Partially active channels produced by PKA site mutation of the cloned renal K+ channel, ROMK2 (kir1.2).

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMID 9729515)

Published in Am J Physiol on September 01, 1998

Authors

G G MacGregor1, J Z Xu, C M McNicholas, G Giebisch, S C Hebert

Author Affiliations

1: Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520, USA.

Articles citing this

Molecular diversity and regulation of renal potassium channels. Physiol Rev (2005) 2.56

A comprehensive guide to the ROMK potassium channel: form and function in health and disease. Am J Physiol Renal Physiol (2009) 2.51

Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. Proc Natl Acad Sci U S A (1999) 1.46

Regulation of ROMK by extracellular cations. Biophys J (2001) 1.21

Structural locus of the pH gate in the Kir1.1 inward rectifier channel. Biophys J (2005) 1.18

Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK). Proc Natl Acad Sci U S A (2005) 1.15

Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase. J Biol Chem (2000) 1.15

CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest (2006) 0.97

Potassium-dependent slow inactivation of Kir1.1 (ROMK) channels. Biophys J (2004) 0.95

A mutation linked with Bartter's syndrome locks Kir 1.1a (ROMK1) channels in a closed state. J Gen Physiol (1999) 0.92

A novel mutation in KCNJ1 in a Bartter syndrome case diagnosed as pseudohypoaldosteronism. Pediatr Nephrol (2007) 0.86

Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation. J Physiol (2002) 0.85

G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. J Mol Signal (2011) 0.85

Hydrolyzable ATP and PIP(2) modulate the small-conductance K+ channel in apical membranes of rat cortical-collecting duct (CCD). J Gen Physiol (2002) 0.84

Articles by these authors

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature (1993) 7.89

Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature (1993) 5.69

Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell (1993) 4.13

Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet (1998) 3.96

Micropuncture study of distal tubular potassium and sodium transport in rat nephron. Am J Physiol (1966) 3.22

Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem (1994) 2.89

A conserved retina-specific gene encodes a basic motif/leucine zipper domain. Proc Natl Acad Sci U S A (1992) 2.79

Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab (1996) 2.33

Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am J Physiol Renal Physiol (2001) 2.28

Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain. J Neurobiol (1997) 2.24

Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation. Nat Genet (1994) 2.23

Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet. Kidney Int (2006) 2.22

Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter. Proc Natl Acad Sci U S A (1993) 2.15

Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A (2001) 2.00

Regulation of small-conductance K+ channel in apical membrane of rat cortical collecting tubule. Am J Physiol (1990) 2.00

Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J Biol Chem (1995) 1.86

Control of NaCl transport in the thick ascending limb. Am J Physiol (1984) 1.72

Micropuncture study of renal tubular hydrogen ion transport in the rat. Am J Physiol (1972) 1.72

ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms. Am J Physiol (1995) 1.72

Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator. Proc Natl Acad Sci U S A (1996) 1.69

Localization of the extracellular Ca2+/polyvalent cation-sensing protein in rat kidney. Am J Physiol (1998) 1.62

Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci U S A (1995) 1.61

Microperfusion study of distal tubular potassium and sodium transfer in rat kidney. Am J Physiol (1966) 1.61

Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor. J Biol Chem (1996) 1.59

Renal K+ channels: structure and function. Annu Rev Physiol (1997) 1.59

Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest (1997) 1.59

A simple and efficient cDNA library subtraction procedure: isolation of human retina-specific cDNA clones. Nucleic Acids Res (1991) 1.57

Potassium secretion by distal tubule after potassium adaptation. Am J Physiol (1971) 1.55

Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells. J Biol Chem (1994) 1.54

Bicarbonate transport along the loop of Henle. I. Microperfusion studies of load and inhibitor sensitivity. J Clin Invest (1991) 1.54

Localization of the thiazide sensitive Na-Cl cotransporter, rTSC1 in the rat kidney. Kidney Int (1996) 1.54

Cell membranes impermeable to NH3. Nature (1989) 1.54

Angiotensin II stimulates both Na(+)-H+ exchange and Na+/HCO3- cotransport in the rabbit proximal tubule. Proc Natl Acad Sci U S A (1990) 1.53

Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. Am J Physiol (1996) 1.51

Localization of the ROMK protein on apical membranes of rat kidney nephron segments. Am J Physiol (1997) 1.50

Dual modulation of renal ATP-sensitive K+ channel by protein kinases A and C. Proc Natl Acad Sci U S A (1991) 1.47

Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice. Am J Physiol (1999) 1.47

Regulation of ROMK1 K+ channel activity involves phosphorylation processes. Proc Natl Acad Sci U S A (1994) 1.46

Effect of reduction in filtration rate on renal tubular sodium and water reabsorption. Am J Physiol (1968) 1.46

Membrane currents in mammalian ventricular heart muscle fibers using a voltage-clamp technique. J Gen Physiol (1971) 1.45

Dual effect of adenosine triphosphate on the apical small conductance K+ channel of the rat cortical collecting duct. J Gen Physiol (1991) 1.44

NaCl transport in mouse medullary thick ascending limbs. I. Functional nephron heterogeneity and ADH-stimulated NaCl cotransport. Am J Physiol (1981) 1.42

