Published in J Immunol on October 15, 1998
Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation. J Exp Med (2005) 2.59
CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunol Rev (2006) 2.49
Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med (1999) 2.33
IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells. Cell Immunol (2009) 1.26
Regulation of CD4+ T-cell contraction during pathogen challenge. Immunol Rev (2010) 1.14
Substrate rigidity regulates human T cell activation and proliferation. J Immunol (2012) 1.09
CD4 T-cell memory can persist in the absence of class II. Philos Trans R Soc Lond B Biol Sci (2000) 0.94
Antigen dose, type of antigen-presenting cell and time of differentiation contribute to the T helper 1/T helper 2 polarization of naive T cells. Immunology (2003) 0.87
Tumour necrosis factor-alpha but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation. Immunology (2003) 0.86
Identification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H1N1 influenza virus and its antigen-driven TCR usage signature in BALB/c mice. Cell Mol Immunol (2016) 0.77
IL-4 directs the development of Th2-like helper effectors. J Immunol (1990) 7.20
T cell memory. Annu Rev Immunol (1998) 5.20
T cell subsets and the recognition of MHC class. Immunol Rev (1983) 5.00
Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol (2000) 4.73
Class II-independent generation of CD4 memory T cells from effectors. Science (1999) 3.96
Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen. Proc Natl Acad Sci U S A (1981) 3.28
Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev (1991) 3.21
Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med (1994) 3.02
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function. Proc Natl Acad Sci U S A (1981) 2.95
Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. J Exp Med (2000) 2.91
The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol (2000) 2.90
Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol (1994) 2.86
Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals. J Immunol (1996) 2.76
Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med (1997) 2.59
Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays. J Exp Med (1983) 2.56
Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med (1999) 2.33
Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements. J Exp Med (1992) 2.30
Qualitative changes accompany memory T cell generation: faster, more effective responses at lower doses of antigen. J Immunol (2000) 2.23
Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor. J Exp Med (1982) 2.22
Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. J Immunol (1987) 2.19
Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J Immunol (1991) 2.15
Antigen-independent changes in naive CD4 T cells with aging. J Exp Med (1996) 2.14
Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. Proc Natl Acad Sci U S A (1987) 2.04
Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci U S A (1996) 2.01
The specific direct interaction of helper T cells and antigen-presenting B cells. Proc Natl Acad Sci U S A (1986) 1.98
E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J (1999) 1.93
Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation. J Immunol (2000) 1.92
CD4(+) T cell effectors can become memory cells with high efficiency and without further division. Nat Immunol (2001) 1.88
Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. J Immunol (1995) 1.74
Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells. J Immunol (1990) 1.73
Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line. J Immunol (1981) 1.73
Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor. J Immunol (1992) 1.72
The Lyt phenotype of a long-term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly-1 cells. Eur J Immunol (1981) 1.72
D-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3. J Rheumatol (1984) 1.69
Monoclonal antibody to L3T4 blocks the function of T cells specific for class 2 major histocompatibility complex antigens. J Immunol (1984) 1.62
Helper cells activated by allogeneic H-2K or H-2D differences have a Ly phenotype distinct from those responsive to I differences. J Immunol (1979) 1.57
Xenogeneic human anti-mouse T cell responses are due to the activity of the same functional T cell subsets responsible for allospecific and major histocompatibility complex-restricted responses. J Exp Med (1983) 1.56
Continuously proliferating allospecific T cells. I. Specificity of cooperation with allogeneic B cells in the humoral antibody response to sheep erythrocytes. J Exp Med (1979) 1.54
Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin. J Exp Med (1994) 1.53
Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen. J Immunol (1993) 1.45
The significance of T-B collaboration across haplotype barriers. Cold Spring Harb Symp Quant Biol (1977) 1.44
T cell replacing factors in the B cell response to antigen. Immunol Rev (1982) 1.44
In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines. J Immunol (1998) 1.43
T-cell memory: new perspectives. Immunol Today (1993) 1.43
Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J Exp Med (1995) 1.41
Small subunit of I-A subregion antigens determines the allospecificity recognized by a monoclonal antibody. Nature (1980) 1.38
Negative allogeneic effects in vitro. I. Allogeneic T cells markedly suppress the secondary antibody-forming cell response. J Immunol (1977) 1.30
Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol (1995) 1.30
Superantigen-induced CD4 T cell tolerance mediated by myeloid cells and IFN-gamma. J Immunol (2000) 1.28
Use of prolonged standing for individuals with spinal cord injuries. Phys Ther (2001) 1.26
B cell response to T helper cell subsets. II. Both the stage of T cell differentiation and the cytokines secreted determine the extent and nature of helper activity. J Immunol (1991) 1.25
Production of Con A-induced helper T cell replacing factor requires a T cell and an Ia-positive non-T cells. J Immunol (1980) 1.23
Role of BCGFII in the differentiation to antibody secretion normal and tumor B cells. J Immunol (1985) 1.21
CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy. J Exp Med (1992) 1.20
Hallmarks of CD4 T cell immunity against influenza. J Intern Med (2011) 1.19
B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors. J Exp Med (1987) 1.17
Single cell analyses of cytokine production. Curr Opin Immunol (1997) 1.15
Transferable anergy: superantigen treatment induces CD4+ T cell tolerance that is reversible and requires CD4-CD8- cells and interferon gamma. J Exp Med (1997) 1.15
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection. J Exp Med (1980) 1.14
Partial purification and characterization of a BCGFII from EL4 culture supernatants. J Immunol (1984) 1.13
Role of antigen-presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages. Eur J Immunol (1994) 1.10
Treatment of poor-prognosis early rheumatoid arthritis. A randomized study of treatment with methotrexate, cyclosporin A, and intraarticular corticosteroids compared with sulfasalazine alone. Arthritis Rheum (2000) 1.07
Regulation of isotype production by IL-4 and IL-5. Effects of lymphokines on Ig production depend on the state of activation of the responding B cells. J Immunol (1989) 1.06
Ly phenotypes and MHC recognition: the allohelper that recognizes K or D is a mature Ly123 cell. J Immunol (1979) 1.06
Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals. Int Immunol (1996) 1.06
B cell response to fresh and effector T helper cells. Role of cognate T-B interaction and the cytokines IL-2, IL-4, and IL-6. J Immunol (1991) 1.05
Fine specificity mapping of two allospecific T cell lines: recognition of private specificities in the H-2 IA subregion. Eur J Immunol (1981) 1.04
The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines. Vaccine (2000) 1.03
Transcriptional repression of the IL-2 gene in Th cells by ZEB. J Immunol (1998) 1.01
The generation and maintenance of memory T and B cells. Immunol Today (1999) 1.00
TGF-beta1: immunosuppressant and viability factor for T lymphocytes. Microbes Infect (1999) 0.99
From naive to memory. Development and regulation of CD4+ T cell responses. Immunol Res (1998) 0.99
Regulation of T cell subsets from naive to memory. J Immunother (1998) 0.99
Evidence for two distinct activation states available to B lymphocytes. J Immunol (1984) 0.98
Association of Ly phenotypes, T cell function and MHC recognition. Fed Proc (1980) 0.97
Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis. J Immunol (1992) 0.96
Regulation of the immune response T-cell interactions. CRC Crit Rev Immunol (1982) 0.96
Deficient sulphoxidation status and D-penicillamine toxicity. Lancet (1983) 0.96
Analysis of CD4+ T cells that provide contact-dependent bystander help to B cells. J Immunol (1992) 0.96
Alloreactivity, the development of the T cell repertoire and the understanding of T cell function. Immunol Rev (1978) 0.95
The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J Immunol (1995) 0.95
Distinct lymphokine production by CD4+ T cells isolated from mucosal and systemic lymphoid organs. Immunology (1993) 0.95
Age-related changes in CD4 T cells of T cell receptor transgenic mice. Mech Ageing Dev (1997) 0.94
CD4 T cells producing IFN-gamma in the lungs of mice challenged with mycobacteria express a CD27-negative phenotype. Clin Exp Immunol (2004) 0.93
Significance of class 1 and class 2 major histocompatibility complex antigens: help to allogeneic K and D antigens does not involve I recognition. J Immunol (1981) 0.93
Regulation of the IgM and IgA anti-dextran B1355S response: synergy between IFN-gamma, BCGF II, and IL 2. J Immunol (1985) 0.93
Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5). J Immunol (1987) 0.90
Negative allogeneic effects in vitro. II. Mapping of histocompatibility differences leading to allosuppression. J Immunol (1977) 0.89
A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion. J Exp Med (1982) 0.89
IL-2 receptor (Tac antigen) protein expression is down-regulated by the 5'-untranslated region of the mRNA. J Immunol (1990) 0.88
Interleukin 18: tipping the balance towards a T helper cell 1 response. J Exp Med (2001) 0.88
Frequency of allogeneic helper T cells responding to whole H-2 differences and to an H-2K difference alone. J Immunol (1979) 0.87
Salicylates and homeopathy. Br J Clin Pharmacol (1979) 0.86
B cell immunodeficiency fails to develop in CD4-deficient mice infected with BM5: murine AIDS as a multistep disease. J Immunol (2001) 0.86
Induction of the H-2 D antigen during B cell activation. J Immunol (1989) 0.84
Role of Ia-positive cells in the production of T cell-replacing factors: blocking of factor production with anti-Ia serum. J Immunol (1980) 0.83