Published in Antimicrob Agents Chemother on October 01, 1998
Determination of nucleoside analog mono-, di-, and tri-phosphates in cellular matrix by solid phase extraction and ultra-sensitive LC-MS/MS detection. J Pharm Biomed Anal (2011) 2.10
Simultaneous quantitation of intracellular zidovudine and lamivudine triphosphates in human immunodeficiency virus-infected individuals. Antimicrob Agents Chemother (2000) 1.20
Effect of ribavirin on intracellular and plasma pharmacokinetics of nucleoside reverse transcriptase inhibitors in patients with human immunodeficiency virus-hepatitis C virus coinfection: results of a randomized clinical study. Antimicrob Agents Chemother (2005) 0.93
Model for intracellular Lamivudine metabolism in peripheral blood mononuclear cells ex vivo and in human immunodeficiency virus type 1-infected adolescents. Antimicrob Agents Chemother (2006) 0.92
Quantitation of intracellular triphosphate of emtricitabine in peripheral blood mononuclear cells from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother (1999) 0.92
Development of enzymatic assays for quantification of intracellular lamivudine and carbovir triphosphate levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother (2002) 0.89
Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents. Antimicrob Agents Chemother (2007) 0.87
Determination of zidovudine triphosphate intracellular concentrations in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals by tandem mass spectrometry. Antimicrob Agents Chemother (1999) 0.86
Enzymatic assay for measurement of intracellular DXG triphosphate concentrations in peripheral blood mononuclear cells from human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother (2003) 0.82
Determination of ddATP levels in human immunodeficiency virus-infected patients treated with dideoxyinosine. Antimicrob Agents Chemother (2004) 0.75
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med (1997) 17.51
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science (1997) 15.12
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci U S A (1986) 8.48
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. Antimicrob Agents Chemother (1993) 5.08
Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science (1995) 4.98
A preliminary trial of lamivudine for chronic hepatitis B infection. N Engl J Med (1995) 4.84
Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC). J Infect Dis (1995) 4.60
Production of antisera with small doses of immunogen: multiple intradermal injections. Methods Enzymol (1981) 3.37
Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2',3'-dideoxynucleoside analogs in resting and activated human cells. J Biol Chem (1994) 2.03
Generation of drug-resistant variants of human immunodeficiency virus type 1 by in vitro passage in increasing concentrations of 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine. Antimicrob Agents Chemother (1993) 1.86
Advances in antiretroviral therapy and viral load monitoring. AIDS (1996) 1.30
Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro. J Infect Dis (1996) 1.26
Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1. J Virol (1996) 1.18
A systemic and cellular model for zidovudine plasma concentrations and intracellular phosphorylation in patients. J Infect Dis (1996) 1.09
Induction of thymidine kinases in phytohaemagglutinin-stimulated human lymphocytes. Biochim Biophys Acta (1977) 1.07
Quantitation of intracellular zidovudine phosphates by use of combined cartridge-radioimmunoassay methodology. Antimicrob Agents Chemother (1996) 1.03
Quantification of zidovudine and individual zidovudine phosphates in peripheral blood mononuclear cells by a combined isocratic high performance liquid chromatography radioimmunoassay method. J Pharm Biomed Anal (1996) 0.92
Regulation of human deoxycytidine kinase expression. Adv Enzyme Regul (1993) 0.84
Cell cycle regulation of deoxycytidine kinase. Evidence for post-transcriptional control. FEBS Lett (1993) 0.81
The production and evaluation of a radioligand and antiserum for the radioimmunoassay of subnanogram per millilitre concentrations of lamivudine. J Pharm Biomed Anal (1994) 0.79
Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob Agents Chemother (1998) 3.01
Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS. N Engl J Med (1993) 2.78
Fetus in fetu: a case report and literature review. Pediatrics (2000) 2.52
Prevention of Pneumocystis carinii pneumonitis in AIDS patients with weekly dapsone. Lancet (1990) 2.44
Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal Chem (1985) 2.22
Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J Virol (2000) 2.18
Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity. Biochem Pharmacol (1987) 2.10
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med (1999) 2.07
The advantage of sex in the RNA virus phi6. Genetics (1997) 1.94
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. J Biol Chem (2001) 1.76
Conformational flexibility of the acetylcholinesterase tetramer suggested by x-ray crystallography. J Biol Chem (1999) 1.72
Impact of virologic breakthrough and HBIG regimen on hepatitis B recurrence after liver transplantation. Am J Transplant (2010) 1.67
Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2. J Biol Chem (1993) 1.65
PrPSc accumulation in myocytes from sheep incubating natural scrapie. Nat Med (2004) 1.63
Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity. Biochem Pharmacol (1987) 1.57
Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells. Mol Pharmacol (1989) 1.54
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates. Antimicrob Agents Chemother (1993) 1.54
Immunohistochemical features of PrP(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies. J Comp Pathol (2006) 1.45
Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cells. Biochem Pharmacol (1993) 1.43
Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters. Antimicrob Agents Chemother (1998) 1.40
Competitive enzyme immunoassay with monoclonal antibody for homovanillic acid measurement in human urine samples. Clin Chem (1997) 1.39
Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol (1988) 1.38
Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells. J Biol Chem (1988) 1.32
Mullerian inhibiting substance inhibits ovarian cell growth through an Rb-independent mechanism. J Biol Chem (2000) 1.31
Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains. Antimicrob Agents Chemother (1998) 1.30
Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells. Antimicrob Agents Chemother (1995) 1.28
Bronchopulmonary cross-colonization and infection related to mycobacterial contamination of suction valves of bronchoscopes. J Infect Dis (1989) 1.26
A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent. Mol Pharmacol (1995) 1.25
New insight into abnormal prion protein using monoclonal antibodies. Biochem Biophys Res Commun (1999) 1.23
Mullerian inhibiting substance inhibits breast cancer cell growth through an NFkappa B-mediated pathway. J Biol Chem (2000) 1.22
A marked disparity between the expression of prion protein and its message by neurones of the CNS. Neuroscience (2002) 1.20
Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo. J Immunol (2001) 1.20
Preferential labeling of alpha-amino N-terminal groups in peptides by biotin: application to the detection of specific anti-peptide antibodies by enzyme immunoassays. J Immunol Methods (1996) 1.19
Antiretroviral effect and safety of abacavir alone and in combination with zidovudine in HIV-infected adults. Abacavir Phase 2 Clinical Team. AIDS (1998) 1.18
Platelet-activating factor (PAF-acether) enhances the concomitant production of tumour necrosis factor-alpha and interleukin-1 by subsets of human monocytes. Immunology (1991) 1.16
Enzyme immunoassays of eicosanoids using acetylcholinesterase. Methods Enzymol (1990) 1.15
Differences in metabolism and cytotoxicity between 9-beta-D arabinofuranosyladenine and 9-beta-D-arabinofuranosyl-2-fluoroadenine in human leukemic lymphoblasts. Cancer Res (1980) 1.14
A preliminary evaluation of 566C80 for the treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome. N Engl J Med (1991) 1.13
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine. Antimicrob Agents Chemother (1997) 1.12
Enzyme immunoassays of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate using acetylcholinesterase. Anal Chem (1989) 1.12
Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neurons. J Biol Chem (2000) 1.11
Effect of methotrexate on deoxyribonucleotide pools and DNA synthesis in human lymphocytic cells. Cancer Res (1974) 1.10
Screening slaughtered cattle for BSE. Nature (2001) 1.09
A systemic and cellular model for zidovudine plasma concentrations and intracellular phosphorylation in patients. J Infect Dis (1996) 1.09
Cellular prion protein status in sheep: tissue-specific biochemical signatures. J Gen Virol (2001) 1.09
Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain. Neuroscience (2007) 1.08
Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells. Antimicrob Agents Chemother (1994) 1.08
Mullerian inhibiting substance regulates NFkappaB signaling and growth of mammary epithelial cells in vivo. J Biol Chem (2001) 1.08
Molecular architecture of acetylcholinesterase collagen-tailed forms; construction of a glycolipid-tailed tetramer. EMBO J (1992) 1.05
Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol (2001) 1.05
Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants. J Infect Dis (1999) 1.05
Effects of the epipodophyllotoxin VP-16-213 on cell cycle traverse, DNA synthesis, and DNA strand size in cultures of human leukemic lymphoblasts. Cancer Res (1983) 1.04
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis. J Biol Chem (1993) 1.04
Two-site enzyme immunometric assays for determination of native and denatured beta-lactoglobulin. J Immunol Methods (1998) 1.04
Quantitation of intracellular zidovudine phosphates by use of combined cartridge-radioimmunoassay methodology. Antimicrob Agents Chemother (1996) 1.03
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine. Mol Pharmacol (1991) 1.03
Differential measurement of constitutive (COX-1) and inducible (COX-2) cyclooxygenase expression in human umbilical vein endothelial cells using specific immunometric enzyme immunoassays. Biochim Biophys Acta (1995) 1.02
