Published in Cell on April 19, 1991
Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol (1996) 2.30
Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding protein. Mol Cell Biol (1994) 2.07
The conserved core of a human SIR2 homologue functions in yeast silencing. Mol Biol Cell (1999) 2.07
CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells. EMBO J (1995) 1.70
Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme. Mol Cell Biol (1998) 1.69
Transcription factor TFIID induces DNA bending upon binding to the TATA element. Proc Natl Acad Sci U S A (1992) 1.67
Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast. Mol Biol Cell (1992) 1.64
TFIIA induces conformational changes in TFIID via interactions with the basic repeat. Mol Cell Biol (1992) 1.55
An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p. Mol Cell Biol (2004) 1.51
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. EMBO J (1997) 1.45
Crystal structure of yeast TATA-binding protein and model for interaction with DNA. Proc Natl Acad Sci U S A (1993) 1.44
Upstream box/TATA box order is the major determinant of the direction of transcription. Nucleic Acids Res (1991) 1.42
The N-terminal domain of the human TATA-binding protein plays a role in transcription from TATA-containing RNA polymerase II and III promoters. EMBO J (1994) 1.37
A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol Cell Biol (1996) 1.37
The yeast SRM1 protein and human RCC1 protein share analogous functions. Cell Regul (1991) 1.34
Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau). Proc Natl Acad Sci U S A (1992) 1.33
Codon reiteration and the evolution of proteins. Proc Natl Acad Sci U S A (1994) 1.29
Yeast TATA binding protein interaction with DNA: fluorescence determination of oligomeric state, equilibrium binding, on-rate, and dissociation kinetics. Biochemistry (1995) 1.28
Evidence for a factor required for transcriptional stimulation by the chimeric acidic activator GAL-VP16 in HeLa cell extracts. Proc Natl Acad Sci U S A (1991) 1.26
The conserved carboxy-terminal domain of Saccharomyces cerevisiae TFIID is sufficient to support normal cell growth. Mol Cell Biol (1991) 1.25
Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo. Mol Cell Biol (1995) 1.25
A new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo. Mol Cell Biol (1996) 1.18
A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo. Mol Cell Biol (1997) 1.16
Biochemical and genetic characterization of a yeast TFIID mutant that alters transcription in vivo and DNA binding in vitro. Mol Cell Biol (1992) 1.14
The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP. Nucleic Acids Res (1994) 1.13
The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.12
Functional substitution of an essential yeast RNA polymerase subunit by a highly conserved mammalian counterpart. Mol Cell Biol (1994) 1.10
A differential response of wild type and mutant promoters to TFIIIB70 overexpression in vivo and in vitro. Nucleic Acids Res (1998) 1.08
TATA-binding protein and nuclear differentiation in Tetrahymena thermophila. Mol Cell Biol (1994) 1.07
Effect of the non-conserved N-terminus on the DNA binding activity of the yeast TATA binding protein. Nucleic Acids Res (1993) 1.06
Functional interchangeability of TFIIIB components from yeast and human cells in vitro. EMBO J (1997) 1.05
Identifying a species-specific region of yeast TF11B in vivo. Mol Cell Biol (1996) 1.01
hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation. Mol Cell Biol (1999) 1.00
SPN1, a conserved gene identified by suppression of a postrecruitment-defective yeast TATA-binding protein mutant. Genetics (2002) 0.97
TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo. Mol Cell Biol (2000) 0.97
STD1 (MSN3) interacts directly with the TATA-binding protein and modulates transcription of the SUC2 gene of Saccharomyces cerevisiae. Nucleic Acids Res (1995) 0.96
Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains. Mol Cell Biol (1997) 0.96
Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein. Mol Cell Biol (1993) 0.95
Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation. Proc Natl Acad Sci U S A (1992) 0.95
The yeast TATA-binding protein (TBP) core domain assembles with human TBP-associated factors into a functional TFIID complex. Mol Cell Biol (1995) 0.92
Near-zero linking difference upon transcription factor IID binding to promoter DNA. Mol Cell Biol (1993) 0.87
Human TATA binding protein inhibits human papillomavirus type 11 DNA replication by antagonizing E1-E2 protein complex formation on the viral origin of replication. J Virol (2002) 0.87
The conserved core domain of the human TATA binding protein is sufficient to assemble the multisubunit RNA polymerase I-specific transcription factor SL1. Proc Natl Acad Sci U S A (1994) 0.87
A TATA-binding protein mutant defective for TFIID complex formation in vivo. Mol Cell Biol (1999) 0.87
Multiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein. Genetics (2001) 0.84
Expression of the two maize TATA binding protein genes and function of the encoded TBP proteins by complementation in yeast. Plant Cell (1993) 0.82
Structural and functional analysis of mutations along the crystallographic dimer interface of the yeast TATA binding protein. Mol Cell Biol (2003) 0.80
In vitro transfection of fresh thymocytes and T cells shows subset-specific expression of viral promoters. Mol Cell Biol (1992) 0.79
Activation of a dual adenovirus promoter containing nonconsensus TATA motifs in Schizosaccharomyces pombe: role of TATA sequences in the efficiency of transcription. Nucleic Acids Res (1993) 0.77
The TATA-binding protein (TBP) from the human fungal pathogen Candida albicans can complement defects in human and yeast TBPs. J Bacteriol (1998) 0.75
High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. Proc Natl Acad Sci U S A (1979) 26.51
Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene (1979) 19.39
Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast. Proc Natl Acad Sci U S A (1985) 13.43
GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell (1985) 11.63
Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell (1986) 11.42
Isolation and characterisation of a yeast chromosomal replicator. Nature (1979) 9.14
Functional genetic expression of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1976) 8.92
Nucleotide sequence and transcriptional mapping of the yeast pet56-his3-ded1 gene region. Nucleic Acids Res (1985) 8.01
The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell (1992) 6.47
Saturation mutagenesis of the yeast his3 regulatory site: requirements for transcriptional induction and for binding by GCN4 activator protein. Science (1986) 6.36
Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature (1999) 6.20
Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure. EMBO J (1995) 5.74
Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast. Cell (1987) 5.59
GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J (1987) 5.32
Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein. Mol Cell Biol (1989) 5.23
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell (1997) 5.07
Production of a functional eukaryotic enzyme in Escherichia coli: cloning and expression of the yeast structural gene for imidazole-glycerolphosphate dehydratase (his3). Proc Natl Acad Sci U S A (1977) 4.86
The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell (1989) 4.72
Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex. Nature (1994) 4.50
Two related regulatory sequences are required for maximal induction of Saccharomyces cerevisiae his3 transcription. Mol Cell Biol (1987) 4.31
Transcription of the his3 gene region in Saccharomyces cerevisiae. J Mol Biol (1981) 4.30
Genetic properties and chromatin structure of the yeast gal regulatory element: an enhancer-like sequence. Proc Natl Acad Sci U S A (1984) 4.16
Deletion mapping a eukaryotic promoter. Proc Natl Acad Sci U S A (1981) 4.14
The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells. Cell (1992) 3.94
Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol Cell (2000) 3.80
The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous. Cell (1987) 3.79
Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein. Proc Natl Acad Sci U S A (1988) 3.79
Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein. Nature (1988) 3.77
Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev (1995) 3.70
Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol (1997) 3.55
Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol (1998) 3.51
TBP-associated factors are not generally required for transcriptional activation in yeast. Nature (1996) 3.45
The yeast his3 promoter contains at least two distinct elements. Proc Natl Acad Sci U S A (1982) 3.40
Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro. Mol Cell Biol (1990) 3.39
Constitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms. Mol Cell Biol (1986) 3.37
A physical, genetic and transcriptional map of the cloned his3 gene region of Saccharomyces cerevisiae. J Mol Biol (1980) 3.35
Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins. Trends Biochem Sci (1989) 3.32
Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase. Cell (1987) 3.26
Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity. Mol Cell Biol (1994) 3.18
The new yeast genetics. Nature (1983) 3.03
Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA. Nature (1990) 2.97
A wide variety of DNA sequences can functionally replace a yeast TATA element for transcriptional activation. Genes Dev (1990) 2.89
Cloning of random-sequence oligodeoxynucleotides. Gene (1986) 2.88
Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1996) 2.88
Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element. EMBO J (1985) 2.87
Promotor mutants of the yeast his3 gene. J Mol Biol (1981) 2.73
Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev (1998) 2.71
Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. Mol Cell (2000) 2.70
Chi-dependent DNA strand cleavage by RecBC enzyme. Cell (1985) 2.70
Direct selection for gene replacement events in yeast. Gene (1983) 2.69
NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev (1994) 2.69
RecBC enzyme nicking at Chi sites during DNA unwinding: location and orientation-dependence of the cutting. Cell (1985) 2.66
ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol Cell Biol (1988) 2.47
The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature (1996) 2.44
Histone acetylation at promoters is differentially affected by specific activators and repressors. Mol Cell Biol (2001) 2.40
An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase. Proc Natl Acad Sci U S A (1989) 2.34
Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain. Nature (1995) 2.20
Isolation of cDNA clones encoding HLA-DR alpha chains. Proc Natl Acad Sci U S A (1982) 2.17
TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivo. Science (2000) 2.14
Regulatory sites for his3 gene expression in yeast. Nature (1982) 2.09
Yeast and human TFIID with altered DNA-binding specificity for TATA elements. Cell (1992) 2.04
Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites. Mol Cell Biol (1990) 2.00
Functional distinctions between yeast TATA elements. Mol Cell Biol (1989) 1.94
Suppressors of Saccharomyces cerevisiae his3 promoter mutations lacking the upstream element. Mol Cell Biol (1985) 1.93
Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity. J Virol (1984) 1.93
Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo. Nature (1995) 1.89
CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters. EMBO J (1993) 1.85
The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell (1994) 1.85
Two forms of the Ia antigen-associated invariant chain result from alternative initiations at two in-phase AUGs. Cell (1986) 1.82
Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain. EMBO J (1986) 1.82
Negative control at a distance mediates catabolite repression in yeast. Nature (1985) 1.81
Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas. Mol Cell Biol (1989) 1.80
Promoter elements, regulatory elements, and chromatin structure of the yeast his3 gene. Cold Spring Harb Symp Quant Biol (1983) 1.78
The use of random-sequence oligonucleotides for determining consensus sequences. Methods Enzymol (1987) 1.78
Isolation of distinct cDNA clones encoding HLA-DR beta chains by use of an expression assay. Proc Natl Acad Sci U S A (1982) 1.77
Roles of RecBC enzyme and chi sites in homologous recombination. Cold Spring Harb Symp Quant Biol (1984) 1.76
The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity. EMBO J (1984) 1.72
Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast. Mol Cell (1998) 1.68
Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo. Science (1994) 1.68
Mechanisms of transcriptional activation in vivo: two steps forward. Trends Genet (1996) 1.67
The TBP-TFIIA interaction in the response to acidic activators in vivo. Science (1995) 1.62
Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain. J Exp Med (1986) 1.61
The N-terminal region of yeast TFIIB contains two adjacent functional domains involved in stable RNA polymerase II binding and transcription start site selection. J Biol Chem (1998) 1.60
ACR1, a yeast ATF/CREB repressor. Mol Cell Biol (1992) 1.57
Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements. Mol Cell Biol (2000) 1.53
Constitutive and coordinately regulated transcription of yeast genes: promoter elements, positive and negative regulatory sites, and DNA binding proteins. Cold Spring Harb Symp Quant Biol (1985) 1.52
Mechanism of differential utilization of the his3 TR and TC TATA elements. Mol Cell Biol (1995) 1.51
Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro. Genes Dev (1992) 1.50
The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. Mol Cell Biol (1998) 1.50
TFIIS enhances transcriptional elongation through an artificial arrest site in vivo. Mol Cell Biol (2001) 1.48
The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA. Genes Dev (1989) 1.48
Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription. Science (1993) 1.46
The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding. Proc Natl Acad Sci U S A (1991) 1.45
Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo. Mol Cell Biol (2001) 1.45
Defining the consensus sequences of E.coli promoter elements by random selection. Nucleic Acids Res (1988) 1.44
Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter. Proc Natl Acad Sci U S A (1991) 1.44
Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol (1991) 1.42
Position effects in Saccharomyces cerevisiae. J Mol Biol (1981) 1.42
The histone H3-like TAF is broadly required for transcription in yeast. Mol Cell (1998) 1.41