Published in J Bacteriol on February 01, 1998
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus. J Bacteriol (2007) 1.19
Natural product discovery: past, present, and future. J Ind Microbiol Biotechnol (2016) 1.02
Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensis. Antimicrob Agents Chemother (2007) 0.99
A novel archaeal alanine dehydrogenase homologous to ornithine cyclodeaminase and mu-crystallin. J Bacteriol (2004) 0.96
Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol (2006) 0.87
Production of novel rapamycin analogs by precursor-directed biosynthesis. Appl Environ Microbiol (2005) 0.87
Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies. J Ind Microbiol Biotechnol (2013) 0.86
A glutamate mutase is involved in the biosynthesis of the lipopeptide antibiotic friulimicin in Actinoplanes friuliensis. Antimicrob Agents Chemother (2003) 0.85
Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster. J Biol Chem (2010) 0.81
Strain development of Streptomyces sp. for tacrolimus production using sequential adaptation. J Ind Microbiol Biotechnol (2009) 0.79
Combinatorial biosynthesis: lesson learned from nature. Proc Natl Acad Sci U S A (1998) 0.78
Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production. J Ind Microbiol Biotechnol (2014) 0.76
An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35. Appl Environ Microbiol (2016) 0.75
An overview of rapamycin: from discovery to future perspectives. J Ind Microbiol Biotechnol (2016) 0.75
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc Natl Acad Sci U S A (1995) 2.70
Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution. Annu Rev Microbiol (1992) 2.10
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase. Gene (1996) 1.34
Ornithine cyclodeaminase from octopine Ti plasmid Ach5: identification, DNA sequence, enzyme properties, and comparison with gene and enzyme from nopaline Ti plasmid C58. J Bacteriol (1989) 1.28
Ornithine cyclodeaminase from Ti plasmid C58: DNA sequence, enzyme properties and regulation of activity by arginine. Eur J Biochem (1988) 1.23
Cloning and location of a gene governing lysine epsilon-aminotransferase, an enzyme initiating beta-lactam biosynthesis in Streptomyces spp. J Bacteriol (1991) 1.19
Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation. Biochemistry (1991) 1.07
Gene disruption and replacement in the rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253. Microbiology (1997) 0.98
A general method for the determination of precursor configuration in biosynthetic precursor-product relationships. Derivation of pipecolic acid from D-lysine, and of piperidine alkaloids from L-lysine. J Am Chem Soc (1973) 0.94
Ornithine cyclase (deaminating). III. Mechanism of the conversion of ornithine to proline. J Biol Chem (1974) 0.93
The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus. Eur J Biochem (1997) 0.91
Generation of novel rapamycin structures by microbial manipulations. J Antibiot (Tokyo) (1995) 0.88
Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus. Appl Microbiol Biotechnol (1995) 0.87
Revised NMR assignments for rapamycin. J Antibiot (Tokyo) (1991) 0.86
Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. Oncogene (1997) 0.85
In vivo immunopharmacology of the macrolides FK 506 and rapamycin: toward the era of rational immunosuppressive drug discovery, development, and use. Transplant Proc (1991) 0.84
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A (2001) 24.34
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature (1990) 3.81
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution. Structure (1996) 2.06
Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Science (1994) 1.92
aex-3 encodes a novel regulator of presynaptic activity in C. elegans. Neuron (1997) 1.86
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. FEBS Lett (1995) 1.79
Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases. Mol Gen Genet (1991) 1.76
Use of community genetic screening to prevent HFE-associated hereditary haemochromatosis. Lancet (2005) 1.68
Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units. Chem Biol (2001) 1.65
A chain initiation factor common to both modular and aromatic polyketide synthases. Nature (1999) 1.62
Engineering broader specificity into an antibiotic-producing polyketide synthase. Science (1998) 1.60
A new indicator of human malignant tumour. Br J Cancer (1984) 1.60
Cloning and structural characterization of the genes coding for adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii. Biochem J (1989) 1.51
A hybrid modular polyketide synthase obtained by domain swapping. Chem Biol (1996) 1.42
Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Science (1995) 1.41
A new marker for testicular cancer. Br J Cancer (1985) 1.39
6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme. Eur J Biochem (1992) 1.39
Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation (1996) 1.39
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase. Gene (1996) 1.34
Alkaloid biosynthesis. XII. The biosynthesis of narcotine. J Chem Soc Perkin 1 (1968) 1.23
Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. Mol Gen Genet (1998) 1.19
Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea. Mol Gen Genet (1997) 1.19
Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens (1994) 1.17
Cloning, characterization, and high-level expression in Escherichia coli of the Saccharopolyspora erythraea gene encoding an acyl carrier protein potentially involved in fatty acid biosynthesis. J Bacteriol (1991) 1.17
Cyclosporine does not prevent cytoplasmic calcium changes associated with lymphocyte activation. Transplantation (1984) 1.16
