Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.

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Published in Immunity on May 01, 1998

Authors

Y Refaeli1, L Van Parijs, C A London, J Tschopp, A K Abbas

Author Affiliations

1: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9. Nature (1982) 2.35

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In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen. J Exp Med (1993) 1.57

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Lomustine (CCNU) for the treatment of resistant lymphoma in dogs. J Vet Intern Med (1999) 1.54

TWEAK can induce cell death via endogenous TNF and TNF receptor 1. Eur J Immunol (1999) 1.52

Role of interleukin 1 in the activation of T lymphocytes. Proc Natl Acad Sci U S A (1988) 1.52

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FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. J Immunol (1998) 1.49

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Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons. EMBO J (1996) 1.48

Circular polymerization of the membranolytic ninth component of complement. Dependence on metal ions. J Biol Chem (1984) 1.48

Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res (2000) 1.47