Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMID 9581684)

Published in Hepatology on May 01, 1998

Authors

C Fang1, K O Lindros, T M Badger, M J Ronis, M Ingelman-Sundberg

Author Affiliations

1: Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Articles citing this

Immunohistochemical characterization of hepatic malondialdehyde and 4-hydroxynonenal modified proteins during early stages of ethanol-induced liver injury. Alcohol Clin Exp Res (2003) 1.18

Alcoholic liver disease. Postgrad Med J (2000) 1.13

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem J (2005) 1.11

Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radic Biol Med (2005) 1.08

Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease. World J Gastroenterol (2002) 1.06

Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Neurotox Res (2009) 1.04

The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat. Alcohol (2010) 0.98

Estrogen-related receptor γ controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. Gut (2012) 0.96

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Hepatobiliary Surg Nutr (2012) 0.91

Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells. World J Gastroenterol (2007) 0.90

miR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1-lipin-1 signaling. Am J Pathol (2015) 0.80

Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models. Arch Biochem Biophys (2015) 0.78

Increased transforming growth factor-beta1 in alcohol dependence. J Korean Med Sci (2009) 0.75

Protective effect of chlormethiazole, a sedative, against acetaminophen-induced liver injury in mice. Korean J Intern Med (1999) 0.75

Articles by these authors

Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev (2001) 3.43

Disassociation between debrisoquine hydroxylation phenotype and genotype among Chinese. Lancet (1989) 2.96

Cytochrome P450 pharmacogenetics and cancer. Oncogene (2006) 2.38

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology (1998) 2.19

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol (1994) 2.09

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci U S A (1993) 2.08

Nomenclature for human CYP2D6 alleles. Pharmacogenetics (1996) 1.91

Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease. Hepatology (2001) 1.90

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine. Lancet (1993) 1.87

Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines. Hepatology (1999) 1.81

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). Biochem Pharmacol (1989) 1.78

Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver. J Hepatol (2000) 1.69

Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population. Biochem Biophys Res Commun (1999) 1.66

Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. Gastroenterology (1997) 1.63

The antiestrogen toremifene protects against alcoholic liver injury in female rats. J Hepatol (2001) 1.57

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther (1996) 1.51

Effects of short-term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition in the rat. Alcohol Clin Exp Res (1991) 1.50

Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology (1996) 1.41

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population. Clin Pharmacol Ther (1992) 1.41

Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. Biochem Biophys Res Commun (1986) 1.37

In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility. Biochem Biophys Res Commun (1997) 1.34

Digitonin-collagenase perfusion for efficient separation of periportal or perivenous hepatocytes. Biochem J (1985) 1.26

Zonation of hepatic cytochrome P-450 expression and regulation. Biochem J (1998) 1.26

Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity. Mol Pharmacol (1997) 1.26

A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity. Br J Clin Pharmacol (1996) 1.26

Role of CYP2C9 polymorphism in losartan oxidation. Drug Metab Dispos (2001) 1.23

Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1. J Pharmacol Exp Ther (2000) 1.23

Models of alcoholic liver disease in rodents: a critical evaluation. Alcohol Clin Exp Res (2001) 1.23

Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population. FEBS Lett (1999) 1.23

Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450. J Biol Chem (1984) 1.21

Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proc Soc Exp Biol Med (2000) 1.21

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther (1995) 1.21

Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes. Biochem Pharmacol (1993) 1.17

PCR-based genotyping for duplicated and deleted CYP2D6 genes. Pharmacogenetics (1996) 1.17

Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population. Br J Clin Pharmacol (2001) 1.17

Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry (1988) 1.16

Sodium periodate, sodium chlorite, and organic hydroperoxides as hydroxylating agents in hepatic microsomal steroid hydroxylation reactions catalyzed by cytochrome P-450. FEBS Lett (1975) 1.16

Functional compartmentation of acetaldehyde oxidation in rat liver. J Biol Chem (1974) 1.15

Medical chemistry: evaluation of active and problem-oriented teaching methods. Med Educ (1985) 1.15

The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem Biophys Res Commun (2000) 1.13

Endocrine mechanisms underlying the growth effects of developmental lead exposure in the rat. J Toxicol Environ Health A (1998) 1.12

