Published in Nature on May 27, 1993
Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses. J Physiol (1996) 2.34
Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism. Nat Neurosci (1999) 1.71
Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learn Mem (1999) 1.59
A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons. Proc Natl Acad Sci U S A (2001) 1.49
Coordinated activation of distinct Ca(2+) sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity. Nat Commun (2016) 1.48
Currents evoked in Bergmann glial cells by parallel fibre stimulation in rat cerebellar slices. J Physiol (1997) 1.47
Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms. Pharmacol Rev (2009) 1.40
When Is the Brain Dead? Living-Like Electrophysiological Responses and Photon Emissions from Applications of Neurotransmitters in Fixed Post-Mortem Human Brains. PLoS One (2016) 1.39
Identification of a genetic cluster influencing memory performance and hippocampal activity in humans. Proc Natl Acad Sci U S A (2006) 1.38
Reduction of resting K+ current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G-proteins. J Physiol (1994) 1.20
Hippocampal place cell firing patterns can induce long-term synaptic plasticity in vitro. J Neurosci (2009) 1.13
Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice. Learn Mem (1999) 1.09
GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission. J Physiol (2003) 1.08
Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord. Br J Pharmacol (1994) 1.07
Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization. J Physiol (2008) 1.04
Dopamine D1/D5 receptors mediate informational saliency that promotes persistent hippocampal long-term plasticity. Cereb Cortex (2012) 1.02
Calcium as an extracellular signalling molecule: perspectives on the Calcium Sensing Receptor in the brain. C R Biol (2005) 1.00
Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family. Proc Natl Acad Sci U S A (2006) 0.99
Kainate receptors and the induction of mossy fibre long-term potentiation. Philos Trans R Soc Lond B Biol Sci (2003) 0.98
Sensing and refilling calcium stores in an excitable cell. Biophys J (1997) 0.97
Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c. Neurobiol Learn Mem (2011) 0.97
Ryanodine produces a low frequency stimulation-induced NMDA receptor-independent long-term potentiation in the rat dentate gyrus in vitro. J Physiol (1996) 0.96
Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors. Learn Mem (2000) 0.96
A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning. Learn Mem (1999) 0.95
Kainic Acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines. Curr Neuropharmacol (2011) 0.95
Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex. Br J Pharmacol (1994) 0.95
Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress. Front Aging Neurosci (2011) 0.94
Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells. Br J Pharmacol (2004) 0.94
An in vitro study of long-term potentiation in the carp (Cyprinus carpio L.) olfactory bulb. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2005) 0.93
Involvement of IP3 receptors in LTP and LTD induction in guinea pig hippocampal CA1 neurons. Learn Mem (2005) 0.91
The pharmacology of neuroplasticity induced by non-invasive brain stimulation: building models for the clinical use of CNS active drugs. J Physiol (2012) 0.91
Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity. J Physiol (2008) 0.88
Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones. Br J Pharmacol (1995) 0.88
Hippocampal metaplasticity is required for the formation of temporal associative memories. J Neurosci (2014) 0.87
Reduction of food intake by cholecystokinin requires activation of hindbrain NMDA-type glutamate receptors. Am J Physiol Regul Integr Comp Physiol (2011) 0.86
Translational Concepts of mGluR5 in Synaptic Diseases of the Brain. Front Pharmacol (2012) 0.86
Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signaling. Synapse (2009) 0.86
Excitatory synaptic potentials dependent on metabotropic glutamate receptor activation in guinea-pig hippocampal pyramidal cells. J Physiol (1995) 0.86
Therapeutic potential of metabotropic glutamate receptor modulators. Curr Neuropharmacol (2012) 0.85
The characteristics of LTP induced in hippocampal slices are dependent on slice-recovery conditions. Learn Mem (2006) 0.85
Increased perinuclear Ca2+ activity evoked by metabotropic glutamate receptor activation in rat hippocampal neurones. J Physiol (1995) 0.84
Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A (1998) 0.84
The role of Homer1c in metabotropic glutamate receptor-dependent long-term potentiation. Hippocampus (2013) 0.84
Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP. Sci Rep (2011) 0.83
Metabotropic Glutamate Receptors and Epileptogenesis. Epilepsy Curr (2002) 0.83