Evaluation of a high IgE-responder mouse model of allergy to bovine beta-lactoglobulin (BLG): development of sandwich immunoassays for total and allergen-specific IgE, IgG1 and IgG2a in BLG-sensitized mice. J Immunol Methods (2000) 1.02
Field intercomparison of a novel optical sensor for formaldehyde quantification. Geophys Res Lett (2000) 1.02
An immunological study of rat acetylcholinesterase: comparison with acetylcholinesterases from other vertebrates. J Neurochem (1984) 1.01
DNA precursors in eukaryotic cells. Nat New Biol (1973) 1.01
Crystal-neutrophil interactions lead to interleukin-1 synthesis. Agents Actions (1991) 1.01
Anomalous accumulation and decay of 2',3'-dideoxyadenosine-5'-triphosphate in human T-cell cultures exposed to the anti-HIV drug 2',3'-dideoxyinosine. Drug Metab Dispos (1993) 1.01
Insulin resistance and promotion of aberrant crypt foci in the colons of rats on a high-fat diet. Nutr Cancer (1997) 1.01
Direct determination of phosphorylated intracellular anabolites of stavudine (d4T) by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2001) 1.00
Development, validation and application of an enzyme immunoassay (EIA) of atriopeptin. Biochem Biophys Res Commun (1987) 1.00
Multicenter case-control study of risk factors for histoplasmosis in human immunodeficiency virus-infected persons. Clin Infect Dis (2001) 0.98
Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies. J Neurochem (2002) 0.98
Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells. Biochemistry (1990) 0.97
Prevention of relapse of histoplasmosis with fluconazole in patients with the acquired immunodeficiency syndrome. Am J Med (1994) 0.97
Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates. Mol Pharmacol (1995) 0.96
Monoclonal antibodies allow precipitation of esterasic but not peptidasic activities associated with butyrylcholinesterase. J Neurochem (1990) 0.96
Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication. Mol Pharmacol (1997) 0.95
Effects of G6P-, 2-deoxy-G6P and UMP on phosphorylase and glycogen synthetase of pigeon liver. Arch Biochem Biophys (1965) 0.95
Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases. Cancer Res (1981) 0.95
The role of the preserved sequences of Dam methylase. Nucleic Acids Res (1993) 0.95
Glucose-insulin-potassium solutions enhance recovery after urgent coronary artery bypass grafting. J Thorac Cardiovasc Surg (1997) 0.94
Immunometric assay of low molecular weight haptens containing primary amino groups. Anal Chem (1994) 0.93
Existence of an inactive pool of acetylcholinesterase in chicken brain. Proc Natl Acad Sci U S A (1993) 0.93
Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group. Antimicrob Agents Chemother (2000) 0.93
An immunoglobulin M monoclonal antibody, recognizing a subset of acetylcholinesterase molecules from electric organs of Electrophorus and Torpedo, belongs to the HNK-1 anti-carbohydrate family. J Neurochem (1987) 0.93
Studies on glycogen synthesis in pigeon liver homogenates. Incorporation of hexose into glycogen. Biochem J (1967) 0.92
Acute nicotine treatment prevents REM sleep deprivation-induced learning and memory impairment in rat. Hippocampus (2010) 0.92
A general method allowing the design of oligonucleotide primers to amplify the variable regions from immunoglobulin cDNA. J Immunol Methods (2003) 0.91
A solid-phase immobilized epitope immunoassay (SPIE-IA) permitting very sensitive and specific measurement of angiotensin II in plasma. J Immunol Methods (1999) 0.91
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2' ,3'-dideoxyguanosine. Biochem Biophys Res Commun (1990) 0.91
Efficacy of adjuvant chemotherapy according to Prion protein expression in patients with estrogen receptor-negative breast cancer. Ann Oncol (2007) 0.91
Kinematics and thermodynamics of a folding heteropolymer. Proc Natl Acad Sci U S A (1993) 0.91
The binding sites of inhibitory monoclonal antibodies on acetylcholinesterase. Identification of a novel regulatory site at the putative "back door". J Biol Chem (1999) 0.90
Immunolocalization of the cellular prion protein in normal brain. Microsc Res Tech (2000) 0.89
Identification of purine deoxyribonucleoside kinases from human leukemia cells: substrate activation by purine and pyrimidine deoxyribonucleosides. Biochemistry (1987) 0.89
Synthesis in vitro of precursors of the catalytic subunits of acetylcholinesterase from Torpedo marmorata and Electrophorus electricus. Eur J Biochem (1984) 0.89
Adenovirus parotitis in patients with AIDS. Clin Infect Dis (1994) 0.88
Aberrant crypt focus promotion and glucose intolerance: correlation in the rat across diets differing in fat, n-3 fatty acids and energy. Carcinogenesis (1998) 0.88
Inhibition of deoxyribonucleic acid chain initiation: a new mode of action for 1-beta-D-arabinofuranosylcytosine in human lymphoblasts. Biochemistry (1977) 0.88
Transcription of granzyme A and B genes is differentially regulated during lymphoid ontogeny. J Exp Med (1995) 0.87
Acetylcholinesterases from Elapidae snake venoms: biochemical, immunological and enzymatic characterization. Biochim Biophys Acta (1997) 0.87