A genetic screen for aminophospholipid transport mutants identifies the phosphatidylinositol 4-kinase, STT4p, as an essential component in phosphatidylserine metabolism.

PubWeight™: 1.25‹?› | Rank: Top 10%

🔗 View Article (PMID 9582361)

Published in J Biol Chem on May 22, 1998

Authors

P J Trotter1, W I Wu, J Pedretti, R Yates, D R Voelker

Author Affiliations

1: Division of Nutritional Sciences and Institute for Cellular and Molecular Biology, The University of Texas, Austin, Texas 78712, USA.

Articles citing this

Membrane lipids: where they are and how they behave. Nat Rev Mol Cell Biol (2008) 13.77

Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21

Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics. Mol Biol Cell (2000) 2.87

Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 2.08

Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell (2001) 1.99

The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol (2006) 1.79

Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell (2007) 1.77

Sac phosphatase domain proteins. Biochem J (2000) 1.69

Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell (2000) 1.66

Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) (2009) 1.41

Role of flippases, scramblases and transfer proteins in phosphatidylserine subcellular distribution. Traffic (2014) 0.99

Identification of gene encoding Plasmodium knowlesi phosphatidylserine decarboxylase by genetic complementation in yeast and characterization of in vitro maturation of encoded enzyme. J Biol Chem (2011) 0.98

Isolation of a Chinese hamster ovary cell mutant defective in intramitochondrial transport of phosphatidylserine. Proc Natl Acad Sci U S A (1999) 0.93

Lipid transport between the endoplasmic reticulum and mitochondria. Cold Spring Harb Perspect Biol (2013) 0.92

Inositol lipid regulation of lipid transfer in specialized membrane domains. Trends Cell Biol (2013) 0.90

Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev Cell (2013) 0.89

A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth. J Cell Biol (2012) 0.87

An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae. J Biol Chem (2013) 0.81

Plasticity of PI4KIIIα interactions at the plasma membrane. EMBO Rep (2015) 0.80

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat Cell Biol (2015) 0.79

Phosphatidylinositol transfer proteins and functional specification of lipid signaling pools. Adv Enzyme Regul (2007) 0.77

Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals. Biochim Biophys Acta (2014) 0.76

Articles by these authors

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol (1992) 11.24

Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure. Heart (2007) 2.04

Identification of a non-mitochondrial phosphatidylserine decarboxylase activity (PSD2) in the yeast Saccharomyces cerevisiae. J Biol Chem (1995) 1.91

An early bone tool industry from the Middle Stone Age at Blombos Cave, South Africa: implications for the origins of modern human behaviour, symbolism and language. J Hum Evol (2001) 1.87

Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae. J Biol Chem (1998) 1.82

Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis by a direct interaction with human macrophages. J Immunol (1995) 1.74

Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele. J Biol Chem (1993) 1.64

Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. A specific biochemical and cytological marker for a unique membrane fraction in rat liver. J Biol Chem (1993) 1.58

Acute hypoxemic respiratory failure in children: case mix and the utility of respiratory severity indices. Intensive Care Med (1998) 1.57

Surfactant protein A and surfactant protein D in health and disease. Am J Physiol (1998) 1.56

Multi-drug resistant escherichia coli with extended-spectrum beta-lactamase activity and fluoroquinolone resistance isolated from clinical infections in dogs. Aust Vet J (2001) 1.55

Phosphatidylserine functions as the major precursor of phosphatidylethanolamine in cultured BHK-21 cells. Proc Natl Acad Sci U S A (1984) 1.55

120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A. J Clin Invest (1992) 1.53

Pulmonary surfactant proteins. J Biol Chem (1994) 1.51

Surfactant protein D binds to Mycobacterium tuberculosis bacilli and lipoarabinomannan via carbohydrate-lectin interactions resulting in reduced phagocytosis of the bacteria by macrophages. J Immunol (1999) 1.47

Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity. Biochem J (2000) 1.42

Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme. J Biol Chem (2001) 1.38

Cellular and enzymic synthesis of sphingomyelin. Biochemistry (1982) 1.37

Phosphatidylserine decarboxylase 2 of Saccharomyces cerevisiáe. Cloning and mapping of the gene, heterologous expression, and creation of the null allele. J Biol Chem (1995) 1.32

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7. Biochim Biophys Acta (1988) 1.31

Surfactant proteins A and D bind CD14 by different mechanisms. J Biol Chem (2000) 1.30

Isolation and characterization of the Saccharomyces cerevisiae DPP1 gene encoding diacylglycerol pyrophosphate phosphatase. J Biol Chem (1998) 1.28

Ultrastructure of the carotid body of the cat as revealed by various fixatives and the use of reserpine. Anat Rec (1967) 1.23