Zonation of cytochrome P450 isozyme expression and induction in rat liver. Eur J Biochem (1992) 1.12

Skeletal effects of developmental lead exposure in rats. Toxicol Sci (2001) 1.12

Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects. Pharmacogenomics J (2012) 1.11

Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes. Gene (1999) 1.11

Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J Pharmacol Exp Ther (1993) 1.10

Distribution of catalase in rat brain: aminergic neurons as possible targets for ethanol effects. Alcohol Alcohol (1996) 1.10

Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region. Biochem Biophys Res Commun (1999) 1.10

Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol (1994) 1.08

Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats. J Pharmacol Exp Ther (1993) 1.08

Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients. Int J Cancer (1999) 1.08

Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1. Proc Soc Exp Biol Med (1994) 1.08

A stress-inducible rat liver endoplasmic reticulum protein, ERp29. Eur J Biochem (1998) 1.08

Ethanol and oxidative stress. Alcohol Clin Exp Res (2001) 1.07

Epigenomics and interindividual differences in drug response. Clin Pharmacol Ther (2012) 1.07

Sex difference in alcohol-related organ injury. Alcohol Clin Exp Res (2001) 1.06

Pharmacoepigenetics: its role in interindividual differences in drug response. Clin Pharmacol Ther (2009) 1.06

Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1). J Biol Chem (2000) 1.05

Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis. Exp Mol Pathol (1993) 1.05

Sustained proliferation accompanies distraction osteogenesis in the rat. J Orthop Res (1997) 1.05

Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology (1995) 1.05

Diet and risk of ethanol-induced hepatotoxicity: carbohydrate-fat relationships in rats. Toxicol Sci (1999) 1.04

Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism. FEBS Lett (1999) 1.04

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43. Biochem Biophys Res Commun (2001) 1.04

Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians. Pharmacogenetics (1997) 1.04

Utilization and metabolic effects of acetaldehyde and ethanol in the perfused rat liver. Biochem J (1972) 1.03

Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes. J Biol Chem (1992) 1.03

Determinants of blood acetaldehyde level during ethanol oxidation in chronic alcoholics. Alcohol Clin Exp Res (1983) 1.03

Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats. J Nutr (1997) 1.03

Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). Biochem Biophys Res Commun (2001) 1.02

Purification and characterization of cytochrome P-450meg. J Biol Chem (1979) 1.01

Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues. Drug Metab Rev (1999) 1.01

A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function. Mol Pharmacol (1997) 1.01

Mechanisms and outcomes of drug- and toxicant-induced liver toxicity in diabetes. Crit Rev Toxicol (2007) 1.00

Characterization of a cytochrome P-450-dependent steroid hydroxylase system present in Bacillus megaterium. J Biol Chem (1976) 1.00

Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population. Pharmacogenetics (1993) 0.99

Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population. Pharmacogenetics (1996) 0.99

Reproductive toxicity and growth effects in rats exposed to lead at different periods during development. Toxicol Appl Pharmacol (1996) 0.99

Regulation and properties of a sex-specific hydroxylase system in female rat liver microsomes active on steroid sulfates. I. General characteristics. J Biol Chem (1974) 0.98

Urea synthesis in freshly isolated and in cultured periportal and perivenous hepatocytes. Biochem J (1986) 0.98

Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures. Biochem Biophys Res Commun (1988) 0.98

Molecular basis for the transport of cytochrome P450 2E1 to the plasma membrane. J Biol Chem (2000) 0.98

Sodium periodate, sodium chloride, organic hydroperoxides, and H2O2 as hydroxylating agents in steroid hydroxylation reactions catalyzed by partially purified cytochrome P-450. Biochem Biophys Res Commun (1975) 0.98

Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system. Neuroscience (1990) 0.97

Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the male rat. J Pharmacol Exp Ther (1977) 0.97

Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. Mol Pharmacol (2003) 0.97

Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism. Pharmacogenomics J (2007) 0.97

The effect of aging on distraction osteogenesis in the rat. J Orthop Res (2001) 0.96

Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiol Biomarkers Prev (2000) 0.96

Protein kinase C-dependent phosphorylation of profilin is specifically stimulated by phosphatidylinositol bisphosphate (PIP2). Biochem Biophys Res Commun (1988) 0.96