Published in Proc Natl Acad Sci U S A on March 28, 2000
Identification of SLEEPLESS, a sleep-promoting factor. Science (2008) 4.56
An integrated micro- and macroarchitectural analysis of the Drosophila brain by computer-assisted serial section electron microscopy. PLoS Biol (2010) 4.50
Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron (2008) 2.73
Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J Neurosci (2006) 2.65
Drosophila free-running rhythms require intercellular communication. PLoS Biol (2003) 2.42
Circadian organization of behavior and physiology in Drosophila. Annu Rev Physiol (2010) 2.36
PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev (2006) 2.31
A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila. Neuron (2007) 2.13
Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Curr Biol (2009) 1.90
PPTGAL, a convenient Gal4 P-element vector for testing expression of enhancer fragments in drosophila. Genesis (2002) 1.84
Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes. J Comp Neurol (2006) 1.71
Adult-specific electrical silencing of pacemaker neurons uncouples molecular clock from circadian outputs. Curr Biol (2011) 1.70
Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila. Curr Biol (2007) 1.66
Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene. Genetics (2007) 1.53
Circadian control of membrane excitability in Drosophila melanogaster lateral ventral clock neurons. J Neurosci (2008) 1.53
Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons. Curr Biol (2012) 1.50
Circadian rhythms in neuronal activity propagate through output circuits. Nat Neurosci (2016) 1.48
Circadian Rhythms in Rho1 Activity Regulate Neuronal Plasticity and Network Hierarchy. Cell (2015) 1.47
Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior. Curr Biol (2013) 1.47
Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. PLoS Genet (2015) 1.46
Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nat Neurosci (2009) 1.43
The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. Curr Biol (2009) 1.43
PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila. J Comp Neurol (2010) 1.41
Circadian remodeling of neuronal circuits involved in rhythmic behavior. PLoS Biol (2008) 1.41
Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF. PLoS Genet (2016) 1.40
Peptide neuromodulation in invertebrate model systems. Neuron (2012) 1.39
A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude. EMBO J (2003) 1.38
Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit. Cell (2012) 1.27
Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci (2008) 1.26
Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells. J Biol Rhythms (2006) 1.25
Sex- and clock-controlled expression of the neuropeptide F gene in Drosophila. Proc Natl Acad Sci U S A (2006) 1.23
PDP1epsilon functions downstream of the circadian oscillator to mediate behavioral rhythms. J Neurosci (2007) 1.23
Drug-induced epigenetic changes produce drug tolerance. PLoS Biol (2007) 1.18
Phase coupling of a circadian neuropeptide with rest/activity rhythms detected using a membrane-tethered spider toxin. PLoS Biol (2008) 1.17
PDF-modulated visual inputs and cryptochrome define diurnal behavior in Drosophila. Nat Neurosci (2009) 1.16
Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol (2004) 1.15
PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila. PLoS One (2011) 1.12
A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell (2015) 1.10
Dominant-negative CK2alpha induces potent effects on circadian rhythmicity. PLoS Genet (2007) 1.09
Flies, clocks and evolution. Philos Trans R Soc Lond B Biol Sci (2001) 1.08
Dual PDF signaling pathways reset clocks via TIMELESS and acutely excite target neurons to control circadian behavior. PLoS Biol (2014) 1.07
The novel gene twenty-four defines a critical translational step in the Drosophila clock. Nature (2011) 1.06
Light-mediated TIM degradation within Drosophila pacemaker neurons (s-LNvs) is neither necessary nor sufficient for delay zone phase shifts. Neuron (2010) 1.05
The blue-light photoreceptor CRYPTOCHROME is expressed in a subset of circadian oscillator neurons in the Drosophila CNS. J Biol Rhythms (2008) 1.05
Impaired clock output by altered connectivity in the circadian network. Proc Natl Acad Sci U S A (2007) 1.04
Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits? Invert Neurosci (2009) 1.04
Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila. BMC Neurosci (2004) 1.03
Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. Cell Rep (2012) 1.02
An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator. J Neurosci (2009) 1.01
CLOCK expression identifies developing circadian oscillator neurons in the brains of Drosophila embryos. BMC Neurosci (2008) 1.00
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Proc Natl Acad Sci U S A (2006) 0.99
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol Neurobiol (2009) 0.99
A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. PLoS Genet (2009) 0.98
