Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.

PubWeight™: 3.80‹?› | Rank: Top 1%

🔗 View Article (PMID 9604935)

Published in Cell on May 15, 1998

Authors

A V Khokhlatchev1, B Canagarajah, J Wilsbacher, M Robinson, M Atkinson, E Goldsmith, M H Cobb

Author Affiliations

1: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas 75235-9041, USA.

Articles citing this

(truncated to the top 100)

Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol (1999) 5.93

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J (1999) 4.68

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol (2000) 4.29

Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J (1998) 3.87

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J (1999) 3.17

Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 3.07

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle (2009) 3.05

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex. Proc Natl Acad Sci U S A (2000) 2.69

Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers. J Clin Oncol (2011) 2.59

Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae. Mol Biol Cell (1999) 2.46

Disease resistance and abiotic stress tolerance in rice are inversely modulated by an abscisic acid-inducible mitogen-activated protein kinase. Plant Cell (2003) 2.39

Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121. Genes Dev (1998) 2.30

Light-activated kinases enable temporal dissection of signaling networks in living cells. J Am Chem Soc (2011) 2.22

MAPK signalling: ERK5 versus ERK1/2. EMBO Rep (2006) 2.19

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol (1999) 2.17

Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim Biophys Acta (2007) 1.97

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol Cell Biol (2002) 1.88

An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors. Genes Dev (2002) 1.73

Smooth muscle signalling pathways in health and disease. J Cell Mol Med (2008) 1.72

Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins. J Cell Biol (1998) 1.69

Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange. Proc Natl Acad Sci U S A (2001) 1.66

Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5. Mol Cell Biol (2005) 1.65

A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Eukaryot Cell (2005) 1.62

Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism. J Cell Biol (2000) 1.60

A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med (2008) 1.56

ERK2 enters the nucleus by a carrier-independent mechanism. Proc Natl Acad Sci U S A (2002) 1.54

Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. J Cell Biol (2001) 1.54

STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7. Mol Biol Cell (2008) 1.54

Phosphorylation meets nuclear import: a review. Cell Commun Signal (2010) 1.49

Autophagy proteins regulate ERK phosphorylation. Nat Commun (2013) 1.47

Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Genes Dev (2000) 1.46

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nat Struct Mol Biol (2013) 1.46

ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation. Plant Physiol (2000) 1.46

Cellular localization and role of kinase activity of PMK1 in Magnaporthe grisea. Eukaryot Cell (2004) 1.44

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J (2002) 1.40

Cortactin: a multifunctional regulator of cellular invasiveness. Cell Adh Migr (2011) 1.36

Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Mol Cell Biol (1999) 1.31

ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation. J Biol Chem (2009) 1.31

Extracellular regulated kinase (ERK) interaction with actin and the calponin homology (CH) domain of actin-binding proteins. Biochem J (1999) 1.29

Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle (2008) 1.25

GnRH signaling, the gonadotrope and endocrine control of fertility. Front Neuroendocrinol (2010) 1.23

Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence. J Neurosci (1999) 1.22

Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. Biochem J (2004) 1.20

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation. Mol Cell Biol (1999) 1.18

Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms. Mol Cell Biol (2006) 1.18

Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways. Mol Cell Biol (2002) 1.17

Control of MAP kinase signaling to the nucleus. Chromosoma (2005) 1.16

Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells. Am J Pathol (2000) 1.15

Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells. J Cell Biol (2004) 1.14

Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta. Mol Cell Biol (2001) 1.13

Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast. Mol Biol Cell (1999) 1.13

Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Mol Carcinog (2010) 1.12

Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation. Mol Cell Biol (1999) 1.11

Effect of the pheromone-responsive G(alpha) and phosphatase proteins of Saccharomyces cerevisiae on the subcellular localization of the Fus3 mitogen-activated protein kinase. Mol Cell Biol (2003) 1.10

Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol (2008) 1.09

Activation-induced nuclear translocation of RING3. J Cell Sci (2000) 1.06

Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye. Development (2003) 1.06

MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing. Development (2005) 1.04

MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development. Mol Cell Biol (2004) 1.04

Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde. Eur J Pharmacol (2007) 1.04

Fibroblast growth factor receptor-1 signaling in pancreatic islet beta-cells is modulated by the extracellular matrix. Mol Endocrinol (2007) 1.03

Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. Mol Cell Biol (2004) 1.02

Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2. Mol Cell Biol (2001) 1.02

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. EMBO J (2006) 1.01

Rice mitogen-activated protein kinase interactome analysis using the yeast two-hybrid system. Plant Physiol (2012) 1.01

Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. J Natl Cancer Inst (2013) 1.01

Active ERK1 is dimerized in vivo: bisphosphodimers generate peak kinase activity and monophosphodimers maintain basal ERK1 activity. J Cell Sci (2005) 1.00

FRET-based detection of different conformations of MK2. EMBO Rep (2001) 0.99

A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells. PLoS One (2009) 0.99

p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. BMC Cancer (2010) 0.99

Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13- acetate-induced apoptotic cells. Mol Cell Biol (2002) 0.98

AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2. Am J Respir Cell Mol Biol (2006) 0.98

