Published in Genetics on May 01, 1998
PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol Cell Biol (1999) 2.29
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock. Genes Dev (2008) 1.70
Natural allelic variation in the temperature-compensation mechanisms of the Arabidopsis thaliana circadian clock. Genetics (2005) 1.67
NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed. Cell (2011) 1.41
Activating PER repressor through a DBT-directed phosphorylation switch. PLoS Biol (2008) 1.20
RNA-interference knockdown of Drosophila pigment dispersing factor in neuronal subsets: the anatomical basis of a neuropeptide's circadian functions. PLoS One (2009) 1.14
Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila. Genetics (2000) 1.14
A proposal for robust temperature compensation of circadian rhythms. Proc Natl Acad Sci U S A (2007) 1.11
Circadian clock-specific roles for the light response protein WHITE COLLAR-2. Mol Cell Biol (2001) 1.10
Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Genetics (2002) 0.93
Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol (2007) 0.91
Adaptive significance of a circadian clock: temporal segregation of activities reduces intrinsic competitive inferiority in Drosophila parasitoids. Proc Biol Sci (2000) 0.88
Even a stopped clock tells the right time twice a day: circadian timekeeping in Drosophila. Pflugers Arch (2007) 0.83
Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects. Neurobiol Dis (2011) 0.83
Casein kinase 1 promotes synchrony of the circadian clock network. Mol Cell Biol (2014) 0.79
Histamine-HisCl1 receptor axis regulates wake-promoting signals in Drosophila melanogaster. PLoS One (2013) 0.78
An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock. G3 (Bethesda) (2016) 0.75
The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: causes and consequences. Hum Genet (1992) 8.20
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
Temporal phosphorylation of the Drosophila period protein. Proc Natl Acad Sci U S A (1994) 3.43
Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell (1997) 3.32
Circadian clock locus frequency: protein encoded by a single open reading frame defines period length and temperature compensation. Proc Natl Acad Sci U S A (1994) 3.23
The classification of amino acid conservation. J Theor Biol (1986) 3.12
Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Cell (1996) 3.08
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene. Nature (1987) 3.05
Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system. Neuron (1988) 2.41
Regulation of nuclear entry of the Drosophila clock proteins period and timeless. Neuron (1996) 2.35
Natural variation in a Drosophila clock gene and temperature compensation. Science (1997) 2.24
Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila. Nature (1987) 2.22
Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. Neuron (1995) 2.12
Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J Neurosci (1992) 2.10
Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms. Cell (1984) 2.10
Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both. J Biol Rhythms (1993) 2.04
Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock. Nature (1987) 1.93
A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron (1994) 1.92
Reciprocal behaviour associated with altered homeostasis and photosensitivity of Drosophila clock mutants. J Neurogenet (1989) 1.91
Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants. J Neurogenet (1986) 1.84
Interspecific comparison of the period gene of Drosophila reveals large blocks of non-conserved coding DNA. EMBO J (1988) 1.80
Genetics and molecular analysis of circadian rhythms. Annu Rev Genet (1996) 1.80
Loss of temperature compensation of circadian period length in the frq-9 mutant of Neurospora crassa. J Biol Rhythms (1986) 1.78
Temperature Compensation of Circadian Period Length in Clock Mutants of Neurospora crassa. Plant Physiol (1981) 1.64
Further evidence that the circadian clock in Drosophila is a population of coupled ultradian oscillators. J Biol Rhythms (1987) 1.52
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am J Hum Genet (1997) 1.52
Alternative myosin hinge regions are utilized in a tissue-specific fashion that correlates with muscle contraction speed. Genes Dev (1990) 1.48
Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster. Proc Natl Acad Sci U S A (1987) 1.43
Effect of constant light and circadian entrainment of perS flies: evidence for light-mediated delay of the negative feedback loop in Drosophila. EMBO J (1996) 1.41
An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian system. J Biol Rhythms (1994) 1.28
The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants. Neuron (1996) 1.27
The analysis of new short-period circadian rhythm mutants suggests features of D. melanogaster period gene function. J Neurogenet (1992) 1.26
Identification of point mutations in 41 unrelated patients affected with Menkes disease. Am J Hum Genet (1997) 1.26
Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster. EMBO J (1990) 1.22
New models in vogue for circadian clocks. Cell (1995) 1.17
Requirement for period gene expression in the adult and not during development for locomotor activity rhythms of imaginal Drosophila melanogaster. J Neurogenet (1990) 1.16
