Published in Proc Natl Acad Sci U S A on October 27, 1998
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore) (2010) 2.26
IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity (2008) 1.83
CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect Immun (2004) 1.70
Pneumococcal infections in humans are associated with increased apoptosis and trafficking of type 1 cytokine-producing T cells. Infect Immun (2002) 1.32
Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans. Eur J Immunol (2012) 1.24
Clinical consequences of defects in the IL-12-dependent interferon-gamma (IFN-gamma) pathway. Clin Exp Immunol (2000) 1.16
Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway. Int J Exp Pathol (2002) 1.07
T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice. PLoS Pathog (2012) 1.01
Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection. Am J Pathol (2001) 0.99
Streptococcus pneumoniae autolysis prevents phagocytosis and production of phagocyte-activating cytokines. Infect Immun (2009) 0.97
Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis. Arthritis Res (2000) 0.94
Optimized immune response elicited by a DNA vaccine expressing pneumococcal surface protein a is characterized by a balanced immunoglobulin G1 (IgG1)/IgG2a ratio and proinflammatory cytokine production. Clin Vaccine Immunol (2008) 0.93
Impaired monocyte IL-12 production before surgery as a predictive factor for the lethal outcome of postoperative sepsis. Ann Surg (2002) 0.91
Optimized expression and specific activity of IL-12 by directed molecular evolution. Proc Natl Acad Sci U S A (2003) 0.83
STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis. Clin Diagn Lab Immunol (2001) 0.83
Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression. Curr Immunol Rev (2005) 0.80
Inhibition of p38 MAP kinase during cellular activation results in IFN-gamma-dependent augmentation of IL-12 production by human monocytes/macrophages. Clin Exp Immunol (2001) 0.80
Regulation of Natural Killer Cell Function by STAT3. Front Immunol (2016) 0.76
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science (1990) 17.86
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med (1989) 10.60
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med (1992) 8.27
A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med (1996) 7.66
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol (1991) 6.30
IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity (1996) 6.16
Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. N Engl J Med (1996) 5.36
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci U S A (1990) 4.60
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science (1998) 4.58
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci U S A (1991) 4.48
Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science (1998) 4.24
Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol (1995) 3.76
Severe combined immunodeficiency due to a specific defect in the production of interleukin-2. N Engl J Med (1990) 2.84
Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J Exp Med (1995) 2.80
Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. J Clin Invest (1998) 2.67
Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood (1995) 2.36
Interleukin-12. J Leukoc Biol (1994) 2.22
Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr Opin Immunol (1995) 1.99
Fatal disseminated Mycobacterium smegmatis infection in a child with inherited interferon gamma receptor deficiency. Clin Infect Dis (1997) 1.96
Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. J Clin Immunol (1994) 1.52
Defective monocyte costimulation for IFN-gamma production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation. J Immunol (1996) 1.39
IL-12: a key cytokine in immune regulation. Immunol Today (1996) 1.31
IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J Immunol (1996) 1.22
CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner. J Immunol (1998) 1.20
Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes. Proc Natl Acad Sci U S A (1990) 1.01
Absence of interleukin 2 production in a severe combined immunodeficiency disease syndrome with T cells. J Exp Med (1990) 1.01
In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood. J Clin Invest (1967) 10.26
Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function. J Clin Invest (1967) 9.01
Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. J Exp Med (1981) 6.82
Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors. J Exp Med (1976) 5.50
Acute poststreptococcal glomerulonephritis: immune deposit disease. J Clin Invest (1966) 4.64
Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet (1968) 4.41
Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen. Proc Natl Acad Sci U S A (1981) 4.38
