Published in Exp Hematol on November 01, 1998
The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science (1988) 9.05
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature (1990) 8.94
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell (1993) 6.04
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell (1993) 4.06
B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J Exp Med (1996) 3.35
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity (1996) 3.33
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci U S A (1993) 2.88
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A (1997) 2.67
Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes (1993) 2.63
Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med (1997) 2.36
The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proc Natl Acad Sci U S A (1992) 2.28
"Viable motheaten," a new allele at the motheaten locus. I. Pathology. Am J Pathol (1984) 2.26
Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice. Science (1986) 2.24
Gamma-interferon is one of several direct B cell-maturing lymphokines. Nature (1984) 2.18
Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun (2007) 2.05
Dissected nucleus-independent chemical shift analysis of pi-aromaticity and antiaromaticity. Org Lett (2001) 2.01
Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol (2009) 2.00
Genetically determined murine models of immunodeficiency. Annu Rev Immunol (1987) 1.98
SCID mouse models of human stem cell engraftment. Stem Cells (1998) 1.98
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet (1996) 1.96
Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered (1976) 1.94
Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol (1997) 1.85
Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus. Arch Dermatol (2001) 1.79
Variables controlling the expression level of exogenous genes in Dictyostelium. Plasmid (1999) 1.76
Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol (2001) 1.73
Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol (1996) 1.68
Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol (2008) 1.68
Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest (1998) 1.67
High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J Infect Dis (1995) 1.58
Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit. Oncogene (1993) 1.58
A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. J Biol Chem (1997) 1.50
Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice. Am J Pathol (1995) 1.49
Humanized SCID mouse models for biomedical research. Curr Top Microbiol Immunol (2008) 1.48
Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. J Immunol (1997) 1.48
Quantitation and detection of isotypes of anti-SS-B antibodies by ELISA and Farr assays using affinity purified antigens. An approach to the investigation of Sjögren's syndrome and systemic lupus erythematosus. Arthritis Rheum (1983) 1.48
The immunodeficient scid mouse as a model for human lymphatic filariasis. J Exp Med (1991) 1.45
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. J Biol Chem (1994) 1.45
Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors. Development (1998) 1.44
Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol (1976) 1.43
Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest (2001) 1.43
Outbreaks of Pneumocystis carinii pneumonia in colonies of immunodeficient mice. Infect Immun (1989) 1.43
The mouse mutation severe combined immune deficiency (scid) is on chromosome 16. Immunogenetics (1989) 1.41
CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia (2008) 1.39
Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J Agric Food Chem (2000) 1.38
Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages. J Leukoc Biol (1996) 1.37
Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med (1997) 1.37
Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells. J Immunol (1993) 1.36
Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor. Am J Pathol (1991) 1.35
Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J Biol Chem (1998) 1.34
Preservation of functioning human thyroid organoids in the scid mouse: 1. System characterization. J Clin Endocrinol Metab (1993) 1.33
Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity. J Biol Chem (1995) 1.33
Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation (1997) 1.33
Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells. Proc Natl Acad Sci U S A (1998) 1.30
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene (1998) 1.30
Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics (1981) 1.30
Follicular dendritic cell (FDC) precursors in primary lymphoid tissues. J Immunol (1998) 1.28
Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood (1997) 1.28
Defects in gliding motility in mutants of Cytophaga johnsonae lacking a high-molecular-weight cell surface polysaccharide. J Bacteriol (1991) 1.24
Transplantable B-cell lymphomas in B10. H-2aH-4bp/Wts mice. Immunogenetics (1982) 1.23
In the absence of a CD40 signal, B cells are tolerogenic. Immunity (1995) 1.23
NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice. Diabetes (1988) 1.22
Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. Blood (1997) 1.21
Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. J Clin Invest (2000) 1.21
The mouse mutant "motheaten." II. Functional studies of the immune system. J Immunol (1978) 1.21
Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages. J Exp Med (1993) 1.20
A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron (2001) 1.20
'Wasted', a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia. Nature (1982) 1.20
Novel B-cell maturation factor from spontaneously autoimmune viable motheaten mice. Proc Natl Acad Sci U S A (1984) 1.20
B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. J Exp Med (2000) 1.19
Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages. Arch Histol Cytol (1999) 1.18
Engagement of Gab1 and Gab2 in erythropoietin signaling. J Biol Chem (1999) 1.17
Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice. Am J Pathol (1997) 1.15
Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. Mol Cell Biol (1994) 1.15
Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. J Biol Chem (1995) 1.15
Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice. Diabetes (1995) 1.14
Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols. Hum Mol Genet (1995) 1.14
High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias. Leukemia (2010) 1.13
Hematopoietic stem cell function in motheaten mice. Exp Hematol (1983) 1.13
Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells. Clin Exp Immunol (2013) 1.13
IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J Immunol (1999) 1.12
NOD mice have a generalized defect in their response to transplantation tolerance induction. Diabetes (1999) 1.12
Small hepatocellular carcinoma in patients with chronic liver damage: prospective comparison of detection with dynamic MR imaging and helical CT of the whole liver. Radiology (1996) 1.11
Pleiotropic effects of deleterious alleles at the "motheaten" locus. Curr Top Microbiol Immunol (1988) 1.11
Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. J Immunol (1978) 1.11
LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Hum Gene Ther (1997) 1.11
Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol (1998) 1.11
Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction. Exp Hematol (1997) 1.10
Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes. J Exp Med (1995) 1.10
Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes (1994) 1.10
Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease. Eur J Immunol (1990) 1.09
Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol (1996) 1.09
Expression of terminal differentiation proteins defines stages of mouse mammary gland development. Vet Pathol (2006) 1.09