Published in J Biol Chem on September 18, 1998
Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid Redox Signal (2010) 2.50
An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation. Free Radic Res (2008) 2.17
Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med (2009) 2.04
Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci (2008) 1.72
Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal (2010) 1.43
Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities. Amino Acids (2010) 1.41
Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria. Free Radic Biol Med (2007) 1.39
Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med (2007) 1.37
Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage. Free Radic Biol Med (2010) 1.35
Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics. Free Radic Biol Med (2011) 1.31
Tumor necrosis factor alpha stimulates killing of Mycobacterium tuberculosis by human neutrophils. Infect Immun (2002) 1.31
Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. Free Radic Biol Med (2009) 1.30
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal (2013) 1.29
Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. Free Radic Biol Med (2008) 1.26
Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice. Free Radic Biol Med (2008) 1.24
Neuroprotection against superoxide anion radical by metallocorroles in cellular and murine models of optic neuropathy. J Neurochem (2010) 1.23
Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. Free Radic Biol Med (2009) 1.17
Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes. J Pharm Biomed Anal (2008) 1.15
Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells. Free Radic Biol Med (2009) 1.11
Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. Free Radic Biol Med (2008) 1.10
Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells. Cancer Res (2009) 1.10
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. Free Radic Biol Med (2012) 1.05
Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide. Cancer Res (2008) 1.02
Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage. J Pharmacol Exp Ther (2011) 1.01
Oxidative stress and redox modulation potential in type 1 diabetes. Clin Dev Immunol (2011) 1.00
SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself. Arch Biochem Biophys (2008) 1.00
Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation. Cancer Res (2013) 0.99
Only one of a wide assortment of manganese-containing SOD mimicking compounds rescues the slow aerobic growth phenotypes of both Escherichia coli and Saccharomyces cerevisiae strains lacking superoxide dismutase enzymes. J Inorg Biochem (2007) 0.99
Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. Free Radic Res (2010) 0.99
Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. Med Princ Pract (2012) 0.99
NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. Mutagenesis (2011) 0.97
Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins. J Pharmacol Exp Ther (2007) 0.96
Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity. Bioorg Med Chem (2007) 0.95
The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus. Am J Respir Cell Mol Biol (2008) 0.92
Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins. Dalton Trans (2011) 0.91
Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite. Biochim Biophys Acta (2013) 0.91
A novel class of cytochrome P450 reductase redox cyclers: cationic manganoporphyrins. Toxicol Sci (2005) 0.90
Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology. Inorg Chem (2013) 0.88
Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+. Free Radic Biol Med (2013) 0.87
Simple biological systems for assessing the activity of superoxide dismutase mimics. Antioxid Redox Signal (2013) 0.86
The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation. PLoS One (2012) 0.86
An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins - From superoxide dismutation to H2O2-driven pathways. Redox Biol (2015) 0.86
Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain. J Med Chem (2011) 0.86
Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells. Antioxid Redox Signal (2013) 0.85
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers. J Med Chem (2013) 0.84
Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents. Inorg Chem (2014) 0.84
Catalytic antioxidants to treat amyotropic lateral sclerosis. Expert Opin Investig Drugs (2006) 0.83
Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind. Diabetes (2012) 0.83
Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer. Free Radic Biol Med (2015) 0.80
Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications. Redox Biol (2013) 0.80
Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate. Dalton Trans (2012) 0.79
MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene. Free Radic Biol Med (2016) 0.79
Towards the mechanisms involved in the antioxidant action of MnIII [meso-tetrakis(4-N-methyl pyridinium) porphyrin] in mitochondria. J Bioenerg Biomembr (2011) 0.77
Manganese superoxide dismutase in cancer prevention. Antioxid Redox Signal (2013) 0.77
Synthesis of water-soluble dinuclear mn-porphyrin with multiple antioxidative activities. ACS Med Chem Lett (2014) 0.76
