Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.

PubWeight™: 3.99‹?› | Rank: Top 1%

🔗 View Article (PMC 2132716)

Published in J Cell Biol on April 06, 1998

Authors

P Oh1, D P McIntosh, J E Schnitzer

Author Affiliations

1: Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachussetts 02215, USA.

Articles citing this

(truncated to the top 100)

Dynamin-mediated internalization of caveolae. J Cell Biol (1998) 5.26

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell (1999) 5.16

Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol (1999) 4.70

Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54

Differential distribution of dynamin isoforms in mammalian cells. Mol Biol Cell (1998) 3.42

Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae. J Cell Biol (2005) 3.26

Caveolae/raft-dependent endocytosis. J Cell Biol (2003) 3.25

A functional link between dynamin and the actin cytoskeleton at podosomes. J Cell Biol (2000) 3.12

Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements. Mol Biol Cell (2004) 2.99

Caveolae as plasma membrane sensors, protectors and organizers. Nat Rev Mol Cell Biol (2013) 2.98

Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking. Mol Biol Cell (2002) 2.84

Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles. J Cell Biol (2005) 2.74

Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms. J Cell Biol (1998) 2.67

Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis. J Cell Biol (2008) 2.66

The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Mol Biol Cell (1999) 2.64

Dynamin at actin tails. Proc Natl Acad Sci U S A (2002) 2.31

Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell (2005) 2.29

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proc Natl Acad Sci U S A (2000) 2.27

The caveolin proteins. Genome Biol (2004) 2.23

Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry. J Virol (2005) 2.12

Selective caveolin-1-dependent endocytosis of glycosphingolipids. Mol Biol Cell (2003) 2.05

Clathrin-dependent and -independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathways. J Cell Biol (2001) 2.04

Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells. Proc Natl Acad Sci U S A (2002) 2.03

Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default. Mol Biol Cell (2001) 2.02

Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway. J Cell Biol (2000) 2.02

Regulation of raft-dependent endocytosis. J Cell Mol Med (2007) 2.01

Internalization of echovirus 1 in caveolae. J Virol (2002) 1.87

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol (2007) 1.84

Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell (2008) 1.84

Modulation of Rac localization and function by dynamin. Mol Biol Cell (2003) 1.75

Molecular mechanisms of clathrin-independent endocytosis. J Cell Sci (2009) 1.72

Essential role of the dynamin pleckstrin homology domain in receptor-mediated endocytosis. Mol Cell Biol (1999) 1.67

The dynamic roles of intracellular lipid droplets: from archaea to mammals. Protoplasma (2011) 1.66

Early steps of polyomavirus entry into cells. J Virol (2000) 1.64

Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives. EMBO J (2000) 1.60

Human papillomavirus type 31 uses a caveolin 1- and dynamin 2-mediated entry pathway for infection of human keratinocytes. J Virol (2007) 1.59

Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes. PLoS Pathog (2008) 1.59

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood (2012) 1.59

H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Mol Cell Biol (2002) 1.55

Molecular aspects of the endocytic pathway. Biochem J (1998) 1.55

Trafficking of prion proteins through a caveolae-mediated endosomal pathway. J Cell Biol (2003) 1.51

The arabidopsis cell plate-associated dynamin-like protein, ADL1Ap, is required for multiple stages of plant growth and development. Plant Physiol (2001) 1.50

Plasma membrane microdomains: organization, function and trafficking. Mol Membr Biol (2004) 1.48

Characterization of rotavirus cell entry. J Virol (2004) 1.46

Screening phage display libraries for organ-specific vascular immunotargeting in vivo. Proc Natl Acad Sci U S A (2005) 1.46

Echovirus 1 endocytosis into caveosomes requires lipid rafts, dynamin II, and signaling events. Mol Biol Cell (2004) 1.45

Ebola virus glycoprotein toxicity is mediated by a dynamin-dependent protein-trafficking pathway. J Virol (2005) 1.44

Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery. Proc Natl Acad Sci U S A (2002) 1.43

A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis. J Virol (2008) 1.41

Different mechanisms of cell entry by human-pathogenic Old World and New World arenaviruses. J Virol (2008) 1.39

Entry of human parechovirus 1. J Virol (2001) 1.39

G-protein coupled receptor kinases as modulators of G-protein signalling. J Physiol (1999) 1.37

Cell surface orifices of caveolae and localization of caveolin to the necks of caveolae in adipocytes. Mol Biol Cell (2003) 1.35

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin. J Cell Biol (2005) 1.35

Tyrosine phosphorylation-dependence of caveolae-mediated endocytosis. J Cell Mol Med (2008) 1.32

Caveolin-1: an ambiguous partner in cell signalling and cancer. J Cell Mol Med (2008) 1.31

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J Cell Biol (2009) 1.30

Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. Proc Natl Acad Sci U S A (2000) 1.30

Helicobacter pylori VacA cytotoxin: a probe for a clathrin-independent and Cdc42-dependent pinocytic pathway routed to late endosomes. Mol Biol Cell (2005) 1.30

Endocytosis of murine norovirus 1 into murine macrophages is dependent on dynamin II and cholesterol. J Virol (2010) 1.27

Caveolae structure and function. J Cell Mol Med (2008) 1.26

Human rhinovirus type 2 is internalized by clathrin-mediated endocytosis. J Virol (2003) 1.25

Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport. PLoS Pathog (2011) 1.25

Clathrin-independent pathways of endocytosis. Cold Spring Harb Perspect Biol (2014) 1.25

Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells. Mol Cell Biol (2002) 1.25

Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein. J Cell Biol (1999) 1.22

Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence. J Neurosci (1999) 1.22

Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery. Mol Biol Cell (2006) 1.21

Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Biochem J (2001) 1.21

EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. Mol Biol Cell (2012) 1.18

Cortactin and dynamin are required for the clathrin-independent endocytosis of gammac cytokine receptor. J Cell Biol (2004) 1.16

Lipid rafts are required for GLUT4 internalization in adipose cells. Proc Natl Acad Sci U S A (2001) 1.14

Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability. Proc Natl Acad Sci U S A (2009) 1.14

Requirements for cell rounding and surface protein down-regulation by Ebola virus glycoprotein. Virology (2008) 1.14

Caveolae internalization repairs wounded cells and muscle fibers. Elife (2013) 1.13

Theoretical model for the formation of caveolae and similar membrane invaginations. Biophys J (2004) 1.12

Cellular entry of lymphocytic choriomeningitis virus. J Virol (2007) 1.12

Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin. EMBO J (2012) 1.12

Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling. EMBO J (2000) 1.10

Intersectin regulates fission and internalization of caveolae in endothelial cells. Mol Biol Cell (2003) 1.10

Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling. J Cell Biol (2010) 1.09

Cellular endocytosis and gene delivery. Mol Med (2010) 1.08

The coxsackie B virus and adenovirus receptor resides in a distinct membrane microdomain. J Virol (2003) 1.06

Clathrin-independent internalization and recycling. J Cell Mol Med (2007) 1.06

Redistribution of caveolae during mitosis. J Cell Sci (2011) 1.05

Constitutive endocytosis and degradation of the pre-T cell receptor. J Exp Med (2002) 1.05

Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells. J Virol (2009) 1.05

The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Proc Natl Acad Sci U S A (2003) 1.04

Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol Biol Cell (2006) 1.03

Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis. Mol Ther (2013) 1.03

Common membrane trafficking defects of disease-associated dynamin 2 mutations. Traffic (2011) 1.02

Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae. J Cell Mol Med (2009) 0.99

Endosome to Golgi transport of ricin is independent of clathrin and of the Rab9- and Rab11-GTPases. Mol Biol Cell (2001) 0.99

Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules. Am J Physiol Heart Circ Physiol (2008) 0.97

