Published in Mol Cell on May 01, 1998
Transcription regulation through promoter-proximal pausing of RNA polymerase II. Science (2008) 5.48
Real-time observation of transcription initiation and elongation on an endogenous yeast gene. Science (2011) 3.67
Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB. Genes Dev (1999) 2.94
Bromodomain factor 1 corresponds to a missing piece of yeast TFIID. Genes Dev (2000) 2.47
Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators. Genetics (2011) 1.65
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
H2A.Z has a function reminiscent of an activator required for preferential binding to intergenic DNA. EMBO J (2003) 1.43
Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. Genes Dev (1999) 1.39
p53 activates transcription by directing structural shifts in Mediator. Nat Struct Mol Biol (2010) 1.33
Gene looping is conferred by activator-dependent interaction of transcription initiation and termination machineries. J Biol Chem (2009) 1.21
Long-distance transcriptional enhancement by the histone acetyltransferase PCAF. Proc Natl Acad Sci U S A (1998) 1.19
An activation-specific role for transcription factor TFIIB in vivo. Proc Natl Acad Sci U S A (1999) 1.12
Artificial recruitment of TFIID, but not RNA polymerase II holoenzyme, activates transcription in mammalian cells. Mol Cell Biol (2000) 1.10
Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences. Proc Natl Acad Sci U S A (1999) 1.09
Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner. Mol Cell Biol (1999) 1.08
An artificial transcriptional activating region with unusual properties. Proc Natl Acad Sci U S A (2000) 1.07
The rye mutants identify a role for Ssn/Srb proteins of the RNA polymerase II holoenzyme during stationary phase entry in Saccharomyces cerevisiae. Genetics (2001) 1.03
Transcriptional activation by artificial recruitment in mammalian cells. Proc Natl Acad Sci U S A (1999) 1.03
Artificially recruited TATA-binding protein fails to remodel chromatin and does not activate three promoters that require chromatin remodeling. Mol Cell Biol (2000) 0.98
Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex. Retrovirology (2004) 0.98
Transcriptional regulation: effects of promoter proximal pausing on speed, synchrony and reliability. PLoS Comput Biol (2011) 0.97
TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo. Mol Cell Biol (2000) 0.97
Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain. Genes Dev (2001) 0.96
TFIIA interacts with TFIID via association with TATA-binding protein and TAF40. Mol Cell Biol (2001) 0.95
Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA. Mol Cell Biol (2012) 0.95
A general strategy to enhance the potency of chimeric transcriptional activators. Proc Natl Acad Sci U S A (1999) 0.92
A TATA-binding protein mutant defective for TFIID complex formation in vivo. Mol Cell Biol (1999) 0.87
The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function. Nucleic Acids Res (2003) 0.85
The development and characterization of synthetic minimal yeast promoters. Nat Commun (2015) 0.84
Identification of histone H4-like TAF in Schizosaccharomyces pombe as a protein that interacts with WD repeat-containing TAF. Nucleic Acids Res (2002) 0.83
Prodos is a conserved transcriptional regulator that interacts with dTAF(II)16 in Drosophila melanogaster. Mol Cell Biol (2001) 0.83
Mutations in the histone fold domain of the TAF12 gene show synthetic lethality with the TAF1 gene lacking the TAF N-terminal domain (TAND) by different mechanisms from those in the SPT15 gene encoding the TATA box-binding protein (TBP). Nucleic Acids Res (2003) 0.81
Yeast Ume6p repressor permits activator binding but restricts TBP binding at the HOP1 promoter. Nucleic Acids Res (2003) 0.81
Mediator Undergoes a Compositional Change during Transcriptional Activation. Mol Cell (2016) 0.79
The yeast protein Xtc1 functions as a direct transcriptional repressor. Nucleic Acids Res (2002) 0.79
Chromatin Association of Gcn4 Is Limited by Post-translational Modifications Triggered by its DNA-Binding in Saccharomyces cerevisiae. Genetics (2016) 0.77
RNA polymerase II pausing as a context-dependent reader of the genome. Biochem Cell Biol (2015) 0.77
Fungal mediator tail subunits contain classical transcriptional activation domains. Mol Cell Biol (2015) 0.76
Discrete promoter elements affect specific properties of RNA polymerase II transcription complexes. Nucleic Acids Res (2000) 0.75
High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. Proc Natl Acad Sci U S A (1979) 26.51
Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene (1979) 19.39
Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast. Proc Natl Acad Sci U S A (1985) 13.43
GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell (1985) 11.63
Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell (1986) 11.42
Isolation and characterisation of a yeast chromosomal replicator. Nature (1979) 9.14
Functional genetic expression of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1976) 8.92
Nucleotide sequence and transcriptional mapping of the yeast pet56-his3-ded1 gene region. Nucleic Acids Res (1985) 8.01
The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell (1992) 6.47
Saturation mutagenesis of the yeast his3 regulatory site: requirements for transcriptional induction and for binding by GCN4 activator protein. Science (1986) 6.36
Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature (1999) 6.20
Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure. EMBO J (1995) 5.74
Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast. Cell (1987) 5.59
GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J (1987) 5.32
Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein. Mol Cell Biol (1989) 5.23
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell (1997) 5.07
Production of a functional eukaryotic enzyme in Escherichia coli: cloning and expression of the yeast structural gene for imidazole-glycerolphosphate dehydratase (his3). Proc Natl Acad Sci U S A (1977) 4.86
The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell (1989) 4.72
Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex. Nature (1994) 4.50
Two related regulatory sequences are required for maximal induction of Saccharomyces cerevisiae his3 transcription. Mol Cell Biol (1987) 4.31
Transcription of the his3 gene region in Saccharomyces cerevisiae. J Mol Biol (1981) 4.30
Genetic properties and chromatin structure of the yeast gal regulatory element: an enhancer-like sequence. Proc Natl Acad Sci U S A (1984) 4.16
Deletion mapping a eukaryotic promoter. Proc Natl Acad Sci U S A (1981) 4.14
The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells. Cell (1992) 3.94
Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol Cell (2000) 3.80
The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous. Cell (1987) 3.79
Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein. Proc Natl Acad Sci U S A (1988) 3.79
Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein. Nature (1988) 3.77
Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev (1995) 3.70
Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol (1997) 3.55
Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol (1998) 3.51
TBP-associated factors are not generally required for transcriptional activation in yeast. Nature (1996) 3.45
The yeast his3 promoter contains at least two distinct elements. Proc Natl Acad Sci U S A (1982) 3.40
Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro. Mol Cell Biol (1990) 3.39
Constitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms. Mol Cell Biol (1986) 3.37
A physical, genetic and transcriptional map of the cloned his3 gene region of Saccharomyces cerevisiae. J Mol Biol (1980) 3.35
Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins. Trends Biochem Sci (1989) 3.32
Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase. Cell (1987) 3.26
Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity. Mol Cell Biol (1994) 3.18
The new yeast genetics. Nature (1983) 3.03
Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA. Nature (1990) 2.97
A wide variety of DNA sequences can functionally replace a yeast TATA element for transcriptional activation. Genes Dev (1990) 2.89
Cloning of random-sequence oligodeoxynucleotides. Gene (1986) 2.88
Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1996) 2.88
Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element. EMBO J (1985) 2.87
Promotor mutants of the yeast his3 gene. J Mol Biol (1981) 2.73
Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev (1998) 2.71
Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. Mol Cell (2000) 2.70
Direct selection for gene replacement events in yeast. Gene (1983) 2.69
NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev (1994) 2.69
ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol Cell Biol (1988) 2.47
The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature (1996) 2.44
Histone acetylation at promoters is differentially affected by specific activators and repressors. Mol Cell Biol (2001) 2.40
