.99
57 Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen. J Virol 1982 1.90
58 Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J Cell Sci 1996 1.84
59 Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol Cell Biol 1993 1.75
60 Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. Proc Natl Acad Sci U S A 1996 1.72
61 The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J 1995 1.67
62 Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J 1994 1.67
63 SV40 T antigen binds specifically to a cellular 53 K protein in vitro. Nature 1981 1.62
64 Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol Cell Biol 1996 1.62
65 Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins. EMBO J 1987 1.61
66 Specific regulation of E2F family members by cyclin-dependent kinases. Mol Cell Biol 1997 1.61
67 Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control. Proc Natl Acad Sci U S A 2000 1.59
68 Adenovirus E1A makes two distinct contacts with the retinoblastoma protein. J Virol 1992 1.54
69 Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome. Cancer Res 2001 1.51
70 Retinoblastoma. For our eyes only. Nature 1992 1.50
71 Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci U S A 1997 1.47
72 Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase. Mol Cell Biol 1993 1.47
73 A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Proc Natl Acad Sci U S A 2001 1.45
74 Opposing roles of pRB and p107 in adipocyte differentiation. Proc Natl Acad Sci U S A 2000 1.43
75 The retinoblastoma protein physically associates with the human cdc2 kinase. Mol Cell Biol 1992 1.40
76 Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases. Proc Natl Acad Sci U S A 1990 1.38
77 Tumour-suppressor genes: evolving definitions in the genomic age. Nat Genet 1997 1.33
78 The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2. J Virol 1993 1.29
79 Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization. J Virol 1991 1.25
80 Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. Science 1991 1.19
81 Adenovirus E1A is associated with a serine/threonine protein kinase. J Virol 1991 1.19
82 Uniform nomenclature for monoclonal antibodies directed against virus-coded proteins of simian virus 40 and polyoma virus. J Virol 1982 1.18
83 Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. J Virol 1994 1.18
84 Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells. EMBO J 1983 1.16
85 Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs. Oncogene 1997 1.10
86 Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells. Cold Spring Harb Symp Quant Biol 2005 1.08
87 An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene. J Biol Chem 1995 0.97
88 Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. Genomics 1995 0.96
89 Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft. Proc Natl Acad Sci U S A 2001 0.91
90 p16 inhibition of transformed and primary squamous epithelial cells. Oncogene 1996 0.90
91 Purification and analysis of CIP/KIP proteins. Methods Enzymol 1997 0.90
92 Cellular proteins that are targetted by DNA tumor viruses for transformation. Princess Takamatsu Symp 1989 0.89
93 No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol Carcinog 1999 0.87
94 Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1. Mol Cell Biol 1999 0.87
95 The cyclin-dependent kinase family. Cold Spring Harb Symp Quant Biol 1991 0.87
96 Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1. Blood 1996 0.85
97 Growth suppression by members of the retinoblastoma protein family. Cold Spring Harb Symp Quant Biol 1994 0.83
98 Two different viral transforming proteins bind the same host tumour antigen. Nature 1982 0.82
99 Transcriptional inhibition by the retinoblastoma protein. Philos Trans R Soc Lond B Biol Sci 1993 0.80
100 Anti-oncogenes and the negative regulation of cell growth. Cold Spring Harb Symp Quant Biol 1988 0.79
101 Cellular proteins that are targets for transformation by DNA tumour viruses. Ciba Found Symp 1990 0.78
102 Twelfth annual Pezcoller symposium: signaling cross-talks in cancer cells. Cancer Res 2000 0.75
103 Postabortion contraceptive services scarce in Turkey. AVSC News 1996 0.75