Pulmonary surfactant protein A modulates the cellular response to smooth and rough lipopolysaccharides by interaction with CD14. J Immunol (1999) 1.23

Pulmonary surfactant apoprotein A structure and modulation of surfactant secretion by rat alveolar type II cells. J Biol Chem (1988) 1.22

Mitral valve replacement in children: mortality, morbidity, and haemodynamic status up to medium term follow up. Heart (2000) 1.22

Isolation and characterization of the Saccharomyces cerevisiae LPP1 gene encoding a Mg2+-independent phosphatidate phosphatase. J Biol Chem (1998) 1.22

Survey of GP registrars' opinions of summative assessment and perceived effect on the training year. Br J Gen Pract (1999) 1.21

Comparison of long-term outcomes of atrial repair of simple transposition with implications for a late arterial switch strategy. Circulation (1999) 1.19

Scientific, ethical, and logistical considerations in introducing a new operation: a retrospective cohort study from paediatric cardiac surgery. BMJ (2000) 1.19

Alveolar type II cells express a high-affinity receptor for pulmonary surfactant protein A. Proc Natl Acad Sci U S A (1988) 1.18

Isolation and characterization of a Chinese hamster ovary cell line requiring ethanolamine or phosphatidylserine for growth and exhibiting defective phosphatidylserine synthase activity. J Biol Chem (1986) 1.15

Jaagsiekte sheep retrovirus proviral clone JSRV(JS7), derived from the JS7 lung tumor cell line, induces ovine pulmonary carcinoma and is integrated into the surfactant protein A gene. J Virol (2001) 1.14

Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures. J Biol Chem (2001) 1.13

KGF increases SP-A and SP-D mRNA levels and secretion in cultured rat alveolar type II cells. Am J Respir Cell Mol Biol (1998) 1.13

ARIMIDEX: a new oral, once-a-day aromatase inhibitor. J Steroid Biochem Mol Biol (1995) 1.11

Characterization of Pneumocystis carinii preparations developed for lipid analysis. J Eukaryot Microbiol (1994) 1.11

Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages. Biochem J (1992) 1.11

Involvement of protein kinase C in pulmonary surfactant secretion from alveolar type II cells. J Biol Chem (1985) 1.09

The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity. J Biol Chem (1996) 1.08

Primary structure of rat pulmonary surfactant protein D. cDNA and deduced amino acid sequence. J Biol Chem (1992) 1.08

The CWH8 gene encodes a dolichyl pyrophosphate phosphatase with a luminally oriented active site in the endoplasmic reticulum of Saccharomyces cerevisiae. J Biol Chem (2001) 1.07

Complications of modified Blalock-Taussig shunts mimicking pulmonary disease. Arch Dis Child (1998) 1.06

Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase. J Biol Chem (1999) 1.06

Lipid transport processes in eukaryotic cells. Biochim Biophys Acta (1994) 1.06

Binding of rat and human surfactant proteins A and D to Aspergillus fumigatus conidia. Infect Immun (1999) 1.06

Idiopathic pulmonary fibrosis. Abnormalities in the bronchoalveolar lavage content of surfactant protein A. Am Rev Respir Dis (1991) 1.05

Trafficking of newly synthesized surfactant protein A in isolated rat alveolar type II cells. Am J Respir Cell Mol Biol (1998) 1.05

Alveolar type II cells, surfactant protein A (SP-A), and the phospholipid components of surfactant in acute silicosis in the rat. Am Rev Respir Dis (1989) 1.04

Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions. Am J Physiol Lung Cell Mol Physiol (2001) 1.02

Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction. J Clin Invest (1998) 1.01

A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14. J Biol Chem (2000) 1.00

Chemical modification of surfactant protein A alters high affinity binding to rat alveolar type II cells and regulation of phospholipid secretion. J Biol Chem (1988) 0.98

Calcium dependent association of surfactant protein A with pulmonary surfactant: application to simple surfactant protein A purification. Arch Biochem Biophys (1996) 0.98

Effect of secretagogues on cytoplasmic free calcium in alveolar type II epithelial cells. Am J Physiol (1987) 0.98

The erosive effects of some mouthrinses on enamel. A study in situ. J Clin Periodontol (2001) 0.96

Interactions of surfactant proteins A and D with Saccharomyces cerevisiae and Aspergillus fumigatus. Infect Immun (2001) 0.96

The role of the amino-terminal domain and the collagenous region in the structure and the function of rat surfactant protein D. J Biol Chem (1995) 0.95

Disruption of phosphatidylserine translocation to the mitochondria in baby hamster kidney cells. J Biol Chem (1985) 0.95

Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity. J Biol Chem (1997) 0.95