An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase. Proc Natl Acad Sci U S A (1989) 2.34
Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain. Nature (1995) 2.20
TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivo. Science (2000) 2.14
Regulatory sites for his3 gene expression in yeast. Nature (1982) 2.09
Yeast and human TFIID with altered DNA-binding specificity for TATA elements. Cell (1992) 2.04
Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites. Mol Cell Biol (1990) 2.00
Functional distinctions between yeast TATA elements. Mol Cell Biol (1989) 1.94
Suppressors of Saccharomyces cerevisiae his3 promoter mutations lacking the upstream element. Mol Cell Biol (1985) 1.93
CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters. EMBO J (1993) 1.85
The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell (1994) 1.85
Negative control at a distance mediates catabolite repression in yeast. Nature (1985) 1.81
Functional differences between yeast and human TFIID are localized to the highly conserved region. Cell (1991) 1.80
Promoter elements, regulatory elements, and chromatin structure of the yeast his3 gene. Cold Spring Harb Symp Quant Biol (1983) 1.78
The use of random-sequence oligonucleotides for determining consensus sequences. Methods Enzymol (1987) 1.78
Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo. Science (1994) 1.68
Mechanisms of transcriptional activation in vivo: two steps forward. Trends Genet (1996) 1.67
The TBP-TFIIA interaction in the response to acidic activators in vivo. Science (1995) 1.62
ACR1, a yeast ATF/CREB repressor. Mol Cell Biol (1992) 1.57
Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements. Mol Cell Biol (2000) 1.53
Constitutive and coordinately regulated transcription of yeast genes: promoter elements, positive and negative regulatory sites, and DNA binding proteins. Cold Spring Harb Symp Quant Biol (1985) 1.52
Mechanism of differential utilization of the his3 TR and TC TATA elements. Mol Cell Biol (1995) 1.51
Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro. Genes Dev (1992) 1.50
TFIIS enhances transcriptional elongation through an artificial arrest site in vivo. Mol Cell Biol (2001) 1.48
Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription. Science (1993) 1.46
The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding. Proc Natl Acad Sci U S A (1991) 1.45
Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo. Mol Cell Biol (2001) 1.45
Defining the consensus sequences of E.coli promoter elements by random selection. Nucleic Acids Res (1988) 1.44
Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter. Proc Natl Acad Sci U S A (1991) 1.44
Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol (1991) 1.42
Position effects in Saccharomyces cerevisiae. J Mol Biol (1981) 1.42
The histone H3-like TAF is broadly required for transcription in yeast. Mol Cell (1998) 1.41
Changing fos oncoprotein to a jun-independent DNA binding protein with GCN4 dimerization specificity by swapping "leucine zippers". Nature (1989) 1.39
Analysis of Saccharomyces cerevisiae his3 transcription in vitro: biochemical support for multiple mechanisms of transcription. Mol Cell Biol (1990) 1.38
Yeast upstream activator protein GCN4 can stimulate transcription when its binding site replaces the TATA element. EMBO J (1989) 1.35
Yeast homologues of higher eukaryotic TFIID subunits. Proc Natl Acad Sci U S A (1996) 1.32
Adaptability at the protein-DNA interface is an important aspect of sequence recognition by bZIP proteins. Proc Natl Acad Sci U S A (1993) 1.30
Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation. Genes Dev (1992) 1.29
Tc, an unusual promoter element required for constitutive transcription of the yeast HIS3 gene. Mol Cell Biol (1990) 1.29
Molecular characterization of GCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation. Nucleic Acids Res (1988) 1.29
Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. Nucleic Acids Res (1992) 1.26
Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo. Mol Cell Biol (1995) 1.25
Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast. Genetics (2000) 1.20
A new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo. Mol Cell Biol (1996) 1.18
A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo. Mol Cell Biol (1997) 1.16
Mutagenesis with degenerate oligonucleotides: an efficient method for saturating a defined DNA region with base pair substitutions. Methods Enzymol (1987) 1.16
Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol (2000) 1.15
MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells. Oncogene (2011) 1.14