Published in Neurology on April 01, 1998
Alzheimer's disease: the challenge of the second century. Sci Transl Med (2011) 4.88
Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol (2011) 3.56
Cerebral amyloid angiopathy in the elderly. Ann Neurol (2011) 2.84
Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy. Neurology (2010) 2.02
Apolipoprotein E genotype predicts hematoma expansion in lobar intracerebral hemorrhage. Stroke (2012) 1.89
Cerebral amyloid angiopathy with and without hemorrhage: evidence for different disease phenotypes. Neurology (2015) 1.61
Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathol (2009) 1.57
APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurol (2011) 1.47
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. Mol Neurodegener (2016) 1.38
Hematoma expansion following acute intracerebral hemorrhage. Cerebrovasc Dis (2013) 1.30
Apolipoprotein E genotype is associated with CT angiography spot sign in lobar intracerebral hemorrhage. Stroke (2012) 1.19
Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms. Mol Neurodegener (2007) 1.04
Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2010) 0.98
APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature. J Neuropathol Exp Neurol (2013) 0.96
Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. Am J Neurodegener Dis (2014) 0.95
Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice. Am J Pathol (2006) 0.94
APOEε2 is associated with milder clinical and pathological Alzheimer disease. Ann Neurol (2015) 0.94
Racial differences in microbleed prevalence in primary intracerebral hemorrhage. Neurology (2008) 0.93
APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis. J Neurol Neurosurg Psychiatry (2013) 0.93
The pattern and pace of hyperacute hemorrhage expansion. Neurocrit Care (2012) 0.92
Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy. Neurology (2014) 0.92
Focal hemosiderin deposits and β-amyloid load in the ADNI cohort. Alzheimers Dement (2013) 0.91
APOE polymorphisms influence longitudinal lipid trends preceding intracerebral hemorrhage. Neurol Genet (2016) 0.91
Treatment targets in intracerebral hemorrhage. Neurotherapeutics (2011) 0.89
Cerebrovascular disease in ageing and Alzheimer's disease. Acta Neuropathol (2015) 0.87
Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype. J Neurol Neurosurg Psychiatry (2005) 0.85
The role of APOE in cerebrovascular dysfunction. Acta Neuropathol (2016) 0.84
APOE and cerebral amyloid angiopathy in community-dwelling older persons. Neurobiol Aging (2015) 0.84
TOMM40 in Cerebral Amyloid Angiopathy Related Intracerebral Hemorrhage: Comparative Genetic Analysis with Alzheimer's Disease. Transl Stroke Res (2012) 0.83
Cerebral amyloid angiopathy-related atraumatic convexal subarachnoid hemorrhage: an ARIA before the tsunami. J Cereb Blood Flow Metab (2015) 0.82
Advances in our Understanding of the Pathophysiology, Detection and Management of Cerebral Amyloid Angiopathy. Eur Neurol Rev (2012) 0.81
Genetic factors in cerebral small vessel disease and their impact on stroke and dementia. J Cereb Blood Flow Metab (2016) 0.81
Intracerebral hemorrhage: toward physiological imaging of hemorrhage risk in acute and chronic bleeding. Front Neurol (2012) 0.80
Genetic animal models of cerebral vasculopathies. Prog Mol Biol Transl Sci (2012) 0.79
Genetic risk factors for spontaneous intracerebral haemorrhage. Nat Rev Neurol (2015) 0.77
Cerebral microbleeds and macrobleeds: should they influence our recommendations for antithrombotic therapies? Curr Cardiol Rep (2013) 0.77
APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL. J Cereb Blood Flow Metab (2016) 0.76
Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. Neurology (2017) 0.75
Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies. Int J Mol Med (2017) 0.75
Clinical neurogenetics: stroke. Neurol Clin (2013) 0.75
Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins. J Lipid Res (2017) 0.75
Prevalence and Natural History of Superficial Siderosis: A Population-Based Study. Stroke (2017) 0.75
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science (1997) 11.53
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology (1992) 9.30
Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol (1985) 7.93
Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet (1998) 7.26
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci (1996) 7.19
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science (1984) 6.86
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol (2000) 6.40
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol (1997) 6.12
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol (1997) 6.02
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex (1992) 5.57
Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34
MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology (2002) 4.67
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology (1992) 4.52
APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol (1997) 4.29
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med (2000) 4.18
CAG repeat number governs the development rate of pathology in Huntington's disease. Ann Neurol (1997) 4.01
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology (2004) 4.00
Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron (1993) 3.92
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci (1999) 3.85
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nat Genet (1997) 3.64
Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol (1995) 3.60
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol (2001) 3.46
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. N Engl J Med (1998) 3.23
Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N Engl J Med (2000) 3.23
Imaging amyloid deposition in Lewy body diseases. Neurology (2008) 3.09
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron (1995) 3.08
Office of Rare Diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol (2002) 3.02
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature (1999) 2.97
Inactivation of the mouse Huntington's disease gene homolog Hdh. Science (1995) 2.96
Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci (1997) 2.91
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol (2000) 2.78
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med (2001) 2.75
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice. Hum Mol Genet (2000) 2.67
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A (1997) 2.53
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med (1996) 2.43
Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy. Stroke (1997) 2.38
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell (1995) 2.37
Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease. Proc Natl Acad Sci U S A (1999) 2.36
Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol (1986) 2.33
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci (1993) 2.27
Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease. Prog Brain Res (1990) 2.26
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol (2000) 2.21
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain. Neuroscience (2006) 2.19
Early and progressive accumulation of reactive microglia in the Huntington disease brain. J Neuropathol Exp Neurol (2001) 2.17
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J Neurosci (2001) 2.12
The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage. Neurology (1993) 2.12
Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci (1993) 2.09
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem (2007) 2.09
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem (2000) 2.00
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol (2001) 1.96
Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology (1996) 1.89
Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice. Stroke (1997) 1.89
Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proc Natl Acad Sci U S A (1995) 1.87
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 1.87
Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology (2011) 1.83
Huntingtin localization in brains of normal and Huntington's disease patients. Ann Neurol (1997) 1.82
Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease. J Neuropathol Exp Neurol (1999) 1.81
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience (2001) 1.80
Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease. J Neuropathol Exp Neurol (1988) 1.79
Pathogenic effects of D23N Iowa mutant amyloid beta -protein. J Biol Chem (2001) 1.74
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet (1993) 1.72
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations. J Biol Chem (2000) 1.72
Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins. Somat Cell Mol Genet (1998) 1.72
H. M.'s medial temporal lobe lesion: findings from magnetic resonance imaging. J Neurosci (1997) 1.71
MRI detection of new hemorrhages: potential marker of progression in cerebral amyloid angiopathy. Neurology (1999) 1.71
Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab (1998) 1.71
Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J Neuropathol Exp Neurol (1998) 1.67
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol (2000) 1.66
Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease. Ann Neurol (1996) 1.66
The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A (2000) 1.65
Stroke in patients with cancer: incidence and etiology. Neurology (2004) 1.65
Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry (1991) 1.64
Clinical and neuropathologic assessment of severity in Huntington's disease. Neurology (1988) 1.62
Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. J Biol Chem (1996) 1.61
Evidence for the GluR6 gene associated with younger onset age of Huntington's disease. Neurology (1999) 1.60
Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke (1996) 1.60
Apolipoprotein E epsilon4 does not modulate amyloid-β-associated neurodegeneration in preclinical Alzheimer disease. AJNR Am J Neuroradiol (2012) 1.57
Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience (1999) 1.54
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption. J Neuropathol Exp Neurol (2001) 1.53
Memory performance is related to amyloid and tau pathology in the hippocampus. J Neurol Neurosurg Psychiatry (2009) 1.52
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories. J Neuropathol Exp Neurol (2003) 1.50
Progression of cerebral amyloid angiopathy: accumulation of amyloid-beta40 in affected vessels. J Neuropathol Exp Neurol (1998) 1.47
Quantitative neuropathological changes in presymptomatic Huntington's disease. Ann Neurol (2001) 1.44
A pilot study of drug-induced hypertension for treatment of acute stroke. Neurology (2001) 1.43
Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. J Neurovirol (1999) 1.43
Petechial hemorrhages accompanying lobar hemorrhage: detection by gradient-echo MRI. Neurology (1996) 1.39