Published in Hepatology on March 01, 1998
Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol (2010) 2.54
Macrophages and tissue injury: agents of defense or destruction? Annu Rev Pharmacol Toxicol (2011) 2.28
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2010) 1.84
Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. Chem Res Toxicol (2009) 1.70
Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicol Sci (2006) 1.16
Animal models of acute hepatic failure. Int J Exp Pathol (2000) 1.10
Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem Pharmacol (2009) 1.10
Retracted A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway. Br J Pharmacol (2002) 1.01
A comparison of the effect of nitroparacetamol and paracetamol on liver injury. Br J Pharmacol (2001) 0.97
Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo. Int J Nanomedicine (2013) 0.94
Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention. J Surg Res (2009) 0.94
Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1. Toxicol Appl Pharmacol (2011) 0.92
Retracted Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice. Br J Pharmacol (2004) 0.90
Role of copper,zinc-superoxide dismutase in catalyzing nitrotyrosine formation in murine liver. Free Radic Biol Med (2008) 0.88
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicol Appl Pharmacol (2012) 0.85
Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol (2012) 0.85
Potential effects of L-NAME on alcohol-induced oxidative stress. World J Gastroenterol (2005) 0.84
Remote ischemic preconditioning as treatment for non-ischemic gastrointestinal disorders: beyond ischemia-reperfusion injury. World J Gastroenterol (2014) 0.84
TNF-alpha dependent production of inducible nitric oxide is involved in PGE(1) protection against acute liver injury. Gut (2000) 0.83
Bee venom phospholipase A2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice. PLoS One (2014) 0.82
Elastomeric free-form blood vessels for interconnecting organs on chip systems. Lab Chip (2016) 0.81
Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol (2014) 0.81
Identification of early biomarkers during acetaminophen-induced hepatotoxicity by fourier transform infrared microspectroscopy. PLoS One (2012) 0.80
Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. PLoS One (2015) 0.80
Curative Effects of Thiacremonone against Acetaminophen-Induced Acute Hepatic Failure via Inhibition of Proinflammatory Cytokines Production and Infiltration of Cytotoxic Immune Cells and Kupffer Cells. Evid Based Complement Alternat Med (2013) 0.77
A Macaca mulatta model of fulminant hepatic failure. World J Gastroenterol (2012) 0.77
Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. Dig Dis Sci (1999) 0.77
A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3β aggravates acetaminophen-induced hepatic protein nitration. Free Radic Biol Med (2013) 0.75
The Alzheimer pandemic: is paracetamol to blame? Inflamm Allergy Drug Targets (2014) 0.75
Effect of S-methylisothiourea in acetaminophen-induced hepatotoxicity in rat. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.75
Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose. Toxicol Rep (2016) 0.75
Ruthenium red protects HepG2 cells overexpressing CYP2E1 against acetaminophen cytotoxicity. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.75
Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst (1993) 8.30
An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels. Anal Biochem (1976) 7.00
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science (1992) 6.51
Structural basis of amino acid alpha helix propensity. Science (1993) 4.36
Retinylidene proteins: structures and functions from archaea to humans. Annu Rev Cell Dev Biol (2000) 4.01
Three-dimensional structure of beta-galactosidase from E. coli. Nature (1994) 3.46
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. J Biol Chem (1986) 3.39
Research on esophageal cancer in China: a review. Cancer Res (1980) 3.17
Molecular basis for interactions of G protein betagamma subunits with effectors. Science (1998) 2.88
Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res (1996) 2.56
Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis (1998) 2.27
Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men. N Engl J Med (2001) 2.26
Supplementation with vitamins C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults. Am J Clin Nutr (1996) 2.08
IFN-gamma is required for viral clearance from central nervous system oligodendroglia. J Immunol (1999) 2.00
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J Mol Biol (1994) 1.95
Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. J Natl Cancer Inst (1993) 1.91
Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. J Biol Chem (1983) 1.91
Functional heterogeneity in liver and lung macrophages. J Leukoc Biol (2001) 1.89
Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol Biomarkers Prev (2001) 1.87
Relationship between fatty acid delivery and fatty acid oxidation during strenuous exercise. J Appl Physiol (1985) (1995) 1.85
Accumulation of p53 protein in human esophageal precancerous lesions: a possible early biomarker for carcinogenesis. Cancer Res (1993) 1.81
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res (1994) 1.80
Efficacy of a high-carbohydrate diet in catabolic illness. Crit Care Med (2001) 1.76
Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev (1995) 1.70
Absorption, distribution, elimination of tea polyphenols in rats. Drug Metab Dispos (1997) 1.69
Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. Biochemistry (1988) 1.69
Hepatitis B virus markers in Chinese twins. Anticancer Res (1989) 1.68
Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol (1993) 1.67
p53 tumor suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan, China. Cancer Res (1994) 1.66
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res (1991) 1.66
Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis. Int J Cancer (1994) 1.63
Measurement of very low stable isotope enrichments by gas chromatography/mass spectrometry: application to measurement of muscle protein synthesis. Metabolism (1997) 1.61
Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin. J Biol Chem (1997) 1.58
Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing. J Biol Chem (1992) 1.58
Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis. Ophthalmology (1998) 1.58
Comparison of the crystal structure of bacteriophage T4 lysozyme at low, medium, and high ionic strengths. Proteins (1991) 1.57
Epstein-Barr virus transcription in nasopharyngeal carcinoma. J Virol (1983) 1.57
Nitric oxide inhibition causes intrauterine growth retardation and hind-limb disruptions in rats. Am J Obstet Gynecol (1994) 1.55
Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. J Natl Cancer Inst (2000) 1.55
Development of esophageal metaplasia and adenocarcinoma in a rat surgical model without the use of a carcinogen. Carcinogenesis (1997) 1.53
Primary human herpesvirus 6 infections in children: a prospective serologic study. J Infect Dis (1992) 1.50
DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas. Carcinogenesis (2001) 1.50
Drug-induced liver injury: mechanisms and test systems. Hepatology (2001) 1.49
Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology (1995) 1.48
LIVER EXTRACT, LIVER ASH AND IRON IN THE TREATMENT OF ANEMIA. J Clin Invest (1930) 1.47
Enhanced production of nitric oxide by rat alveolar macrophages after inhalation of a pulmonary irritant is associated with increased expression of nitric oxide synthase. J Immunol (1993) 1.46
Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemoprevention. Carcinogenesis (2001) 1.45
Identification of a locus for porokeratosis palmaris et plantaris disseminata to a 6.9-cM region at chromosome 12q24.1-24.2. Br J Dermatol (2003) 1.44
Harry M. Vars Research Award. A new model to determine in vivo the relationship between amino acid transmembrane transport and protein kinetics in muscle. JPEN J Parenter Enteral Nutr (1992) 1.44
CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst (1997) 1.43
Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. J Virol (1987) 1.42
Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes. Xenobiotica (1982) 1.41
Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J Pharmacol Exp Ther (1990) 1.38
Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics. J Biol Chem (1983) 1.37
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1. Chem Res Toxicol (1991) 1.37
Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia. J Leukoc Biol (1994) 1.37
Relationship between expression of Bcl-2 genes and growth factors in ischemic acute renal failure in the rat. J Am Soc Nephrol (2000) 1.36
High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation. Protein Sci (2000) 1.36
Molecular cloning, expression, and characterization of podocalyxin-like protein 1 from rabbit as a transmembrane protein of glomerular podocytes and vascular endothelium. J Biol Chem (1995) 1.34
Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev (2001) 1.34
Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)O(2) production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis (2000) 1.34
Cigarette smoking, alcohol consumption and risk of nasopharyngeal carcinoma in Taiwan. Cancer Causes Control (1999) 1.32
PCBs: structure-function relationships and mechanism of action. Environ Health Perspect (1985) 1.32
Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes. Virology (1995) 1.32
Growth inhibition and apoptosis induction of Sulindac on Human gastric cancer cells. World J Gastroenterol (2001) 1.32
Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins. Cancer Res (1997) 1.31
A simple, non-chromatographic purification procedure for monoclonal antibodies. Isolation of monoclonal antibodies against cytochrome P450 isozymes. J Immunol Methods (1987) 1.31
An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload. Carcinogenesis (1999) 1.29
Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol (2000) 1.28
Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil. Cancer Res (1981) 1.27
Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice. Cancer Res (1992) 1.27
Purification of characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls. Arch Biochem Biophys (1982) 1.27
The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet (1972) 1.26
Glucosyltransferase gene polymorphism among Streptococcus mutans strains. Infect Immun (1991) 1.26
Production of nitric oxide by rat type II pneumocytes: increased expression of inducible nitric oxide synthase following inhalation of a pulmonary irritant. Am J Respir Cell Mol Biol (1994) 1.26
An improved method for the determination of green and black tea polyphenols in biomatrices by high-performance liquid chromatography with coulometric array detection. Anal Biochem (2000) 1.26
Identification of a homeodomain binding element in the bone sialoprotein gene promoter that is required for its osteoblast-selective expression. J Biol Chem (2000) 1.26
Chemotactic activity of collagen-like polypeptides for human peripheral blood neutrophils. J Leukoc Biol (1986) 1.22
Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res (1999) 1.22
Glycerol gluconeogenesis in fasting humans. Nutrition (1995) 1.22
Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol (2001) 1.22
Inhibition of glucosyltransferase activities of Streptococcus mutans by a monoclonal antibody to a subsequence peptide. Infect Immun (1993) 1.21
Oxidative damage in an esophageal adenocarcinoma model with rats. Carcinogenesis (2000) 1.21
Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes. Arch Biochem Biophys (1979) 1.21
Accommodation of amino acid insertions in an alpha-helix of T4 lysozyme. Structural and thermodynamic analysis. J Mol Biol (1994) 1.20
Vegetable consumption, serum retinol level, and risk of hepatocellular carcinoma. Cancer Res (1995) 1.19
Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis (1993) 1.18
Inhibition of macrophages with gadolinium chloride abrogates ozone-induced pulmonary injury and inflammatory mediator production. Am J Respir Cell Mol Biol (1995) 1.18
Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes. Mol Pharmacol (1981) 1.17
Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene. J Biol Chem (1979) 1.17
Refined localization of a punctate palmoplantar keratoderma gene to a 5.06-cM region at 15q22.2-15q22.31. Br J Dermatol (2005) 1.17