Published in World J Gastroenterol on October 07, 2007
Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin. J Biol Chem (2011) 1.38
Mechanisms and cell signaling in alcoholic liver disease. Biol Chem (2010) 1.19
Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver. Hepatology (2009) 1.14
Ethanol exerts dual effects on calcium homeostasis in CCK-8-stimulated mouse pancreatic acinar cells. BMC Cell Biol (2009) 0.81
Alcohol consumption impairs hepatic protein trafficking: mechanisms and consequences. Genes Nutr (2009) 0.81
Increased calcium influx in the presence of ethanol in mouse pancreatic acinar cells. Int J Exp Pathol (2009) 0.80
Structure, function and metabolism of hepatic and adipose tissue lipid droplets: implications in alcoholic liver disease. Curr Mol Pharmacol (2015) 0.75
Safety of Desmodium adscendens extract on hepatocytes and renal cells. Protective effect against oxidative stress. J Intercult Ethnopharmacol (2014) 0.75
Thromboxane inhibitors attenuate inflammatory and fibrotic changes in rat liver despite continued ethanol administrations. Alcohol Clin Exp Res (2012) 0.75
The Fas death factor. Science (1995) 13.81
The transforming growth factor-beta family. Annu Rev Cell Biol (1990) 10.62
Transforming growth factor beta in tissue fibrosis. N Engl J Med (1994) 9.73
Apoptosis. Immunol Today (1993) 4.23
Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13
Mechanisms of cell death in oxidative stress. Antioxid Redox Signal (2007) 3.33
Cytokines in alcoholic liver disease. Semin Liver Dis (1999) 2.37
Alcohol, oxidative stress and free radical damage. Proc Nutr Soc (2006) 2.29
Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol (2002) 2.17
WIF-B cells: an in vitro model for studies of hepatocyte polarity. J Cell Biol (1993) 2.04
Apoptosis: a different type of cell death. FASEB J (1992) 1.99
Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol (2001) 1.93
Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology (2003) 1.72
Cytokine regulation of liver injury and repair. Immunol Rev (2000) 1.58
CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med (2001) 1.44
Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. Hepatology (2000) 1.43
Apoptosis and the liver. Semin Cancer Biol (2000) 1.37
Death receptor-mediated apoptosis and the liver. J Hepatol (2002) 1.37
Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. Int J Biochem Cell Biol (2005) 1.34
Intracellular survival pathways in the liver. Liver Int (2006) 1.26
Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. Hepatology (2003) 1.26
Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. Hepatology (1992) 1.22
Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates. J Biol Chem (1996) 1.22
Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol (2001) 1.20
TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms. FASEB J (2003) 1.18
Mitochondrial glutathione: hepatocellular survival-death switch. J Gastroenterol Hepatol (2006) 1.16
Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism. Hepatology (2002) 1.14
Nonpolarized cells selectively sort apical proteins from cell surface to a novel compartment, but lack apical retention mechanisms. Mol Biol Cell (2002) 1.13
Hypothesis: alcoholic liver injury and the covalent binding of acetaldehyde. Alcohol Clin Exp Res (1985) 1.13
Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1. Free Radic Biol Med (2005) 1.08
Raised plasma soluble Fas and Fas-ligand in alcoholic liver disease. Lancet (1998) 1.08
Tumor necrosis factor alpha and toxicology. Crit Rev Toxicol (1999) 1.08
Abrogation of hepatocyte apoptosis and early appearance of liver dysplasia in ethanol-fed p53-deficient mice. Biochem Biophys Res Commun (2004) 1.07
The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. Hepatology (2001) 1.07
Apoptosis in diseases of the liver. Crit Rev Clin Lab Sci (2001) 1.06
WIF-B cells as a model for alcohol-induced hepatocyte injury. Biochem Pharmacol (2004) 1.05
Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. J Biol Chem (1997) 1.04
Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Am J Physiol Gastrointest Liver Physiol (2004) 1.03
Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole. Hepatology (1998) 1.02
Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol (2005) 1.01
Hybrid cell lines constitute a potential reservoir of polarized cells: isolation and study of highly differentiated hepatoma-derived hybrid cells able to form functional bile canaliculi in vitro. J Cell Biol (1991) 1.01
Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway. Alcohol Clin Exp Res (2006) 1.01
Subcellular changes and apoptosis induced by ethanol in rat liver. J Hepatol (1988) 1.00
Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcohol Clin Exp Res (1999) 0.99
Ethanol-induced apoptosis and oxidative stress in hepatocytes. Alcohol Clin Exp Res (1996) 0.98
Apoptosis and bcl-2 protein expression in experimental alcoholic liver disease in the rat. Alcohol Clin Exp Res (1995) 0.98
Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. J Biol Chem (1996) 0.97
Establishment of hepatic cell polarity in the rat hepatoma-human fibroblast hybrid WIF-B9. A biphasic phenomenon going from a simple epithelial polarized phenotype to an hepatic polarized one. J Cell Sci (1996) 0.96
Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide. Alcohol Clin Exp Res (1999) 0.93
Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Mol Cell Biochem (2000) 0.92
Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression. IUBMB Life (2005) 0.92
Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells. J Cell Biol (2001) 0.91
S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease. Alcohol (2002) 0.91
Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver. J Hepatol (1994) 0.90
Impaired plasma membrane glycoprotein assembly in the liver following acute ethanol administration. Biochem Biophys Res Commun (1984) 0.87
Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines. Alcohol Clin Exp Res (2003) 0.87
Trends in cirrhosis morbidity and mortality: United States, 1979-1988. Semin Liver Dis (1993) 0.85
Liver toxicity and apoptosis: role of TGF-beta1, cytochrome c and the apoptosome. Toxicol Lett (2001) 0.85
Apoptosis induced in HepG2 cells by short exposure to millimolar concentrations of ethanol involves the Fas-receptor pathway. J Cancer Res Clin Oncol (2001) 0.84
The structural and functional polarity of the hepatic human/rat hybrid WIF-B is a stable and dominant trait. Hepatology (1999) 0.84
Activation of a caspase-dependent oxidative damage response mediates TGFbeta1 apoptosis in rat hepatocytes. Exp Mol Pathol (2003) 0.84
Efficient in vitro vectorial transport of a fluorescent conjugated bile acid analogue by polarized hepatic hybrid WIF-B and WIF-B9 cells. Hepatology (1998) 0.84
Signaling for ethanol-induced apoptosis and repair in vitro. Clin Biochem (2001) 0.83
Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis (1996) 0.82
Novel morphologic findings in alcoholic liver disease. Clin Biochem (1999) 0.82
Effects of chronic ethanol administration on hepatic glycoprotein secretion in the rat. Gastroenterology (1983) 0.81
Liver and apoptosis. Ital J Gastroenterol Hepatol (1999) 0.81
Ethanol and hepatocellular injury. Clin Lab Med (1996) 0.80
Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria. Free Radic Biol Med (2002) 0.80
Expression of cytochrome P4502E1 in rat fetal hepatocyte culture. Mol Pharmacol (1996) 0.80
Malondialdehyde-acetaldehyde adducts and anti-malondialdehyde-acetaldehyde antibodies in rheumatoid arthritis. Arthritis Rheumatol (2015) 1.58
Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J Hepatol (2006) 1.39
Dangerous byproducts of alcohol breakdown--focus on adducts. Alcohol Res Health (2003) 1.34
A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes. J Nutr (2005) 1.20
Relationship between acetaldehyde levels and cell survival in ethanol-metabolizing hepatoma cells. Hepatology (2002) 1.19
Inhibition of markers of hepatic stellate cell activation by the hormone relaxin. Biochem Pharmacol (2003) 1.18
Microtubules are more stable and more highly acetylated in ethanol-treated hepatic cells. J Hepatol (2005) 1.15
Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. J Cell Biol (2013) 1.14
Betaine administration corrects ethanol-induced defective VLDL secretion. Mol Cell Biochem (2009) 1.12