Impact of SOD-Mimetic Manganoporphyrins on Spin Trapping of Superoxide and Related Artifacts. Appl Magn Reson (2011) 0.75
Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation. PLoS One (2017) 0.75
DNA-Accelerated Catalysis of Carbene-Transfer Reactions by a DNA/Cationic Iron Porphyrin Hybrid. Angew Chem Int Ed Engl (2016) 0.75
NADPH Oxidase-Derived Superoxide Provides a Third Signal for CD4 T Cell Effector Responses. J Immunol (2016) 0.75
The metalloporphyrin antioxidant, MnTE-2-PyP, inhibits Th2 cell immune responses in an asthma model. Int J Mol Sci (2012) 0.75
Mangafodipir a Selective Cytoprotectant - with Special Reference to Oxaliplatin and Its Association to Chemotherapy-Induced Peripheral Neuropathy (CIPN). Transl Oncol (2017) 0.75
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem (1969) 43.83
Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem (1971) 28.59
The biology of oxygen radicals. Science (1978) 13.21
The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem (1972) 12.87
An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase. Proc Natl Acad Sci U S A (1971) 8.82
Superoxide dismutases. Annu Rev Biochem (1975) 8.00
Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds. Arch Biochem Biophys (1979) 5.43
Superoxide dismutases. Adv Enzymol Relat Areas Mol Biol (1974) 5.40
A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase. J Biol Chem (1970) 5.26
Superoxide dismutase from escherichia coli B. A new manganese-containing enzyme. J Biol Chem (1970) 5.10
Superoxide radical: an endogenous toxicant. Annu Rev Pharmacol Toxicol (1983) 4.91
Superoxide dismutases. Adv Enzymol Relat Areas Mol Biol (1986) 4.89
Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase. J Biol Chem (1970) 4.85
The reduction of cytochrome c by milk xanthine oxidase. J Biol Chem (1968) 4.72
Superoxide dismutase. Organelle specificity. J Biol Chem (1973) 4.67
Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. J Biol Chem (1973) 4.32
Biological effects of the superoxide radical. Arch Biochem Biophys (1986) 4.22
Induction of superoxide dismutase by molecular oxygen. J Bacteriol (1973) 4.09
Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. Anal Biochem (1987) 4.04
Superoxide dismutases of Escherichia coli: intracellular localization and functions. J Bacteriol (1973) 3.96
Purification of the o-dianisidine peroxidase from Escherichia coli B. Physicochemical characterization and analysis of its dual catalatic and peroxidatic activities. J Biol Chem (1979) 3.90
Enzymatic defenses against the toxicity of oxygen and of streptonigrin in Escherichia coli. J Bacteriol (1977) 3.89
Regulation of the synthesis of superoxide dismutase in Escherichia coli. Induction by methyl viologen. J Biol Chem (1977) 3.81
Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria. J Biol Chem (2001) 3.78
Oxygen toxicity and the superoxide dismutase. J Bacteriol (1973) 3.66
Superoxide sensitivity of the Escherichia coli aconitase. J Biol Chem (1991) 3.64
An iron-containing superoxide dismutase from Escherichia coli. J Biol Chem (1973) 3.59
Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system. J Biol Chem (1975) 3.53
Assay of metabolic superoxide production in Escherichia coli. J Biol Chem (1991) 3.43
The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme. Biochemistry (1975) 3.43
Manganese and defenses against oxygen toxicity in Lactobacillus plantarum. J Bacteriol (1981) 3.22
Preparation and assay of superoxide dismutases. Methods Enzymol (1978) 3.21
Isozymes of superoxide dismutase from wheat germ. Biochim Biophys Acta (1973) 3.17
Effects of molecular oxygen on detection of superoxide radical with nitroblue tetrazolium and on activity stains for catalase. Anal Biochem (1984) 3.13
Fumarase C, the stable fumarase of Escherichia coli, is controlled by the soxRS regulon. Proc Natl Acad Sci U S A (1992) 3.09
Regulation of the synthesis of catalase and peroxidase in Escherichia coli. J Biol Chem (1978) 3.04
Mechanism of the antibiotic action pyocyanine. J Bacteriol (1980) 3.00
Superoxide radical inhibits catalase. J Biol Chem (1982) 2.91
The scavenging of superoxide radical by manganous complexes: in vitro. Arch Biochem Biophys (1982) 2.85
The generation of superoxide radical during the autoxidation of hemoglobin. J Biol Chem (1972) 2.83
Paraquat and Escherichia coli. Mechanism of production of extracellular superoxide radical. J Biol Chem (1979) 2.82
The utility of superoxide dismutase in studying free radical reactions. I. Radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. J Biol Chem (1969) 2.82
Superoxide radical and the oxygen enhancement of the toxicity of paraquat in Escherichia coli. J Biol Chem (1978) 2.78
Superoxide dismutases. Prog Nucleic Acid Res Mol Biol (1991) 2.65
alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme. J Biol Chem (1987) 2.61
Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical. J Biol Chem (1992) 2.60
DNA strand scission by enzymically generated oxygen radicals. Arch Biochem Biophys (1981) 2.49
Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic Biol Med (1998) 2.44