The functions of the thymus system and the bursa system in the chicken. J Exp Med (1966) 4.07
Fatal granulomatous disease of childhood. An inborn abnormality of phagocytic function. Lancet (1966) 3.97
The IgA system. I. Studies of the transport and immunochemistry of IgA in the saliva. J Exp Med (1966) 3.97
Primary immunodeficiencies. Report of a World Health Organization Committee. Pediatrics (1971) 3.69
Wiskott-Aldrich syndrome. An immunologic deficiency disease involving the afferent limb of immunity. Am J Med (1968) 3.54
Protection of phagocytized bacteria from the killing action of antibiotics. Nature (1966) 3.12
Identification of a p69,71 complex expressed on human T cells sharing determinants with B-type chronic lymphatic leukemic cells. J Exp Med (1980) 2.89
Complement activity and inflammatory neutrophil exudation in man. Studies in patients with glomerulonephritis, essential hypocomplementemia and agammaglobulinemia. Int Arch Allergy Appl Immunol (1967) 2.64
Genetic linkage of hyper-IgE syndrome to chromosome 4. Am J Hum Genet (1999) 2.63
The cellular immune defect in chronic mucocutaneous candidiasis. Lancet (1969) 2.53
C2 deficiency. Development of lupus erythematosus. J Clin Invest (1973) 2.52
A newly defined X-linked trait in man with demonstration of the Lyon effect in carrier females. Lancet (1967) 2.47
Influence of diet on survival of mice. Proc Natl Acad Sci U S A (1976) 2.45
An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family. Proc Natl Acad Sci U S A (1992) 2.43
Deficient immunologic functions of NZB mice. Proc Soc Exp Biol Med (1968) 2.41
The complement profile in acute glomerulonephritis systemic lupus erythematosus and hypocomplementemic chronic glomerulonephritis. Contrasts and experimental correlations. Int Arch Allergy Appl Immunol (1968) 2.38
Effects of protein insufficiency on immune responsiveness. Am J Clin Nutr (1974) 2.37
Localization of immunological complexes fixing beta1C (C3) in germinal centers of lymph nodes. J Exp Med (1969) 2.36
Chemical suppression of adaptive immunity. Adv Immunol (1967) 2.35
Growth of a pure population of mouse mast cells in vitro with conditioned medium derived from concanavalin A-stimulated splenocytes. Proc Natl Acad Sci U S A (1981) 2.33
NK1.1+ CD4+ CD8- thymocytes with specific lymphokine secretion. Eur J Immunol (1993) 2.32
Effect of antibiotics on the bactericidal activity of human leukocytes. J Lab Clin Med (1968) 2.31
Occurrence of malignancy in immunodeficiency diseases. A literature review. Cancer (1971) 2.31
T-cell depletion of HLA-identical transplants in leukemia. Blood (1991) 2.25
Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction. Proc Natl Acad Sci U S A (1981) 2.16
Suppression of B-cell differentiation by leukocytes from hypogammaglobulinemic patients. J Clin Invest (1976) 2.15
Improved tests for the evaluation of neutrophil function in human disease. J Lab Clin Med (1968) 2.11
A mammalian equivalent of the avian bursa of Fabricius. Lancet (1966) 2.11
Development and function of the immunoglobulin producing system. I. Effect of bursectomy at different stages of development on germinal centers, plasma cells, immunoglobulins and antibody production. Int Arch Allergy Appl Immunol (1969) 2.06
Kaposi's sarcoma: a review and recent developments. CA Cancer J Clin (1981) 2.05
Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A (1999) 2.04
Development of "autoimmune processes" in rabbits after neonatal removal of central lymphoid tissue. Lancet (1965) 2.04
Influence of the human T-lymphotropic virus/lymphadenopathy-associated virus on functions of human lymphocytes: evidence for immunosuppressive effects and polyclonal B-cell activation by banded viral preparations. Proc Natl Acad Sci U S A (1985) 2.04
Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation. Proc Natl Acad Sci U S A (1985) 2.03
Phytohaemagglutinin unresponsiveness of lymphocytes from babies with congenital rubella. Nature (1967) 1.99
Mechanism of action of migration inhibitory factor (MIF). I. Evidence for a receptor for MIF present on the peritoneal macrophage but not on the alveolar macrophage. J Exp Med (1972) 1.99
Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation. Blood (1990) 1.98
Rationale for bone marrow transplantation in the treatment of autoimmune diseases. Proc Natl Acad Sci U S A (1985) 1.97
The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations. J Clin Invest (1966) 1.96
Humoral and cell-mediated immune responses in fully allogeneic bone marrow chimera in mice. J Exp Med (1980) 1.94
Chronic glomerulonephritis associated with low serum complement activity (chronic hypocomplementemic glomerulonephritis). Medicine (Baltimore) (1970) 1.94
Glomerular localization and transport of aggregated proteins in mice. Lab Invest (1967) 1.94
