Tetrahymena mutants with short telomeres.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 1460368)

Published in Genetics on October 01, 1998

Authors

S Ahmed1, H Sheng, L Niu, E Henderson

Author Affiliations

1: Department of Zoology and Genetics, Signal Transduction Training Group, Iowa State University, Ames, Iowa 50011, USA.

Articles cited by this

Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature (1989) 13.18

Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A (1992) 10.19

Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (1997) 10.10

The RNA component of human telomerase. Science (1995) 9.86

Origin of concatemeric T7 DNA. Nat New Biol (1972) 9.08

TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science (1994) 9.08

A mutant with a defect in telomere elongation leads to senescence in yeast. Cell (1989) 8.69

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell (1987) 8.32

Control of telomere length by the human telomeric protein TRF1. Nature (1997) 7.62

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17

An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell (1993) 6.89

Loss of a yeast telomere: arrest, recovery, and chromosome loss. Cell (1993) 6.83

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature (1990) 6.82

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med (1997) 6.55

Telomere loss: mitotic clock or genetic time bomb? Mutat Res (1992) 6.50

All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus. Proc Natl Acad Sci U S A (1981) 5.75

Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science (1996) 5.55

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell (1997) 4.86

Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs. Cell (1987) 4.85

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics (1996) 4.78

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet (1993) 4.78

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev (1992) 4.53

A conserved secondary structure for telomerase RNA. Cell (1991) 4.52

Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature (1997) 4.49

A mammalian telomerase-associated protein. Science (1997) 4.37

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res (1996) 4.37

RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell (1990) 4.25

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell (1995) 4.20

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev (1997) 4.05

The telomerase reverse transcriptase: components and regulation. Genes Dev (1998) 3.63

Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr Biol (1998) 3.63

The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation. Cell (1994) 3.52

TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell (1997) 3.30

Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell (1995) 3.23

Growth of chromosome ends in multiplying trypanosomes. Nature (1983) 3.16

Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A (1997) 3.11

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet (1998) 3.01

The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res (1996) 2.90

Ciliate telomerase RNA structural features. Nucleic Acids Res (1995) 2.87

An overhanging 3' terminus is a conserved feature of telomeres. Mol Cell Biol (1989) 2.85

Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev (1997) 2.75

Telomerase and DNA end replication: no longer a lagging strand problem? Science (1995) 2.67

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene (1998) 2.56

Dynamics of telomere length variation in Tetrahymena thermophila. Cell (1987) 2.56

A yeast telomere binding activity binds to two related telomere sequence motifs and is indistinguishable from RAP1. Curr Genet (1989) 2.31

High frequency vector-mediated transformation and gene replacement in Tetrahymena. Nucleic Acids Res (1994) 2.31

Est1 has the properties of a single-stranded telomere end-binding protein. Genes Dev (1996) 2.30

Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element. Cell (1986) 2.29

Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature (1996) 2.24

Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res (1995) 2.11

Altering specific telomerase RNA template residues affects active site function. Genes Dev (1995) 1.92

Architecture of telomerase RNA. EMBO J (1994) 1.88

The terminal organization of macronuclear DNA in Oxytricha fallax. Nucleic Acids Res (1982) 1.72

DNA damage and repair in telomeres: relation to aging. Proc Natl Acad Sci U S A (1995) 1.56

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells. Cytogenet Cell Genet (1995) 1.51

TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.37

Transformation of Tetrahymena thermophila with a mutated circular ribosomal DNA plasmid vector. Proc Natl Acad Sci U S A (1989) 1.37

Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe. Mol Biol Cell (1998) 1.27

Telomere length regulation: getting the measure of chromosome ends. Biol Chem (1997) 1.08

Tetrahymena telomerase RNA levels increase during macronuclear development. Dev Genet (1992) 1.01

Stochastic developmental variation in the ratio of allelic rDNAs among newly differentiated, heterozygous macronuclei of Tetrahymena thermophila. Dev Genet (1992) 0.93

Axenic storage of small volumes of Tetrahymena cultures under liquid nitrogen: A miniaturized procedure. Cryobiology (1979) 0.84

Collective Capitalism and Economic Theory. Science (1957) 0.76

Articles by these authors

(truncated to the top 100)

Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging (1999) 13.26

Methicillin-resistant Staphylococcus aureus in tertiary care institutions on the Canadian prairies 1990-1992. Infect Control Hosp Epidemiol (1994) 3.27

Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. Gastroenterology (2001) 3.13

