Published in Trends Pharmacol Sci on May 01, 1998
Adenosine receptors as therapeutic targets. Nat Rev Drug Discov (2006) 6.15
The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol (2006) 1.94
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. J Med Chem (2000) 1.65
Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists. Br J Pharmacol (2001) 1.53
Investigational A₃ adenosine receptor targeting agents. Expert Opin Investig Drugs (2011) 1.49
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proc Natl Acad Sci U S A (2001) 1.47
Pharmacological and therapeutic effects of A3 adenosine receptor agonists. Drug Discov Today (2011) 1.44
Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem (1998) 1.32
Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. J Med Chem (2001) 1.21
Controlling murine and rat chronic pain through A3 adenosine receptor activation. FASEB J (2012) 1.20
The cross-species A3 adenosine-receptor antagonist MRS 1292 inhibits adenosine-triggered human nonpigmented ciliary epithelial cell fluid release and reduces mouse intraocular pressure. Curr Eye Res (2005) 1.17
Adenosine-induced presynaptic inhibition of IPSCs and EPSCs in rat hypothalamic supraoptic nucleus neurones. J Physiol (1999) 1.16
Adenosine receptors and cancer. Handb Exp Pharmacol (2009) 1.14
A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system. Am J Respir Cell Mol Biol (2008) 1.14
Pharmacogenomics of the cystic fibrosis transmembrane conductance regulator (CFTR) and the cystic fibrosis drug CPX using genome microarray analysis. Mol Med (1999) 1.11
New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC. Inflamm Bowel Dis (2009) 1.09
Behavioral characterization of mice lacking the A3 adenosine receptor: sensitivity to hypoxic neurodegeneration. Cell Mol Neurobiol (2003) 1.07
A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge. Am J Respir Cell Mol Biol (2006) 1.07
A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists. J Biol Chem (2000) 1.06
Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics. J Neurosci (2015) 1.03
Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg (2010) 1.01
Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line. Br J Pharmacol (2001) 0.96
Adenosine and protection from acute kidney injury. Curr Opin Nephrol Hypertens (2012) 0.96
Xanthines as adenosine receptor antagonists. Handb Exp Pharmacol (2011) 0.96
Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells. Br J Pharmacol (2001) 0.94
Activation and Desensitization of Rat A3-Adenosine Receptors by Selective Adenosine Derivatives and Xanthine-7-Ribosides. Drug Dev Res (1998) 0.91
A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation. Mol Pharmacol (2002) 0.91
A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats. Am J Pathol (2011) 0.91
p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA. Biochem Pharmacol (2002) 0.91
Role of adenosine A3 receptors on CA1 hippocampal neurotransmission during oxygen-glucose deprivation episodes of different duration. Biochem Pharmacol (2007) 0.86
Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability. Am J Physiol Heart Circ Physiol (2006) 0.85
Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics. Br J Pharmacol (2016) 0.84
Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.84
Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation. Front Immunol (2012) 0.83
Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Rep (2013) 0.83
Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors. Purinergic Signal (2015) 0.83
Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety. Bioorg Med Chem (2005) 0.82
Functionalized congeners of 1,4-dihydropyridines as antagonist molecular probes for A3 adenosine receptors. Bioconjug Chem (1999) 0.82
Adenosine A3 receptor activation attenuates lung ischemia-reperfusion injury. Ann Thorac Surg (2013) 0.81
A1 adenosine receptors inhibit multiple voltage-gated Ca2+ channel subtypes in acutely isolated rat basolateral amygdala neurons. Br J Pharmacol (2001) 0.79
Adenosine and its receptors as therapeutic targets: An overview. Saudi Pharm J (2012) 0.79
Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium. Pflugers Arch (2006) 0.79
Intracellular ATP concentration contributes to the cytotoxic and cytoprotective effects of adenosine. PLoS One (2013) 0.78
Adenosine receptors and renal ischaemia reperfusion injury. Acta Physiol (Oxf) (2014) 0.78
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes. Purinergic Signal (2007) 0.77
Adenosine receptor subtypes and the heart failure phenotype: translating lessons from mice to man. Trans Am Clin Climatol Assoc (2011) 0.77
Adenosine and ischemic preconditioning. Curr Pharm Des (1999) 0.77
Adenosine kinase is a new therapeutic target to prevent ischemic neuronal death. Open Drug Discov J (2010) 0.76
Adenosine A3 Receptor: A promising therapeutic target in cardiovascular disease. Curr Cardiol Rev (2016) 0.75