Passive hemolysis by serum and cobra venom factor: a new mechanism inducing membrane damage by complement. Proc Natl Acad Sci U S A (1969) 1.92
Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation. J Exp Med (1977) 1.91
Rosette-formation with mouse erythrocytes. II. A marker for human B and non-T lymphocytes. Clin Exp Immunol (1976) 1.87
Decreased properdin activity in acute glomerulonephritis. Int Arch Allergy Appl Immunol (1969) 1.83
A proposed classification of primary immunologic deficiencies. Am J Med (1968) 1.83
Association of renal allograft rejection with virus infections. Am J Med (1974) 1.83
Abnormalities of in vitro lymphocyte responses during rubella virus infections. J Exp Med (1968) 1.82
Pneumocystis carinii infection. Medicine (Baltimore) (1973) 1.79
Voluntary school screening for scoliosis in Minnesota. J Bone Joint Surg Am (1982) 1.78
Hypothalamic-pituitary-adrenal axis suppression associated with the use of inhaled fluticasone propionate. J Allergy Clin Immunol (1998) 1.77
Subpopulations of human T lymphocytes. II. Effect of thymopoietin, corticosteroids, and irradiation. Cell Immunol (1977) 1.76
Role of the thymus and other central lymphoid tissues in immunological disease. Annu Rev Med (1967) 1.76
Hereditary C2 deficiency: Genetic studies and association with the HL-A system. J Exp Med (1975) 1.75
Complete absence of the third component of complement in man. J Clin Invest (1975) 1.75
Absence of enhancing antibody in cell mediated immunity to tumour heterografts in protein deficient rats. Nature (1971) 1.74
N.B.T. test stimulated. Lancet (1970) 1.73
B and T lymphocytes in primary immunodeficiency disease in man. J Clin Invest (1973) 1.72
Ontogeny of lymphocyte subpopulations in human fetal liver. Proc Natl Acad Sci U S A (1976) 1.71
Biosynthesis and secretion of immunoglobulins by peripheral-blood lymphocytes in severe hypogammaglobulinaemia. Lancet (1972) 1.71
Transplantation for acute leukaemia with HLA-A and B nonidentical parental marrow cells fractionated with soybean agglutinin and sheep red blood cells. Lancet (1981) 1.70
Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity. Lab Invest (1970) 1.69
Subpopulations of human T lymphocytes. I. Studies in immunodeficient patients. Clin Exp Immunol (1977) 1.69
Lymphoid tissue abnormalities associated with ataxia-telangiectasia. Am J Med (1966) 1.69
Growth in children with cerebral palsy fed via gastrostomy. Pediatrics (1988) 1.69
Role of helper, suppressor and B-cell defects in the pathogenesis of the hypogammaglobulinemias. N Engl J Med (1978) 1.64
Complement and complement-like activity in lower vertebrates and invertebrates. J Exp Med (1970) 1.61
Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. Proc Natl Acad Sci U S A (1999) 1.61
Three distinct stages of B-cell defects in common varied immunodeficiency. Proc Natl Acad Sci U S A (1982) 1.60
Lymphocyte studies in congenital thymic dysplasia: The one-way stimulation test. J Pediatr (1968) 1.59
Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. Proc Natl Acad Sci U S A (1979) 1.59
Fatal (chronic) granulomatous disease of childhood: a hereditary defect of leukocyte function. Semin Hematol (1968) 1.58
Age, thymic involution, and circulating thymic hormone activity. J Clin Endocrinol Metab (1978) 1.58
Treatment of lymphopenic hypogammaglobulinemia and bone-marrow aplasia by transplantation of allogeneic marrow. Crucial role of histocompatiility matching. N Engl J Med (1969) 1.58
Dyschondrosteosis. The most common cause of Madelung's deformity. J Pediatr (1966) 1.57
Complement-dependent biological functions in complement deficiency in man. Lancet (1966) 1.56
Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance. Proc Natl Acad Sci U S A (1990) 1.56
Complement inactivation by serum from patients with acute and hypocomplementemic chronic glomerulonephritis. J Lab Clin Med (1968) 1.54
Stimulatory and inhibitory influences of human immunodeficiency virus on normal B lymphocytes. Proc Natl Acad Sci U S A (1986) 1.54
Pathogenesis of avian lymphoid leukosis. I. Histogenesis. J Natl Cancer Inst (1968) 1.54
Ontogeny of circulating immunoglobulin in normal, bursectomized and irradiated chickens. J Immunol (1969) 1.54
A model for colostral IgA. Proc Natl Acad Sci U S A (1966) 1.53
Influence of dietary restriction on immunologic function and renal disease in (NZB x NZW) F1 mice. Proc Natl Acad Sci U S A (1978) 1.52
C1r deficiency: an inborn error associated with cutaneous and renal disease. J Clin Invest (1972) 1.52
Suppression of immunoglobulin synthesis and secretion by peripheral blood lymphocytes from normal donors. Proc Natl Acad Sci U S A (1977) 1.50
Prevention of the localized and generalized Shwartzman reactions by an anticomplementary agent, cobra venom factor. J Exp Med (1971) 1.49