Dynamin: possible mechanism of "Pinchase" action. Biophys J (1999) 0.95

Endothelial transcytotic machinery involves supramolecular protein-lipid complexes. Mol Biol Cell (2001) 0.95

Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences. Glycoconj J (2001) 0.95

Japanese encephalitis virus enters rat neuroblastoma cells via a pH-dependent, dynamin and caveola-mediated endocytosis pathway. J Virol (2012) 0.95

CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts. FASEB J (2009) 0.95

Functional roles of short sequence motifs in the endocytosis of membrane receptors. Front Biosci (Landmark Ed) (2009) 0.94

Articles cited by this

Caveolin, a protein component of caveolae membrane coats. Cell (1992) 12.50

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J Cell Biol (1994) 11.55

Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma S in nerve terminals. Nature (1995) 7.81

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding. Nature (1995) 7.55

Mutations in human dynamin block an intermediate stage in coated vesicle formation. J Cell Biol (1993) 7.37

Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic. Nature (1991) 6.29

Separation of caveolae from associated microdomains of GPI-anchored proteins. Science (1995) 5.25

Effects of mutant rat dynamin on endocytosis. J Cell Biol (1993) 5.05

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol (1994) 4.87

Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis. Nature (1991) 4.69

Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae. J Histochem Cytochem (1994) 4.61

Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. Nature (1990) 4.30

Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J Cell Biol (1994) 4.30

Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature (1982) 4.22

Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J Cell Biol (1995) 3.92

Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval. J Neurosci (1989) 3.78

De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin. Proc Natl Acad Sci U S A (1995) 3.73

Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem (1996) 3.62

Caveolae: where incoming and outgoing messengers meet. Proc Natl Acad Sci U S A (1993) 3.53

Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1. J Cell Biol (1983) 3.44

Possible temperature-dependent blockage of synaptic vesicle recycling induced by a single gene mutation in Drosophila. J Neurobiol (1983) 3.36

Oligomeric structure of caveolin: implications for caveolae membrane organization. Proc Natl Acad Sci U S A (1995) 3.13

Endocytosis of simian virus 40 into the endoplasmic reticulum. J Cell Biol (1989) 3.06

VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro. Mol Biol Cell (1995) 3.05

Reversible alteration in the neuromuscular junctions of Drosophila melanogaster bearing a temperature-sensitive mutation, shibire. J Cell Biol (1979) 2.76

Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis. J Cell Biol (1986) 2.73

Rapid endocytosis coupled to exocytosis in adrenal chromaffin cells involves Ca2+, GTP, and dynamin but not clathrin. Proc Natl Acad Sci U S A (1995) 2.51

Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J Biol Chem (1995) 2.41

Transcytosis of albumin in capillary endothelium. J Cell Biol (1987) 2.33

Tightly regulated and inducible expression of dominant interfering dynamin mutant in stably transformed HeLa cells. Methods Enzymol (1995) 2.19

Albondin-mediated capillary permeability to albumin. Differential role of receptors in endothelial transcytosis and endocytosis of native and modified albumins. J Biol Chem (1994) 2.11

Activation of dynamin GTPase by acidic phospholipids and endogenous rat brain vesicles. J Biol Chem (1993) 2.04

Membranous intermediates in endocytosis are labile, as shown in a temperature-sensitive mutant. Proc Natl Acad Sci U S A (1989) 1.97

Role of GTP hydrolysis in fission of caveolae directly from plasma membranes. Science (1996) 1.95

Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains. J Biol Chem (1997) 1.79

Caveolae from luminal plasmalemma of rat lung endothelium: microdomains enriched in caveolin, Ca(2+)-ATPase, and inositol trisphosphate receptor. Proc Natl Acad Sci U S A (1995) 1.66

A binding site for SH3 domains targets dynamin to coated pits. J Biol Chem (1996) 1.42

Activation of dynamin GTPase is a result of positive cooperativity. J Biol Chem (1994) 1.29

