Published in Ann Intern Med on September 15, 1998
Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies. Cancer (2008) 2.11
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. Mol Cell Biol (2005) 2.03
Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4). Mol Cell Endocrinol (2013) 1.71
Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. Endocr Relat Cancer (2009) 1.21
Comparative genomic hybridization reveals frequent losses of chromosomes 1p and 3q in pheochromocytomas and abdominal paragangliomas, suggesting a common genetic etiology. Am J Pathol (2000) 1.21
Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening. Langenbecks Arch Surg (2007) 1.06
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1. Cancer Res (2009) 1.05
Well-differentiated pancreatic neuroendocrine tumors: from genetics to therapy. Nat Rev Gastroenterol Hepatol (2012) 1.04
Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. World J Surg (2006) 1.03
Causes of death and prognostic factors in multiple endocrine neoplasia type 1: a prospective study: comparison of 106 MEN1/Zollinger-Ellison syndrome patients with 1613 literature MEN1 patients with or without pancreatic endocrine tumors. Medicine (Baltimore) (2013) 1.00
Clinical genetic testing and early surgical intervention in patients with multiple endocrine neoplasia type 1 (MEN 1). Ann Surg (2004) 0.97
Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value. World J Surg (2009) 0.92
Anterior pituitary adenomas: inherited syndromes, novel genes and molecular pathways. Expert Rev Endocrinol Metab (2010) 0.90
Long-term results of surgery for pancreatic neuroendocrine neoplasms in patients with MEN1. Langenbecks Arch Surg (2011) 0.88
Recurrence of secondary hyperparathyroidism in patients after total parathyroidectomy with autotransplantation: technical and therapeutic aspects. Eur Arch Otorhinolaryngol (2011) 0.86
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice. Endocrinology (2010) 0.85
10 rare tumors that warrant a genetics referral. Fam Cancer (2013) 0.84
The current strategy for managing pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1. Gut Liver (2012) 0.84
Sporadic pancreatic polypeptide secreting tumors (PPomas) of the pancreas. World J Surg (2008) 0.83
Insulin secretion and insulin-producing tumors. Expert Rev Endocrinol Metab (2010) 0.81
Causes and treatment of recurrent hyperparathyroidism after subtotal parathyroidectomy in the presence of multiple endocrine neoplasia 1. World J Surg (2010) 0.81
MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics. Neuroendocrinology (2015) 0.80
Gastroenteropancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1. Cancers (Basel) (2012) 0.79
A report of a national mutation testing service for the MEN1 gene: clinical presentations and implications for mutation testing. J Med Genet (2005) 0.78
Rapid development of thymic neuroendocrine carcinoma despite transcervical thymectomy in a patient with multiple endocrine neoplasia type 1. Indian J Endocrinol Metab (2013) 0.78
Multiple Endocrine Neoplasia: Genetics and Clinical Management. Surg Oncol Clin N Am (2015) 0.77
Isolated familial somatotropinomas: clinical and genetic considerations. Trans Am Clin Climatol Assoc (2003) 0.77
Surgical treatment of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. Clinics (Sao Paulo) (2012) 0.77
Case Report: A case report of acromegaly associated with primary aldosteronism. F1000Res (2014) 0.75
Genetics of multiple endocrine neoplasia type 1 syndrome: what's new and what's old. F1000Res (2017) 0.75
Genetic analysis of a patient with coexisting acromegaly, thyroid papillary carcinoma and subcutaneous fibroma. Oncol Lett (2014) 0.75
Concomitant existence of pheochromocytoma in a patient with multiple endocrine neoplasia type 1. Surg Case Rep (2016) 0.75
An unusual presentation of a patient with multiple endocrine neoplasia- 1. J Clin Diagn Res (2014) 0.75
Thymoma (World Health Organization type B3) with neuroendocrine differentiation in multiple endocrine neoplasia type 1. J Surg Case Rep (2017) 0.75
Pituitary tumors in patients with MEN1 syndrome. Clinics (Sao Paulo) (2012) 0.75
Hereditary syndromes predisposing to endocrine tumors and their skin manifestations. Rev Endocr Metab Disord (2016) 0.75
Impact of a novel 14 bp MEN1 deletion in a patient with hyperparathyroidism and gastrinoma. Endocrinol Diabetes Metab Case Rep (2015) 0.75
Fast-growing pancreatic neuroendocrine carcinoma in a patient with multiple endocrine neoplasia type 1: a case report. J Med Case Rep (2008) 0.75
Genetics of pancreatic neuroendocrine tumors: implications for the clinic. Expert Rev Gastroenterol Hepatol (2015) 0.75
Minimally Invasive Versus Open Pancreatic Surgery in Patients with Multiple Endocrine Neoplasia Type 1. World J Surg (2016) 0.75
Multiple endocrine neoplasia type 1 syndrome: single centre experience from western India. Fam Cancer (2016) 0.75
Natural History of MEN1 GEP-NET: Single-Center Experience After a Long Follow-Up. World J Surg (2017) 0.75
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Laser capture microdissection. Science (1996) 12.21
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A (1986) 12.14
Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res (1991) 9.56
Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95
Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method. Proc Natl Acad Sci U S A (1984) 7.38
The mammalian gene collection. Science (1999) 7.19
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med (1991) 7.17
Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. Biochemistry (1982) 6.87
Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol (1993) 6.53
Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature (1980) 5.84
The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals. Nat Genet (1995) 5.83
Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet (1997) 5.58
The molecular genetics of human hemoglobin. Prog Nucleic Acid Res Mol Biol (1984) 5.50
Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst (1988) 5.42
The hypocalciuric or benign variant of familial hypercalcemia: clinical and biochemical features in fifteen kindreds. Medicine (Baltimore) (1981) 5.29
Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science (1996) 5.06
Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. Cancer Res (1986) 5.05
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79
Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene. Proc Natl Acad Sci U S A (1990) 4.74