Eocytes: a new ribosome structure indicates a kingdom with a close relationship to eukaryotes. Proc Natl Acad Sci U S A (1984) 3.11

A comparison of the reproducibility and the sensitivity to change of visual analogue scales, Borg scales, and Likert scales in normal subjects during submaximal exercise. Chest (1999) 3.01

Efficiency of transformation of lymphocytes by Epstein-Barr virus. Virology (1977) 2.94

Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol (1991) 2.34

Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science (1992) 2.25

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 2.16

Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol (1997) 2.16

Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models. Cancer Res (2000) 2.05

Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins. Mol Cell Biol (1991) 2.04

Mapping evolution with ribosome structure: intralineage constancy and interlineage variation. Proc Natl Acad Sci U S A (1982) 2.00

Ventricular arrhythmias in patients with hypertensive left ventricular hypertrophy. N Engl J Med (1987) 1.94

Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates. Biochemistry (1991) 1.93

Discrimination of DNA hybridization using chemical force microscopy. Biophys J (1999) 1.86

Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. Gut (2008) 1.85

Effect of captopril, an angiotensin-converting enzyme inhibitor, in patients with angina pectoris and heart failure. J Am Coll Cardiol (1991) 1.82

Structure of the allosteric regulatory enzyme of purine biosynthesis. Science (1994) 1.81

Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a CALGB study. Blood (1982) 1.79

Hair loss in psychopharmacology. Ann Clin Psychiatry (2000) 1.76

Fluid mechanics of arterial stenosis: relationship to the development of mural thrombus. Ann Biomed Eng (1997) 1.74

An autopsy study of 1206 acute and chronic leukemias (1958 to 1982). Cancer (1987) 1.72

Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequence. Mol Cell Biol (1990) 1.68

Colloidal gold particles as an incompressible atomic force microscope imaging standard for assessing the compressibility of biomolecules. Biophys J (1993) 1.66

Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J Biol Chem (2000) 1.64

Eubacteria, halobacteria, and the origin of photosynthesis: the photocytes. Proc Natl Acad Sci U S A (1985) 1.63

Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. J Biol Chem (2000) 1.58

Photolabile precursors of glutamate: synthesis, photochemical properties, and activation of glutamate receptors on a microsecond time scale. Proc Natl Acad Sci U S A (1994) 1.57

A new ribosome structure. Science (1984) 1.56

The effects of pyrogallol and hydroquinone on the response to NANC nerve stimulation in the rat anococcygeus and the bovine retractor penis muscles. Br J Pharmacol (1990) 1.54

Recognition and elongation of telomeres by telomerase. Genome (1989) 1.54

XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol Endocrinol (1994) 1.54

The Chlamydomonas reinhardtii ODA3 gene encodes a protein of the outer dynein arm docking complex. J Cell Biol (1997) 1.53

Deletion of the Escherichia coli pseudouridine synthase gene truB blocks formation of pseudouridine 55 in tRNA in vivo, does not affect exponential growth, but confers a strong selective disadvantage in competition with wild-type cells. RNA (2000) 1.52

Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat. Anesthesiology (1997) 1.50

Three-dimensional imaging of living neurons and glia with the atomic force microscope. J Cell Sci (1993) 1.48

A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts. Am J Physiol (1991) 1.47

Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: evidence of differential tropism. J Virol (1996) 1.47

G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res (1996) 1.44

Hodgkin disease survivors at increased risk for problems in psychosocial adaptation. The Cancer and Leukemia Group B. Cancer (1992) 1.44

Impact of free verotoxin testing on epidemiology of diarrhea caused by verotoxin-producing Escherichia coli. J Clin Microbiol (1995) 1.44

Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infection of rats with Borna disease virus. J Virol (1992) 1.43

Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. J Neurosci (2001) 1.38

Atomic force microscopy of oriented linear DNA molecules labeled with 5nm gold spheres. Nucleic Acids Res (1993) 1.38

Steady flow in an aneurysm model: correlation between fluid dynamics and blood platelet deposition. J Biomech Eng (1996) 1.37

Non-invasive determination of cardiac output by Doppler echocardiography and electrical bioimpedance. Br Heart J (1990) 1.36

Novel exercise protocol suitable for use on a treadmill or a bicycle ergometer. Br Heart J (1990) 1.36

A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. Gastroenterology (1997) 1.35

Influence of haemoglobin and erythrocytes on the effects of EDRF, a smooth muscle inhibitory factor, and nitric oxide on vascular and non-vascular smooth muscle. Br J Pharmacol (1988) 1.35

Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA. J Biol Chem (1999) 1.35

MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. Cell Death Differ (2011) 1.33

Aberrant recombination events in B cell lines derived from a kappa-deficient human. Nucleic Acids Res (1985) 1.33

A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy. Nucleic Acids Res (1995) 1.29

16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp102 residue, and sequence comparison among all other pseudouridine synthases. RNA (1999) 1.28

Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle. Br J Pharmacol (1991) 1.25

G-wires: self-assembly of a telomeric oligonucleotide, d(GGGGTTGGGG), into large superstructures. Biochemistry (1994) 1.24

The association of bacteriuria with resident characteristics and survival in elderly institutionalized men. Ann Intern Med (1987) 1.24

Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. Mol Cell Biol (1997) 1.21

Localization of individual calcium channels at the release face of a presynaptic nerve terminal. Neuron (1994) 1.20

Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone. Bone (2006) 1.19

A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip. Br J Pharmacol (1989) 1.18

Yersinia-related arthritis in the Pacific Northwest. Arthritis Rheum (1977) 1.18

The prognostic value of submaximal exercise testing with radionuclide ventriculography before hospital discharge in patients with recent myocardial infarction. Circulation (1981) 1.18

Alcohol dependence and conduct disorder among Navajo Indians. J Stud Alcohol (1999) 1.17

Radiobiological inactivation of Epstein-Barr virus. J Virol (1978) 1.17

Not so peculiar: fission yeast telomere repeats. Trends Biochem Sci (1998) 1.16

Transforming growth factor-beta1 promotes invasiveness after cellular transformation with activated Ras in intestinal epithelial cells. Exp Cell Res (2001) 1.16

HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. Br J Cancer (2005) 1.15

Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene. J Clin Invest (2000) 1.15

Human telomeric C-strand tetraplexes. Nat Struct Biol (1994) 1.14

A protein from Tetrahymena thermophila that specifically binds parallel-stranded G4-DNA. Biochemistry (1994) 1.12

Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase. J Virol (1993) 1.12

The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene. Mol Endocrinol (1995) 1.12

Participation of the lysine pathway in dipicolinic acid synthesis in Bacillus cereus T. Biochem Biophys Res Commun (1967) 1.11

Functional CT imaging of angiogenesis in rabbit VX2 soft-tissue tumour. Phys Med Biol (2001) 1.11

A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia. Brain Res (2000) 1.11

The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment. J Biol Chem (2000) 1.10

Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation. J Biol Chem (2000) 1.09

Urinary collagen crosslinks reflect the radiographic severity of knee osteoarthritis. Br J Rheumatol (1992) 1.08

Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis (1999) 1.07

DNA hybridization electron microscopy: ribosomal RNA nucleotides 1392-1407 are exposed in the cleft of the small subunit. Proc Natl Acad Sci U S A (1986) 1.05

Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors. Cancer and Leukemia Group B. Ann Oncol (1998) 1.04

TGF-beta1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression. Oncogene (1998) 1.04

Visualization of nucleosomal substructure in native chromatin by atomic force microscopy. Biochemistry (1995) 1.03

Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription. J Biol Chem (1994) 1.03

Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia. J Cereb Blood Flow Metab (1997) 1.03

Formation of novel hairpin structures by telomeric C-strand oligonucleotides. Nucleic Acids Res (1992) 1.03

Differential effects of rabies and borna disease viruses on immediate-early- and late-response gene expression in brain tissues. J Virol (1993) 1.02

Effects of cyclic GMP on smooth muscle relaxation. Adv Pharmacol (1994) 1.02

Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study. Neuroimage (2001) 1.01

Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits with inhibition of both thrombosis and lipid-deposition. Bone (2006) 1.01

Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study. J Hum Hypertens (2008) 1.01

Chloroflexus aurantiacus has 30S ribosomal subunits of the eubacterial type. J Bacteriol (1983) 1.00

The L7/L12 stalk, a conserved feature of the prokaryotic ribosome, is attached to the large subunit through its N terminus. J Mol Biol (1981) 1.00

A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia (2001) 0.99

Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis. J Neurol Sci (1995) 0.99

Serum antibody levels against T mycoplasmas in two North American Indian populations predisposed to spondylitis. Arthritis Rheum (1977) 0.99

Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. Neoplasia (2001) 0.98

Epstein-Barr virus: transformation of lymphocytes separated by size or exposed to bromodeoxyuridine and light. Virology (1977) 0.97