Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid.

The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest (2005) 1.56

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res (2010) 1.39

Metabolites of cerebellar neurons and hippocampal neurons play opposite roles in pathogenesis of Alzheimer's disease. PLoS One (2009) 1.07

17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiol Aging (2010) 1.04

Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease. Biol Chem (2008) 0.96

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol (2011) 0.95

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline. J Clin Invest (2014) 0.89

Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. J Biol Chem (2012) 0.88

Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from Aβ42 induced cytotoxicity. Sci Rep (2013) 0.87

Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro. Biochemistry (2010) 0.87

Therapeutic effects of glatiramer acetate and grafted CD115⁺ monocytes in a mouse model of Alzheimer's disease. Brain (2015) 0.87

Role of water-soluble amyloid-beta in the pathogenesis of Alzheimer's disease. Int J Exp Pathol (2005) 0.86

Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta Neuropathol (2010) 0.83

Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease. J Alzheimers Dis (2013) 0.83

Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model. Brain (2014) 0.81

Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease. Proc Jpn Acad Ser B Phys Biol Sci (2013) 0.80

Young microglia restore amyloid plaque clearance of aged microglia. EMBO J (2016) 0.80

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration. BMC Neurosci (2013) 0.79

Natural Products from Microalgae with Potential against Alzheimer's Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors. Mar Drugs (2016) 0.77

Beta-amyloidolysis and glutathione in Alzheimer's disease. J Blood Med (2013) 0.77

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease. Acta Neuropathol (2015) 0.76

Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population. Neural Regen Res (2012) 0.75

ACE overexpression in myelomonocytic cells: effect on a mouse model of Alzheimer's disease. Curr Hypertens Rep (2014) 0.75

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron (1995) 2.90

Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J (1994) 2.33

Spatial resolution of fodrin proteolysis in postischemic brain. J Biol Chem (1993) 1.35

Positive regulation of mu-calpain action by polyphosphoinositides. J Biol Chem (1992) 1.28

Distinct kinetics of subunit autolysis in mammalian m-calpain activation. FEBS Lett (1994) 0.96

In situ capture of mu-calpain activation in platelets. J Biol Chem (1993) 0.96

Purification and characterization of protein kinase C epsilon from rabbit brain. Biochemistry (1992) 0.96

Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus. J Biol Chem (1994) 0.88

Proteolysis of protein kinase C by calpain: effect of acidic phospholipids. Biomed Biochim Acta (1991) 0.86

[Calcium-activated neutral proteases in cell injury]. Tanpakushitsu Kakusan Koso (1990) 0.75

[Neurodegenerative diseases as proteolytic disorders: brain ischemia and Alzheimer's disease]. Tanpakushitsu Kakusan Koso (1997) 0.75