Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV).

PubWeight™: 0.85‹?›

🔗 View Article (PMID 9733953)

Published in Brain Res on September 14, 1998

Authors

P J Attwell1, N Singh Kent, D E Jane, M J Croucher, H F Bradford

Author Affiliations

1: Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK. p.attwell@ucl.ac.uk

Articles by these authors

Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology (1999) 4.48

The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology (1998) 2.16

Respiration in vitro of synaptosomes from mammalian cerebral cortex. J Neurochem (1969) 2.08

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature (1993) 1.81

(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology (1997) 1.61

Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J Neurosci (1994) 1.59

The inhibitory effect of sodium n-dipropyl acetate on the degradative enzymes of the GABA shunt. FEBS Lett (1975) 1.44

NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol (2007) 1.40

Distinct NMDA receptor subpopulations contribute to long-term potentiation and long-term depression induction. J Neurosci (2000) 1.38

Stimulation and solubilization of the sodium ion-activated adenosine triphosphatase of cerebral microsomes by surface-active agents, especially polyoxyethylene ethers: actions of phospholipases and a neuraminidase. Biochem J (1964) 1.36

Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. Eur J Pharmacol (1993) 1.30

Anticonvulsant action of excitatory amino acid antagonists. Science (1982) 1.29

Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J Neurosci (1992) 1.28

Metabolism of glucose and glutamate by synaptosomes from mammalian cerebral cortex. J Neurochem (1969) 1.24

Ionic basis for the depolarization of cerebral tissues by excitatory acidic amino acids. J Neurochem (1966) 1.16

Glutamine--a major substrate for nerve endings. J Neurochem (1978) 1.16

Metabolic response of synaptosomes to electrical stimulation: release of amino acids. Brain Res (1970) 1.13

Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience (1993) 1.10

The metabolism of glucose 6-phosphate by mammalian cerebral cortex in vitro. Biochem J (1971) 1.09

Biochemical evidence for the presence of presynaptic receptors on dopaminergic nerve terminals. Brain Res (1978) 1.07

Glutamine and glucose as precursors of transmitter amino acids: ex vivo studies. J Neurochem (1983) 1.07

(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology (2001) 1.07

Metabolism of beds of mammalian cortical synaptosomes: response to depolarizing influences. J Neurochem (1972) 1.06

Specific release of endogenous glutamate from piriform cortex stimulated in vitro. Brain Res (1976) 1.06

Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus. Eur J Pharmacol (1993) 1.03

Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br J Pharmacol (1996) 1.01

In vivo release from cerebral cortex of [14C]glutamate synthesized from [U-14C]glutamine. J Neurochem (1983) 1.00

Glutamate release in experimental ischaemia of the retina: an approach using microdialysis. J Neurochem (1992) 1.00

Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures. Arzneimittelforschung (1984) 0.98

alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology (1996) 0.97

Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. J Neurosci (1994) 0.96

Stimulated incorporation of amino acids into proteins of synaptosomal fractions induced by depolarizing treatments. J Neurochem (1977) 0.96

Depolarizing stimuli and the release of physiologically active amino acids from suspensions of mammalian synaptosomes. J Neurochem (1973) 0.93

Constituents of a microsomal fraction from the mammalian brain: their solubilization, especially by detergents. Biochem J (1964) 0.92

Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, Papio papio. Neurosci Lett (1983) 0.92

Pharmacological evidence for an involvement of group II and group III mGluRs in the presynaptic regulation of excitatory synaptic responses in the CA1 region of rat hippocampal slices. Neuropharmacology (1995) 0.92

Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration. Eur J Pharmacol (1983) 0.90

Tetanus toxin inhibits amino acid release from nerve endings in vitro. Nat New Biol (1973) 0.90

Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease. Eur J Neurosci (2005) 0.90

Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br J Pharmacol (1996) 0.90

Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. Br J Pharmacol (1999) 0.90

The stimulus-induced release of acetylcholine from synaptosome beds and its calcium dependence. J Neurochem (1972) 0.89

Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones. Br J Pharmacol (1995) 0.88

Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Br J Pharmacol (1995) 0.88

Native N-methyl-D-aspartate receptors containing NR2A and NR2B subunits have pharmacologically distinct competitive antagonist binding sites. J Pharmacol Exp Ther (2000) 0.88

Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem (1980) 0.87

Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones. Eur J Neurosci (2010) 0.87

The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol (1996) 0.86

Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro. Neuropharmacology (2000) 0.86

Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG. Neuropharmacology (2002) 0.86

Patterns of amino acid release from nerve-endings isolated from spinal cord and medulla. J Neurochem (1973) 0.85

On glutaminase activity in mammalian synaptosomes. Brain Res (1976) 0.84

The action of gamma-vinyl-GABA and gamma-acetylenic-GABA on the resting and stimulated release of GABA in vivo. Brain Res (1980) 0.84