Pyran Template Approach to the Design of Novel A3 Adenosine Receptor Antagonists. Drug Dev Res (1999) 0.75
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells. Br J Pharmacol (2001) 0.75
Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor. Mol Pharmacol (2016) 0.75
Adenosine 2A receptors in acute kidney injury. Acta Physiol (Oxf) (2015) 0.75
Adenosine and its role in asthma. Indian J Clin Biochem (2001) 0.75
Pyrazolo derivatives as potent adenosine receptor antagonists: an overview on the structure-activity relationships. Int J Med Chem (2011) 0.75
Chapter 13. A3 Adenosine Receptors. Annu Rep Med Chem (1) 0.75
The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area. Sci Rep (2016) 0.75
125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor. Mol Pharmacol (1994) 2.65
Adenosine A3 receptor stimulation and cerebral ischemia. Eur J Pharmacol (1994) 2.33
Adenosine receptor subtypes: characterization and therapeutic regulation. Annu Rev Pharmacol Toxicol (1995) 2.19
Molecular cloning and characterization of the human A3 adenosine receptor. Proc Natl Acad Sci U S A (1993) 2.08
Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions. Trends Pharmacol Sci (1994) 1.87
Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacology (1997) 1.86
Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. J Immunol (1996) 1.75
Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Mol Pharmacol (1997) 1.74
Tissue distribution of adenosine receptor mRNAs in the rat. Br J Pharmacol (1996) 1.72
Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart. Cardiovasc Res (1994) 1.62
Direct preconditioning of cultured chick ventricular myocytes. Novel functions of cardiac adenosine A2a and A3 receptors. J Clin Invest (1996) 1.57
A3-adenosine receptors: design of selective ligands and therapeutic prospects. Drugs Future (1995) 1.41
G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain. Mol Pharmacol (1995) 1.40
Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution. Mol Pharmacol (1993) 1.40
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. J Med Chem (1996) 1.31
Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus. J Neurosci (1997) 1.29
Adenosine A3 receptor expression and function in eosinophils. Am J Respir Cell Mol Biol (1997) 1.28
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia. Am J Physiol (1997) 1.27
Differential interaction with and regulation of multiple G-proteins by the rat A3 adenosine receptor. J Biol Chem (1995) 1.26
Mast cell degranulation following adenosine A3 receptor activation in rats. Eur J Pharmacol (1996) 1.25
Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A(3) receptor agonists. Biochem Biophys Res Commun (1996) 1.23
Adenosine A3 receptors in mast cells. Trends Pharmacol Sci (1994) 1.21
Selective adenosine A3 receptor stimulation reduces ischemic myocardial injury in the rabbit heart. Cardiovasc Res (1997) 1.19
Activation of A3 adenosine receptors on human eosinophils elevates intracellular calcium. Blood (1996) 1.14
Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J Immunol (1997) 1.14
Adenosine-induced vasoconstriction in vivo. Role of the mast cell and A3 adenosine receptor. Circ Res (1996) 1.14
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem (1996) 1.13
Adenosine A3 receptor stimulation inhibits migration of human eosinophils. J Leukoc Biol (1997) 1.12
The A3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton, and distribution of Bcl-XL: studies in human astroglioma cells. Biochem Biophys Res Commun (1997) 1.10
Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists. J Med Chem (1997) 1.09
Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line. J Pharmacol Exp Ther (1996) 1.02
Adenosine inhibits the adhesion of anti-CD3-activated killer lymphocytes to adenocarcinoma cells through an A3 receptor. Cancer Res (1994) 1.00
In vivo role of the adenosine A3 receptor: N6-2-(4-aminophenyl)ethyladenosine induces bronchospasm in BDE rats by a neurally mediated mechanism involving cells resembling mast cells. J Pharmacol Exp Ther (1996) 0.99
Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists. Biochem Biophys Res Commun (1997) 0.96
Characterization of adenosine receptors involved in adenosine-induced bronchoconstriction in allergic rabbits. Br J Pharmacol (1996) 0.93
Molecular basis for subtype-specific desensitization of inhibitory adenosine receptors. Analysis of a chimeric A1-A3 adenosine receptor. J Biol Chem (1996) 0.93
[125I]4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I)AB-MECA) labels multiple adenosine receptor subtypes in rat brain. Brain Res (1997) 0.89
Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors? Drug Dev Res (1996) 0.89
Adenosine A3 receptors potentiate hippocampal calcium current by a PKA-dependent/PKC-independent pathway. Neuropharmacology (1997) 0.86
Modulation of apoptosis by adenosine in the central nervous system: a possible role for the A3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders. Ann N Y Acad Sci (1997) 0.80