Surfactant protein A (SP-A) gene targeted mice.

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Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. Am J Hum Genet (2008) 2.53

Genetic disorders of surfactant dysfunction. Pediatr Dev Pathol (2009) 1.77

Surfactant protein-D and pulmonary host defense. Respir Res (2000) 1.41

Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. J Biol Chem (2010) 1.38

Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis. Infect Immun (2001) 1.24

Surfactant proteins A and D protect mice against pulmonary hypersensitivity induced by Aspergillus fumigatus antigens and allergens. J Clin Invest (2001) 1.24

Surfactant alteration and replacement in acute respiratory distress syndrome. Respir Res (2001) 1.23

Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation. J Allergy Clin Immunol (2008) 1.10

Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid. Immunology (2004) 1.09

Acute-phase proteins: As diagnostic tool. J Pharm Bioallied Sci (2011) 1.00

The role of surfactant in asthma. Respir Res (2001) 0.96

Ureaplasma and BPD. Semin Perinatol (2013) 0.95

Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancy. J Immunol (2010) 0.90

Interactions of pulmonary collectins with Bordetella bronchiseptica and Bordetella pertussis lipopolysaccharide elucidate the structural basis of their antimicrobial activities. Infect Immun (2004) 0.89

Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice. Proteome Sci (2010) 0.83

Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure. Respir Res (2009) 0.79

Pulmonary surfactant protein a is expressed in mouse retina by Müller cells and impacts neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci (2014) 0.78

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev (2001) 5.67

Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science (1994) 4.81

A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med (2001) 4.68

Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem (2000) 3.95

GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity (2001) 3.13

Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci U S A (1995) 3.08

Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice. Dev Biol (1993) 2.79

The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol Cell Biol (1994) 2.76

Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice. Proc Natl Acad Sci U S A (1993) 2.74

Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. J Clin Invest (1996) 2.49

Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells. J Biol Chem (1995) 2.43

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci U S A (2000) 2.32

Altered surfactant function and structure in SP-A gene targeted mice. Proc Natl Acad Sci U S A (1996) 2.29

Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR. Science (1994) 2.24

Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Am J Respir Crit Care Med (1999) 2.20

Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J Clin Invest (1995) 2.20

Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury. J Biol Chem (1992) 2.18

cis-acting elements that confer lung epithelial cell expression of the CC10 gene. J Biol Chem (1992) 2.18

Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung. J Immunol (2000) 2.12

FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am J Physiol Lung Cell Mol Physiol (2001) 2.12

Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J Clin Invest (1991) 2.11

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J Histochem Cytochem (1996) 2.03

Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest (1994) 1.96

Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol (1998) 1.92

Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas. Mod Pathol (1996) 1.90

Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. Cancer Res (1992) 1.86

Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood. Am J Physiol Lung Cell Mol Physiol (2004) 1.84

Surfactant protein D enhances clearance of influenza A virus from the lung in vivo. J Immunol (2001) 1.79

Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem (1998) 1.77

Surfactant protein A-deficient mice are susceptible to group B streptococcal infection. J Immunol (1997) 1.77

Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys. J Clin Invest (1999) 1.77

Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury. Am J Respir Cell Mol Biol (1999) 1.75

Function and regulation of expression of pulmonary surfactant-associated proteins. Biochem J (1991) 1.73

Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice. Am J Physiol (1991) 1.72

Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung. J Histochem Cytochem (1996) 1.69

Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc Natl Acad Sci U S A (2001) 1.68

Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene. Dev Biol (1996) 1.65

Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B. DNA (1989) 1.63

GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection. J Clin Invest (1999) 1.59

Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. Dev Biol (2001) 1.59

Lung cell-specific expression of the murine surfactant protein A (SP-A) gene is mediated by interactions between the SP-A promoter and thyroid transcription factor-1. J Biol Chem (1995) 1.58

Temporal-spatial distribution of SP-B and SP-C proteins and mRNAs in developing respiratory epithelium of human lung. J Histochem Cytochem (1994) 1.58

cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe). Proc Natl Acad Sci U S A (1987) 1.58

Tumor progression and cellular differentiation of pulmonary adenocarcinomas in SV40 large T antigen transgenic mice. Am J Respir Cell Mol Biol (1997) 1.55

Aberrant processing of surfactant protein C in hereditary SP-B deficiency. Am J Physiol (1995) 1.55

Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice. Proc Natl Acad Sci U S A (1990) 1.54

Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: evidence of persistent surfactant deficiency. J Pediatr Surg (1994) 1.54

Transient surfactant protein B deficiency in a term infant with severe respiratory failure. J Pediatr (1998) 1.53

Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice. J Immunol (2000) 1.52

Surfactant-associated protein inhibits phospholipid secretion from type II cells. J Appl Physiol (1985) (1987) 1.50

Molecular mechanisms controlling lung morphogenesis. Clin Genet (1999) 1.49

VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo. Dev Dyn (1998) 1.47

Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways. J Immunol (2001) 1.46

SP-A deficiency in primate model of bronchopulmonary dysplasia with infection. In situ mRNA and immunostains. Am J Respir Crit Care Med (1995) 1.46

Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation. Am J Physiol (1996) 1.46

Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo. Am J Physiol Lung Cell Mol Physiol (2000) 1.45

The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. Mol Cell Biol (1993) 1.44

Allelic heterogeneity in hereditary surfactant protein B (SP-B) deficiency. Am J Respir Crit Care Med (2000) 1.42

Pulmonary collectins and innate host defense of the lung. Microbes Infect (2001) 1.39

Clara cell secretory protein decreases lung inflammation after acute virus infection. Am J Physiol (1998) 1.39

Surfactant protein deficiency in familial interstitial lung disease. J Pediatr (2001) 1.37

Hydrophobic surfactant-associated protein in whole lung surfactant and its importance for biophysical activity in lung surfactant extracts used for replacement therapy. Pediatr Res (1986) 1.37

Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum Gene Ther (1995) 1.35

Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. Proc Natl Acad Sci U S A (2001) 1.35

Pulmonary dysfunction in neonatal SP-B-deficient mice. Am J Physiol (1997) 1.34

Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice. J Clin Invest (1994) 1.33

Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants. Am Rev Respir Dis (1992) 1.32

GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol (1997) 1.30

Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells. Mol Cell Biol (1996) 1.28

Purification of a cell-surface receptor for surfactant protein A. J Biol Chem (1996) 1.26

HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung. J Histochem Cytochem (1999) 1.26

Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival. EMBO J (1994) 1.25

Interleukin-4 alters epithelial cell differentiation and surfactant homeostasis in the postnatal mouse lung. Am J Respir Cell Mol Biol (1997) 1.24

Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice. Am J Respir Cell Mol Biol (1999) 1.24

Surfactant protein SP-B induces ordering at the surface of model membrane bilayers. Biochemistry (1990) 1.24

Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis. Hybridoma (1996) 1.23

Two SP-C genes encoding human pulmonary surfactant proteolipid. J Biol Chem (1988) 1.23

Ontogeny of surfactant proteins A and B in human amniotic fluid as indices of fetal lung maturity. Pediatr Res (1991) 1.22

GM-CSF regulates protein and lipid catabolism by alveolar macrophages. Am J Physiol Lung Cell Mol Physiol (2001) 1.21

Phospholipid binding and biophysical activity of pulmonary surfactant-associated protein (SAP)-35 and its non-collagenous COOH-terminal domains. J Biol Chem (1986) 1.21

Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. Am J Physiol (1996) 1.21

VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol (2004) 1.20

Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. Am J Physiol (1999) 1.19

Thyroid transcription factor-1 and cytokeratins 7 and 20 in pulmonary and breast carcinoma. Acta Cytol (1998) 1.18

In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum Gene Ther (1994) 1.17

Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung. Proc Natl Acad Sci U S A (1995) 1.16

Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein. J Clin Invest (1990) 1.16

Surfactant metabolism in SP-D gene-targeted mice. Am J Physiol Lung Cell Mol Physiol (2000) 1.16

Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1. Am J Physiol Lung Cell Mol Physiol (2005) 1.15

Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse. J Biol Chem (1990) 1.14

Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity. Am J Physiol (1992) 1.12

Biophysical and biological activity of a synthetic 8.7-kDa hydrophobic pulmonary surfactant protein SP-B. Proc Natl Acad Sci U S A (1990) 1.11

Utility of surfactant protein B precursor and thyroid transcription factor 1 in differentiating adenocarcinoma of the lung from malignant mesothelioma. Hum Pathol (1999) 1.11

GATA-6 activates transcription of surfactant protein A. J Biol Chem (2000) 1.11

Decreased lung compliance and air trapping in heterozygous SP-B-deficient mice. Am J Respir Cell Mol Biol (1997) 1.10

Cis-active elements controlling lung cell-specific expression of human pulmonary surfactant protein B gene. J Biol Chem (1993) 1.10

Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates. Hum Gene Ther (1996) 1.09

Immunologic identification of a pulmonary surfactant-associated protein of molecular weight = 6000 daltons. Pediatr Res (1986) 1.09

Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo. Am J Physiol Lung Cell Mol Physiol (2000) 1.08