Identification of a complex peptidergic neuroendocrine network in the hard tick, Rhipicephalus appendiculatus. Cell Tissue Res (2008) 0.98
From genetics to structure to function: exploring sleep in Drosophila. Int Rev Neurobiol (2011) 0.95
Cryptochrome restores dampened circadian rhythms and promotes healthspan in aging Drosophila. Aging Cell (2013) 0.95
The transcription factor Mef2 is required for normal circadian behavior in Drosophila. J Neurosci (2010) 0.94
Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. PLoS One (2010) 0.93
The regulation of circadian clocks by light in fruitflies and mice. Philos Trans R Soc Lond B Biol Sci (2001) 0.93
The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. J Neurosci (2009) 0.93
A mechanism for circadian control of pacemaker neuron excitability. J Biol Rhythms (2012) 0.93
Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Genetics (2002) 0.93
Neuroarchitecture of peptidergic systems in the larval ventral ganglion of Drosophila melanogaster. PLoS One (2007) 0.93
PDF and cAMP enhance PER stability in Drosophila clock neurons. Proc Natl Acad Sci U S A (2014) 0.92
Perturbing dynamin reveals potent effects on the Drosophila circadian clock. PLoS One (2009) 0.92
The circadian clock in the brain: a structural and functional comparison between mammals and insects. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2004) 0.91
Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol (2007) 0.91
Comparative analysis of Pdf-mediated circadian behaviors between Drosophila melanogaster and D. virilis. Genetics (2009) 0.91
Genetic analysis of ectopic circadian clock induction in Drosophila. J Biol Rhythms (2009) 0.90
Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons. Mol Cell Biol (2008) 0.90
Defective transfer of seminal-fluid materials during matings of semi-fertile fruitless mutants in Drosophila. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2006) 0.90
A functional misexpression screen uncovers a role for enabled in progressive neurodegeneration. PLoS One (2008) 0.90
Analysis of cell identity, morphology, apoptosis and mitotic activity in a primary neural cell culture system in Drosophila. Neural Dev (2012) 0.89
Pigment-dispersing factor modulates pheromone production in clock cells that influence mating in drosophila. Neuron (2013) 0.89
Function of the Shaw potassium channel within the Drosophila circadian clock. PLoS One (2008) 0.88
Differentially timed extracellular signals synchronize pacemaker neuron clocks. PLoS Biol (2014) 0.87
The transcription factor Mef2 links the Drosophila core clock to Fas2, neuronal morphology, and circadian behavior. Neuron (2013) 0.87
In vitro imaging of primary neural cell culture from Drosophila. Nat Protoc (2013) 0.87
Studying circadian rhythms in Drosophila melanogaster. Methods (2014) 0.86
The central clock neurons regulate lipid storage in Drosophila. PLoS One (2011) 0.86
The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila. EMBO Rep (2011) 0.86
Pigment-Dispersing Factor Signaling and Circadian Rhythms in Insect Locomotor Activity. Curr Opin Insect Sci (2014) 0.86
Adult circadian behavior in Drosophila requires developmental expression of cycle, but not period. PLoS Genet (2011) 0.86
The clock input to the first optic neuropil of Drosophila melanogaster expressing neuronal circadian plasticity. PLoS One (2011) 0.85
Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep. Genetics (2012) 0.85
Clk post-transcriptional control denoises circadian transcription both temporally and spatially. Nat Commun (2015) 0.84
A self-organized model for cell-differentiation based on variations of molecular decay rates. PLoS One (2012) 0.83
Fluorescence/luminescence circadian imaging of complex tissues at single-cell resolution. J Biol Rhythms (2010) 0.83
Altered LARK expression perturbs development and physiology of the Drosophila PDF clock neurons. Mol Cell Neurosci (2009) 0.82
A rapid MALDI-TOF mass spectrometry workflow for Drosophila melanogaster differential neuropeptidomics. Mol Brain (2013) 0.82
Spatial and circadian regulation of cry in Drosophila. J Biol Rhythms (2008) 0.82
Positive geotactic behaviors induced by geomagnetic field in Drosophila. Mol Brain (2016) 0.82
Cellular requirements for LARK in the Drosophila circadian system. J Biol Rhythms (2012) 0.81
Daily rhythms in locomotor circuits in Drosophila involve PDF. J Neurophysiol (2013) 0.81
Insulin/IGF-regulated size scaling of neuroendocrine cells expressing the bHLH transcription factor Dimmed in Drosophila. PLoS Genet (2013) 0.81
Synergistic interactions between the molecular and neuronal circadian networks drive robust behavioral circadian rhythms in Drosophila melanogaster. PLoS Genet (2014) 0.80
Mmp1 processing of the PDF neuropeptide regulates circadian structural plasticity of pacemaker neurons. PLoS Genet (2014) 0.79
Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation. Neuron (2016) 0.79
A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein. Genetics (2011) 0.79
