Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry.

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Published in Nat Med on November 01, 1998

Authors

J M Kilby1, S Hopkins, T M Venetta, B DiMassimo, G A Cloud, J Y Lee, L Alldredge, E Hunter, D Lambert, D Bolognesi, T Matthews, M R Johnson, M A Nowak, G M Shaw, M S Saag

Author Affiliations

1: Department of Medicine, University of Alabama at Birmingham, 35294-2050, USA.

Associated clinical trials:

Effect of an Enfuvirtide-based Anti-HIV Drug Regimen on Latent HIV Reservoirs in Treatment Naive Adults | NCT00051831

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Mosaic genome structure of simian immunodeficiency virus from west African green monkeys. EMBO J (1994) 3.19

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Species-specific diversity among simian immunodeficiency viruses from African green monkeys. J Virol (1991) 2.70

Inner-city residents, ethnic minorities and primary health care. Postgrad Med J (1983) 2.70

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Clinical and genetic studies of Birt-Hogg-Dubé syndrome. J Med Genet (2002) 2.65

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Coinfection and the evolution of parasite virulence. Proc Biol Sci (1995) 2.59

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Causes of HIV diversity. Nature (1995) 2.48

Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest (1999) 2.48