A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury. Alcohol Clin Exp Res (2008) 1.10
Betaine lowers elevated s-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats. J Nutr (2003) 1.06
Relaxin receptors in hepatic stellate cells and cirrhotic liver. Biochem Pharmacol (2006) 1.06
Chronic ethanol consumption induces global hepatic protein hyperacetylation. Alcohol Clin Exp Res (2009) 1.05
Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine. Biochem Pharmacol (2005) 1.05
WIF-B cells as a model for alcohol-induced hepatocyte injury. Biochem Pharmacol (2004) 1.05
Hybrid malondialdehyde and acetaldehyde protein adducts form in the lungs of mice exposed to alcohol and cigarette smoke. Alcohol Clin Exp Res (2011) 1.05
Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells. Hepatology (2007) 1.04
Methionine synthase. a possible prime site of the ethanolic lesion in liver. Alcohol (2002) 1.02
Microtubule acetylation and stability may explain alcohol-induced alterations in hepatic protein trafficking. Hepatology (2008) 1.02
Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway. Alcohol Clin Exp Res (2006) 1.01
Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells. Alcohol Clin Exp Res (2004) 1.00
The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes. Hepatology (2002) 0.97
Malondialdehyde-acetaldehyde-adducted protein inhalation causes lung injury. Alcohol (2011) 0.97
Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins. Mol Pharmacol (2005) 0.97
Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function. Hepatology (2008) 0.95
Malondialdehyde-acetaldehyde adducts decrease bronchial epithelial wound repair. Alcohol (2005) 0.95
Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells. Autophagy (2012) 0.94
Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-L-isoaspartyl methyltransferase activity. J Hepatol (2007) 0.94
Betaine treatment attenuates chronic ethanol-induced hepatic steatosis and alterations to the mitochondrial respiratory chain proteome. Int J Hepatol (2011) 0.93
Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver disease. Alcohol Clin Exp Res (2004) 0.93
Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation. Alcohol Clin Exp Res (2002) 0.93
Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis. Free Radic Biol Med (2010) 0.92
Effect of chronic ethanol administration on the in vitro production of proinflammatory cytokines by rat Kupffer cells in the presence of apoptotic cells. Alcohol Clin Exp Res (2007) 0.92
Ethanol metabolism results in a G2/M cell-cycle arrest in recombinant Hep G2 cells. Hepatology (2003) 0.92
Malondialdehyde-acetaldehyde (MAA) modified proteins induce pro-inflammatory and pro-fibrotic responses by liver endothelial cells. Comp Hepatol (2004) 0.90
Ethanol feeding potentiates the pro-inflammatory response of Kupffer cells to cellular fibronectin. Alcohol Clin Exp Res (2011) 0.90
Fibronectin: functional character and role in alcoholic liver disease. World J Gastroenterol (2011) 0.89
An in vitro method of alcoholic liver injury using precision-cut liver slices from rats. Biochem Pharmacol (2008) 0.89
Transforming growth factor-beta induces contraction of activated hepatic stellate cells. J Hepatol (2004) 0.88
Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol. Biochem Pharmacol (2005) 0.88
Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites. Alcohol Clin Exp Res (2010) 0.88
T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated. Int Immunopharmacol (2003) 0.87
Recent advances in alcohol-induced adduct formation. Alcohol Clin Exp Res (2005) 0.87
Carbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice. Biochem Pharmacol (2009) 0.87
Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. Alcohol Clin Exp Res (2007) 0.87
Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption. Methods Mol Biol (2008) 0.87
Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells. World J Gastroenterol (2009) 0.87
Impaired methylation as a novel mechanism for proteasome suppression in liver cells. Biochem Biophys Res Commun (2009) 0.87
Molecular mechanism of alcoholic fatty liver. Indian J Pharmacol (2012) 0.87