Mxi2 promotes stimulus-independent ERK nuclear translocation. EMBO J (2007) 0.97

Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun (2013) 0.96

Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase. Biochem J (2002) 0.96

Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif. J Biol Chem (2009) 0.96

Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7. Mol Biol Cell (2007) 0.95

Interface analysis of the complex between ERK2 and PTP-SL. PLoS One (2009) 0.94

h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells. Mol Biol Cell (2010) 0.94

Homodimerization of Nemo-like kinase is essential for activation and nuclear localization. Mol Biol Cell (2010) 0.94

Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site. EMBO J (2005) 0.93

Novel membrane-targeted ERK1 and ERK2 chimeras which act as dominant negative, isotype-specific mitogen-activated protein kinase inhibitors of Ras-Raf-mediated transcriptional activation of c-fos in NIH 3T3 cells. Mol Cell Biol (1999) 0.93

Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Mol Biol Cell (2003) 0.93

Dimerization in protein kinase signaling. J Biol (2006) 0.93

Interference with ERK(Thr188) phosphorylation impairs pathological but not physiological cardiac hypertrophy. Proc Natl Acad Sci U S A (2013) 0.93

Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell (1999) 0.93

Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions. J Cell Sci (2010) 0.92

Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation. Mol Cell Biol (2004) 0.92

Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution. J Cell Biol (2000) 0.92

Intermolecular interactions between retroviral Gag proteins in the nucleus. J Virol (2007) 0.92

Constitutive activity of JNK2 alpha2 is dependent on a unique mechanism of MAPK activation. J Biol Chem (2008) 0.92

A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours. Br J Cancer (2014) 0.92

Localization of ERK/MAP kinase is regulated by the alphaherpesvirus tegument protein Us2. J Virol (2006) 0.92

Combination of two activating mutations in one HOG1 gene forms hyperactive enzymes that induce growth arrest. Mol Cell Biol (2003) 0.91

Phosphorylation-dependent changes in structure and dynamics in ERK2 detected by SDSL and EPR. Biophys J (2004) 0.91

Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria. PLoS One (2008) 0.91

The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions. Genes Dev (2003) 0.91

Activated ERK2 is a monomer in vitro with or without divalent cations and when complexed to the cytoplasmic scaffold PEA-15. Biochemistry (2011) 0.90

Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6). Biochem J (2004) 0.90

Protein phosphorylation in plant immunity: insights into the regulation of pattern recognition receptor-mediated signaling. Front Plant Sci (2012) 0.90

Articles by these authors

Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science (2001) 24.48

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54

Mitogen-activated protein kinase pathways. Curr Opin Cell Biol (1997) 9.10

Whole-genome association study of bipolar disorder. Mol Psychiatry (2008) 6.80

Differential regulation and properties of MAPKs. Oncogene (2007) 6.36

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell (1992) 5.11

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature (1994) 4.97

MAP kinases. Chem Rev (2001) 4.70

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science (1990) 4.63

Codon usage can affect efficiency of translation of genes in Escherichia coli. Nucleic Acids Res (1984) 4.51

Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med (2001) 4.27

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell (1997) 4.26

Is your 'double-blind' design truly double-blind? Br J Psychiatry (1989) 3.98

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem (2000) 3.97

Phosphorylation activates the insulin receptor tyrosine protein kinase. Proc Natl Acad Sci U S A (1983) 3.94

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J (1995) 3.86

Palliative intubation of oesophagogastric neoplasms at fibreoptic endoscopy. Gut (1982) 3.68

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. J Biol Chem (1993) 3.57

5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology (1987) 3.35

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc Natl Acad Sci U S A (1991) 3.31

Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol (1998) 3.22

Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81. Thorax (1990) 3.02

Non-steroidal anti-inflammatory drugs and benign oesophageal stricture. Br Med J (Clin Res Ed) (1982) 2.99

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul (1991) 2.88

Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors. Proc Natl Acad Sci U S A (1998) 2.80

Coping with winter bed crises. New surveillance systems might help. BMJ (1999) 2.78

Effect of different operation policies on mortality from bleeding peptic ulcer. Lancet (1979) 2.74

Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding. N Engl J Med (1983) 2.72

Validation of the Hospital Anxiety and Depression Scale for use with adolescents. Br J Psychiatry (1999) 2.68

Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. Mol Cell Biol (1997) 2.63

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J (1997) 2.57

Nizatidine versus placebo in gastroesophageal reflux disease: a 12-week, multicenter, randomized, double-blind study. Am J Gastroenterol (1991) 2.54

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proc Natl Acad Sci U S A (1982) 2.40

New insights into the control of MAP kinase pathways. Exp Cell Res (1999) 2.39

Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1995) 2.33

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J Biol Chem (1992) 2.29

THE RENAL CLEARANCE OF PENICILLINS F, G, K, AND X IN RABBITS AND MAN. J Clin Invest (1947) 2.29

Pneumatic dilatation in achalasia. Gut (1983) 2.29

Performance of the ACG case-mix system in two Canadian provinces. Med Care (2001) 2.27