Superoxide dismutase and oxygen toxicity in a eukaryote. J Bacteriol (1974) 2.42
The role of O2.- in the production of HO.: in vitro and in vivo. Free Radic Biol Med (1994) 2.36
Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase. J Biol Chem (1991) 2.36
Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide. J Biol Chem (1977) 2.35
Permeation of the erythrocyte stroma by superoxide radical. J Biol Chem (1978) 2.32
Escherichia coli expresses a copper- and zinc-containing superoxide dismutase. J Biol Chem (1994) 2.24
Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not. J Biol Chem (1994) 2.20
Visualization of catalase on acrylamide gels. Anal Biochem (1974) 2.18
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem (1994) 2.15
Hepatic sulfite oxidase. A functional role for molybdenum. J Biol Chem (1971) 2.13
A direct demonstration of the catalytic action of superoxide dismutase through the use of pulse radiolysis. J Biol Chem (1972) 2.10
The univalent reduction of oxygen by reduced flavins and quinones. J Biol Chem (1972) 2.07
Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys (1997) 2.03
Oxygen metabolism in Lactobacillus plantarum. J Bacteriol (1974) 2.03
The generation of superoixide radical during the autoxidation of ferredoxins. J Biol Chem (1971) 2.03
Hyperoxia during reperfusion is a factor in reperfusion injury. Free Radic Biol Med (1989) 2.02
Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite. Circ Res (2001) 2.01
NADPH: ferredoxin oxidoreductase acts as a paraquat diaphorase and is a member of the soxRS regulon. Proc Natl Acad Sci U S A (1994) 2.00
Purification and characterization of hydroperoxidase II of Escherichia coli B. J Biol Chem (1979) 1.95
On the stability of bovine superoxide dismutase. The effects of metals. J Biol Chem (1973) 1.94
Manganese, superoxide dismutase, and oxygen tolerance in some lactic acid bacteria. J Bacteriol (1981) 1.93
Superoxide dismutase and oxygen metabolism in Streptococcus faecalis and comparisons with other organisms. J Bacteriol (1978) 1.86
Luminol and lucigenin as detectors for O2.-. Free Radic Biol Med (1993) 1.86
The biology and pathology of oxygen radicals. Ann Intern Med (1978) 1.84
The utility of superoxide dismutase in studying free radical reactions. II. The mechanism of the mediation of cytochrome c reduction by a variety of electron carriers. J Biol Chem (1970) 1.83
Requirement for superoxide in excitotoxic cell death. Neuron (1996) 1.80
Climate change and the integrity of science. Science (2010) 1.80
Isolation and characterization of the pseudocatalase of Lactobacillus plantarum. J Biol Chem (1983) 1.78
The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: chemiluminescence and peroxidation. Biochemistry (1975) 1.76
Effects of superoxide on the erythrocyte membrane. J Biol Chem (1978) 1.75
Induction of superoxide dismutase in Escherichia coli by heat shock. Proc Natl Acad Sci U S A (1987) 1.74
Superoxide radicals and phagocytosis. Arch Biochem Biophys (1974) 1.66
Inactivation of glutathione peroxidase by superoxide radical. Arch Biochem Biophys (1985) 1.65
Investigations of the state of the manganese in Lactobacillus plantarum. Arch Biochem Biophys (1982) 1.64
Oxygen: boon and bane. Am Sci (1975) 1.63
Editorial: Oxygen toxicity. Introduction to a protective enzyme: superoxide dismutase. Circulation (1973) 1.62
In vivo competition between iron and manganese for occupancy of the active site region of the manganese-superoxide dismutase of Escherichia coli. J Biol Chem (1991) 1.61
Hepatic sulfite oxidase. Purification and properties. J Biol Chem (1971) 1.57
Pulse radiolytic investigations of superoxide catalyzed disproportionation. Mechanism for bovine superoxide dismutase. J Am Chem Soc (1973) 1.53
Isolation and characterization of the iron-containing superoxide dismutase of Methanobacterium bryantii. Arch Biochem Biophys (1981) 1.52
Regulation of superoxide dismutase synthesis in Escherichia coli: glucose effect. J Bacteriol (1977) 1.52
Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. J Neurosci (2001) 1.38
Increased superoxide radical production evokes inducible DNA repair in Escherichia coli. J Biol Chem (1985) 1.38
Hepatic sulfite oxidase. The nature and function of the heme prosthetic groups. J Biol Chem (1971) 1.38
Inductions of superoxide dismutases in Escherichia coli under anaerobic conditions. Accumulation of an inactive form of the manganese enzyme. J Biol Chem (1988) 1.38
Isolation and characterization of a manganese-containing superoxide dismutase from yeast. J Biol Chem (1975) 1.37
Inhibition of superoxide dismutases by azide. Arch Biochem Biophys (1978) 1.37
Suppression of oxidative envelope damage by pseudoreversion of a superoxide dismutase-deficient mutant of Escherichia coli. J Bacteriol (1992) 1.36
Oxygen toxicity in Streptococcus sanguis. The relative importance of superoxide and hydroxyl radicals. J Biol Chem (1982) 1.36
The production of superoxide radical during the decomposition of potassium peroxochromate(V). Biochemistry (1974) 1.34
Superoxide and iron: partners in crime. IUBMB Life (1999) 1.33
Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants. Chem Res Toxicol (1999) 1.33