Published in Cell on September 18, 1998
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Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities. Mol Cancer (2004) 1.46
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Proteasome activity is required for anthrax lethal toxin to kill macrophages. Infect Immun (1999) 1.32
Arabidopsis protein disulfide isomerase-5 inhibits cysteine proteases during trafficking to vacuoles before programmed cell death of the endothelium in developing seeds. Plant Cell (2008) 1.31
Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer (2000) 1.31
Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein. J Exp Med (1999) 1.31
The role of galectin-3 in cancer drug resistance. Drug Resist Updat (2007) 1.23
Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. J Neurosci (2008) 1.19
A plant caspase-like protease activated during the hypersensitive response. Plant Cell (2003) 1.18
Caspase and bid involvement in Clostridium difficile toxin A-induced apoptosis and modulation of toxin A effects by glutamine and alanyl-glutamine in vivo and in vitro. Infect Immun (2006) 1.18
c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol (2000) 1.18
Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of Fas signaling. J Virol (2001) 1.17
Programmed cell death in castor bean endosperm is associated with the accumulation and release of a cysteine endopeptidase from ricinosomes. Proc Natl Acad Sci U S A (1999) 1.16
Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Am J Pathol (2003) 1.14
Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4. Mol Cell Biol (2003) 1.13
Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production. Mol Biol Cell (2000) 1.10
The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells. J Virol (2000) 1.10
Programmed cell death during pollination-induced petal senescence in petunia. Plant Physiol (2000) 1.08
Inflammation & apoptosis in spinal cord injury. Indian J Med Res (2012) 1.08
Interferon gamma inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis. Gut (2001) 1.07
Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. J Exp Med (2001) 1.07
Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond. J Physiol (2014) 1.07
Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria. J Virol (2006) 1.06
Accumulation of herpes simplex virus type 1 early and leaky-late proteins correlates with apoptosis prevention in infected human HEp-2 cells. J Virol (2001) 1.05
Effects of exercise intensity on lymphocyte apoptosis induced by oxidative stress in men. Eur J Appl Physiol (2005) 1.05
Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim Biophys Acta (2013) 1.04
Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase. J Exp Med (2000) 1.03
Characterization of the anti-apoptotic mechanism of Bcl-B. Biochem J (2003) 1.03
Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma. Cancer (2008) 1.03
Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells. J Biol Chem (2011) 1.03
Mitochondria in Ca2+ signaling and apoptosis. J Bioenerg Biomembr (2000) 1.03
Viruses and apoptosis. Int J Exp Pathol (2001) 1.03
TNF-alpha in pregnancy loss and embryo maldevelopment: a mediator of detrimental stimuli or a protector of the fetoplacental unit? J Assist Reprod Genet (2003) 1.02
Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin. BMC Cell Biol (2002) 1.02
The role of p38 MAPK activation in auranofin-induced apoptosis of human promyelocytic leukaemia HL-60 cells. Br J Pharmacol (2005) 1.02
Effects of Chinese Jianpi herbs on cell apoptosis and related gene expression in human gastric cancer grafted onto nude mice. World J Gastroenterol (2002) 1.01
Bench-to-bedside review: severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors. Crit Care (2003) 1.01
Induction of cell death in rat small intestine by ischemia reperfusion: differential roles of Fas/Fas ligand and Bcl-2/Bax systems depending upon cell types. Histochem Cell Biol (2005) 1.01
Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies. Oncotarget (2015) 1.00
Non-invasive in vivo imaging of myocardial apoptosis and necrosis. Eur J Nucl Med Mol Imaging (2003) 0.99
Alterations in mitochondrial function as a harbinger of cardiomyopathy: lessons from the dystrophic heart. J Mol Cell Cardiol (2009) 0.99
Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis. Arthritis Res Ther (2007) 0.99
Electron transport chain defects in heart failure. Heart Fail Rev (2002) 0.99
