Published in Cell on October 27, 2000
Cellular and molecular mechanisms of pain. Cell (2009) 9.36
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Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A (2003) 3.87
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A (2003) 2.95
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Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2003) 2.50
Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circ Res (2006) 2.49
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Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet (2009) 2.32
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Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet (2009) 2.21
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest (2008) 2.20
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
The micromachinery of mechanotransduction in hair cells. Annu Rev Neurosci (2007) 2.17
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TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc Natl Acad Sci U S A (2002) 2.03
Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum (2009) 2.02
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J (2003) 1.97
The WNKs: atypical protein kinases with pleiotropic actions. Physiol Rev (2011) 1.88
The mechanosensitive nature of TRPV channels. Pflugers Arch (2005) 1.84
The molecular basis for water taste in Drosophila. Nature (2010) 1.81
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Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS One (2007) 1.79
TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol (2009) 1.76
Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis Rheum (2010) 1.75
Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci U S A (2001) 1.74
Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A (2007) 1.72
Probing the pore of the auditory hair cell mechanotransducer channel in turtle. J Physiol (2004) 1.71
TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol (2005) 1.68
A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells. J Biol Chem (2010) 1.67
Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc Natl Acad Sci U S A (2011) 1.65
Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology (2008) 1.63
The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures. J Biol Chem (2009) 1.61
TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease. J Am Soc Nephrol (2013) 1.60
Molecular mechanism of TRP channels. Compr Physiol (2013) 1.58
Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J Biol Chem (2009) 1.54
TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest Ophthalmol Vis Sci (2008) 1.54
Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain (2010) 1.51
How is the highly positive endocochlear potential formed? The specific architecture of the stria vascularis and the roles of the ion-transport apparatus. Pflugers Arch (2009) 1.51
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol (2007) 1.51
Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension (2009) 1.51
Mammalian somatosensory mechanotransduction. Curr Opin Neurobiol (2009) 1.51
An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Proc Natl Acad Sci U S A (2011) 1.49
Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments. Genetics (2004) 1.49
The cell biology of touch. J Cell Biol (2010) 1.45
Mechanosensitive channels: what can they do and how do they do it? Structure (2011) 1.45
TRPV channels as thermosensory receptors in epithelial cells. Pflugers Arch (2005) 1.44
Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo. Hear Res (2006) 1.39
Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channel. Biophys J (2001) 1.39
Function and expression of the epithelial Ca(2+) channel family: comparison of mammalian ECaC1 and 2. J Physiol (2001) 1.39
TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. Mol Pain (2011) 1.38
Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis. Hear Res (2005) 1.37
Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J Physiol (2011) 1.37
Polycystins: polymodal receptor/ion-channel cellular sensors. Pflugers Arch (2005) 1.37
OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis. Nature (2014) 1.34
The versatile nature of the calcium-permeable cation channel TRPP2. EMBO Rep (2006) 1.34
Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors. Toxicol Sci (2003) 1.34
Coiled coils direct assembly of a cold-activated TRP channel. Neuron (2006) 1.33
The puzzle of TRPV4 channelopathies. EMBO Rep (2013) 1.33
Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force. J Biol Chem (2010) 1.32
Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol (2006) 1.31
Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther (2007) 1.30
Activation of the TRPV4 ion channel is enhanced by phosphorylation. J Biol Chem (2009) 1.30
TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect (2011) 1.29
Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Ann N Y Acad Sci (2010) 1.26
The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. J Neurosci (2011) 1.26
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A (2013) 1.26
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A (2009) 1.25
TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch (2008) 1.24
Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons. Proc Natl Acad Sci U S A (2015) 1.24
The transient receptor potential channel on the yeast vacuole is mechanosensitive. Proc Natl Acad Sci U S A (2003) 1.24
Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone. Proc Natl Acad Sci U S A (2012) 1.24
High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. Am J Respir Cell Mol Biol (2007) 1.24
Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. Br J Pharmacol (2010) 1.23
Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb) (2010) 1.23
IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. J Cell Biol (2008) 1.22
A specific subset of transient receptor potential vanilloid-type channel subunits in Caenorhabditis elegans endocrine cells function as mixed heteromers to promote neurotransmitter release. Genetics (2006) 1.22
Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Am J Physiol Heart Circ Physiol (2011) 1.20
A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy. J Biol Chem (2009) 1.20
Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD. Gastroenterology (2010) 1.20
Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. Am J Physiol Renal Physiol (2009) 1.19
TRPV channels and vascular function. Acta Physiol (Oxf) (2010) 1.16
Temperature sensing across species. Pflugers Arch (2007) 1.16
TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. J Physiol (2005) 1.16
Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Proc Natl Acad Sci U S A (2006) 1.15
TRPV4 channels augment macrophage activation and ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2010) 1.15
TRPV1 activation is required for hypertonicity-stimulated inflammatory cytokine release in human corneal epithelial cells. Invest Ophthalmol Vis Sci (2011) 1.15
The role of the TRPV6 channel in cancer. J Physiol (2012) 1.14
Transient receptor potential channels in the vasculature. Physiol Rev (2015) 1.14
Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. J Neurosci (2011) 1.14
Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations. PLoS One (2011) 1.13
Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles. Nat Med (2014) 1.12
Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. Pain (2013) 1.12
TRPV4 enhances the cellular uptake of aminoglycoside antibiotics. J Cell Sci (2008) 1.11
Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol (2008) 1.10
Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol (2014) 1.10
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