A rat model to determine the biomedical consequences of concurrent ethanol ingestion and cigarette smoke exposure. Alcohol Clin Exp Res (2004) 0.86
Effect of malondialdehyde-acetaldehyde-protein adducts on the protein kinase C-dependent secretion of urokinase-type plasminogen activator in hepatic stellate cells. Biochem Pharmacol (2002) 0.86
Ethanol and membrane protein trafficking: diverse mechanisms of ethanol action. Alcohol Clin Exp Res (2002) 0.85
Chronic ethanol treatment impairs Rac and Cdc42 activation in rat hepatocytes. Alcohol Clin Exp Res (2006) 0.84
Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis. Am J Physiol Gastrointest Liver Physiol (2010) 0.84
Ethanol selectively impairs clathrin-mediated internalization in polarized hepatic cells. Biochem Pharmacol (2009) 0.83
Changes in the pathogenesis of alcohol-induced liver disease -- preclinical studies. Exp Mol Pathol (2013) 0.83
Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines. Chem Res Toxicol (2005) 0.82
Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity. Front Biosci (2004) 0.82
Impaired receptor-mediated endocytosis by the asialoglycoprotein receptor in ethanol-fed mice: implications for studying the role of this receptor in alcoholic apoptosis. Biochem Pharmacol (2003) 0.81
Lipid droplet accumulation and impaired fat efflux in polarized hepatic cells: consequences of ethanol metabolism. Int J Hepatol (2012) 0.81
Rab GTPases associate with isolated lipid droplets (LDs) and show altered content after ethanol administration: potential role in alcohol-impaired LD metabolism. Alcohol Clin Exp Res (2013) 0.81
Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells. Biochem Pharmacol (2003) 0.80
Lysine acetylation induced by chronic ethanol consumption impairs dynamin-mediated clathrin-coated vesicle release. Hepatology (2012) 0.80
Relaxin decreases the severity of established hepatic fibrosis in mice. Liver Int (2013) 0.80
Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis. Ann N Y Acad Sci (2009) 0.79
Receptor-mediated endocytosis by the asialoglycoprotein receptor: effect of ethanol administration on endosomal distribution of receptor and ligand. Liver Int (2003) 0.79
Susceptibility to T cell-mediated liver injury is enhanced in asialoglycoprotein receptor-deficient mice. Int Immunopharmacol (2013) 0.78
Hepatic microtubule acetylation and stability induced by chronic alcohol exposure impair nuclear translocation of STAT3 and STAT5B, but not Smad2/3. Am J Physiol Gastrointest Liver Physiol (2012) 0.78
Cellular fibronectin stimulates hepatocytes to produce factors that promote alcohol-induced liver injury. World J Hepatol (2011) 0.78
Alcohol, carcinoembryonic antigen processing and colorectal liver metastases. Adv Exp Med Biol (2015) 0.78
Impact of asialoglycoprotein receptor deficiency on the development of liver injury. World J Gastroenterol (2009) 0.77
Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde. Int Immunopharmacol (2008) 0.77
Malondialdehyde-acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells. Int Immunopharmacol (2002) 0.77
Inhibition of hepatic stellate cell collagen synthesis by N-(methylamino)isobutyric acid. Biochem Pharmacol (2002) 0.77
An in vivo Method for Determination of Endosomal Distribution of Both Ligand and Asialoglycoprotein Receptor in Rat Liver. Comp Hepatol (2004) 0.77
ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane. Arch Biochem Biophys (2002) 0.77
Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity. Alcohol Clin Exp Res (2013) 0.77
Relaxin receptor expression in hepatic stellate cells and in cirrhotic rat liver tissue. Ann N Y Acad Sci (2005) 0.77
In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability. Alcohol Clin Exp Res (2002) 0.76
Cyanamide potentiates the ethanol-induced impairment of receptor-mediated endocytosis in a recombinant hepatic cell line expressing alcohol dehydrogenase activity. Int J Hepatol (2012) 0.76
Alcohol and lipid traffic don't mix. Hepatology (2011) 0.76
Halothane potentiates the alcohol-adduct induced TNF-alpha release in heart endothelial cells. BMC Anesthesiol (2005) 0.75
Alcohol-induced defects in hepatic transcytosis may be explained by impaired dynein function. Mol Cell Biochem (2014) 0.75