Chronobiological analysis and mass spectrometric characterization of pigment-dispersing factor in the cockroach Leucophaea maderae. J Insect Sci (2005) 0.78
A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma (1989) 16.41
Molecular bases for circadian clocks. Cell (1999) 13.96
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science (1998) 5.72
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell (1999) 5.14
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell (1998) 4.81
A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell (1999) 4.08
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86
Ectopic expression in Drosophila. Methods Cell Biol (1994) 3.50
PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol Cell Biol (1999) 2.29
A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster. Mol Cell Biol (1997) 2.11
Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants. J Comp Physiol A (1998) 1.89
The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc Natl Acad Sci U S A (1995) 1.58
Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling. J Neurosci (1997) 1.47
Development of pigment-dispersing hormone-immunoreactive neurons in the nervous system of Drosophila melanogaster. J Comp Neurol (1997) 1.40
Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity. J Comp Neurol (1993) 1.39
Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster. J Biol Rhythms (1998) 1.38
Organization of the circadian system in insects. Chronobiol Int (1998) 1.32
A molecular rhythm mediating circadian clock output in Drosophila. Neuron (1998) 1.26
A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock. EMBO J (1997) 1.17
Neural substrates of Drosophila rhythms revealed by mutants and molecular manipulations. Curr Opin Neurobiol (1998) 1.15
A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression. EMBO J (1996) 1.14
Ontogeny of a biological clock in Drosophila melanogaster. Proc Natl Acad Sci U S A (1992) 1.14
Involvement of the period gene in developmental time-memory: effect of the perShort mutation on phase shifts induced by light pulses delivered to Drosophila larvae. J Biol Rhythms (2000) 0.96
Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics (1972) 22.68
Nucleotide sequences that signal the initiation of transcription and translation in Bacillus subtilis. Mol Gen Genet (1982) 12.95
Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. J Virol (1999) 7.72
Three abundance classes in HeLa cell messenger RNA. Nature (1974) 6.79
Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 gene. Nucleic Acids Res (1984) 6.78
Number and distribution of polyadenylated RNA sequences in yeast. Cell (1977) 5.93
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature (1990) 5.69
Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm. Cell (1989) 5.46
Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing. Cell (1989) 5.42
Independent photoreceptive circadian clocks throughout Drosophila. Science (1997) 5.18
Isolation of yeast histone genes H2A and H2B. Cell (1979) 5.17
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell (1999) 5.14
Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes. Nature (1987) 5.13
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev (1997) 5.13
PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature (1993) 4.96
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell (1998) 4.81
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell (2001) 4.73
B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol (1989) 4.61
Microarray analysis and organization of circadian gene expression in Drosophila. Cell (2001) 4.59
The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr Biol (1997) 4.35
A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5' cleavage site. EMBO J (1988) 4.34
A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP. Cell (2000) 4.33
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev (1998) 4.29
CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell (1998) 4.22
Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant. Proc Natl Acad Sci U S A (1993) 4.18
Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: implications for U1 RNA and metazoan mRNA splicing. Cell (1983) 4.13
Quantitative analysis of Drosophila period gene transcription in living animals. J Biol Rhythms (1997) 4.09
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci U S A (1997) 4.07
The effect of temperature-sensitive RNA mutants on the transcription products from cloned ribosomal protein genes of yeast. Cell (1981) 3.97
Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast. Proc Natl Acad Sci U S A (1983) 3.90
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89
Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol (2001) 3.86
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86
Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell (1997) 3.85
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron (2000) 3.73
