IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

PubWeight™: 1.86‹?› | Rank: Top 3%

🔗 View Article (PMID 9498741)

Published in J Immunol on March 01, 1998

Authors

B T Konieczny1, Z Dai, E T Elwood, S Saleem, P S Linsley, F K Baddoura, C P Larsen, T C Pearson, F G Lakkis

Author Affiliations

1: The Carlos and Marguerite Mason Transplantation Research Center, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30033, USA.

Articles citing this

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med (2008) 2.26

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest (2001) 2.19

IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med (2005) 2.07

Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J Clin Invest (1998) 1.99

Translating costimulation blockade to the clinic: lessons learned from three pathways. Immunol Rev (2009) 1.66

Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med (1998) 1.65

Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis. J Exp Med (2001) 1.60

Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. J Clin Invest (2010) 1.55

Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc Natl Acad Sci U S A (2001) 1.48

CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol (2008) 1.36

Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol (2008) 1.36

Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis. Am J Pathol (2004) 1.34

CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase. J Clin Invest (2007) 1.23

Myeloid-derived suppressor cells in transplantation and cancer. Immunol Res (2012) 1.23

Neutrophils mediate parenchymal tissue necrosis and accelerate the rejection of complete major histocompatibility complex-disparate cardiac allografts in the absence of interferon-gamma. Am J Pathol (2003) 1.21

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest (2000) 1.19

IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses. Am J Transplant (2005) 1.14

CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigens. J Clin Invest (2004) 1.14

An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant (2007) 1.12

Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest (2002) 1.12

Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo. J Clin Invest (2001) 1.11

Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A (2011) 1.10

Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis. Am J Pathol (2001) 1.00

IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival. J Immunol (2011) 1.00

Central memory CD8+ T lymphocytes mediate lung allograft acceptance. J Clin Invest (2014) 0.99

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Eur J Immunol (2010) 0.99

Interleukin-17 promotes early allograft inflammation. Am J Pathol (2010) 0.97

Recent progress and new perspectives in studying T cell responses to allografts. Am J Transplant (2010) 0.96

Routes to transplant tolerance versus rejection; the role of cytokines. Immunity (2004) 0.95

IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses. J Immunol (2009) 0.93

Finally, CTLA4Ig graduates to the clinic. J Clin Invest (1999) 0.93

The classical complement pathway in transplantation: unanticipated protective effects of C1q and role in inductive antibody therapy. Am J Transplant (2008) 0.92

Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb. Transplantation (1999) 0.92

Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease. Biol Blood Marrow Transplant (2007) 0.91

Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells. Hum Immunol (2009) 0.90

Implications for Interleukin-33 in solid organ transplantation. Cytokine (2013) 0.89

Inflammation and transplantation tolerance. Semin Immunopathol (2011) 0.87

Transplantation tolerance and its outcome during infections and inflammation. Immunol Rev (2014) 0.86

Absence of MyD88 signaling induces donor-specific kidney allograft tolerance. J Am Soc Nephrol (2012) 0.86

Lung transplantation: infection, inflammation, and the microbiome. Semin Immunopathol (2011) 0.86

IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells. Am J Transplant (2009) 0.85

Bystander activation of iNKT cells occurs during conventional T-cell alloresponses. Am J Transplant (2011) 0.84

Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism. Immunol Rev (2008) 0.83

The role of T helper cell differentiation in promoting nerve allograft survival with costimulation blockade. J Neurosurg (2010) 0.79

Interferon- γ triggers hepatic stellate cell-mediated immune regulation through MEK/ERK signaling pathway. Clin Dev Immunol (2013) 0.79

Early exposure of interferon-γ inhibits signal transducer and activator of transcription-6 signalling and nuclear factor κB activation in a short-term monocyte-derived dendritic cell culture promoting 'FAST' regulatory dendritic cells. Clin Exp Immunol (2012) 0.79

The effects of tolerance on allograft damage caused by the innate immune system. Transplantation (2008) 0.79

Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation. Liver Transpl (2008) 0.78

CD8(+)IL-17(+) T Cells Mediate Neutrophilic Airway Obliteration in T-bet-Deficient Mouse Lung Allograft Recipients. Am J Respir Cell Mol Biol (2015) 0.78

Interferon Gamma and Contact-dependent Cytotoxicity Are Each Rate Limiting for Natural Killer Cell-Mediated Antibody-dependent Chronic Rejection. Am J Transplant (2016) 0.77

Murine mobilized peripheral blood stem cells have a lower capacity than bone marrow to induce mixed chimerism and tolerance. Am J Transplant (2008) 0.77

Elevated levels of interferon-γ production by memory T cells do not promote transplant tolerance resistance in aged recipients. PLoS One (2013) 0.75

Working toward immune tolerance in lung transplantation. J Clin Invest (2014) 0.75

Administration of a negative vaccination induces hyporesponsiveness to islet allografts. Cell Transplant (2012) 0.75

Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant (2016) 0.75

Immune activation during the implantation phase causes preeclampsia-like symptoms via the CD40-CD40 ligand pathway in pregnant mice. Hypertens Res (2016) 0.75

Role of NK, NKT cells and macrophages in liver transplantation. World J Gastroenterol (2016) 0.75

Indoleamine 2,3-dioxygenase in human hematopoietic stem cell transplantation. Int J Tryptophan Res (2010) 0.75