Mutation analysis for heterozygote detection and the prenatal diagnosis of cystic fibrosis. N Engl J Med (1990) 4.60
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature (1992) 4.42
Direct sequencing of enzymatically amplified human genomic DNA. Proc Natl Acad Sci U S A (1988) 4.41
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene (2001) 4.40
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell (1995) 4.34
Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis. Nat Genet (1996) 4.19
Genetic discrimination and health insurance: an urgent need for reform. Science (1995) 4.08
Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res (1974) 3.96
Laser capture microdissection: molecular analysis of tissue. Science (1997) 3.93
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science (1993) 3.88
Construction of a general human chromosome jumping library, with application to cystic fibrosis. Science (1987) 3.87
Tumor invasion and the extracellular matrix. Lab Invest (1983) 3.81
Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A (1997) 3.76
Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Nature (1989) 3.75
High-resolution serum proteomic features for ovarian cancer detection. Endocr Relat Cancer (2004) 3.75
General mechanisms of metastasis. Cancer (1997) 3.71
Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell (1990) 3.70
Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human gamma and epsilon globin genes. Mol Cell Biol (1992) 3.57
The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res (1976) 3.47
Laminin receptor on human breast carcinoma cells. Proc Natl Acad Sci U S A (1983) 3.32
A de novo Alu insertion results in neurofibromatosis type 1. Nature (1991) 3.29
Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell (1991) 3.21
Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc Natl Acad Sci U S A (1986) 3.21
Surgery to cure the Zollinger-Ellison syndrome. N Engl J Med (1999) 3.21
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell (1999) 3.16
Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes. Science (1991) 3.12
Biochemical interactions of tumor cells with the basement membrane. Annu Rev Biochem (1986) 3.06
Isolation of a tumor cell laminin receptor. Biochem Biophys Res Commun (1983) 3.05
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum Mol Genet (1995) 3.05
Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res (1981) 3.00
Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain. J Biol Chem (1987) 2.99
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem (1992) 2.93
Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing's syndrome. N Engl J Med (1991) 2.93
Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. J Biol Chem (1989) 2.87
Detection of gene deletion in single metastatic tumour cells in lymphnode tissue by fluorescent in-situ hybridisation. Lancet (1997) 2.77
Forty-eight-hour fast: the diagnostic test for insulinoma. J Clin Endocrinol Metab (2000) 2.75
Genetic and clinical features of 42 kindreds with resistance to thyroid hormone. The National Institutes of Health Prospective Study. Ann Intern Med (1995) 2.74
Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus. JAMA (1997) 2.73
Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J Cell Biol (1990) 2.69
Positional cloning: let's not call it reverse anymore. Nat Genet (1992) 2.69
Strategies for mapping and cloning macroregions of mammalian genomes. Methods Enzymol (1987) 2.68
Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci. Nucleic Acids Res (1990) 2.62
Laser-capture microdissection: opening the microscopic frontier to molecular analysis. Trends Genet (1998) 2.60
Immuno-LCM: laser capture microdissection of immunostained frozen sections for mRNA analysis. Am J Pathol (1999) 2.59
A microdissection technique for archival DNA analysis of specific cell populations in lesions < 1 mm in size. Am J Pathol (1995) 2.59
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A (2001) 2.57
Genetic counseling for families with inherited susceptibility to breast and ovarian cancer. JAMA (1993) 2.51
Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas. A prospective study. Ann Intern Med (1996) 2.51
Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res (1995) 2.50
Role of laminin in the attachment and metastasis of murine tumor cells. Cancer Res (1982) 2.49
Detection of eight BRCA1 mutations in 10 breast/ovarian cancer families, including 1 family with male breast cancer. Am J Hum Genet (1995) 2.42
Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines. Cancer Res (1990) 2.40
Menin, the product of the MEN1 gene, is a nuclear protein. Proc Natl Acad Sci U S A (1998) 2.39
Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res (1989) 2.39
A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell (1990) 2.36
A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin. Nature (1985) 2.33
Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies. Proc Natl Acad Sci U S A (1989) 2.31
Comparison of computed and conventional whole lung tomography in detecting pulmonary nodules: a prospective radiologic-pathologic study. AJR Am J Roentgenol (1978) 2.29
Tumor cell autocrine motility factor. Proc Natl Acad Sci U S A (1986) 2.28
Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J (1993) 2.28
Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor. Proc Natl Acad Sci U S A (1979) 2.25
Molecular aspects of tumor cell invasion and metastasis. Cancer (1993) 2.24
Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia. Blood (1995) 2.23
Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis. Curr Opin Oncol (1994) 2.21
Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells. J Clin Invest (1998) 2.20
Strategies for mutational analysis of the large multiexon ATM gene using high-density oligonucleotide arrays. Genome Res (1998) 2.17
Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia. Am J Pathol (1992) 2.17
Tumor cell invasion inhibited by TIMP-2. J Natl Cancer Inst (1991) 2.15
Resistance to multiple hormones in patients with pseudohypoparathyroidism. Association with deficient activity of guanine nucleotide regulatory protein. Am J Med (1983) 2.14
Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex) J Clin Endocrinol Metab (1997) 2.14
Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. Nat Genet (1993) 2.10
Signal transduction by guanine nucleotide binding proteins. Mol Cell Endocrinol (1987) 2.06
Localization of insulinomas to regions of the pancreas by intra-arterial stimulation with calcium. Ann Intern Med (1995) 2.05