Quality control of mRNA 3'-end processing is linked to the nuclear exosome. Nature (2001) 3.69
The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Cell (1997) 3.68
Solitary necrotic nodules of the liver simulating hepatic metastases. J Clin Pathol (1983) 3.67
Messenger and heterogeneous nuclear RNA in HeLa cells: differential inhibition by cordycepin. Proc Natl Acad Sci U S A (1970) 3.67
Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol (1994) 3.66
CDKN2A mutations in multiple primary melanomas. N Engl J Med (1998) 3.52
Temporal phosphorylation of the Drosophila period protein. Proc Natl Acad Sci U S A (1994) 3.43
mRNA splicing efficiency in yeast and the contribution of nonconserved sequences. Cell (1985) 3.42
Gains in bone mineral density with resolution of vitamin D intoxication. Ann Intern Med (1997) 3.36
Conditioned responses in courtship behavior of normal and mutant Drosophila. Proc Natl Acad Sci U S A (1979) 3.31
Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell (1996) 3.30
Epitopes that span the tau molecule are shared with paired helical filaments. Neuron (1988) 3.28
Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure. Genes Dev (1992) 3.26
Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials. Lancet (2000) 3.25
Fas-induced caspase denitrosylation. Science (1999) 3.21
Isolation of cloned DNA sequences containing ribosomal protein genes from Saccharomyces cerevisiae. Cell (1979) 3.19
The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition. Genes Dev (1994) 3.14
Specific small nuclear RNAs are associated with yeast spliceosomes. Cell (1986) 3.08
Polynucleotide sequences in eukaryotic DNA and RNA that form ribonuclease-resistant complexes with polyuridylic acid. J Mol Biol (1974) 3.07
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene. Nature (1987) 3.05
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast. Cell (1995) 3.03
Fate mapping of nervous system and other internal tissues in genetic mosaics of Drosophila melanogaster. Dev Biol (1976) 2.99
Necrotising granulomata in prostatic resection specimens--a sequel to previous operation. J Clin Pathol (1983) 2.97
Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity (1998) 2.95
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A (1988) 2.95
Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J Neurosci (1990) 2.93
Chromosome segregation influenced by two alleles of the meiotic mutant c(3)G in Drosophila melanogaster. Genetics (1972) 2.92
Antigens displayed on murine B lymphocyte precursors. J Immunol (1981) 2.91
A light-entrainment mechanism for the Drosophila circadian clock. Nature (1996) 2.84
Central melanocortin receptors regulate insulin action. J Clin Invest (2001) 2.83
A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science (1990) 2.80
Two genes for ribosomal protein 51 of Saccharomyces cerevisiae complement and contribute to the ribosomes. Mol Cell Biol (1984) 2.80
The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae. EMBO J (1999) 2.80
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res (1995) 2.79
Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev (1998) 2.76
Laryngoscopy: time to change our view. Anaesthesia (2009) 2.70
Presence of depressive symptoms during early pregnancy and the risk of preterm delivery: a prospective cohort study. Hum Reprod (2008) 2.68
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res (1993) 2.65
A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. Genes Dev (1998) 2.64
Early commitment of yeast pre-mRNA to the spliceosome pathway. Mol Cell Biol (1988) 2.64
Bright light treatment of winter depression: a placebo-controlled trial. Arch Gen Psychiatry (1998) 2.62
Neuroanatomy of cells expressing clock genes in Drosophila: transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J Comp Neurol (2000) 2.61
The practice of neurology, 2000-2010: report of the AAN Member Research Subcommittee. Neurology (2011) 2.59
Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene. J Mol Biol (1985) 2.58
A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. RNA (1998) 2.55
Disproportionate distribution of Burkholderia cepacia complex species and transmissibility markers in cystic fibrosis. Am J Respir Crit Care Med (2001) 2.55
A Drosophila Minute gene encodes a ribosomal protein. Nature (1985) 2.53
Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol (1989) 2.50
Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song. Proc Natl Acad Sci U S A (1980) 2.50
S. cerevisiae U1 RNA is large and has limited primary sequence homology to metazoan U1 snRNA. Cell (1987) 2.48
Symmetrical peripheral gangrene and disseminated intravascular coagulation. Arch Dermatol (1985) 2.45
Stopping time: the genetics of fly and mouse circadian clocks. Annu Rev Neurosci (2001) 2.44
Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology (1984) 2.42
A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription. Mol Cell (2001) 2.41
Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system. Neuron (1988) 2.41