Reversible inhibition of endocytosis in cultured neurons from the Drosophila temperature-sensitive mutant shibirets1. J Neurogenet (1990) 1.25

Dynamin forms polymeric complexes in the presence of lipid vesicles. Characterization of chemically cross-linked dynamin molecules. J Biol Chem (1995) 1.22

Regulation of dynamin I GTPase activity by G protein betagamma subunits and phosphatidylinositol 4,5-bisphosphate. J Biol Chem (1996) 1.18

High affinity binding, endocytosis, and degradation of conformationally modified albumins. Potential role of gp30 and gp18 as novel scavenger receptors. J Biol Chem (1993) 1.15

NEM inhibits transcytosis, endocytosis, and capillary permeability: implication of caveolae fusion in endothelia. Am J Physiol (1995) 1.01

Update on the cellular and molecular basis of capillary permeability. Trends Cardiovasc Med (2011) 0.99

Articles by these authors

Separation of caveolae from associated microdomains of GPI-anchored proteins. Science (1995) 5.25

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A (1996) 3.83

Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem (1997) 3.14

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene (1998) 2.59

Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default. Mol Biol Cell (2001) 2.02

Role of GTP hydrolysis in fission of caveolae directly from plasma membranes. Science (1996) 1.95

Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains. J Biol Chem (1997) 1.79

In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association. J Biol Chem (1998) 1.48

Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae. J Biol Chem (1998) 1.29

Immunoisolation of caveolae with high affinity antibody binding to the oligomeric caveolin cage. Toward understanding the basis of purification. J Biol Chem (1999) 1.26

Isolation and partial characterization of the luminal plasmalemma of microvascular endothelium from rat lungs. Eur J Cell Biol (1992) 1.12

Delivery of ricin and abrin A-chains to human carcinoma cells in culture following covalent linkage to monoclonal antibody LICR-LOND-Fib 75. Cancer Drug Deliv (1984) 1.10

The effect of ricin B chain on the intracellular trafficking of an A chain immunotoxin. Br J Cancer (1991) 1.08

Caveolae require intact VAMP for targeted transport in vascular endothelium. Am J Physiol (1999) 0.98

Transfer of ricin toxicity by spleen cells. Toxicon (1984) 0.95

Antibody to a 63 kilodalton insect protein in ankylosing spondylitis. Ann Rheum Dis (1992) 0.92

Identification of endothelial cell-surface proteins as targets for diagnosis and treatment of disease. Nat Med (1996) 0.91

The carriage and delivery of substances to lymphatic tissues by recirculating lymphocytes. I. The concentration of ricin in lymphocyte traffic areas. Immunology (1985) 0.88

Lung vascular targeting using antibody to aminopeptidase P: CT-SPECT imaging, biodistribution and pharmacokinetic analysis. J Vasc Res (2010) 0.87

Ricin B chain converts a non-cytotoxic antibody-ricin A chain conjugate into a potent and specific cytotoxic agent. FEBS Lett (1983) 0.82

Vascular proteomic mapping in vivo. J Thromb Haemost (2007) 0.81

Liposome-mediated delivery of ribosome inactivating proteins to cells in vitro. Biochim Biophys Acta (1982) 0.79

An ineffective monoclonal antibody-ricin A chain conjugate is converted to a tumouricidal agent in vivo by subsequent systemic administration of ricin B chain. Cancer Immunol Immunother (1987) 0.77

Clobazam and norclobazam quantitation in serum by capillary gas chromatography with electron-capture detection. Clin Biochem (1993) 0.75

Analysis of lipids in caveolae. Methods Mol Biol (1999) 0.75

Relationship of 99mTc-MDP uptake to regional osseous circulation in skeletally immature and mature dogs. Skeletal Radiol (1982) 0.75

Antibody-toxin conjugates: a new approach to cancer therapy. Adv Biotechnol Processes (1984) 0.75

Quantitation of regional chondro-osseous circulation in canine tibia and femur. Am J Physiol (1982) 0.75