IFN-γ: The Dr. Jekyll and Mr. Hyde of immunology? Am J Transplant (2013) 0.75

Articles by these authors

Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat Biotechnol (2001) 14.57

Experimental annotation of the human genome using microarray technology. Nature (2001) 10.39

CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature (1996) 6.61

A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am J Transplant (2010) 5.40

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science (1992) 5.36

Role of the CD28 receptor in T-cell activation. Immunol Today (1990) 4.89

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol (1993) 4.65

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell (1992) 4.34

Regulation of the Bacillus anthracis protective antigen gene: CO2 and a trans-acting element activate transcription from one of two promoters. J Bacteriol (1994) 3.98

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med (1994) 3.66

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies. Hum Mol Genet (2001) 3.58

4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med (1997) 3.31

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med (1995) 3.16

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc Natl Acad Sci U S A (1992) 2.98

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell (1993) 2.92

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations. J Exp Med (1992) 2.79

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp Med (1993) 2.71

Treatment of murine lupus with CTLA4Ig. Science (1994) 2.69

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med (1993) 2.62

CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest (1999) 2.58

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med (1995) 2.48

Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med (1992) 2.42

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci U S A (1996) 2.40

Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression. Am J Transplant (2010) 2.37

Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes. J Immunol (1992) 2.36

Transplantation tolerance induced by CTLA4-Ig. Transplantation (1994) 2.36

Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity (1995) 2.29

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol (1995) 2.28

Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J Clin Invest (1999) 2.26

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med (1994) 2.23

Restriction fragment length polymorphisms associated with immunoglobulin C gamma genes reveal linkage disequilibrium and genomic organization. Proc Natl Acad Sci U S A (1983) 2.23

Viscosity and retinal vein thrombosis. Br J Ophthalmol (1976) 2.12

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J Immunol (1994) 2.09

Induction of Crassulacean Acid Metabolism in the Facultative Halophyte Mesembryanthemum crystallinum by Abscisic Acid. Plant Physiol (1990) 2.04

Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat Genet (1995) 2.03

Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science (1992) 1.98

Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis. Br J Haematol (2005) 1.96

Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. J Immunol (2001) 1.96

Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients. Am J Transplant (2011) 1.93

Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression. Infect Immun (1996) 1.85

Effect of haematocrit on cerebral blood-flow in man. Lancet (1977) 1.80

Cerebral blood-flow in polycythaemia. Lancet (1977) 1.79

Photosynthetic and photorespiratory characteristics of flaveria species. Plant Physiol (1991) 1.78

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J Biol Chem (1994) 1.76

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J Exp Med (1994) 1.76

Highly diastereoselective alpha-mannopyranosylation in the absence of participating protecting groups. J Org Chem (2000) 1.72

Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Eur J Immunol (1992) 1.72

Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors. Am J Transplant (2014) 1.70

Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant (2009) 1.69

A mouse model for polyomavirus-associated nephropathy of kidney transplants. Am J Transplant (2006) 1.65

CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation (1996) 1.63

4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. J Immunol (1999) 1.63

Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med (1991) 1.62

Introducing care pathway commissioning to primary dental care: measuring performance. Br Dent J (2011) 1.61

Donor-recipient microchimerism is not required for tolerance induction following recipient pretreatment with donor-specific transfusion and anti-CD4 antibody. Evidence of a clear role for short-term antigen persistence. Transplantation (1995) 1.58

Costimulation of T cells for tumor immunity. Immunol Today (1993) 1.57

Organ donation and utilization, 1995-2004: entering the collaborative era. Am J Transplant (2006) 1.57

Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. Am J Transplant (2012) 1.54

Microchimerism and rejection in clinical transplantation. Lancet (1997) 1.53

Costimulation of T-cell growth. Curr Opin Immunol (1992) 1.53

Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia. Lancet (1978) 1.52

Cumulative exposure to gamma interferon-dependent chemokines CXCL9 and CXCL10 correlates with worse outcome after lung transplant. Am J Transplant (2011) 1.51

Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. Am J Transplant (2014) 1.50

Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance. J Immunol (2001) 1.49

Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation. Am J Transplant (2010) 1.48

Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. J Exp Med (2000) 1.47

Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. J Immunol (2001) 1.46

B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J Immunol (1997) 1.46

Waldenstrom's macroglobulinemia evolving into acute lymphoblastic leukemia: a case report and a review of the literature. Leukemia (2004) 1.45

Oxygen desaturation in apparent and relative polycythaemia. BMJ (1991) 1.45

CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo. J Immunol (1997) 1.44

Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J Immunol (1994) 1.43

Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol (2000) 1.43

The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. J Exp Med (1991) 1.41

The classification and diagnostic criteria of the erythrocytoses (polycythaemias) Clin Lab Haematol (1999) 1.41

Cutting edge: Secondary lymphoid organs are essential for maintaining the CD4, but not CD8, naive T cell pool. J Immunol (2001) 1.41

Postpartum thrombosis in primary thrombocythaemia. Eur J Haematol (1997) 1.40

Isolation and characterization of dendritic cells from mouse heart and kidney. J Immunol (1994) 1.40

[Are children properly classified within the scope of expert assessment to determine need for services?]. Gesundheitswesen (2000) 1.39

FasL is important in costimulation blockade-resistant skin graft rejection. Transplantation (2001) 1.39

Intravenous immunoglobulin therapy in thrombocytopenic infectious mononucleosis. Clin Lab Haematol (1989) 1.39