Reassessment of the effect of biological rhythm mutations on learning in Drosophila melanogaster. J Comp Physiol A (1991) 1.15
Circadian rhythms in Drosophila melanogaster: analysis of period as a function of gene dosage at the per (period) locus. J Theor Biol (1986) 1.11
Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster. Genetics (1990) 1.11
Expression of a Drosophila mRNA is under circadian clock control during pupation. Development (1989) 1.10
A new mutation at the period locus of Drosophila melanogaster with some novel effects on circadian rhythms. J Neurogenet (1989) 1.05
Genetics in rhythm. Trends Genet (1997) 0.99
Circadian rhythms: from behaviour to molecules. Bioessays (1997) 0.98
Messenger RNA sequence complexity and homology in developmental stages of Drosophila. Dev Biol (1981) 0.93
On the role of protein synthesis in the circadian clock of Neurospora crassa. Proc Natl Acad Sci U S A (1988) 0.90
Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics (1972) 22.68
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature (1990) 5.69
Independent photoreceptive circadian clocks throughout Drosophila. Science (1997) 5.18
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell (1999) 5.14
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell (1998) 4.81
CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell (1998) 4.22
Quantitative analysis of Drosophila period gene transcription in living animals. J Biol Rhythms (1997) 4.09
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86
Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies. Science (1996) 3.36
Conditioned responses in courtship behavior of normal and mutant Drosophila. Proc Natl Acad Sci U S A (1979) 3.31
Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell (1996) 3.30
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci U S A (2000) 3.11
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene. Nature (1987) 3.05
Subdivision of the Drosophila mushroom bodies by enhancer-trap expression patterns. Neuron (1995) 3.03
Fate mapping of nervous system and other internal tissues in genetic mosaics of Drosophila melanogaster. Dev Biol (1976) 2.99
Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J Neurosci (1990) 2.93
Chromosome segregation influenced by two alleles of the meiotic mutant c(3)G in Drosophila melanogaster. Genetics (1972) 2.92
Relationships between the physical and genetic maps of a 470 x 10(3) base-pair region around the terminus of Escherichia coli K12 DNA replication. J Mol Biol (1982) 2.76
Production of refractory dissolved organic matter by bacteria. Science (2001) 2.72
Neuroanatomy of cells expressing clock genes in Drosophila: transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J Comp Neurol (2000) 2.61
Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song. Proc Natl Acad Sci U S A (1980) 2.50
Physical characterisation of the "Rac prophage" in E. coli K12. Mol Gen Genet (1979) 2.49
Symmetrical peripheral gangrene and disseminated intravascular coagulation. Arch Dermatol (1985) 2.45
Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology (1984) 2.42
Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system. Neuron (1988) 2.41
A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Cell (1994) 2.31
Circadian oscillations in period gene mRNA levels are transcriptionally regulated. Proc Natl Acad Sci U S A (1992) 2.29
Drosophila CRY is a deep brain circadian photoreceptor. Neuron (2000) 2.28
P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster. Cell (1984) 2.24
Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila. Nature (1987) 2.22
The role of female movement in the sexual behavior of Drosophila melanogaster. Behav Genet (1982) 2.21
GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of Drosophila. Dev Dyn (1997) 2.18
Genetics of acetylcholinesterase in Drosophila melanogaster. Genetics (1976) 2.16
The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory. Cell (2000) 2.10
Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J Neurosci (1992) 2.10
Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms. Cell (1984) 2.10
The circadian clock of fruit flies is blind after elimination of all known photoreceptors. Neuron (2001) 2.07
Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both. J Biol Rhythms (1993) 2.04
Spatial, temporal, and sexually dimorphic expression patterns of the fruitless gene in the Drosophila central nervous system. J Neurobiol (2000) 2.04
Functional dissection of the Drosophila mushroom bodies by selective feminization of genetically defined subcompartments. Neuron (1995) 1.93
A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron (1994) 1.92
Conditioned courtship in Drosophila and its mediation by association of chemical cues. Behav Genet (1983) 1.90
A new role for cryptochrome in a Drosophila circadian oscillator. Nature (2001) 1.85
Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants. J Neurogenet (1986) 1.84
Control of male reproductive behavior by the central nervous system of Drosophila: dissection of a courtship pathway by genetic mosaics. Genetics (1979) 1.83
A unique circadian-rhythm photoreceptor. Nature (2000) 1.83
Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila. EMBO J (1997) 1.82
Courtship among males due to a male-sterile mutation in Drosophila melanogaster. Behav Genet (1978) 1.81
Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell (2001) 1.81
Interspecific comparison of the period gene of Drosophila reveals large blocks of non-conserved coding DNA. EMBO J (1988) 1.80
Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaster. Science (1991) 1.78
The molecular biology of circadian rhythms. Neuron (1989) 1.77
Interspecific genetic control of courtship song production and reception in Drosophila. Science (1986) 1.73
Extended reproductive roles of the fruitless gene in Drosophila melanogaster revealed by behavioral analysis of new fru mutants. Genetics (1997) 1.71
Can a weight loss of one pound a week be achieved with a 3500-kcal deficit? Commentary on a commonly accepted rule. Int J Obes (Lond) (2013) 1.70
Chemosensory elements of courtship in normal and mutant, olfaction-deficient Drosophila melanogaster. Behav Genet (1986) 1.69
Acetylcholinesterase mutants in Drosophila and their effects on the structure and function of the central nervous system. J Comp Neurol (1980) 1.66
Thidiazuron induces shoot organogenesis at low concentrations and somatic embryogenesis at high concentrations on leaf and petiole explants of African violet (Saintpaulia ionantha Wendl). Plant Cell Rep (2002) 1.66
Portions of the central nervous system controlling reproductive behavior in Drosophila melanogaster. Behav Genet (1977) 1.63
Behavioral and neurobiological implications of sex-determining factors in Drosophila. Dev Genet (1994) 1.63
Oligodeoxyribonucleotides containing 1,3-propanediol as nucleoside substitute. Nucleic Acids Res (1987) 1.62
Identification of Brain Sites Controlling Female Receptivity in Mosaics of DROSOPHILA MELANOGASTER. Genetics (1983) 1.62
Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors. Br J Pharmacol (1985) 1.61
Novel features of drosophila period Transcription revealed by real-time luciferase reporting. Neuron (1996) 1.61
Half-life of truth in surgical literature. Lancet (1997) 1.59
Spatial and temporal expression of the period gene in Drosophila melanogaster. Genes Dev (1988) 1.58
A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J Neurosci (1996) 1.57
Genetics of the nervous system in Drosophila. Q Rev Biophys (1982) 1.54
Courtship anomalies caused by doublesex mutations in Drosophila melanogaster. Genetics (1996) 1.54
Acquiring surgical skills. Br J Surg (2000) 1.51
Behavior and cytogenetics of fruitless in Drosophila melanogaster: different courtship defects caused by separate, closely linked lesions. Genetics (1989) 1.50
The period gene encodes a predominantly nuclear protein in adult Drosophila. J Neurosci (1992) 1.49
Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling. J Neurosci (1997) 1.47
A newly uncovered phenotype associated with the fruitless gene of Drosophila melanogaster: aggression-like head interactions between mutant males. Behav Genet (2000) 1.44
Genetic analysis of the Drosophila ellipsoid body neuropil: organization and development of the central complex. J Neurobiol (1999) 1.44
Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster. Proc Natl Acad Sci U S A (1987) 1.43
The development of undergraduate curricula in surgery: I. General issues. ANZ J Surg (2001) 1.41
Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. Genetics (2001) 1.39
On the nature of sbcA mutations in E. coli K 12. Mol Gen Genet (1980) 1.39
The dissonance mutant of courtship song in Drosophila melanogaster: isolation, behavior and cytogenetics. Genetics (1988) 1.38
Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster. J Biol Rhythms (1998) 1.38
Transplanted Drosophila excretory tubules maintain circadian clock cycling out of phase with the host. Curr Biol (2000) 1.35
The period gene of Drosophila carries species-specific behavioral instructions. EMBO J (1988) 1.34
Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. J Neurosci (2000) 1.33
The association of GRB 060218 with a supernova and the evolution of the shock wave. Nature (2006) 1.32
A short gamma-ray burst apparently associated with an elliptical galaxy at redshift z = 0.225. Nature (2005) 1.32
Elements of the fruitless locus regulate development of the muscle of Lawrence, a male-specific structure in the abdomen of Drosophila melanogaster adults. Development (1991) 1.30
Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster. Neuron (1998) 1.29
Genetic analysis of Drosophila neurobiology. Annu Rev Genet (1979) 1.29
Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos. J Cell Sci (1996) 1.29
Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. J Cell Sci (1998) 1.28
An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian system. J Biol Rhythms (1994) 1.28
Metamorphosis of the mushroom bodies; large-scale rearrangements of the neural substrates for associative learning and memory in Drosophila. Learn Mem (1999) 1.28
The origin of Q-independent derivatives of phage lambda. Mol Gen Genet (1980) 1.27
The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants. Neuron (1996) 1.27
The analysis of new short-period circadian rhythm mutants suggests features of D. melanogaster period gene function. J Neurogenet (1992) 1.26
RNA editing in the Drosophila DMCA1A calcium-channel alpha 1 subunit transcript. J Neurogenet (1998) 1.24
The malpighian tubules of Drosophila melanogaster: a novel phenotype for studies of fluid secretion and its control. J Exp Biol (1994) 1.23