Published in Lancet on September 10, 1977
Familial canine dermatomyositis. Initial characterization of the cutaneous and muscular lesions. Am J Pathol (1984) 0.96
Does Toxoplasma cause polymyositis? Report of a case of polymyositis associated with toxoplasmosis and a critical review of the literature. Acta Neuropathol (1983) 0.83
Association of myasthenia gravis and polymyositis with neoplasia, infection and autoimmune disorders. Acta Neuropathol (1982) 0.80
Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science (1992) 14.70
Weight-reducing effects of the plasma protein encoded by the obese gene. Science (1995) 13.05
Abnormal splicing of the leptin receptor in diabetic mice. Nature (1996) 7.71
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell (2000) 5.73
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet (1996) 4.84
Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev (2000) 4.57
Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. Science (1988) 4.50
Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest (2001) 3.82
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A (1997) 3.81
Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol (2000) 3.60
Glycogen storage disease in adults. Ann Intern Med (1994) 3.58
Diagnostic criteria for schwannomatosis. Neurology (2005) 3.41
Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet (2002) 3.35
Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci U S A (1995) 3.33
Acute stimulation of glucose metabolism in mice by leptin treatment. Nature (1997) 3.12
Cocrystal structure of an editing complex of Klenow fragment with DNA. Proc Natl Acad Sci U S A (1988) 3.02
Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science (2001) 2.98
Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem (2001) 2.91
Mortality in neurofibromatosis 1: an analysis using U.S. death certificates. Am J Hum Genet (2001) 2.78
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1994) 2.71
NF1 gene and neurofibromatosis 1. Am J Epidemiol (2000) 2.58
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A (1997) 2.57
Insights into the pathogenesis of neurofibromatosis 1 vasculopathy. Clin Genet (2000) 2.49
Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc Natl Acad Sci U S A (1994) 2.47
Procurement of cadaver donor organs: evisceration technique. Transplant Proc (1972) 2.40
Prevention of acute graft rejection by the prostaglandin E1 analogue misoprostol in renal-transplant recipients treated with cyclosporine and prednisone. N Engl J Med (1990) 2.23
Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate. Biochemistry (1993) 2.19
Population-based analyses of mortality in trisomy 13 and trisomy 18. Pediatrics (2003) 2.11
Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. N Engl J Med (1996) 2.10
The longitudinal study of surgical residents, 1994 to 1996. J Am Coll Surg (1999) 2.06
A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha. J Med Genet (2007) 1.94
Partial splenic embolization in the treatment of hypersplenism. AJR Am J Roentgenol (1979) 1.88
Drug safety in pregnant women and their babies: ignorance not bliss. Clin Pharmacol Ther (2007) 1.87
Linkage of functional and structural heterogeneity in proteins: dynamic hole burning in carboxymyoglobin. Science (1987) 1.87
Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci U S A (1997) 1.85
Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet (2003) 1.85
Increasing the specificity of diagnostic criteria for schwannomatosis. Neurology (2006) 1.85
Use of "unidentified bright objects" on MRI for diagnosis of neurofibromatosis 1 in children. Neurology (2000) 1.83
Quantification of keratan sulfate in blood as a marker of cartilage catabolism. Arthritis Rheum (1985) 1.82
On the use of population attributable fraction to determine sample size for case-control studies of gene-environment interaction. Epidemiology (2003) 1.82
Use of the national institutes of health criteria for diagnosis of neurofibromatosis 1 in children. Pediatrics (2000) 1.79
Teratogenicity of recently introduced medications in human pregnancy. Obstet Gynecol (2002) 1.76
Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data. BMC Bioinformatics (2007) 1.75
Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression. Mol Cell Biol (1986) 1.73
Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1. Am J Med Genet (2000) 1.70
Submicroscopic deletions and duplications in individuals with intellectual disability detected by array-CGH. Am J Med Genet A (2005) 1.68
A reevaluation of risk of in utero exposure to lithium. JAMA (1994) 1.68
Evolving knowledge of the teratogenicity of medications in human pregnancy. Am J Med Genet C Semin Med Genet (2011) 1.68
Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Hum Hered (2001) 1.67
Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology (2005) 1.65
Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. J Mol Biol (1984) 1.63
Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation (2006) 1.58
Evaluation of clinical diagnostic criteria for neurofibromatosis 2. Neurology (2002) 1.53
Comparison of the 15q deletions in Prader-Willi and Angelman syndromes: specific regions, extent of deletions, parental origin, and clinical consequences. Am J Med Genet (1990) 1.53
The nodular form of local hepatic tuberculosis. A review. J Clin Gastroenterol (1990) 1.51
Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin. Proc Natl Acad Sci U S A (1996) 1.51
The effect of salicylate on the metabolism of normal and stimulated human lymphocytes in vitro. J Clin Invest (1971) 1.50
Update on new developments in the study of human teratogens. Teratology (2002) 1.49
Excited state lifetimes in cytochromes measured from Raman scattering data: evidence for iron-porphyrin interactions. Proc Natl Acad Sci U S A (1977) 1.48
Release of kallikrein from guinea pig lung during anaphylaxis. J Exp Med (1966) 1.47
Race-ethnicity differences in folic acid intake in women of childbearing age in the United States after folic acid fortification: findings from the National Health and Nutrition Examination Survey, 2001-2002. Am J Clin Nutr (2007) 1.46
Transient Raman study of CO-haemoprotein photolysis: origin of the quantum yield. Nature (1980) 1.43
The longitudinal study of surgical residents, 1993 to 1994. J Am Coll Surg (1996) 1.43
Workshop report: evaluation of genetic and epigenetic risks associated with assisted reproductive technologies and infertility. Fertil Steril (2007) 1.42
Juvenile dermatomyositis presenting with rash alone. Pediatrics (1997) 1.42
A pregnant surgical resident? Oh my! JAMA (1991) 1.41
Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1. Am J Med Genet (1999) 1.40
Primary immunization of infants and children with group A streptococcal M protein. J Infect Dis (1969) 1.38
Predictors of the risk of mortality in neurofibromatosis 2. Am J Hum Genet (2002) 1.37
The iron-proximal histidine linkage and protein control of oxygen binding in hemoglobin. A transient Raman study. J Biol Chem (1983) 1.35
del(20p) with manifestations of arteriohepatic dysplasia. Am J Med Genet (1986) 1.35
Saethre-Chotzen syndrome: a broad and variable pattern of skeletal malformations. J Pediatr (1977) 1.35
Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain. Bioconjug Chem (2003) 1.34
Cellular and antibody reactions to streptococcal M protein types 1, 3, 6 and 12. J Immunol (1970) 1.32
Expression of ob gene in adipose cells. Regulation by insulin. J Biol Chem (1996) 1.31
Clinical, genetic, and epidemiological factors in neural tube defects. Am J Hum Genet (1988) 1.31
Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db). Proc Natl Acad Sci U S A (1991) 1.30
Structure, dynamics, and reactivity in hemoglobin. Science (1985) 1.29
Incidence and timing of hypothermia in trauma patients undergoing operations. J Trauma (1991) 1.28
Gene expression during liver regeneration. J Mol Biol (1984) 1.27
Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1). Neurology (2002) 1.25
Protein-heme interaction in hemoglobin: evidence from Raman difference spectroscopy. Proc Natl Acad Sci U S A (1979) 1.24
Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am J Clin Nutr (2008) 1.23
Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci U S A (1999) 1.23
Plasma levels, half-life values, and correlation with physiologic assays for growth and immunity. J Pediatr (1978) 1.21
Teratology Society Consensus Statement on use of folic acid to reduce the risk of birth defects. Teratology (1997) 1.19
Prevalence of Coxsackie B virus antibodies in patients with juvenile dermatomyositis. Arthritis Rheum (1986) 1.18
Genetic disease in the offspring of older fathers. Obstet Gynecol (1981) 1.17
Angiotensin II receptor antagonist treatment during pregnancy. Birth Defects Res A Clin Mol Teratol (2005) 1.17
Heme-heme interactions in a homodimeric cooperative hemoglobin. Evidence from transient Raman scattering. J Biol Chem (1993) 1.17
Structural studies of Klenow fragment: an enzyme with two active sites. Cold Spring Harb Symp Quant Biol (1987) 1.16
Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med (1997) 1.16
Molecular mapping of the mouse db mutation. Proc Natl Acad Sci U S A (1990) 1.14
Survival in infants with Down syndrome, Metropolitan Atlanta, 1979-1998. J Pediatr (2006) 1.14
Prospective study of prevalence, incidence, and source of herpesvirus infections in patients with renal allografts. J Infect Dis (1977) 1.14
Capillary hemangioma of the maxilla. A report of two cases in which angiography and embolization were used. Oral Surg Oral Med Oral Pathol (1990) 1.13
The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res (1995) 1.13