On the site of origin of transmitter amino acids released by depolarization of nerve terminals in vitro. J Neurochem (1977) 0.84

Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine. Neuropharmacology (1995) 0.84

Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats. Brain Res (1998) 0.84

A comparison of the anticonvulsant potency of (+/-) 2-amino-5-phosphonopentanoic acid and (+/-) 2-amino-7-phosphonoheptanoic acid. Neuroscience (1983) 0.83

Brain-derived neurotrophic factor in human platelets. Biochem Pharmacol (1997) 0.83

Inhibition of the development of electrical kindling of the prepyriform cortex by daily focal injections of excitatory amino acid antagonists. Eur J Pharmacol (1988) 0.83

The distribution of cation-stimulated adenosine triphosphatase in subcellular fractions from bovine cerebral cortex. J Neurochem (1966) 0.83

Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence. Neuropharmacology (2001) 0.83

Effect of amygdaloid kindling on the content and release of amino acids from the amygdaloid complex: in vivo and in vitro studies. J Neurochem (1995) 0.82

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology (2001) 0.82

Participation of intracellular sites in the action of Ca2+ channel blockers. Eur J Pharmacol (1986) 0.82

Glucose and amino acid metabolism in some invertebrate nervous systems. J Neurochem (1969) 0.82

The BDNF content of postnatal and adult rat brain: the effects of 6-hydroxydopamine lesions in adult brain. Brain Res Dev Brain Res (1996) 0.82

Presynaptic control of the synthesis and release of dopamine from striatal synaptosomes: a comparison between the effects of 5-hydroxytryptamine, acetylcholine, and glutamate. J Neurochem (1980) 0.82

(S)-homoquisqualate: a potent agonist at the glutamate metabotropic receptor. Br J Pharmacol (1992) 0.82

Actions of a tremorgenic mycotoxin on amino acid transmitter release in vivo. Biochem Pharmacol (1982) 0.81

Inhibitory actions of opioid compounds on calcium fluxes and neurotransmitter release from mammalian cerebral cortical slices. Br J Pharmacol (1986) 0.81

Enhancement of depolarization-induced synaptosomal calcium uptake and neurotransmitter release by Bay K8644. Biochem Pharmacol (1986) 0.81

The stimulatory effect of brain-derived neurotrophic factor on dopaminergic phenotype expression of embryonic rat cortical neurons in vitro. Brain Res Dev Brain Res (1994) 0.81

Excitatory amino acid receptors and depolarization-induced Ca2+ influx into hippocampal slices. J Neurochem (1987) 0.81

Anti-epileptogenic and anticonvulsant activity of L-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist. Brain Res (1997) 0.81

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors. Bioorg Med Chem Lett (2001) 0.81

Evidence for a role of presynaptic AMPA receptors in the control of neuronal glutamate release in the rat forebrain. Eur J Pharmacol (1997) 0.81

Relative activities of glutamine synthetase and glutaminase in mammalian synaptosomes. J Neurochem (1979) 0.81

Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived neurotrophic factor and glial-cell derived neurotrophic factor. Brain Res Dev Brain Res (2001) 0.81

The response of human and rat fetal ventral mesencephalon in culture to the brain-derived neurotrophic factor treatment. Brain Res (1994) 0.81

On the specificity of verapamil as a calcium channel-blocker. Biochem Pharmacol (1985) 0.81

Metabotropic glutamate receptor antagonists, like GABA(B) antagonists, potentiate dorsal root-evoked excitatory synaptic transmission at neonatal rat spinal motoneurons in vitro. Neuroscience (1997) 0.81

Evidence for presynaptic cholinergic receptors on dopaminergic terminals: degeneration studies with 6-hydroxydopamine. Neurosci Lett (1979) 0.81

Effects of gamma-acetylenic GABA and gamma-vinyl GABA on synaptosomal release and uptake of GABA. Biochem Pharmacol (1981) 0.81

Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4. Neuropharmacology (1995) 0.81

Comparison of human recombinant adenosine A2B receptor function assessed by Fluo-3-AM fluorometry and microphysiometry. Br J Pharmacol (2003) 0.80

Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells. Br J Pharmacol (1995) 0.80

Comparative effects of benztropine and nomifensine on dopamine uptake and release from striatal synaptosomes. Biochem Pharmacol (1981) 0.80

Co-release of acetylcholine, glutamate and taurine from synaptosomes of Torpedo electric organ. Neurosci Lett (1987) 0.80

Depolarisation-induced changes in muscarinic cholinergic receptors in synaptosomes. Nature (1979) 0.80

Competitive NMDA receptor antagonists raise electrically kindled generalized seizure thresholds. Neurochem Res (1992) 0.80

Striatal extracts promote the survival and phenotypic expression of rat fetal dopaminergic neurons in vitro. Neurosci Lett (2000) 0.80

Compartmentation of synaptosomal dopamine. Adv Biochem Psychopharmacol (1978) 0.80