Published in Gene on January 19, 1998
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J (2000) 3.26
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A (2001) 1.24
FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes. Sci Rep (2015) 0.81
The effect of amino-acid infusion during off-pump coronary arterial bypass surgery on thermogenic and hormonal regulation. J Anesth (2008) 0.80
Counterregulation of insulin by leptin as key component of autonomic regulation of body weight. World J Diabetes (2014) 0.79
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A (1998) 39.20
A whole-genome assembly of Drosophila. Science (2000) 38.48
Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet (1994) 10.14
Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification. Nucleic Acids Res (1988) 9.94
DNA diagnostics--molecular techniques and automation. Science (1988) 8.85
Alu polymerase chain reaction: a method for rapid isolation of human-specific sequences from complex DNA sources. Proc Natl Acad Sci U S A (1989) 8.68
The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J (2001) 7.97
Gene therapy restores vision in a canine model of childhood blindness. Nat Genet (2001) 7.88
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature (2001) 7.35
PSORTb v.2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis. Bioinformatics (2004) 7.15
Absence of expression of the FMR-1 gene in fragile X syndrome. Cell (1991) 7.04
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet (1997) 6.83
Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene. Proc Natl Acad Sci U S A (1984) 6.48
Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics (1992) 6.40
DNA typing and genetic mapping with trimeric and tetrameric tandem repeats. Am J Hum Genet (1991) 6.20
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science (2001) 6.17
Automated DNA sequencing of the human HPRT locus. Genomics (1990) 5.92
Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase. Science (1988) 5.72
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science (1995) 5.65
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30
Construction of plasmids that express E. coli beta-galactosidase in mammalian cells. Nucleic Acids Res (1989) 5.02
Identification of the gene responsible for Best macular dystrophy. Nat Genet (1998) 4.89
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev (1995) 4.87
Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. Nature (1993) 4.87
Evolution of organic aerosols in the atmosphere. Science (2009) 4.82
Direct fluorescence analysis of genetic polymorphisms by hybridization with oligonucleotide arrays on glass supports. Nucleic Acids Res (1994) 4.77
Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. Nucleic Acids Res (1996) 4.75
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature (2010) 4.52
Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell (1995) 4.48
The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. Proc Natl Acad Sci U S A (2008) 4.45
Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid. Proc Natl Acad Sci U S A (1997) 4.38
DNA methylation represses FMR-1 transcription in fragile X syndrome. Hum Mol Genet (1992) 4.22
Mechanisms and rates of decay of marine viruses in seawater. Appl Environ Microbiol (1992) 4.22
Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. Nature (1986) 4.13
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nat Cell Biol (2001) 4.08
Bacterial peptide chain release factors: conserved primary structure and possible frameshift regulation of release factor 2. Proc Natl Acad Sci U S A (1985) 3.94
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development (2000) 3.91
Expression of peptide chain release factor 2 requires high-efficiency frameshift. Nature (1986) 3.60
Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature (1999) 3.57
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J Biol Chem (1993) 3.52
Complete genomic sequence of Pasteurella multocida, Pm70. Proc Natl Acad Sci U S A (2001) 3.51
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis (2000) 3.46
Good clinical outcomes following transjugular intrahepatic portosystemic stent-shunts in Budd-Chiari syndrome. Aliment Pharmacol Ther (2014) 3.39
Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. Science (2001) 3.39
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med (1997) 3.32
Detection of preinvasive cancer cells. Nature (2000) 3.20
Giant electrocaloric effect in thin-film PbZr(0.95)Ti(0.05)O3. Science (2006) 3.17
The American Society of Human Genetics statement on cystic fibrosis screening. Am J Hum Genet (1990) 3.07
Disease diagnosis by recombinant DNA methods. Science (1987) 3.06
A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet (2004) 3.05
HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat Med (1999) 3.01
Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants. Nucleic Acids Res (1982) 3.00
Identification of mutations leading to the Lesch-Nyhan syndrome by automated direct DNA sequencing of in vitro amplified cDNA. Proc Natl Acad Sci U S A (1989) 2.97
Advances in statistical methods to map quantitative trait loci in outbred populations. Genetics (1997) 2.90
Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature (1995) 2.88
Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families. Genomics (1990) 2.84
Organization of the HPRT gene and related sequences in the human genome. Somat Cell Mol Genet (1984) 2.84
Comparison of Western immunoblots and gene detection assays for identification of potentially enterotoxigenic isolates of Clostridium perfringens. J Clin Microbiol (1994) 2.81
Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan. Hum Mutat (1996) 2.80
The MYCN oncogene is a direct target of miR-34a. Oncogene (2008) 2.80
Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature (1999) 2.80
Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci U S A (1993) 2.79
Histochemical staining of clonal mammalian cell lines expressing E. coli beta galactosidase indicates heterogeneous expression of the bacterial gene. Somat Cell Mol Genet (1987) 2.77
A three-allele restriction-fragment-length polymorphism at the hypoxanthine phosphoribosyltransferase locus in man. Proc Natl Acad Sci U S A (1983) 2.73
8-Azaguanine resistance in mammalian cells. I. Hypoxanthine-guanine phosphoribosyltransferase. Genetics (1972) 2.71
Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A (2000) 2.70
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochim Biophys Acta (1996) 2.64
Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences. Proc Natl Acad Sci U S A (1982) 2.62
Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. J Neurol Neurosurg Psychiatry (2000) 2.55
A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Natl Acad Sci U S A (1996) 2.52
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52
The HPRT locus. Cell (1979) 2.49
Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus. Gastroenterology (2001) 2.46
Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem (2001) 2.40
Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer (2009) 2.39
Retrovirus packaging cells based on 10A1 murine leukemia virus for production of vectors that use multiple receptors for cell entry. J Virol (1996) 2.36
Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol (1992) 2.35
The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet (1999) 2.32
Fluorous mixture synthesis: a fluorous-tagging strategy for the synthesis and separation of mixtures of organic compounds. Science (2001) 2.31
PCR test for cystic fibrosis deletion. Nature (1990) 2.26
The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation. J Biol Chem (2001) 2.25
High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart (2003) 2.25
Stoichiometry of a recombinant GABAA receptor. J Neurosci (1996) 2.23
Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy. Hum Mol Genet (1996) 2.23
Patterns of cytosine methylation in an elite rice hybrid and its parental lines, detected by a methylation-sensitive amplification polymorphism technique. Mol Gen Genet (1999) 2.23
Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa. impacts on lignin structure and implications for the biosynthesis of G and S lignin. Plant Cell (2001) 2.23
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med (1998) 2.20
Sequential translation of trinucleotide codons for the initiation and termination of protein synthesis. Science (1968) 2.20
An economic evaluation of a genetic screening program for Tay-Sachs disease. Am J Hum Genet (1978) 2.17
Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology (1999) 2.16
Nodeless superconducting gap in A(x)Fe2Se2 (A=K,Cs) revealed by angle-resolved photoemission spectroscopy. Nat Mater (2011) 2.16
NFAT signaling in vertebrate development. Curr Opin Genet Dev (2001) 2.15
Evaluation of 13 short tandem repeat loci for use in personal identification applications. Am J Hum Genet (1994) 2.15