Isolation and culture of human alveolar type II epithelial cells. Characterization of their phospholipid secretion. Am Rev Respir Dis (1984) 0.94

Hormonal regulation of the growth and steroidogenic function of human granulosa cells. J Clin Endocrinol Metab (1992) 0.94

Surfactant protein A binds to the fusion glycoprotein of respiratory syncytial virus and neutralizes virion infectivity. J Infect Dis (1999) 0.94

Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae. J Biol Chem (1998) 0.93

Characterization of phosphatidylserine transport to the locus of phosphatidylserine decarboxylase 2 in permeabilized yeast. J Biol Chem (2000) 0.93

Perforation of the heart by a swallowed open safety-pin in an infant. J R Coll Surg Edinb (1998) 0.93

Expression and localization of a novel Rab small G protein (Rab38) in the rat lung. Am J Pathol (2001) 0.93

The Cys6 intermolecular disulfide bond and the collagen-like region of rat SP-A play critical roles in interactions with alveolar type II cells and surfactant lipids. J Biol Chem (1997) 0.92

A specific ligand for beta(2)-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages. J Lipid Res (2001) 0.92

Synthesis and intracellular transport of aminoglycerophospholipids in permeabilized cells of the yeast, Saccharomyces cerevisiae. J Biol Chem (1995) 0.92

Is the Autism Treatment Evaluation Checklist a useful tool for monitoring progress in children with autism spectrum disorders? J Intellect Disabil Res (2011) 0.92

Quality of life in children following mitral valve replacement. Heart (2000) 0.92

Analysis of chimeric proteins identifies the regions in the carbohydrate recognition domains of rat lung collectins that are essential for interactions with phospholipids, glycolipids, and alveolar type II cells. J Biol Chem (1998) 0.92

Chimeras of surfactant proteins A and D identify the carbohydrate recognition domains as essential for phospholipid interaction. J Biol Chem (1994) 0.91

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria. J Med Chem (1998) 0.90

The structure and function of surfactant protein A. Hydroxyproline- and carbohydrate-deficient mutant proteins. J Biol Chem (1994) 0.90

Adsorption of pulmonary surfactant protein D to phospholipid monolayers at the air-water interface. Biochemistry (1997) 0.90

Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology (Berl) (1998) 0.89

Altered carbohydrate recognition specificity engineered into surfactant protein D reveals different binding mechanisms for phosphatidylinositol and glucosylceramide. J Biol Chem (1995) 0.89

Effects of recombinant LH treatment on folliculogenesis and responsiveness to FSH stimulation. Hum Reprod (2007) 0.89

The Na+/H+ antiporter in rat alveolar type II cells and its role in stimulated surfactant secretion. Biochim Biophys Acta (1988) 0.88

Hybridomas expressing gammadelta T-cell receptors respond to cardiolipin and beta2-glycoprotein 1 (apolipoprotein H). Scand J Immunol (2003) 0.88

Improving response rates to primary and supplementary questionnaires by changing response and instruction burden: cluster randomised trial. Aust N Z J Public Health (2005) 0.87

Dilated cardiomyopathy in dystrophic epidermolysis bullosa. Arch Dis Child (2000) 0.87

Regulatory mechanisms of surfactant secretion. Biochim Biophys Acta (1998) 0.87

Macromolecular assemblies regulate nonvesicular phosphatidylserine traffic in yeast. Biochem Soc Trans (2006) 0.87

The 45- and 104-kDa forms of phosphatidate phosphatase from Saccharomyces cerevisiae are regulated differentially by phosphorylation via cAMP-dependent protein kinase. J Biol Chem (1992) 0.87

Does growth hormone-releasing factor assist follicular development in poor responder patients undergoing ovarian stimulation for in-vitro fertilization? Hum Reprod (1999) 0.86

Temporal segregation of surfactant secretion and lamellar body biogenesis in primary cultures of rat alveolar type II cells. Am J Respir Cell Mol Biol (1991) 0.86

Surfactant protein A amino acids Glu195 and Arg197 are essential for receptor binding, phospholipid aggregation, regulation of secretion, and the facilitated uptake of phospholipid by type II cells. J Biol Chem (1994) 0.85

Pharmacokinetics and tolerability of the orally active selective epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in healthy volunteers. Clin Pharmacokinet (2001) 0.85

The effect of transmission bandwidth on diagnostic accuracy in remote fetal ultrasound scanning. J Telemed Telecare (1997) 0.84

Expression of anticardiolipin cofactor, human beta 2-glycoprotein I, by a recombinant baculovirus/insect cell system. Clin Exp Immunol (1993) 0.84

Respiratory health in Aboriginal and Torres Strait Islander children in the Australian Capital Territory. J Paediatr Child Health (2003) 0.84