Isolation of MEK5 and differential expression of alternatively spliced forms. J Biol Chem (1995) 2.23

Oesophageal acid-perfusion in the diagnosis of precordial pain. Lancet (1966) 2.22

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Curr Biol (1998) 2.20

Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system. Gut (1982) 2.19

The Leeds University Maternity Audit Project. Int J Qual Health Care (2002) 2.19

A prospective comparison of laser therapy and intubation in endoscopic palliation for malignant dysphagia. Gastroenterology (1991) 2.18

Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone (1996) 2.11

The differentiation between oesophageal and cardiac pain. Lancet (1966) 2.11

Nizatidine versus placebo in gastro-oesophageal reflux disease: a 12-week, multicentre, randomised, double-blind study. Br J Clin Pract Suppl (1994) 2.09

Carcinogenic effects of acrylamide in Sencar and A/J mice. Cancer Res (1984) 2.07

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell (1998) 2.07

ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties. Gene Ther (2003) 2.05

Multicentre survey of radiologically inserted gastrostomy feeding tube (RIG) in the UK. Clin Radiol (2012) 2.04

Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. J Biol Chem (1997) 2.03

Fibreoptic endoscopic palliative intubation of inoperable oesophagogastric neoplasms. Br Med J (1977) 2.03

'But they don't see the whole child...' health visitors may not welcome systematic reviews of child health surveillance. Br J Gen Pract (1999) 2.02

Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. Biochemistry (1991) 2.01

Single pass sequencing and physical and genetic mapping of human brain cDNAs. Nat Genet (1992) 2.01

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol (1996) 2.00

Tube introducer and modified Celestin tube for use in palliative intubation of oesophagogastric neoplasms at fibreoptic endoscopy. Gut (1978) 2.00

The function of the urinary tubules in the frog. J Physiol (1921) 1.97

Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma. Gut (1992) 1.96

Value of endoscopic surveillance in the detection of neoplastic change in Barrett's oesophagus. Br J Surg (1988) 1.91

Comparison of surgical and medical management of bleeding peptic ulcers. Br Med J (Clin Res Ed) (1982) 1.90

Structural basis of inhibitor selectivity in MAP kinases. Structure (1998) 1.89

Maintenance chemotherapy for anaplastic small cell carcinoma of the bronchus: a randomised, controlled trial. Cancer Chemother Pharmacol (1986) 1.87

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation. J Biol Chem (1998) 1.86

Homograft replacement of the aortic valve. Immediate results and follow-up. Lancet (1968) 1.85

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc Natl Acad Sci U S A (1992) 1.83

The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc Natl Acad Sci U S A (1997) 1.83

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proc Natl Acad Sci U S A (1992) 1.83

Non-invasive evaluation of liver cirrhosis using ultrasound. Clin Radiol (2009) 1.82

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J Immunol (2000) 1.82

A prospective, randomised study of endoscopy and radiology in acute upper-gastrointestinal-tract bleeding. Lancet (1977) 1.81

The effects of emotions on short-term power spectrum analysis of heart rate variability . Am J Cardiol (1995) 1.80

Gastroenterology services: a regional review of changes over a five year period (1981-86). Gut (1989) 1.79

Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. Biochemistry (1996) 1.78

Esophageal intraluminal pH recording in the assessment of gastroesophageal reflux and its consequences. Am J Dig Dis (1977) 1.76

Dental caries and microbial acid production in twins. Caries Res (2005) 1.73

A comparison of the national registry of myocardial infarction 2 with the cooperative cardiovascular project. J Am Coll Cardiol (1999) 1.71

Gastroenterology services: a regional review. Br Med J (Clin Res Ed) (1984) 1.71

Ki-ras mutations in adenomas: a characteristic of cancer-bearing colorectal mucosa. J Pathol (1996) 1.70

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A (1994) 1.67

Molecular mapping of wheat: major genes and rearrangements in homoeologous groups 4, 5, and 7. Genetics (1995) 1.67

Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer (1993) 1.67

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1995) 1.65

Studies of incidence and prevalence of achalasia in the Nottingham area. Q J Med (1985) 1.64

Relationships between B-lineage lymphocytes and stromal cells in long-term bone marrow cultures. Eur J Immunol (1987) 1.64

Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases. J Biol Chem (1998) 1.64

Alternative medicine consultations and remedies in patients with the irritable bowel syndrome. Gut (1986) 1.63

Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. J Biol Chem (1999) 1.63

High-throughput profiling of the mitochondrial proteome using affinity fractionation and automation. Electrophoresis (2000) 1.61

The accuracy of diagnoses as reported in families with cancer: a retrospective study. J Med Genet (1999) 1.61

Mesalamine capsules for treatment of active ulcerative colitis: results of a controlled trial. Pentasa Study Group. Am J Gastroenterol (1993) 1.61

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol (2000) 1.60

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

An evaluation of multiphasic screening on admission to hospital. Precis of a report to the National Health and Medical Research Council. Med J Aust (1976) 1.59

Description of a protein kinase derived from insulin-treated 3T3-L1 cells that catalyzes the phosphorylation of ribosomal protein S6 and casein. J Biol Chem (1983) 1.59