Studies of enzyme-mediated reactions. Part 13. Stereochemical course of the formation of histamine by decarboxylation of (2S)-histidine with enzymes from Clostridium welchii and Lactobacillus 30a. J Chem Soc Perkin 1 (1980) 1.14
Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea. Mol Gen Genet (1998) 1.12
Purification and characterization of methylmalonyl-CoA epimerase from Propionibacterium shermanii. Biochem J (1981) 1.12
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea. FEBS Lett (1992) 1.10
Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis. Mol Microbiol (1989) 1.09
The subunit structure of methylmalonyl-CoA mutase from Propionibacterium shermanii. Biochem J (1986) 1.09
Monoclonal antibody which agglutinates erythrocytes from cancer patients. Lancet (1982) 1.07
A bacterial calcium-binding protein homologous to calmodulin. Nature (1987) 1.06
Gender differences in the efficacy of fluoxetine and maprotiline in depressed patients: a double-blind trial of antidepressants with serotonergic or norepinephrinergic reuptake inhibition profile. Eur Neuropsychopharmacol (2001) 1.06
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues. Chem Biol (1999) 1.05
Energetics of triosephosphate isomerase: deuterium isotope effects in the enzyme-catalyzed reaction. Biochemistry (1976) 1.05
Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. J Biol Chem (1988) 1.05
Purification and characterization of pyruvate: ferredoxin oxidoreductase from the anaerobic protozoon Trichomonas vaginalis. Biochem J (1987) 1.04
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase. Chem Biol (2001) 1.04
Evidence for a double-helical structure for modular polyketide synthases. Nat Struct Biol (1996) 1.04
Chromosomes and human pregnancy wastage. Am J Obstet Gynecol (1966) 1.02
A small, discrete acyl carrier protein is involved in de novo fatty acid biosynthesis in Streptomyces erythraeus. FEBS Lett (1987) 1.01
An ABC-transporter from Streptomyces longisporoflavus confers resistance to the polyether-ionophore antibiotic tetronasin. Mol Microbiol (1994) 1.01
Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase. Eur J Biochem (1993) 1.00
Crystallization and preliminary diffraction data for adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii. J Mol Biol (1988) 1.00
Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates. Chem Biol (2001) 0.99
Proton transfer in methylmalonyl-CoA epimerase from Propionibacterium shermanii. Studies with specifically tritiated (2R)-methylmalonyl-CoA as substrate. Biochem J (1983) 0.98
The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase. Biochemistry (1997) 0.98
Prokaryotic calcium-binding protein of the calmodulin superfamily. Calcium binding to a Saccharopolyspora erythraea 20 kDa protein. FEBS Lett (1992) 0.97
Simple method of monitoring colonising microbial load in chronic bronchial sepsis: pilot comparison of reduction in colonising microbial load with antibiotics given intermittently and continuously. J Clin Pathol (1987) 0.96
Cloning, characterization, and heterologous expression of the Saccharopolyspora erythraea (Streptomyces erythraeus) gene encoding an EF-hand calcium-binding protein. J Bacteriol (1989) 0.95
Subunit interactions in Propionibacterium shermanii methylmalonyl-CoA mutase studied by analytical ultracentrifugation. Biochem J (1989) 0.95
Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster. J Ind Microbiol Biotechnol (2001) 0.95
Magnetism of FePt surface alloys. Phys Rev Lett (2009) 0.95
Triosephosphate isomerase: isotope studies on the mechanistic pathway. Cold Spring Harb Symp Quant Biol (1972) 0.95
Induction, purification and characterisation of acyl-ACP thioesterase from developing seeds of oil seed rape (Brassica napus). Plant Mol Biol (1992) 0.95
An acyl-carrier-protein-thioesterase domain from the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-level production, purification and characterisation in Escherichia coli. Eur J Biochem (1991) 0.95
Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase. J Biol Chem (1994) 0.94
Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8. Eur J Immunol (1992) 0.94
Phosphorylation of the periplasmic binding protein in two transport systems for arginine incorporation in Escherichia coli K-12 is unrelated to the function of the transport system. J Bacteriol (1998) 0.93
Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase. Chem Biol (1999) 0.93
Identification of two distinct microtubule binding domains on recombinant rat MAP 1B. Eur J Cell Biol (1992) 0.91
Physical map location of the new Escherichia coli gene sbm. J Bacteriol (1992) 0.91
The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus. Eur J Biochem (1997) 0.91
Synthesis of methyl[3H]acetimidate of high specific radioactivity, a reagent for radiolabeling proteins. Anal Biochem (1980) 0.90
Adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii. Active holoenzyme produced from Escherichia coli. Biochem J (1990) 0.90
Evidence for the effectiveness of olanzapine among patients nonresponsive and/or intolerant to risperidone. J Clin Psychiatry (2001) 0.89
Evaluation of a multi-disease carrier screening programme in Ashkenazi Jewish high schools. Clin Genet (2010) 0.89
Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. Chem Biol (2000) 0.89
Construction of new vectors for high-level expression in actinomycetes. Gene (1998) 0.88
Polyketide synthesis in vitro on a modular polyketide synthase. Chem Biol (1995) 0.88
Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase. Biochemistry (2000) 0.87