Functional interaction of NMDA and group I metabotropic glutamate receptors in negatively reinforced learning in rats. Psychopharmacology (Berl) (2006) 0.82
A Ca-Based Computational Model for NMDA Receptor-Dependent Synaptic Plasticity at Individual Post-Synaptic Spines in the Hippocampus. Front Synaptic Neurosci (2010) 0.82
Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells. J Physiol (2012) 0.82
Inositol 1,3,4,5-tetrakisphosphate enhances long-term potentiation by regulating Ca2+ entry in rat hippocampus. J Physiol (1999) 0.82
A protein factor that inhibits ATP-dependent glutamate and gamma-aminobutyric acid accumulation into synaptic vesicles: purification and initial characterization. Proc Natl Acad Sci U S A (1997) 0.82
β-Adrenergic Control of Hippocampal Function: Subserving the Choreography of Synaptic Information Storage and Memory. Cereb Cortex (2016) 0.80
From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain. J Neural Transm (Vienna) (2006) 0.80
Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells. Br J Pharmacol (1995) 0.80
Gating of NMDA receptor-mediated hippocampal spike timing-dependent potentiation by mGluR5. Neuropharmacology (2012) 0.79
Role of Glycogenolysis in Memory and Learning: Regulation by Noradrenaline, Serotonin and ATP. Front Integr Neurosci (2016) 0.79
Distinct temporal profiles of activity-dependent calcium increase in pyramidal neurons of the rat visual cortex. J Physiol (1999) 0.79
Synaptic plasticity and Ca2+ signalling in astrocytes. Neuron Glia Biol (2010) 0.79
A novel form of low-frequency hippocampal mossy fiber plasticity induced by bimodal mGlu1 receptor signaling. J Neurosci (2011) 0.78
Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts. Evid Based Complement Alternat Med (2015) 0.77
Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k. Neurobiol Learn Mem (2015) 0.77
Interactions between adenosine and metabotropic glutamate receptors in the rat hippocampal slice. Br J Pharmacol (2003) 0.76
Developmental effects of wheel running on hippocampal glutamate receptor expression in young and mature adult rats. Neuroscience (2015) 0.76
Prior activation of inositol 1,4,5-trisphosphate receptors suppresses the subsequent induction of long-term potentiation in hippocampal CA1 neurons. Learn Mem (2016) 0.75
An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo. Hippocampus (2015) 0.75
The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies. Curr Neuropharmacol (2016) 0.75
Learning abilities depend on NMDA-receptor density in hippocampus in adult rats. J Neural Transm (Vienna) (1997) 0.75
Molecular mechanisms of group I metabotropic glutamate receptor mediated LTP and LTD in basolateral amygdala in vitro. Psychopharmacology (Berl) (2016) 0.75
A synaptic model of memory: long-term potentiation in the hippocampus. Nature (1993) 29.13
Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol (1965) 7.58
Excitatory amino acid transmitters. Annu Rev Pharmacol Toxicol (1981) 6.70
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol (1983) 6.04
Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology (1999) 4.48
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature (1994) 3.33
Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J Physiol (1990) 2.96
Modulation of AMPA receptor unitary conductance by synaptic activity. Nature (1998) 2.95
NSF binding to GluR2 regulates synaptic transmission. Neuron (1998) 2.92
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol (1982) 2.83
The pharmacology of amino acids related to gamma-aminobutyric acid. Pharmacol Rev (1965) 2.81
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature (1997) 2.74
Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron (1999) 2.60
PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron (2000) 2.56
Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations. J Physiol (1980) 2.53
Kainate receptors are involved in synaptic plasticity. Nature (1999) 2.43
Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology (2010) 2.31
Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse (1989) 2.23
The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology (1998) 2.16
Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J Neurosci (2001) 2.15
The synaptic activation of kainate receptors. Nature (1997) 2.15
GABA autoreceptors regulate the induction of LTP. Nature (1991) 2.13
L-glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes. Nature (1984) 2.10
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation. Neurosci Lett (1981) 2.08
Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron (1999) 2.00
The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events. J Neurosci Methods (2001) 1.99
Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism. Nature (1986) 1.90
Electrocardiographic measures of left ventricular hypertrophy show greater heritability than echocardiographic left ventricular mass. Eur Heart J (2002) 1.89