Potassium transport across renal distal tubules during acid-base disturbances. Am J Physiol (1971) 1.42

Renal potassium channels and their regulation. Annu Rev Physiol (1992) 1.42

Micropuncture study of electrolyte transport across papillary collecting duct of the rat. Am J Physiol (1973) 1.41

Renal tubular sodium and water reabsorption in the isotonic sodium chloride-loaded rat. Am J Physiol (1967) 1.41

Effect of amiloride, ouabain, and furosemide on distal tubular function in the rat. Am J Physiol (1971) 1.37

Mechanisms of chloride transport in the proximal tubule. Am J Physiol (1997) 1.37

Electrogenic properties of the epithelial and neuronal high affinity glutamate transporter. J Biol Chem (1995) 1.37

The extracellular calcium-sensing receptor: its role in health and disease. Annu Rev Med (1998) 1.36

Calcium-ion-sensing cell-surface receptors. N Engl J Med (1995) 1.35

ATP is a coupling modulator of parallel Na,K-ATPase-K-channel activity in the renal proximal tubule. Proc Natl Acad Sci U S A (1992) 1.35

Thiazide treatment of rats provokes apoptosis in distal tubule cells. Kidney Int (1996) 1.34

Identification and localization of extracellular Ca(2+)-sensing receptor in rat intestine. Am J Physiol (1998) 1.33

pH-dependent modulation of the cloned renal K+ channel, ROMK. Am J Physiol (1998) 1.31

Control mechanisms of bicarbonate transport across the rat proximal convoluted tubule. Am J Physiol (1982) 1.31

Multi-barrelled K channels in renal tubules. Nature (1987) 1.31

Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase. J Biol Chem (1996) 1.31

Role of NHE3 in mediating renal brush border Na+-H+ exchange. Adaptation to metabolic acidosis. J Biol Chem (1996) 1.30

Calcium ions as extracellular messengers. Cell (1995) 1.30

Electrolyte transport in kidney tubule cells. Philos Trans R Soc Lond B Biol Sci (1971) 1.30

Expression of the Na(+)-K(+)-2Cl- cotransporter BSC2 in the nervous system. Am J Physiol (1997) 1.29

Expression of the mouse Na-K-2Cl cotransporter, mBSC2, in the terminal inner medullary collecting duct, the glomerular and extraglomerular mesangium, and the glomerular afferent arteriole. J Clin Invest (1996) 1.28

Protein tyrosine kinase regulates the number of renal secretory K channels. Am J Physiol Renal Physiol (2000) 1.28

Effects of flow rate and potassium intake on distal tubular potassium transfer. Am J Physiol (1975) 1.27

Effect of ionic substitutions on distal potential differences in rat kidney. Am J Physiol (1966) 1.27

Tubular action of diuretics: distal effects on electrolyte transport and acidification. Kidney Int (1985) 1.26

Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol. Anal Biochem (1993) 1.26

Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL. Am J Physiol (1996) 1.25

Structural and functional study of the rat distal nephron: effects of potassium adaptation and depletion. Kidney Int (1981) 1.25

NMR measurements of intracellular sodium in the rabbit proximal tubule. Am J Physiol (1985) 1.24

Localization of the extracellular Ca(2+)-sensing receptor and PTH/PTHrP receptor in rat kidney. Am J Physiol (1996) 1.23

A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop. Am J Physiol (1990) 1.22

Some electrical properties of distal tubular epithelium in the rat. Am J Physiol (1972) 1.21

Functional organization of proximal and distal tubular electrolyte transport. Nephron (1969) 1.21

Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem (1998) 1.20

Morphological heterogeneity of the rabbit collecting duct. Kidney Int (1988) 1.20

Kinetics of luminal acidification in cortical tubules of the rat kidney. J Physiol (1977) 1.20

Relationship between sodium and bicarbonate transport in the rat proximal convoluted tubule. Am J Physiol (1981) 1.20

Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. Proc Natl Acad Sci U S A (2000) 1.20

Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol (2000) 1.20

NaCl transport in mouse medullary thick ascending limbs. II. ADH enhancement of transcellular NaCl cotransport; origin of transepithelial voltage. Am J Physiol (1981) 1.19

Microperfusion study of fluid reabsorption in proximal tubules of rat kidneys. Am J Physiol (1967) 1.18

Potassium and sodium transport across single distal tubules of Amphiuma. J Gen Physiol (1971) 1.16

Electrical properties of chloride transport across the necturus proximal tubule. J Membr Biol (1982) 1.15

Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase. J Biol Chem (2000) 1.15

Reflection coefficients and water permeability in rat proximal tubule. Am J Physiol (1989) 1.14

Effects of nephrectomy on renal salt and water transport in the remaining kidney. Kidney Int (1976) 1.14

Critical role for intracellular calcium in tight junction biogenesis. J Cell Physiol (1994) 1.14

Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats. Am J Physiol (1998) 1.13

Apical localization of the Na-K-Cl cotransporter, rBSC1, on rat thick ascending limbs. Kidney Int (1996) 1.13

Molecular site for nucleotide binding on an ATP-sensitive renal K+ channel (ROMK2). Am J Physiol (1996) 1.13