Chemokine receptors: keys to AIDS pathogenesis?

PubWeight™: 2.15‹?› | Rank: Top 2%

🔗 View Article (PMID 9630212)

Published in Cell on May 29, 1998

Authors

D R Littman1

Author Affiliations

1: Howard Hughes Medical Institute, Department of Microbiology, New York University Medical Center, New York 10016, USA.

Articles citing this

Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56

Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120. J Virol (2000) 6.71

Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection. EMBO Rep (2000) 3.23

High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation. Blood (2008) 3.19

Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci U S A (1998) 3.18

Leukocyte polarization in cell migration and immune interactions. EMBO J (1999) 3.08

Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1. J Virol (2000) 2.95

Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol (2005) 2.83

Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5. J Virol (1999) 2.23

G protein βγ subunits: central mediators of G protein-coupled receptor signaling. Cell Mol Life Sci (2008) 2.05

Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J (2001) 1.94

Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J Clin Invest (1999) 1.91

Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein. Proc Natl Acad Sci U S A (1999) 1.66

Chemokines in tumor angiogenesis and metastasis. Cancer Metastasis Rev (2007) 1.63

N-linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic human immunodeficiency virus type 1 isolate DH12 gp120 affect coreceptor usage and cellular tropism. J Virol (2001) 1.51

A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. J Virol (1999) 1.48

HCV/ HIV co-infection: time to re-evaluate the role of HIV in the liver? J Viral Hepat (2008) 1.45

Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope. J Virol (1999) 1.40

Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors. EMBO J (2001) 1.39

Blocking of HIV-1 infection by targeting CD4 to nonraft membrane domains. J Exp Med (2002) 1.28

Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries. J Virol (1999) 1.24

The neutral glycosphingolipid globotriaosylceramide promotes fusion mediated by a CD4-dependent CXCR4-utilizing HIV type 1 envelope glycoprotein. Proc Natl Acad Sci U S A (1998) 1.23

Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120. BMC Infect Dis (2001) 1.21

Anti-HIV-1 activity of cellulose acetate phthalate: synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles. BMC Infect Dis (2002) 1.20

HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization. Proc Natl Acad Sci U S A (2000) 1.19

HIV: master of the host cell. Genome Biol (2001) 1.18

Human immunodeficiency virus type 1 (HIV-1)-induced GRO-alpha production stimulates HIV-1 replication in macrophages and T lymphocytes. J Virol (2001) 1.17

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. Proc Natl Acad Sci U S A (1999) 1.11

Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells. J Clin Invest (1999) 1.09

Envelope-dependent restriction of human immunodeficiency virus type 1 spreading in CD4(+) T lymphocytes: R5 but not X4 viruses replicate in the absence of T-cell receptor restimulation. J Virol (1999) 1.07

Pharmacological characterization of the chemokine receptor, CCR5. Br J Pharmacol (2002) 1.00

Sensitivity to a nonpeptidic compound (RPR103611) blocking human immunodeficiency virus type 1 Env-mediated fusion depends on sequence and accessibility of the gp41 loop region. J Virol (2000) 0.98

R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4+ T-cell cultures than X4 HIV-1. J Virol (2004) 0.98

Chemokines as molecular targets for therapeutic intervention. J Clin Immunol (1999) 0.96

Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and world populations and its implication in AIDS epidemiology. Am J Hum Genet (1999) 0.93

Modulation of gut-specific mechanisms by chronic δ(9)-tetrahydrocannabinol administration in male rhesus macaques infected with simian immunodeficiency virus: a systems biology analysis. AIDS Res Hum Retroviruses (2014) 0.92

Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor. EMBO J (2003) 0.92

Human immunodeficiency virus type 1 envelope-mediated neuronal death: uncoupling of viral replication and neurotoxicity. J Virol (2003) 0.91

Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors. J Exp Med (1999) 0.90

Selective inhibition of HIV replication in primary macrophages but not T lymphocytes by macrophage-derived chemokine. Proc Natl Acad Sci U S A (2000) 0.89

CD4-independent infection of two CD4(-)/CCR5(-)/CXCR4(+) pre-T-cell lines by human and simian immunodeficiency viruses. J Virol (2000) 0.89

Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents. Bioorg Med Chem Lett (2010) 0.87

Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents. Curr Med Chem (2015) 0.87

cDNA cloning and characterization of guinea-pig leukotriene B4 receptor. Biochem J (1999) 0.85

Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. J Virol (2000) 0.84

Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models. J Chem Inf Model (2009) 0.84

Cytotoxic HIV-1 p55gag-specific CD4+ T cells produce HIV-inhibitory cytokines and chemokines. J Clin Immunol (2002) 0.83

CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth. Mol Cancer Ther (2009) 0.82

Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes. J Virol (2009) 0.80

HLA-G/C, miRNAs, and their role in HIV infection and replication. Biomed Res Int (2013) 0.79

Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines. Virol J (2013) 0.78

HIV-1 Transmission, Replication Fitness and Disease Progression. Virology (Auckl) (2008) 0.78

Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5. Genes Immun (2005) 0.76

Infection with HIV-1. BMJ (1998) 0.76

Genetic diversity and prevalence of CCR2-CCR5 gene polymorphisms in the Omani population. Genet Mol Biol (2013) 0.75

Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers. J Org Chem (2011) 0.75