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res (1982) 1.86
The antagonism of amino acid-induced excitations of rat hippocampal CA1 neurones in vitro. J Physiol (1983) 1.86
A new intrathalamic pathway linking modality-related nuclei in the dorsal thalamus. Nat Neurosci (1998) 1.84
Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation. Nature (1989) 1.84
Inhibitory post-synaptic currents in rat hippocampal CA1 neurones. J Physiol (1984) 1.79
Neuronal metabolism governs cortical network response state. Proc Natl Acad Sci U S A (2006) 1.78
Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord. J Physiol (1979) 1.76
The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. Neuropharmacology (1999) 1.71
Phospholipid model membranes. II. Permeability properties of hydrated liquid crystals. Biochim Biophys Acta (1967) 1.71
CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity. Brain Res (1986) 1.70
Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature (1991) 1.65
Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein. J Neurosci (2001) 1.65
Leptin: a potential cognitive enhancer? Biochem Soc Trans (2005) 1.62
Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. J Physiol (2002) 1.61
(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology (1997) 1.61
A model of atropine-resistant theta oscillations in rat hippocampal area CA1. J Physiol (2002) 1.61
The surface properties of pure phospholipids in relation to those of lung extracts. Biochim Biophys Acta (1968) 1.61
PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. J Neurosci (2000) 1.60
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology (1999) 1.60
Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J Neurosci (1994) 1.59
Regulation of glutamate release by presynaptic kainate receptors in the hippocampus. Nature (1996) 1.59
Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis. Brain Res (1984) 1.59
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice. Mol Cell Neurosci (2001) 1.58
Cardiac energetics are abnormal in Friedreich ataxia patients in the absence of cardiac dysfunction and hypertrophy: an in vivo 31P magnetic resonance spectroscopy study. Cardiovasc Res (2001) 1.58
Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons. J Neurosci (2001) 1.58
Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia (1992) 1.57
CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices. Neurosci Lett (1988) 1.52
Excitation of mammalian central neurones by acidic amino acids. Brain Res (1972) 1.52
The role of GSK-3 in synaptic plasticity. Br J Pharmacol (2008) 1.52
Kainate receptors: subunits, synaptic localization and function. Trends Pharmacol Sci (1999) 1.50
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology (2004) 1.48
Magnesium ions block an N-methyl-D-aspartate receptor-mediated component of synaptic transmission in rat hippocampus. Neurosci Lett (1985) 1.47
Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors. J Physiol (1993) 1.46
Specific antagonism of excitant amino acids in the isolated spinal cord of the neonatal rat. Eur J Pharmacol (1978) 1.45
NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol (2007) 1.40
Ventral root responses of the hemisected amphibian spinal cord to perfused amino acids in the presence of procaine. Br J Pharmacol (1975) 1.38
Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine. Proc Natl Acad Sci U S A (1988) 1.38
Distinct NMDA receptor subpopulations contribute to long-term potentiation and long-term depression induction. J Neurosci (2000) 1.38
A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro. J Physiol (2001) 1.37
Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br J Pharmacol (1979) 1.36
Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception. Neuropharmacology (2001) 1.35
A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices. Neurosci Lett (1985) 1.33
Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1. Br J Pharmacol (2008) 1.32
Structure-activity relations of excitatory amino acids on frog and rat spinal neurones. Br J Pharmacol (1976) 1.31
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. Eur J Pharmacol (1993) 1.30
A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation. Nature (1994) 1.30
Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous systems. Comp Biochem Physiol C (1982) 1.30
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J Neurosci (1992) 1.28
Developmental changes in synaptic AMPA and NMDA receptor distribution and AMPA receptor subunit composition in living hippocampal neurons. J Neurosci (2000) 1.28
Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by D-alpha-aminoadipate, alpha,epsilon-diaminopimelic acid and HA-966. Eur J Pharmacol (1977) 1.27
A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP. Neuron (2001) 1.27
D-alpha-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones. Nature (1978) 1.26