Activation and specificity of human caspase-10. Biochemistry (2010) 0.98
Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease. Gut (2004) 0.97
PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells. Nucleic Acids Res (2005) 0.97
Mitochondria-immobilized pH-sensitive off-on fluorescent probe. J Am Chem Soc (2014) 0.96
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. Proc Natl Acad Sci U S A (2000) 0.96
Transglutaminase 2 inhibits apoptosis induced by calcium- overload through down-regulation of Bax. Exp Mol Med (2010) 0.94
Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria. Free Radic Biol Med (2009) 0.94
Neem oil limonoids induces p53-independent apoptosis and autophagy. Carcinogenesis (2012) 0.94
Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. PLoS One (2012) 0.93
Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res (2009) 0.93
Apoptosis and sphingomyelin hydrolysis. The flip side. J Cell Biol (2000) 0.92
Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody. J Clin Invest (2000) 0.92
Herpes simplex virus type 1 immediate-early gene expression is required for the induction of apoptosis in human epithelial HEp-2 cells. J Virol (2004) 0.92
Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases. Biochem J (2003) 0.92
Redistribution of cytochrome c precedes the caspase-dependent formation of ultracondensed mitochondria, with a reduced inner membrane potential, in apoptotic monocytes. Am J Pathol (1999) 0.91
Activation of dual apoptotic pathways in human melanocytes and protection by survivin. J Invest Dermatol (2006) 0.91
Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2. Br J Cancer (2008) 0.90
Apoptosis Induced by Manganese on Neuronal SK-N-MC Cell Line: Endoplasmic Reticulum (ER) Stress and Mitochondria Dysfunction. Environ Health Toxicol (2011) 0.90
Habitual physical activity in mitochondrial disease. PLoS One (2011) 0.89
A cyclic HSV1-TK reporter for real-time PET imaging of apoptosis. Proc Natl Acad Sci U S A (2014) 0.89
Mitochondrial Factors and VACTERL Association-Related Congenital Malformations. Mol Syndromol (2013) 0.89
Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs. Int J Oncol (2013) 0.89
Assessment of apoptosis in human breast tissue using an antibody against the active form of caspase 3: relation to tumour histopathological characteristics. Br J Cancer (2001) 0.88
The short prodomain influences caspase-3 activation in HeLa cells. Biochem J (2000) 0.88
Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency. J Virol (2004) 0.88
Mitochondria: redox metabolism and dysfunction. Biochem Res Int (2012) 0.87
Herpes simplex virus blocks apoptosis by precluding mitochondrial cytochrome c release independent of caspase activation in infected human epithelial cells. Apoptosis (2007) 0.87
Listeria monocytogenes infection in caspase-11-deficient mice. Infect Immun (2002) 0.87
Intracellular energy depletion triggers programmed cell death during petal senescence in tulip. J Exp Bot (2008) 0.86
Systemic hypoxia promotes lymphocyte apoptosis induced by oxidative stress during moderate exercise. Eur J Appl Physiol (2009) 0.86
NLRP3 inflammasome activation in dialyzed chronic kidney disease patients. PLoS One (2015) 0.85
IL-4 and IL-10 inhibition of spontaneous monocyte apoptosis is associated with Flip upregulation. Inflammation (2004) 0.85
Ammonia as an accelerator of tumor necrosis factor alpha-induced apoptosis of gastric epithelial cells in Helicobacter pylori infection. Infect Immun (2001) 0.85
Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha. Nucleic Acids Res (2001) 0.85
Activation of caspases in intestinal villus epithelial cells of normal and nematode infected rats. Gut (2002) 0.84
Oncogenes and tumor suppressors regulate glutamine metabolism in cancer cells. J Cancer Prev (2013) 0.84
ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice. Cell Death Dis (2013) 0.84
NF-kappa B DNA-binding activity in embryos responding to a teratogen, cyclophosphamide. BMC Dev Biol (2002) 0.84
Differential cell killing by lymphomagenic murine leukemia viruses occurs independently of p53 activation and mitochondrial damage. J Virol (2004) 0.83
Tgf-beta-mediated FasL-Fas-Caspase pathway is crucial during palatogenesis. J Dent Res (2011) 0.83
The point of no return: mitochondria, caspases, and the commitment to cell death. Results Probl Cell Differ (1998) 1.02
Harm's way: polyglutamine repeats and the activation of an apoptotic pathway. Neuron (1999) 0.79